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IE800429L - Penicillanic acid 1,1-dioxides - Google Patents

Penicillanic acid 1,1-dioxides

Info

Publication number
IE800429L
IE800429L IE800429A IE42980A IE800429L IE 800429 L IE800429 L IE 800429L IE 800429 A IE800429 A IE 800429A IE 42980 A IE42980 A IE 42980A IE 800429 L IE800429 L IE 800429L
Authority
IE
Ireland
Prior art keywords
penicillanic acid
vivo
readily hydrolyzable
esters
dioxide
Prior art date
Application number
IE800429A
Other versions
IE49535B1 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IE800429L publication Critical patent/IE800429L/en
Publication of IE49535B1 publication Critical patent/IE49535B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)

Abstract

A process for the preparation of penicillanic acid 1,1-dioxide and esters thereof readily hydrolyzable in vivo. Said process involves dehalogenation of a 6-halo or 6,6-dihalo derivative of penicillanic acid 1,1-dioxide or ester thereof readily hydrolyzable in vivo or a carboxy protected derivative thereof (e.g. by hydrogenolysis). The 6-halo and 6,6-dihalo derivatives of penicillanic acid 1,1-dioxides, esters thereof readily hydrolyzable in vivo, and carboxy protected derivatives thereof are novel intermediates. Penicillanic acid 1,1-dioxide, and esters thereof readily hydrolyzable in vivo, are known compounds which are useful as beta- lactamase inhibitors and for enhancing the effectiveness of certain beta-lactam antibiotics (e.g. the penicillins) in the treatment of bacterial infections in mammals, particularly humans. [GB2045755A]
IE429/80A 1979-03-05 1980-03-04 Process and intermediates for penicillanic acid 1,1-dioxide and esters thereof IE49535B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1781079A 1979-03-05 1979-03-05
US1780879A 1979-03-05 1979-03-05

Publications (2)

Publication Number Publication Date
IE800429L true IE800429L (en) 1980-09-05
IE49535B1 IE49535B1 (en) 1985-10-16

Family

ID=26690337

Family Applications (1)

Application Number Title Priority Date Filing Date
IE429/80A IE49535B1 (en) 1979-03-05 1980-03-04 Process and intermediates for penicillanic acid 1,1-dioxide and esters thereof

Country Status (36)

Country Link
KR (1) KR850001339B1 (en)
AR (1) AR225031A1 (en)
AT (1) AT366693B (en)
AU (1) AU522572B2 (en)
BG (1) BG33292A3 (en)
CH (1) CH644608A5 (en)
CS (1) CS215130B2 (en)
DD (1) DD149367A5 (en)
DE (1) DE3008257C2 (en)
DK (2) DK159852C (en)
EG (1) EG14437A (en)
ES (1) ES489185A0 (en)
FI (1) FI70024C (en)
FR (1) FR2450836B1 (en)
GB (1) GB2045755B (en)
GR (1) GR67234B (en)
HK (1) HK66587A (en)
HU (1) HU186304B (en)
IE (1) IE49535B1 (en)
IL (1) IL59515A (en)
IN (1) IN153685B (en)
IT (1) IT1130300B (en)
KE (1) KE3464A (en)
LU (1) LU82215A1 (en)
MX (1) MX6032E (en)
MY (1) MY8500319A (en)
NL (1) NL180317C (en)
NO (2) NO800618L (en)
PL (1) PL125197B1 (en)
PT (1) PT70897A (en)
RO (1) RO80112A (en)
SE (2) SE449103B (en)
SG (1) SG55884G (en)
SU (1) SU1192626A3 (en)
UA (1) UA6342A1 (en)
YU (1) YU42328B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419284A (en) * 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
IN159362B (en) * 1981-03-23 1987-05-09 Pfizer
US4360463A (en) 1981-09-02 1982-11-23 Pfizer Inc. Pure 6,6-diiodopenicillanic acid and process for its preparation
PT76526B (en) * 1982-04-19 1986-01-21 Gist Brocades Nv Preparation of 6-alpha-bromo- and/or 6,6-dibromopenicillanic acid 1,1-dioxides
IT1190897B (en) * 1982-06-29 1988-02-24 Opos Biochimica Srl PROCEDURE FOR THE PREPARATION OF THE 1-ETHOXYCARBONYLOXYETHYL ACID ACID 6- (D (-) - ALPHA AMINOALPHA-PHENYLACETAMIDE) -PENICILLANIC
US4606865A (en) * 1982-09-20 1986-08-19 Astra Lakemedel Aktiebolag Methods for the preparation of α-bromodiethylcarbonate
EP0139047A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the preparation of 6,6-dibromopenicillanic acid 1,1-dioxide
EP0139048A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the dehalogenation of 6,6-dibromopenicillanic acid 1,1-dioxide
US4596677A (en) * 1984-04-06 1986-06-24 Bristol-Myers Company Anhydropenicillin intermediates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN149747B (en) * 1977-06-07 1982-04-03 Pfizer
CA1158639A (en) * 1978-12-11 1983-12-13 Eric M. Gordon 6-bromopenicillanic acid sulfone
DE3068390D1 (en) * 1979-01-10 1984-08-09 Beecham Group Plc Penicillin derivatives, process for their preparation and pharmaceutical compositions containing certain of these compounds
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates

Also Published As

Publication number Publication date
DK145690D0 (en) 1990-06-14
SE8603309L (en) 1986-08-04
MY8500319A (en) 1985-12-31
ES8103094A1 (en) 1981-02-16
YU42328B (en) 1988-08-31
HU186304B (en) 1985-07-29
GB2045755A (en) 1980-11-05
FI800661A7 (en) 1980-09-06
IT1130300B (en) 1986-06-11
IL59515A0 (en) 1980-06-30
PL222448A1 (en) 1981-01-02
DE3008257C2 (en) 1984-03-01
SE8603309D0 (en) 1986-08-04
FR2450836A1 (en) 1980-10-03
PL125197B1 (en) 1983-04-30
UA6342A1 (en) 1994-12-29
KR850001339B1 (en) 1985-09-19
IE49535B1 (en) 1985-10-16
CS215130B2 (en) 1982-07-30
DK92680A (en) 1980-09-06
DK159852C (en) 1991-05-06
HK66587A (en) 1987-09-25
DK166353B (en) 1993-04-13
FR2450836B1 (en) 1986-03-21
AT366693B (en) 1982-04-26
ATA119080A (en) 1981-09-15
EG14437A (en) 1984-09-30
DK159852B (en) 1990-12-17
YU58580A (en) 1983-02-28
NL180317B (en) 1986-09-01
FI70024B (en) 1986-01-31
KE3464A (en) 1984-10-12
IL59515A (en) 1983-02-23
IT8020367A0 (en) 1980-03-05
BG33292A3 (en) 1983-01-14
SG55884G (en) 1985-03-08
NL180317C (en) 1987-02-02
NO823127L (en) 1980-09-08
MX6032E (en) 1984-10-04
GR67234B (en) 1981-06-25
AU522572B2 (en) 1982-06-17
ES489185A0 (en) 1981-02-16
IN153685B (en) 1984-08-04
SE449103B (en) 1987-04-06
DE3008257A1 (en) 1980-09-11
AR225031A1 (en) 1982-02-15
GB2045755B (en) 1983-01-26
DD149367A5 (en) 1981-07-08
DK145690A (en) 1990-06-14
NL8001285A (en) 1980-09-09
CH644608A5 (en) 1984-08-15
FI70024C (en) 1986-09-12
PT70897A (en) 1980-04-01
LU82215A1 (en) 1980-09-24
RO80112A (en) 1982-10-26
SU1192626A3 (en) 1985-11-15
NO800618L (en) 1980-09-08
AU5610480A (en) 1980-09-11
DK166353C (en) 1993-09-06
SE8000512L (en) 1980-09-06

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Legal Events

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