IE68591B1 - A process for the preparation of 2,7-diazabicyclo[3.3.0]octanes - Google Patents
A process for the preparation of 2,7-diazabicyclo[3.3.0]octanesInfo
- Publication number
- IE68591B1 IE68591B1 IE134390A IE134390A IE68591B1 IE 68591 B1 IE68591 B1 IE 68591B1 IE 134390 A IE134390 A IE 134390A IE 134390 A IE134390 A IE 134390A IE 68591 B1 IE68591 B1 IE 68591B1
- Authority
- IE
- Ireland
- Prior art keywords
- ethyl
- concentrated
- residue
- carbamate
- diazabicyclo
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- YETODIXQMRZKEG-UHFFFAOYSA-N 1,2,3,3a,4,5,6,6a-octahydropyrrolo[2,3-c]pyrrole Chemical class C1NCC2NCCC21 YETODIXQMRZKEG-UHFFFAOYSA-N 0.000 title claims abstract description 6
- 150000001875 compounds Chemical class 0.000 claims abstract description 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 21
- -1 preferably florine Inorganic materials 0.000 claims description 16
- 239000000460 chlorine Substances 0.000 claims description 10
- 229910052794 bromium Inorganic materials 0.000 claims description 9
- 229910052801 chlorine Inorganic materials 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 9
- 150000002367 halogens Chemical group 0.000 claims description 9
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 8
- 150000003862 amino acid derivatives Chemical class 0.000 claims description 8
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 8
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 7
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- 150000001728 carbonyl compounds Chemical class 0.000 claims description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
- 229910052731 fluorine Inorganic materials 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 3
- 239000011737 fluorine Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 125000006239 protecting group Chemical group 0.000 claims description 3
- 238000006736 Huisgen cycloaddition reaction Methods 0.000 claims description 2
- XTFIVUDBNACUBN-UHFFFAOYSA-N 1,3,5-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)N1CN([N+]([O-])=O)CN([N+]([O-])=O)C1 XTFIVUDBNACUBN-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000002253 acid Substances 0.000 abstract description 7
- 150000007513 acids Chemical class 0.000 abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 239000000543 intermediate Substances 0.000 abstract description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 129
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 98
- 239000000203 mixture Substances 0.000 description 79
- 238000009835 boiling Methods 0.000 description 74
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 52
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 51
- 238000010992 reflux Methods 0.000 description 51
- 229910000027 potassium carbonate Inorganic materials 0.000 description 49
- 235000011181 potassium carbonates Nutrition 0.000 description 46
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 42
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 32
- 239000000243 solution Substances 0.000 description 28
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 27
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 27
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 27
- 239000000284 extract Substances 0.000 description 25
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 22
- 239000000706 filtrate Substances 0.000 description 21
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 20
- 238000006243 chemical reaction Methods 0.000 description 17
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
- 229910052799 carbon Inorganic materials 0.000 description 14
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 13
- 239000000047 product Substances 0.000 description 13
- RSJKGSCJYJTIGS-UHFFFAOYSA-N undecane Chemical compound CCCCCCCCCCC RSJKGSCJYJTIGS-UHFFFAOYSA-N 0.000 description 13
- 239000008346 aqueous phase Substances 0.000 description 12
- 239000003054 catalyst Substances 0.000 description 12
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 11
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 11
- 235000019341 magnesium sulphate Nutrition 0.000 description 11
- AYJRCSIUFZENHW-UHFFFAOYSA-L barium carbonate Chemical compound [Ba+2].[O-]C([O-])=O AYJRCSIUFZENHW-UHFFFAOYSA-L 0.000 description 10
- 229910052763 palladium Inorganic materials 0.000 description 10
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 10
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 9
- IQQODTFRDRREIO-UHFFFAOYSA-N ethyl n-(2-oxoethyl)-n-prop-2-enylcarbamate Chemical compound CCOC(=O)N(CC=C)CC=O IQQODTFRDRREIO-UHFFFAOYSA-N 0.000 description 9
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 9
- 239000012074 organic phase Substances 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 9
- 229920006395 saturated elastomer Polymers 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 8
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 8
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 7
- 235000019253 formic acid Nutrition 0.000 description 7
- KGSVNOLLROCJQM-UHFFFAOYSA-N 2-(benzylamino)acetic acid Chemical compound OC(=O)CNCC1=CC=CC=C1 KGSVNOLLROCJQM-UHFFFAOYSA-N 0.000 description 6
- HTZCNXWZYVXIMZ-UHFFFAOYSA-M benzyl(triethyl)azanium;chloride Chemical compound [Cl-].CC[N+](CC)(CC)CC1=CC=CC=C1 HTZCNXWZYVXIMZ-UHFFFAOYSA-M 0.000 description 6
- LBLQPBVEGKLIEU-UHFFFAOYSA-N ethyl n-(2,2-dimethoxyethyl)carbamate Chemical compound CCOC(=O)NCC(OC)OC LBLQPBVEGKLIEU-UHFFFAOYSA-N 0.000 description 6
- 239000012280 lithium aluminium hydride Substances 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 230000002152 alkylating effect Effects 0.000 description 5
- 239000002585 base Substances 0.000 description 5
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 5
- 238000004817 gas chromatography Methods 0.000 description 5
- 125000005394 methallyl group Chemical group 0.000 description 5
- 230000007935 neutral effect Effects 0.000 description 5
- 238000006722 reduction reaction Methods 0.000 description 5
- 108010077895 Sarcosine Proteins 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- 150000001299 aldehydes Chemical class 0.000 description 4
- IADUEWIQBXOCDZ-UHFFFAOYSA-N azetidine-2-carboxylic acid Chemical compound OC(=O)C1CCN1 IADUEWIQBXOCDZ-UHFFFAOYSA-N 0.000 description 4
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 4
- VUPDMKQEMLQJCE-UHFFFAOYSA-N ethyl 1-benzyl-6-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[3,4-b]pyrrole-5-carboxylate Chemical compound C12C(C)N(C(=O)OCC)CC2CCN1CC1=CC=CC=C1 VUPDMKQEMLQJCE-UHFFFAOYSA-N 0.000 description 4
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 4
- 230000007062 hydrolysis Effects 0.000 description 4
- 238000006460 hydrolysis reaction Methods 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 239000002808 molecular sieve Substances 0.000 description 4
- 229940043230 sarcosine Drugs 0.000 description 4
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 4
- 239000012279 sodium borohydride Substances 0.000 description 4
- 229910000033 sodium borohydride Inorganic materials 0.000 description 4
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 3
- QKWWDTYDYOFRJL-UHFFFAOYSA-N 2,2-dimethoxyethanamine Chemical compound COC(CN)OC QKWWDTYDYOFRJL-UHFFFAOYSA-N 0.000 description 3
- YSEQNZOXHCKLOG-UHFFFAOYSA-N 2-methyl-octanoic acid Chemical compound CCCCCCC(C)C(O)=O YSEQNZOXHCKLOG-UHFFFAOYSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 3
- GDFAOVXKHJXLEI-VKHMYHEASA-N N-methyl-L-alanine Chemical compound C[NH2+][C@@H](C)C([O-])=O GDFAOVXKHJXLEI-VKHMYHEASA-N 0.000 description 3
- 125000004036 acetal group Chemical group 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- BHELZAPQIKSEDF-UHFFFAOYSA-N allyl bromide Chemical compound BrCC=C BHELZAPQIKSEDF-UHFFFAOYSA-N 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- FATAVLOOLIRUNA-UHFFFAOYSA-N formylmethyl Chemical group [CH2]C=O FATAVLOOLIRUNA-UHFFFAOYSA-N 0.000 description 3
- 235000015320 potassium carbonate Nutrition 0.000 description 3
- LUMVCLJFHCTMCV-UHFFFAOYSA-M potassium;hydroxide;hydrate Chemical compound O.[OH-].[K+] LUMVCLJFHCTMCV-UHFFFAOYSA-M 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 3
- 239000008096 xylene Substances 0.000 description 3
- RLIHXKPTGKETCC-QMMMGPOBSA-N (2s)-2-(benzylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NCC1=CC=CC=C1 RLIHXKPTGKETCC-QMMMGPOBSA-N 0.000 description 2
- SPEUIVXLLWOEMJ-UHFFFAOYSA-N 1,1-dimethoxyethane Chemical compound COC(C)OC SPEUIVXLLWOEMJ-UHFFFAOYSA-N 0.000 description 2
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 2
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 2
- BSQHVKZJTOVHBK-UHFFFAOYSA-N 2-chloro-3-iodoprop-1-ene Chemical compound ClC(=C)CI BSQHVKZJTOVHBK-UHFFFAOYSA-N 0.000 description 2
- PMQQFSDIECYOQV-UHFFFAOYSA-N 5,5-dimethyl-1,3-thiazolidin-3-ium-4-carboxylate Chemical compound CC1(C)SCNC1C(O)=O PMQQFSDIECYOQV-UHFFFAOYSA-N 0.000 description 2
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 description 2
- IADUEWIQBXOCDZ-VKHMYHEASA-N Azetidine-2-carboxylic acid Natural products OC(=O)[C@@H]1CCN1 IADUEWIQBXOCDZ-VKHMYHEASA-N 0.000 description 2
- KZMGYPLQYOPHEL-UHFFFAOYSA-N Boron trifluoride etherate Chemical compound FB(F)F.CCOCC KZMGYPLQYOPHEL-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 2
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical group CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 2
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- YOJJKWKUCMSWAP-UHFFFAOYSA-N diethyl 1-benzyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrole-2,5-dicarboxylate Chemical compound CCOC(=O)C1CC2CN(C(=O)OCC)CC2N1CC1=CC=CC=C1 YOJJKWKUCMSWAP-UHFFFAOYSA-N 0.000 description 2
- YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 description 2
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- 150000002169 ethanolamines Chemical class 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- ODPJDFZFCLMBII-UHFFFAOYSA-N ethyl 1,6-dimethyl-2,3,3a,4,6,6a-hexahydropyrrolo[3,4-b]pyrrole-5-carboxylate Chemical compound C1CN(C)C2C(C)N(C(=O)OCC)CC21 ODPJDFZFCLMBII-UHFFFAOYSA-N 0.000 description 2
- YPNVJYVXTBJLRR-UHFFFAOYSA-N ethyl 1-benzyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrole-5-carboxylate Chemical compound C12CN(C(=O)OCC)CC2CCN1CC1=CC=CC=C1 YPNVJYVXTBJLRR-UHFFFAOYSA-N 0.000 description 2
- UOEVJQYCGBVGJE-UHFFFAOYSA-N ethyl 1-benzyl-3a-fluoro-3,4,6,6a-tetrahydro-2h-pyrrolo[2,3-c]pyrrole-5-carboxylate Chemical compound C1CC2(F)CN(C(=O)OCC)CC2N1CC1=CC=CC=C1 UOEVJQYCGBVGJE-UHFFFAOYSA-N 0.000 description 2
- KNGZLYTYXDDEGZ-UHFFFAOYSA-N ethyl 1-benzyl-4-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrole-5-carboxylate Chemical compound CC1N(C(=O)OCC)CC2C1CCN2CC1=CC=CC=C1 KNGZLYTYXDDEGZ-UHFFFAOYSA-N 0.000 description 2
- CLJCFUFTHUZDSW-UHFFFAOYSA-N ethyl 1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrole-5-carboxylate Chemical compound C1CN(C)C2CN(C(=O)OCC)CC21 CLJCFUFTHUZDSW-UHFFFAOYSA-N 0.000 description 2
- VZBXIBFQHZLEPX-UHFFFAOYSA-N ethyl 4-methyl-2,3,3a,4,6,6a-hexahydro-1h-pyrrolo[2,3-c]pyrrole-5-carboxylate Chemical compound N1CCC2C(C)N(C(=O)OCC)CC21 VZBXIBFQHZLEPX-UHFFFAOYSA-N 0.000 description 2
- BMWBBANWORCCIJ-UHFFFAOYSA-N ethyl n-but-2-enyl-n-(2-oxoethyl)carbamate Chemical compound CCOC(=O)N(CC=O)CC=CC BMWBBANWORCCIJ-UHFFFAOYSA-N 0.000 description 2
- 150000004678 hydrides Chemical class 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- VXGABWCSZZWXPC-UHFFFAOYSA-N methyl 2-(methylamino)acetate Chemical compound CNCC(=O)OC VXGABWCSZZWXPC-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000007800 oxidant agent Substances 0.000 description 2
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
- HXEACLLIILLPRG-UHFFFAOYSA-N pipecolic acid Chemical compound OC(=O)C1CCCCN1 HXEACLLIILLPRG-UHFFFAOYSA-N 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- OJOJNFHDXZKHBM-UHFFFAOYSA-N tert-butyl 1-benzyl-2,3,3a,4,5,6-hexahydropyrrolo[1,2-b]pyrazole-5-carboxylate Chemical compound N12CC(C(=O)OC(C)(C)C)CC2CCN1CC1=CC=CC=C1 OJOJNFHDXZKHBM-UHFFFAOYSA-N 0.000 description 2
- NYGXZCRPVBPJTA-UHFFFAOYSA-N tert-butyl 2,3,3a,4,6,6a-hexahydro-1h-pyrrolo[2,3-c]pyrrole-5-carboxylate Chemical compound C1CNC2CN(C(=O)OC(C)(C)C)CC21 NYGXZCRPVBPJTA-UHFFFAOYSA-N 0.000 description 2
- DZLNHFMRPBPULJ-UHFFFAOYSA-N thioproline Chemical compound OC(=O)C1CSCN1 DZLNHFMRPBPULJ-UHFFFAOYSA-N 0.000 description 2
- PMMYEEVYMWASQN-IMJSIDKUSA-N trans-4-Hydroxy-L-proline Natural products O[C@@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-IMJSIDKUSA-N 0.000 description 2
- 150000003738 xylenes Chemical class 0.000 description 2
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- NPKSPKHJBVJUKB-UHFFFAOYSA-N N-phenylglycine Chemical compound OC(=O)CNC1=CC=CC=C1 NPKSPKHJBVJUKB-UHFFFAOYSA-N 0.000 description 1
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- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 150000001241 acetals Chemical class 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 1
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000000010 aprotic solvent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 description 1
- 229910001863 barium hydroxide Inorganic materials 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- FECVKNICXSFXTN-UHFFFAOYSA-N but-2-enyl(2-oxoethyl)carbamic acid Chemical compound CC=CCN(CC=O)C(=O)O FECVKNICXSFXTN-UHFFFAOYSA-N 0.000 description 1
- SDORYAWUDLLWGZ-UHFFFAOYSA-N but-3-en-2-yl(2-oxoethyl)carbamic acid Chemical compound C=CC(C)N(C(O)=O)CC=O SDORYAWUDLLWGZ-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- JYYOBHFYCIDXHH-UHFFFAOYSA-N carbonic acid;hydrate Chemical compound O.OC(O)=O JYYOBHFYCIDXHH-UHFFFAOYSA-N 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
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- 238000003776 cleavage reaction Methods 0.000 description 1
- MLUCVPSAIODCQM-NSCUHMNNSA-N crotonaldehyde Chemical compound C\C=C\C=O MLUCVPSAIODCQM-NSCUHMNNSA-N 0.000 description 1
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- 229940019778 diethylene glycol diethyl ether Drugs 0.000 description 1
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- 238000004821 distillation Methods 0.000 description 1
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- CSRHYENXHRZHLX-UHFFFAOYSA-N ethyl 1-benzyl-3-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[3,4-b]pyrrole-5-carboxylate Chemical compound C12CN(C(=O)OCC)CC2C(C)CN1CC1=CC=CC=C1 CSRHYENXHRZHLX-UHFFFAOYSA-N 0.000 description 1
- SPXSRDIGJZWHFQ-UHFFFAOYSA-N ethyl 1-phenyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrole-5-carboxylate Chemical compound C12CN(C(=O)OCC)CC2CCN1C1=CC=CC=C1 SPXSRDIGJZWHFQ-UHFFFAOYSA-N 0.000 description 1
- BTKSUULMJNNXHG-UHFFFAOYSA-N ethyl 2-(methylamino)acetate Chemical compound CCOC(=O)CNC BTKSUULMJNNXHG-UHFFFAOYSA-N 0.000 description 1
- OPKJNHZUUAFSDV-UHFFFAOYSA-N ethyl 2-methyl-2,3,3a,4,6,6a-hexahydro-1h-pyrrolo[2,3-c]pyrrole-5-carboxylate Chemical compound C1C(C)NC2CN(C(=O)OCC)CC21 OPKJNHZUUAFSDV-UHFFFAOYSA-N 0.000 description 1
- FJOZTSGWBFMMTO-UHFFFAOYSA-N ethyl 3,3a,4,5,6,6a-hexahydro-2h-pyrrolo[2,3-c]pyrrole-1-carboxylate Chemical compound C1NCC2N(C(=O)OCC)CCC21 FJOZTSGWBFMMTO-UHFFFAOYSA-N 0.000 description 1
- CXRFMXSUOUANLS-UHFFFAOYSA-N ethyl 3a-(fluoromethyl)-1-methyl-3,4,6,6a-tetrahydro-2h-pyrrolo[2,3-c]pyrrole-5-carboxylate Chemical compound CN1CCC2(CF)CN(C(=O)OCC)CC21 CXRFMXSUOUANLS-UHFFFAOYSA-N 0.000 description 1
- UQPAYBHPLKFSPJ-UHFFFAOYSA-N ethyl 3a-chloro-1,2-dimethyl-3,4,6,6a-tetrahydro-2h-pyrrolo[2,3-c]pyrrole-5-carboxylate Chemical compound CN1C(C)CC2(Cl)CN(C(=O)OCC)CC21 UQPAYBHPLKFSPJ-UHFFFAOYSA-N 0.000 description 1
- SYLDVKUPWUXTSQ-UHFFFAOYSA-N ethyl 3a-chloro-1-methyl-3,4,6,6a-tetrahydro-2h-pyrrolo[2,3-c]pyrrole-5-carboxylate Chemical compound CN1CCC2(Cl)CN(C(=O)OCC)CC21 SYLDVKUPWUXTSQ-UHFFFAOYSA-N 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- IBEFOHVJHZDMSX-UHFFFAOYSA-N ethyl n-(1,1-dimethoxypropan-2-yl)carbamate Chemical compound CCOC(=O)NC(C)C(OC)OC IBEFOHVJHZDMSX-UHFFFAOYSA-N 0.000 description 1
- SKIKWIXDRSCDFJ-UHFFFAOYSA-N ethyl n-but-3-en-2-yl-n-(2,2-dimethoxyethyl)carbamate Chemical compound CCOC(=O)N(C(C)C=C)CC(OC)OC SKIKWIXDRSCDFJ-UHFFFAOYSA-N 0.000 description 1
- UAXWVRFBCVPAQD-UHFFFAOYSA-N ethyl n-but-3-en-2-yl-n-(2-oxoethyl)carbamate Chemical compound CCOC(=O)N(CC=O)C(C)C=C UAXWVRFBCVPAQD-UHFFFAOYSA-N 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 238000007327 hydrogenolysis reaction Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000007517 lewis acids Chemical class 0.000 description 1
- HIVDOHPKFIBYPZ-VIFPVBQESA-N methyl (2s)-2-(benzylamino)propanoate Chemical compound COC(=O)[C@H](C)NCC1=CC=CC=C1 HIVDOHPKFIBYPZ-VIFPVBQESA-N 0.000 description 1
- UAWVZBDVSNLPDT-UHFFFAOYSA-N methyl 2-(benzylamino)acetate Chemical compound COC(=O)CNCC1=CC=CC=C1 UAWVZBDVSNLPDT-UHFFFAOYSA-N 0.000 description 1
- OSBZZNKSHHOBHG-UHFFFAOYSA-N methyl n-but-2-enyl-n-(2-oxoethyl)carbamate Chemical compound COC(=O)N(CC=O)CC=CC OSBZZNKSHHOBHG-UHFFFAOYSA-N 0.000 description 1
- SJHMJBAWVVGZQL-UHFFFAOYSA-N methyl n-but-3-en-2-yl-n-(2-oxoethyl)carbamate Chemical compound COC(=O)N(CC=O)C(C)C=C SJHMJBAWVVGZQL-UHFFFAOYSA-N 0.000 description 1
- XONPDZSGENTBNJ-UHFFFAOYSA-N molecular hydrogen;sodium Chemical class [Na].[H][H] XONPDZSGENTBNJ-UHFFFAOYSA-N 0.000 description 1
- YTYXITBYMINXLZ-UHFFFAOYSA-N n-(2,2-dimethoxyethyl)but-2-en-1-amine Chemical compound COC(OC)CNCC=CC YTYXITBYMINXLZ-UHFFFAOYSA-N 0.000 description 1
- UNYRQLQNOQRXLN-UHFFFAOYSA-N n-(2,2-dimethoxypropyl)acetamide Chemical compound COC(C)(OC)CNC(C)=O UNYRQLQNOQRXLN-UHFFFAOYSA-N 0.000 description 1
- VLGVNRUPRMUDOJ-UHFFFAOYSA-N n-but-2-enyl-n-(2-oxoethyl)acetamide Chemical compound CC=CCN(C(C)=O)CC=O VLGVNRUPRMUDOJ-UHFFFAOYSA-N 0.000 description 1
- AYCPQIBUCJYJQT-UHFFFAOYSA-N n-but-2-enyl-n-(2-oxoethyl)benzamide Chemical compound CC=CCN(CC=O)C(=O)C1=CC=CC=C1 AYCPQIBUCJYJQT-UHFFFAOYSA-N 0.000 description 1
- MQQDNWMJDSONRK-UHFFFAOYSA-N n-but-3-en-2-yl-n-(2-oxoethyl)acetamide Chemical compound C=CC(C)N(C(C)=O)CC=O MQQDNWMJDSONRK-UHFFFAOYSA-N 0.000 description 1
- FTQLXSYCNFCWST-UHFFFAOYSA-N n-but-3-en-2-yl-n-(2-oxoethyl)benzamide Chemical compound C=CC(C)N(CC=O)C(=O)C1=CC=CC=C1 FTQLXSYCNFCWST-UHFFFAOYSA-N 0.000 description 1
- UHXHEZZUORBPBE-UHFFFAOYSA-N octahydro-1h-azeto[1,2-a]pyrrolo[3,4-d]pyrrole Chemical compound C1NCC2N3CCC3CC21 UHXHEZZUORBPBE-UHFFFAOYSA-N 0.000 description 1
- NXJCBFBQEVOTOW-UHFFFAOYSA-L palladium(2+);dihydroxide Chemical compound O[Pd]O NXJCBFBQEVOTOW-UHFFFAOYSA-L 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- OYTWKHGDADKPNF-UHFFFAOYSA-N propan-2-yl n-but-3-en-2-yl-n-(2-oxoethyl)carbamate Chemical compound CC(C)OC(=O)N(CC=O)C(C)C=C OYTWKHGDADKPNF-UHFFFAOYSA-N 0.000 description 1
- 229940080818 propionamide Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 150000003219 pyrazolines Chemical class 0.000 description 1
- 238000006268 reductive amination reaction Methods 0.000 description 1
- 239000012260 resinous material Substances 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000007142 ring opening reaction Methods 0.000 description 1
- 108700027361 sarcosine methyl ester Proteins 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
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- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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Abstract
The invention relates to 2,7-diazabicyclo[3.3.0]octanes of the formula (I)
<IMAGE>
in which the substituents R<1> to R<8> have the meaning given in the description, and to a process for their preparation. The compounds according to the invention are useful intermediates for the preparation of highly active antibacterial quinolonecarboxylic acids.
<??>The invention furthermore also relates to compounds of the formula (II)
<IMAGE>
in which R<1> to R<8> likewise have the meaning given in the description.
Description
The present invention relates to processes for the preparation of 2,7-diazabicyclo[3.3.0]octanes. These compounds are useful intermediates for the preparation of highly active antibacterial quinolonecarboxylic acids.
EP-A-0,350,733 and EP-A-0,391,132 have already disclosed 2.7- diazabicyclo(3.3.0)octanes and guinolonecarboxylic acid derivatives obtainable through them.
It has already been disclosed that 2,7-diazabicyclo [3.3.0] octane (octahydropyrrolo [ 3,4-b ] pyrrole) can be prepared by reduction with lithium aluminium hydride from 2,7-diazabicyclo[3.3.0]octane-3,8-dione. This compound was prepared by addition of diazomethane to dimethyl glutaconate and subsequent cleavage by hydrogenation of the intermediate pyrazoline derivative (Justus Liebigs Ann. Chemie 677. 154 (1964)). This process involves the disadvantage of contact with the highly toxic and explosive diazomethane and is of no use for industrial application. Moreover, substituted glutaconic acid esters can only be prepared with difficulty, so that this process is not easily capable of general application.
The invention relates to processes for the preparation of 2.7- diazabicyclo[3.3.0]octanes of the formula (I) where R1, R3, R4, R5, R7 and R8 identical or different and in each case denote H, Cj-Cj-alkyl, optionally substituted by halogen, hydroxyl or C1-C4-alkoxy, Cj2 C3-alkoxycarbonyl or q-Cjj-aryl, preferably H, Cx-C3alkyl, q-q-alkoxycarbonyl or phenyl, particularly preferably H or methyl, ft R4 additionally denotes halogen, preferably fluorine, chlorine or bromine, particularly preferably chlor- * ine or bromine, Ra and R6 may be identical or different and denote H, C3Cj-alkyl, benzyl, Ce-C12-aryl, Cj-q-alkanoyl, benzoyl or Cj-Cj-alkoxycarbonyl, preferably H, Cj-C3-alkyl, benzyl, Ce-C12-aryl, C1'-C2-alkanoyl, benzoyl or Cj-qalkoxycarbonyl, particularly preferably H, methyl, phenyl, acetyl or C2-C4-alkoxycarbonyl and R2 and R3 together optionally denote a bridge of the structure (CH2)n, n - 2 - 4, CH2-CHOH-CH2, CH2-S-CH2 or C(CH3)2-S-CH2.
Compounds which are particularly preferably prepared are those of the following formulae: x^N-H I cooc2h5 ch3 X CHx*^n-ch3 I CH3 H jo X> dd d h3c H3CV h3csZ^-h X^N-H I CHg >xssn-ch3 fX^-CHg EtOOCClBr fX^-CHg CH, I H χΧ^Ν-CH.
HgCX^NX 3 I H - 4 χ'^-Η , F-CHgCHo X^MQ-H XaM4-H X^N-CHcooc2h5 X^N-H I ch3η3<χΊι cooc2h5 I COOC2H5 The Cg-C^-aryl radical can be substituted or 5 unsubstituted. Possible substituents are 1 to 3, preferably 1 substituent(s), from the group comprising halogen, in particular Cl, Br or F, amino, Cx-Cs-alkylamino, 0χ-03dialkylamino, hydroxyl, Cx-^-alkoxy, Ci-Cg-alkyl or cyano.
It has furthermore been found that 2,7 -diazΒΙΟ bicyclof3.3.0)octanes of the formula (I) (I) rSx'Xnx'Xr7 R6 where R1, R3, R*, R5, R7 and R8 may be identical or different and in each case denote H, Cx-Cs-alkyl, optionally substituted by halogen, hydroxyl or C1-C3-alko^, Cx-C3alkoxycarbonyl or CeC12 -aryl, preferably H, Cx-C3alkyl, Cx-C3-alkoxycarbonyl or phenyl, particularly preferably H and methyl, R* additionally denotes halogen, preferably fluorine, chlorine or bromine, particularly preferably chlorine or bromine, R2 and R6 may be identical or different and denote Η, ΟχCs-alkyl, benzyl, Ce-C^-aryl, Cx-C3-alkanoyl, benzoyl or Cx-C5-alkoxycarbonyl, preferably H, Cx-C3-alkyl, benzyl , C6-C12 -aryl, Cx-C2-alkanoyl, benzoyl or Cx-C4alkoxycarbonyl, particularly preferably H, methyl, phenyl, acetyl or C2-C4-alkoxycarbonyl and R2 and R3 together optionally denote a bridge of the structure (CH2)B, n = 2 - 4, CH2-CH0H-CH2, CH2-S-CH2 or C(CH3)2-S-CH2, are obtained by a process in which unsaturated carbonyl compounds of the formula (II) are reacted with amino acid derivatives of the formula (III) in an intramolecular 1,3-dipolar cycloaddition, Le A 26 686 (I) ♦ co2 ♦ h2o (II) (XII) in which R' represents H or Ci-Cj-elkyl and where R1 - R8 have the abovementioned meaning. The sub5 stituents R2 or R8, which have a protective group function, can then be removed.
The advantage of the process according to the invention consists in the sia^licity of carrying it out and in the easy accessibility of the starting compounds (II) and (III). The high stereoselectivity of the process must be designated as particularly advantageous. This is particularly surprising since similar cyclizations can lead to product mixtures (J. Chem. Soc., Chem. Comm. 1984, 182). Owing to the selectivity of the process claimed here, a high-loss and uneconomical separation of undesired diastereomers is unnecessary.
The course of the reaction of the process according to the invention may be illustrated by the following examples: Le A 26 686 - 6 H2C^ CH I CHO I ch2-n-ch2 ♦ ch3-nh-ch2-cooh cooc2h5 -ch. cooc2h5 H2C^ CH CHO I I CH,-N-CH, cooc2h5 CH, Le A 26 686 The unsaturated carbonyl compounds of the formula (II) needed as starting compounds are new. They can be prepared by the following methods: 1. Starting from commercially available aminoacetal5 dehyde dimethyl acetal, the amino group is acylated, the amide is alkylated with allyl halides in the presence of strong bases and the acetal is cleaved under acidic conditions. h2nx*^ch (och3>2 ♦ R6-C1 —’ R6-NH-CH2CH(OCH R4 X = Cl, Sr, I The known acetamidoacetone dimethyl acetal (Synthesis 1988, 381) can be alkylated with allyl halides in the presence of strong bases and the acetal group hydrolyzed under acidic conditions.
Le A 26 686 - 8 CH3CONH-CH2-C(0CH3)2 CH, R4 Base >8 ,8 CHr I CH2-C(OCH3)2 I coch3 [SxkjjI CH2-C0-CH3 COCH3 2. Starting from commercially available or known (EP 249,530, 03.06.1986) «-ketoaldehyde monoacetals, these can be reductively aminated with allylamines. After introducing a (protective) group R6 by alkylating or acylating, the acetal group is hydrolyzed under acidic conditions.
R7-CO-CH(OAlkyl>2 H Le A 26 686 - 9 η ^-*R CHO I L * R® 3. Unsaturated aldehydes or ketones can be reductively aminated with aminoacetaldehyde dimethyl acetal. After introducing the group R® by alkylating or acylating, the acetal group can be cleaved under acidic conditions.
H2Nx*KCH(OCH3)2 4. M-Allylamino alcohols are obtained a) by ring opening of epoxides with allylamines (J.
Le A 26 686 - 10 Pharm. Soc. Japan 73. 1330 (1953)), b) by alkylating substituted ethanolamines with allyl halides (J. Am. Chem. Soc. 64. 1692 (1942); 72, 3536 ((1950)), c) by reductive amination of unsaturated aldehydes or ketones with substituted ethanolamines.
After introducing the group R6 by alkylating or acylating, the alcohol function is oxidised with suitable oxidizing agents to give compounds of the formula (II). »4 R8 R5 R* R * Η2Ν-^γθΗ R* R' ♦ R6-X R8 R5 R8 R5 RJ Le A 26 686 . Enantiomerically pure precursors of the formula (II) are obtained by alkylating N-acylated amino acid esters with allyl halides in the presence of strong bases. Using suitable reducing agents, the ester function can be a) reduced to the aldehyde function or b) reduced to the alcohol and then oxidized to the aldehyde function using suitable oxidizing agents.
* R6-NH-CH-COO Alkyl R7 be A 26 C86 Examples of precursors of the formula (II) which may be mentioned are: methyl N-allyl-N- (2-oxoethyl) -carbamate, ethyl N-allyl-N- (2-oxoethyl) -carbamate, isopropyl N-allyl-N- (2-oxoethyl) -carbamate, tert. -butyl N-allyl-N- (2-oxoethyl) -carbamate, N-allyl-N- (2-oxoethyl) -acetamide, N-allyl-N-(2-oxoethyl)-propionamide, N-allyl-N- (2-oxoethyl) -benzamide, methyl N-allyl-N-(l-oxopxop-2-yl)-carbamate, ethyl N-allyl-N- (l-oxoprop-2-yl) -carbamate, propyl N-allyl-N- (1-oxoprop-2 -yl) -carbamate, N-allyl-N-(l-oxoprop-2-yl)-acetamide, N-allyl-N- (1-oxoprop-2 -yl) -benzamide , methyl N-(buten-3-yl)-N-(2-oxoethyl)-carbamate, ethyl N- (buten-3-yl) -N- (2-oxoethyl) -carbamate, isopropyl N- (buten-3-yl) -N- (2-oxoethyl) -carbamate, tert. -butyl N- (buten-3-yl) -N- (2-oxoethyl) -carbamate, N-(buten-3-yl)-N-(2-oxoethyl)-acetamide, N- (buten-3-yl) -N- (2-oxoethyl) -benzamide, methyl N- ( 2-methylallyl) -N- (2-oxoethyl) -carbamate, ethyl N- (2-methylallyl) -N- (2-oxoethyl) -carbamate, N- (2-methylallyl) -N- (2-oxoethyl) -acetamide, N- (2-methylallyl) -N- (2-oxoethyl) -benzamide, methyl N-(2-f luoroallyl )-N-( 2-oxoethyl)-carbamate, ethyl N- (2-fluoroallyl) -N- (2-oxoethyl) -carbamate, N- (2-f luoroallyl) -N- (2-oxoethyl) -acetamide, N- (2-f luoroallyl) -N- (2-oxoethyl) -benzamide, methyl N- (2-chloroallyl) -N- (2-oxoethyl) -carbamate, ethyl N-(2-chloroallyl)-N-(2-oxoethyl)-carbamate, Le A ,2$ &£$ - 13 N-(2-chloroallyl)-N-(2-oxoethyl)-acetamide, N-(2-chloroallyl)-N-(2-oxoethyl)-benzamide, methyl N-(2-bromoallyl)-N-(2-oxoethyl)-carbamate, ethyl N- (2-bromoallyl) -N- (2-oxoethyl) -carbamate, N-(2-bromoallyl)-N-(2-oxoethyl)-acetamide, N- (2-bromo allyl) -N- (2-oxoethyl) -benzamide, methyl N-(2-ethoxycarbonylallyl)-N-(2-oxoethyl)carbamate, ethyl N- (2-ethoxycarbonylallyl) -N- (2-oxoethyl) -carbamate, N- (2-ethoxycarbonylallyl) -N- (2-oxoethyl) -acetamide, N- (2-ethoxycarbonylallyl) -N- (2-oxoethyl) -benzamide, ethyl N- (2 -oxoethyl) -N- (2 -phenylallyl) -carbamate, methyl N- (2-buten-1-yl) -N- (2-oxoethyl) -carbamate, ethyl N- (2 -buten- 1-yl) -N- (2-oxoethyl) -carbamate, N- (2-buten-1-yl) -N- (2-oxoethyl) -acetamide, N-(2-buten-1-yl)-N-(2-oxoethyl)-benzamide, methyl N-(3-chloroallyl)-N-(2-oxoethyl)-carbamate, ethyl N-(3-chloroallyl)-N-(2-oxoethyl)-carbamate, N-(3-chloroallyl)-N-(2-oxoethyl)-acetamide, N-(3-chloroallyl)-N-(2-oxoethyl)-benzamide, methyl N- (3-phenylallyl) -N- (2-oxoethyl) -carbamate, ethyl N- (3-phenylallyl) -N- (2-oxoethyl) -carbamate, N- (3-phenylallyl) -N- (2-oxoethyl) -acetamide, N-(3-phenylallyl)-N-(2-oxoethyl)-benzamide, methyl N-(3-ethoxycarbonylallyl)-N-(2-oxoethyl)carbamate, ethyl N- (3-ethoxycarbonylallyl) -N- (2-oxoethyl) -carbamate, N- (3-ethoxycarbonylallyl) -N- (2-oxoethyl) -acetamide, ethyl N-allyl-N- (2-oxopropyl) -carbamate, N-allyl-N- (2-oxopropyl) -acetamide, Le A 26 686 N-allyl-N- (2-oxopropyl) -benzamide, N-allyl-N- (2-oxo-2-phenylethyl) -acetamide, N-allyl-N- (2-ethoxycarbonyl-2-oxoethyl) -acetamide, N-allyl-N-benzyl-N-2- (oxopropyl) -amine, N-benzyl-N- (2-methylallyl) -N- (2-oxoethyl) -amine.
The starting compounds of the formula (III) are known from the literature and are, for the most part, commercially available.
Examples of precursors of the formula (III) which may be mentioned are: sarcosine, N-ethylglycine, N-propylglycine, N-isopropylglycine, N-phenylglycine, N-benzyl glycine, N-methylalanine, N-phenylalanine, N-methylphenylglycine, Nbenzylphenylglycine, azetidine-2-carboxylic acid, proline, trans-4-hydroxyproline, piperidine-2-carboxylic acid, thiazolidine-4-carboxylic acid, 5,5-dimethylthiazolidine-4-carboxylic acid, sarcosine methyl ester,. sarcosine ethyl ester, N-benzylglycine methyl ester and Nbenzylglycine ethyl ester.
The reaction of (II) with (III) by the process according to the invention is carried out in a solvent. Hydrocarbons such as benzene, toluene, xylenes or tetralin, ethers such as dioxane, dibutyl ether, dimethoxyethane, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, alcohols such as butanol, pentanol, ethylene glycol, ethylene glycol monomethyl ether and ethylene glycol monoethyl ether, and dipolar aprotic solvents such as dimethylformamide, dimethyl sulphoxide, N-methylpyrrolidone and sulpholane can be used. Toluene, xylenes and dimethylformamide are particularly preferred.
Le A 26 686 The reaction temperature can be varied within a relatively wide range. In general, the reactions are carried out between 20*C and 200°C, preferably between 80’C and 150eC.
The reaction can be carried out at normal pressure, but also at elevated pressure. In general, the reaction is carried out at pressures between about 1 bar and 100 bar, preferably between about 1 bar and 10 bar.
When carrying out the process according to the invention, 0.5 to 6 moles, preferably 0.5 to 2 moles, of amino acid derivative (III) are employed per mole of unsaturated carbonyl compound (II).
The reaction can be carried out by adding the unsaturated carbonyl compound dropwise to a suspension or solution of the amino acid derivative (III) in one of the solvents indicated. However, both components can also be initially introduced in a solvent and the reaction can be carried out in the temperature range indicated. The water of reaction set free in the reaction can be distilled off with the solvent as an azeotrope. The course of the reaction can easily be followed by the evolution of CO2 which occurs. Working up is carried out, if appropriate after separating off unreacted amino acid (III), by removing the solvent and distillation. It is also possible to extract the basic products from the organic solvent using an acid, such as, for example hydrochloric acid, in order to separate off neutral impurities.
In a further step of the process according to the invention, the substituents Ra and R®, if they have a protective group function, can be removed.
Le A 26 686 - 16 Acyl radicals are removed by hydrolysis. Strong acids or strong bases are suitable for the hydrolysis. Aqueous hydrochloric acid, hydrobromic acid or trifluoroacetic acid are preferably used for the acidic hydrolysis. The basic hydrolysis is carried out using alkali metal hydroxides or alkaline earth metal hydroxides, lithium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide and barium hydroxide being preferred. Solvents used are water and alcohols, water, ethanol or mixtures of these solvents being preferred. The hydrolysis can be carried out at temperatures between 0* and 200 C, preferably between 20* and 140 °C. Pressures between about 1 bar and 100 bar are used here, preferably between about 1 bar and 10 bar.
If the radicals R2 or R6 are benzyl radicals, these radicals can be removed by hydrogenolysis. Water, alcohols, carboxylic acids, alcoholic hydrochloric acid, cyclic ethers or mixtures thereof can be used as solvents. Catalysts used are palladium, both as a sponge and on supports such as active carbon, calcium carbonate or barium sulphate, and palladium hydroxide on active carbon. The reaction is carried out at temperatures between about 0* and 200* and hydrogen pressures from 1 bar to 200 bar.
The process according to the invention moreover comprises the conversion of the radicals R2 and R6, if these are acyl radicals, into alkyl radicals by reduction. The reduction can be carried out both catalytically and using hydrides or complex hydrides of the elements of the third main group. The reduction is preferably carried Le A 26 686 out using diborane, lithium aluminium hydride and sodium borohydride, in the last case with the addition of Lewis acids such as titanium tetrachloride, aluminium trichloride or boron trifluoride.
The reaction is carried out in inert organic solvents such as ethers, for example diethyl ether, dibutyl ether, methyl tert.-butyl ether, tetrahydrofuran, dioxane or ethylene glycol dimethyl ether or hydrocarbons such as toluene or xylene. The temperatures can be varied between about 0° and 2C0’C. In order to attain high reaction temperatures, the reaction can be carried out at pressures up to 100 bar.
Preferably, the reduction is carried out using lithium aluminium hydride or sodium borohydride/boron trifluoride etherate in tetrahydrofuran or dioxane at the reflux temperature of the solvent.
The compounds according to the invention are used as starting substances for antibacterially active quinolone- or naphthyridonecarboxylic acids.
Thus, for example, 8-chloro-l-cyclopropyl-6,7dif luoro-1,4-dihydro-4-oxo-3-guinolinecarboxylic acid can be reacted with 2-methyl-2,7-diaxabicyclo [3.3.0 ] octane to give 8-chloro-l-cyclopropyl-6-f luoro-1,4-dihydro-7- (2methyl-2,7-diazabicyclo[3.3.0]oct-7-yl)-4-oxo-3-quinolinecarboxylic acid, which has a high antibacterial activity.
Le A 26 686 - 18 Example 1 2.7-Diazablcvclor 3.3.01octane a) Ethyl N- (2,2-dimethoxy ethyl) -carbamate H3C2OOC-NH-CH2-CH (OCH3) 2 214 g (2 mol) of ethyl chloroformate are added dropwise at 10’C to 214 g (2 mol) of aminoacetaldehyde dimethyl acetal in 1 1 of toluene and 90 g of NaOH in 500 ml of water. The mixture is stirred for a further 2 hours at room temperature, and the aqueous phase is separated off, saturated with sodium chloride and extracted using toluene. The toluene solutions are dried over magnesium sulphate, concentrated and distilled. Yield: 338 g (95.4% of theory) Boiling point: 60*C/0.03 mbar b) Ethyl N-allyl-N- (2,2 - dime t ho xy ethyl) -carbamate CH CH<0CH3>2 CH, CH2 cooc2h5 500 g (2.82 mol) of ethyl N-(2,2-dimethoxyethyl)carbamate, 625 g of powdered potassium hydroxide and 10 g of triethylbenzylammonium chloride are initially introduced into 2.7 1 of toluene and 345 g (2.85 mol) of allyl bromide are added dropwise at room temperature. The mixture is stirred overnight at room temperature, the salts are filtered off with suction, and the filtrate is be A 26 686 washed once with saturated sodium chloride solution, dried over potassium carbonate, concentrated and distilled.
Yield: 582 g (95% of theory) Boiling point: 64*C/0.1 mbar c) Ethyl N-allyl-N-(2-oxoethyl)-carbamate H2C5t CH CHO cooc2h5 g (0.313 mol) of ethyl N-allyl-N-(2,2-dimeth10 oxyethyl)-carbamate are heated at 100 °C for an hour with 150 ml of formic acid. The mixture is poured onto ice, extracted several times with methylene chloride, and the organic phases are washed with sodium hydrogen carbonate solution, dried over magnesium sulphate, concentrated and distilled.
Yield: 46.7 g (87.2% of theory) Boiling point: 58*C/0.09 mbar d) N-Benzylglycine 225,8 g (1.17 mol) of N-benzylglycine ethyl ester (J. Am. Chem. Soc. 72. 1238 (1950)) are heated under Le A 26 686 - 20 reflux overnight in 600 ml of water. Product which has crystallized out is filtered off with suction and the filtrate is extracted once with tert.-butyl methyl ether. The aqueous phase is concentrated and the crystals obtained are dried over phosphorus pentoxide in a desiccator together with the product filtered off.
Yield: 184 g (95% of theory) Melting point: 199’C e) Ethyl 2-benzyl-2,7-diazabicyclo[3.3.0]octane-710 carboxylate 42.8 g (0.25 mol) of ethyl N-allyl-N-(2-oxoethyl)-carbamate are heated under reflux overnight with 41.3 g (0.25 mol) of N-benzylglycine in 750 ml of toluene. The mixture is concentrated and the residue is distilled.
Yield: 59.6 g (87% of theory) Boiling point: 140eC / 0.09 mbar Le A 26 686 - 21 f) Ethyl 2,7-diazabicyclo[3.3.0]octane-7rcarboxylate I cooc2h5 21.2 g (77.3 mmol) of ethyl 2-benzyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate In 400 ml of ethanol are hydrogenated at 100’C and 100 bar on 3 g of palladium-active carbon (10% Pd). The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.
Yield: 10.3 g (72.3% of theory) Boiling point: 82 - 92 C / 0.1 mbar g) 2,7-Diazabicyclo[3.3.OJoctane H15 g (48.8 mmol) of ethyl 2,7-diazabicyclo[3.3.OJoctane-7-carboxylate are heated under reflux overnight with 32 g (100 mmol) of Ba(0H)2 * 8H20 in 140 ml of water. The mixture is saturated with potassium carbonate, barium carbonate is filtered off with suction and the filtrate is extracted ten times with 100 ml of chloroform each Le A 26 686 — 22 — time. The extract ie dried over potassium carbonate and concentrated, and the residue is distilled.
Yield: 3.4 g (62% of theory) Boiling point: 70*C / 6 mbar 5 Example 2 2-Benzvl-2.7-diazabicycloΓ 3.3.01 octane H I 55.6 g (0.2 mol) of ethyl 2-benzyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight with 300 ml of concentrated hydrochloric acid. The mixture is then rendered alkaline with potassium carbonate and extracted five times with 100 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Yield: 31 g (76.6% of theory) Boiling point: 105’C / 0.45 mbar Le A 2_6 fig,ft - 23 Example 3 Ethvl 2.7-diazabicvcloΓ 3.3.0 Ίoctane-2-carboxylate a) tert.-Butyl 2-benzyldiazabicyclo[3.3.0]octane-7 carboxylate cooccch3)3 .2 g (0.1 mol) of 2-benzyl-2,7-diazabicyclo[3.3.0]octane are dissolved in 125 ml of tert.-butanol, a solution of 4.2 g of sodium hydroxide in 100 ml of water is added and 23 g (0.105 mol) of di-tert.-butyl pyrocarbonate are added dropwise at room temperature. The mixture is stirred overnight at room temperature and extracted five times with 100 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Yields 24.8 g (82% of theory) Boiling points 145 - 149’C / 0.8 mbar Le A 26 686 b) tert.-Butyl 2,7-diazabicyclo[3.3.0]octane-7carboxylate I COOC(CH3)3 24 g (79.4 mmol) of tert.-butyl 2-benzyldiazabicyclo[3.3.0]octane-7-carboxylate in 400 ml of ethanol are hydrogenated at 100 °C and 100 bar on 3 g of palladium-active carbon (10% Pd). The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.
Yield: 13.1 g (77.7% of theory) Boiling point: 87°C / 0.1 mbar c) 2-Ethyl 7-tert.-butyl 2,7-diazabicyclo[3.3.0 joctane2,7-dicarboxylate g (61.2 mmol) of tert.-butyl 2,7-diazabicyclo[3.3.0]octane-7-carboxylate are dissolved in 100 ml of toluene, a solution of 3 g of sodium hydroxide in 20 ml of water is added and 7 g (64.5 mmol) of ethyl chloroLe A 26 686 - 25 formate are added dropwise at room temperature. The mixture is stirred for three hours at room temperature, and the aqueous phase is separated off and extracted twice with 100 ml of methylene chloride each time. The organic solutions are dried over magnesium sulphate and concentrated, and the residue is distilled.
Yields 16 g (91.9% of theory) Boiling point; 125*C / 0.13 mbar d) Ethyl 2,7-diazabicyclo[3.3.0]octane-2-carboxylate 10 --- .2 g (53.5 mmol) of 2-ethyl 7-tert.-butyl 2,7diazabicyclo[3.3.0]octane-2,7-dicarboxylate in 10Q ml of chloroform are heated under reflux for five hours with .5 g (55.3 mol) of para-toluenesulphonic acid. The mixture is washed with 50 ml of 10% strength sodium hydroxide solution, the organic phase is dried over potassium carbonate and concentrated, and the residue is distilled.
Yields 9.5 g (96.4% of theory) Boiling point: 80 - 90°C / 0.1 mbar fre A. 21.6.8$ - 26 Example 4 2-Methvl-2,7-diazabicvclor 3.3.01octane a) Ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7carboxylate I C00C2H5 8.6 g (50 mmol) of ethyl N-allyl-N-(2-oxoethyl)carbamate are heated under reflux overnight with 4.5 g (50 mmol) of aarcosine in 200 ml of toluene. The mixture is concentrated and the residue is distilled.
Yield: 7.5 g (75.7% of theory) Boiling point: 80 - 82C / 0.1 mbar b) 2-Methyl-2,7-diazabicyclo[3.3.0]octane I H g (45.4 mmol) of ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight with 50 ml of concentrated hydrochloric acid. The mixture is rendered alkaline with potassium carbonate, extracted ten times using 50 ml of chloroform Le A 26 686 each time, dried over potassium carbonate and concentrated, and the residue is distilled.
Yields 4.5 g (78% of theory) Boiling points 72*C / 25 mbar Example 5 2-Phenvl-2.7-diazabicvcloΓ 3.3.01octane a) Ethyl 2-phenyl-2,7-diazabicyclo[3.3.0]octane-7carboxylate 8.6 g (50 mmol) of ethyl N-allyl-N-(2-oxoethyl)carbamate and 7.6 (50 mmol) of phenylglycine are heated under reflux overnight in 200 ml of toluene. The mixture is decanted from resinous material and concentrated, and the residue is distilled.
Yields 8.1 g (62.2% of theory) Boiling points 151*C / 0.12 mbar b) 2-Phenyl-2,7-diazabicvclo Γ 3.3.01octane I H 7.6 g (31.6 nmol) of ethyl 2-phenyl-2,7-diaza20 bicyclo( 3.3.0] octane-7 -carboxylate are heated under fre A 2£ ,06 - 28 reflux overnight with 50 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 50 ml of 10% strength sodium hydroxide solution and the mixture is extracted five times using 50 ml of chloroform each time. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Yield: 3.7 g (62% of theory) Boiling point: 103°C / 0.08 mbar Example 6 3-Methyl-2.7-diazabicvclor 3.3.0 loctane a) N-Benzvlalanine 333 g (1.72 mmol) of N-benzylalanine methyl ester (J. Chem. Soc. 4374 (1952)) are heated under reflux overnight with 860 ml of water. Product which has deposi« ted is filtered off with suction and the filtrate is extracted once with tert.-butyl methyl ether. The aqueous solution is concentrated and the crystals obtained are dried over phosphorus pentoxide in a desiccator with the first crystal fraction.
Yield: 280 g (91% of theory) Melting point: 270 - 276°C (decomposition) Le A 26.686 b) Ethyl 2-benzyl-3-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxvlate 42.8 g (0.25 mol) of ethyl N-allyl-N-(2-oxoethyl)-carbamate are heated under reflux overnight with 44.8 g (0.25 mol) of N-benzylalanine in 750 ml of toluene. The mixture is concentrated and the residue is distilled twice.
Yield: 32 g (44.4% of theory) Boiling point: 128-133C/0.06 mbar The product consists to 96% of a stereoisomer, c) Ethyl 3-methyl-2,7-diazabicyclo[3.3.0Joctane-7carboxvlate I COOC2H5 g (0.11 mol) of ethyl 2-benzyl-3-methyl-2,7diazabicyclo[3.3.OJoctane-7-carboxylate in 560 ml of ethanol are hydrogenated at 100°C and 100 bar on 4.5 g of palladium-active carbon. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.
Le A 26 686 - 30 Yield: 17.1 g (77.7% of theory) Boiling point: 140-145*0/8 mbar d) 3-Methyl-2,7-diazabicvclor 3.3.0 Ί octane H g (85.7 mmol) of ethyl 3-methyl-2,7-diazabicyclo[3.3.0]octane-7 -carboxylate are heated under reflux overnight with 100 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 50 ml of water, rendered alkaline with potassium carbonate and extracted ten times using 50 ml of chloroform each time. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled. Yield: 6 g (55% of theory) Boiling point: 68-70*C/6 mbar Example 7 2.3-Dimethvl-2.7-diazabicyclo Γ 3.3.0 Ί octane a) Ethyl 2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane-7carboxvlate; CH cooc2h5 17.2 g (0.1 mol) of ethyl N-allyl-N-(2-oxoethyl) Le A 26 686 carbamate are heated under reflux overnight with 10.5 g (0.1 mol) of N-methylalanine in 300 ml of toluene. The mixture is concentrated and the residue is distilled. Yield: 11.3 g (53.2% of theory) Boiling points 8lC/0.25 mbar b) 2.3-Dimethyl-2.7-diazabicvcloΓ 3.3.01octane --N I H 7.25 g (34.2 mmol) of ethyl 2, S-dimethyl^^diazabicyclotS. 3.0]octane-7-carboxylate are heated under reflux overnight with 50 ml of concentrated hydrochloric acid. The mixture is rendered alkaline with potassium carbonate and extracted ten times using 50 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled. Yield: 3 g (62.5% of theory) Boiling point: 72-74°C/10 mbar Example 8 2.8-Dimethvl-2.7-diazablcvcloΓ 3.3.01octane a) Ethyl N- f 1.l-dimethoxvprop-2-vl1-carbamate H5C200C-NH-CH-CH(OCH3 ί 2 ch3 g (0.73 mol) of ethyl chloroformate are added dropwise with ice-cooling to 86.2 g (0.72 mol) of 2aminopropionaldehyde dimethyl acetal in 350 ml of toluene fre A 2$ W - 32 and 32 g (0.8 mol) of NaOH in 300 ml of water. The mixture is stirred for a further 2 hours at room temperature, the organic phase is separated off, the aqueous phase is extracted using toluene and the toluene solutions are dried over K2CO3. The extracts are concentrated and the residue is distilled.
Yield: 132 g (95% of theory) Boiling point: 55°C/0.06 mbar b) Ethvl N-allvl-N-(1.l-dimethoxvprop-2-vl)-carbamate H2C^ CH CHCOCH,), I I h,c-n-ch-ch, 2 I cooc2h5 151 g (0.79 mol) of ethyl N-(1,1-dimethoxyprop2-yl)-carbamate, 175 g of powdered potassium hydroxide and 2.8 g of triethylbenzylammonium chloride are initially introduced into 750 ml of toluene and 94 g. (0.777 mol) of allyl bromide are added dropwise at room temperature. After stirring overnight at room temperature, a further 10 g (82.6 mmol) of allyl bromide are added dropwise and the mixture is stirred for one day at room temperature. Water is added until all salts have gone into solution, and the aqueous phase is separated off and extracted twice with 150 ml of toluene each time. The extracts are dried over K2CO3 and concentrated, and the residue is distilled.
Yield: 173 g (94.7% of theory) Boiling point: 68’C/O.l mbar Le A 26 686 - 33 c) Allvl-(1»l-dimethoxvprop-2-vl)-amine CH CH(OCH,)2 1 1 HgC^NX^CHg H g of molecular sieve are added to 12 g (0.1 mol) of 1,1-dimethoxyacetone in 100 ml of ethanol and 7 g (0.12 mol) of allylamine are then added dropwise. The mixture is allowed to stand overnight at room temperature, decanted from the molecular sieve and cooled in an ice-bath to O’C, and 4 g (0.1 mol) of sodium borohydride are added in small portions. The mixture is stirred overnight at room temperature and concentrated, the residue is taken up in 100 ml of water, and the mixture is saturated with potassium carbonate and extracted five times with 100 ml of chloroform each time. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Yield: 10.3 g (64.7% of theory) Boiling point: 75’C/25 mbar d) Ethvl N-allvl-N-11. l-dimethoxvprop-2-vl) -carbamate H,C II CH CH(0CH3)2 H2ON<\CH3 cooc2h5 125 g (0.785 mol) of allyl-(1,l-dimethoxyprop-2yl)amine are initially introduced into 400 ml of toluene, a solution of 40 g of sodium hydroxide in 200 ml of water Le A 26 686 - 34 h2C II CH H9C^N> is added, the mixture is cooled in an ice-bath to 0°C and 95 g (0.876 mol) of ethyl chloroformate are added dropwise. The mixture is then stirred for 3 hours at room temperature, and the aqueous phase is separated off and extracted twice using 100 ml of toluene each time. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Yield: 170.8 g (94% of theory) Boiling point: 55*C/0.05 mbar e) Ethyl N-allvl-N- (1-oxoprop-2-vl) -carbamate CHO ^H3 cooc2h5 182 g (0.787 mol) of ethyl N-allyl-N-(1,1-dimethoxyprop-2-yl) -carbamate in 1.5 1 of water are heated under reflux for three hours with 80 ml of formic acid.
The mixture is saturated with sodium chloride, the organic phase is separated off and the aqueous phase is extracted twice with 500 ml of methylene chloride each time. The organic solutions are washed with saturated sodium hydrogen carbonate solution until neutral, dried » over magnesium sulphate and concentrated, and the residue is distilled.
Yield: 134 g (91.9% of theory) Boiling point: 65eC/0.23 mbar Le A 26 686 - 35 f) Ethyl 2,8-dimethyl-2,7-diazabicyclo[3.3.0]octane-7carboxvlate 18.5 g (0.1 mol) of ethyl N-allyl-N-(1-oxoprop5 2-yl)-carbamate are heated under ref lux - overnight In a water separator with 9 g (0.1 mol) of sarcosine in 300 ml of toluene. The mixture is concentrated and the residue is distilled.
Yield: 17 g (80% of .theory) Boiling point: 140-150"C/8 mbar g) 2.8-Dimethvl-2,7-diazabicycloΓ 3.3.0 Ίoctane H 16.9 g (79.6 mol) of ethyl 2,8-dimethyl-2,7diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight with 130 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 50 ml of water, and the mixture is rendered alkaline with potassium carbonate and extracted five times using 50 ml of chloroform each time. The extracts are dried over potassium carbonate and concentrated, and the Le A 26 686 - 36 residue is distilled.
Yield: 6.6 g (58.5% of theory) Boiling point: 60-62C/6 mbar Example 9 -Chloro-2-methvl-2.7-diazabicvclo Γ 3.3.0 Ί octane a) Ethyl N-(2-chloroallyl)-N-(2,2-dimethoxyethyl)carbamate h2c II^Cl C CHCOCH,), I I 2 I C00C2H5 115 g (0.65 mol) of ethyl N-(2,2-dimethoxyethyl)10 carbamate, 130 g of powdered potassium hydroxide and 2 g of triethylbenzylammonium chloride are initially introduced into 650 ml of toluene and 142 g (0.7 mol) of 2chloroallyl iodide are added dropwise at room temperature. After stirring overnight, a gas chromatogram showed incomplete conversion, hence 65 g of powdered potassium hydroxide and 1 g of triethylbenzylammonium chloride were added again and a further 71 g (0.35 mol) of 2-chloroallyl iodide were added dropwise. After stirring overnight at room temperature, the salts were filtered off with suction, the filtrate was washed with saturated sodium chloride solution, dried over magnesium sulphate and concentrated, and the residue was distilled.
Yield: 140.9 g (86% of theory) Boiling point: 92-97*0/0.8 mbar Le A 26 686 - 37 b) Ethvl N- (2-chloroallvl 1 -Ν-12-oxoethvl 1 -carbamate 151 g (0.6 mol) of ethyl N-(2-chloroallyl)-N(2,2-dimethoxyethyl)-carbamate are heated under reflux for 3 hours with 60 ml of formic acid in 1.2 1 of water The mixture is saturated with sodium chloride, and the aqueous phase is separated off and extracted twice with 300 ml of methylene chloride each time. The organic phases are washed with saturated sodium hydrogen car10 bonate solution until neutral, dried over magnesium sulphate and concentrated, and the residue is distilled. Yield: 97.1 g (78% of theory) Boiling point: 88-91°C/0.06 mbar c) Ethyl 5-chloro-2-methyl-2,7-diazabicyclo[3.3.0]15 octane-7-carboxvlate_ Cl cooc2h5 .3 g (50 mmol) of ethyl N-(2-chloroallyl)-N-(2oxoethyl)-carbamate are heated under reflux overnight with 4.5 g (50 mmol) of sarcosine in 200 ml of toluene.
The mixture is concentrated and the residue is distilled. Yield: 10.6 g (91% of theory) be A 26 686 - 38 Boiling point: . 80’C/O.l mbar d) 5-Chloro-2-methvl-2.7-diazabicyclo[3.3.0 Ίoctane 9.3 g (40 nmol) of ethyl 5-chloro-2-methyl-2,7diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight with 50 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 30 ml of water, and the mixture is rendered alkaline with potassium carbonate and extracted five times with 50 ml of chloroform each time. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Yield: 4.7 g (72% of theory) Boiling point: 73C/4 mbar Example 10 -Chloro-2,3-dimethvl-2.7-diazabicvclo Γ 3.3.01octane a) Ethyl 5-chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate .3 g (50 mmol) of ethyl N-( 2-chloroallyl )-N-( 2 Le A 26 686 - 39 oxoethyl)-carbamate are heated under reflux overnight with 5.2 g (50.5 mmol) of N-methylalanine in 200 ml of toluene. The mixture is concentrated and the residue is distilled.
Yield: 8.1 g (65.7% of theory) Boiling point: 87C/0.08 mbar b) 5-Chloro-2,3-dimethvl-2,7-diazabicvclor 3.3.0loctane H H 7.6 g (30.8 mmol) of ethyl 5-chloro-2,3-dimethyl10 2,7-diazabicyclo[3.3.0 ] octane-7-carboxylate are heated under reflux overnight with 30 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 30 ml of water, and the mixture is rendered alkaline with potassium carbonate, extracted five times with 50 ml of chloroform each time, dried over potassium carbonate and concentrated, and the residue is distilled. Yield: 3.7 g (68.4% of theory) Boiling point: 95-97C/6 mbar Le A M.....63$ - 40 Example 11 1,4-Diazatricyclo [6.2.0.02*6] decane a) Ethyl l,4-diazatricyclo[6.2.0.02,6]decane-45 carboxylate_ I cooc2h5 17.1 g (0.1 mol) of ethyl N-allyl-N-(2-oxoethyl)carbamate are heated under reflux overnight in a water separator with 10 g (0.1 mol) of azetidine-2-carboxylic acid in 200 ml of toluene. Unreacted amino acid is filtered off with suction, the filtrate is concentrated and the residue is distilled.
Yields 13.8 g (65.6% of theory) Boiling point: 108*C/0.35 mbar b) 1,4-Diazatricyclo [6.2.0.02,6 ]decane H 13.7 g (65.1 mmol) of ethyl 1,4-diazatricyclo[6.2.0.02,6]decane-4-carboxylate are heated under reflux overnight with 42 g of Ba(0H)2.8H20 in 150 ml of water.
Le A 26 686 - 41 Potassium carbonate is added, barium carbonate is filtered off with suction and the filtrate is extracted ten times using 100 ml of chloroform each time. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Yield: 5.3 g (58.9% of theory) Boiling point: 85*C/6 mbar Example 12 1,4-Diazatricyclo[6.3.0.02,B]undecane ---- I cooc2h5 8.6 g (50 mmol) of ethyl N-allyl-N-(2-oxoethyl)15 carbamate are heated under reflux overnight with 5.8 g (50 mmol) of proline in 200 ml of toluene. The mixture is concentrated and the residue is distilled.
Yield: 9.6 g (86% of theory) Boiling point: 102-112C/0.13-0.15 mbar Le A b) 1,4-Diazatricyclo[ 6.3.0. Oz**]undecane I H g (40 mmol) of ethyl 1,4-diazatricyclo5 [6.3.0.02>s]undecane-4-carboxylate are heated under reflux overnight with 50 ml of concentrated hydrochloric acid. The mixture is rendered alkaline with potassium carbonate and extracted ten times using 50 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Yield: 4.9 g (80.5% of theory) Boiling point: 50C/0.05 mbar Example 13 -Hydroxy-1,4-diazatricyclo [6.3.0.02,s]undecane a) Ethyl 10-hydroxy-l, 4-diazatricyclo[ 6.3.0.02,6]undecane-4-carboxvlate OH I cooc2h5 8.6 g (50 mmol) of ethyl N-allyl-N-(2-oxoethyl)I»e A 26 686 - 43 carbamate are . heated at 120°C overnight with 6.6 g (50 mmol) of trans-4-hydroxyproline in 200 ml of dimethylformamide. The mixture is concentrated and the residue is distilled.
Yield: 9.7 g (81% of theory) Boiling point: 170°C/0.3 mbar The product consists predominantly of two stereoisomers in the ratio 1:1. b) 10-Hydroxy-l, 4-diazatricyclo [6.3.0.02,6]undecane OH I H g (33.3 mmol) of ethyl 10-hydroxy-l,4-diazatricyclo[6.3.0.02B]uridecane-4-carboxylate are heated under reflux overnight with 21 g of Ba(QH)2.8H2O in 150 ml of water. The mixture is saturated with potassium carbonate, barium carbonate is filtered off with suction and the. filtrate is extracted ten times using 100 ml of chloroform each time. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Yield: 4.6 g (82% of theory) Boiling point: 110-115*0/0.1 mbar Le A 26 686 - 44 Example 14 1,4-Diazatricyclo [6.4.0.02>s]dodecane a) Ethyl l,4-diazatricyclo[6.4.0.02,e)dodecane-4- I cooc2h5 17.1 g (0.1 mol) of ethyl N-allyl-N-(2-oxoethyl)carhamate are heated under reflux overnight with 13 g (0.1 mol) of piperidine-2-carboxylic acid in 200 ml of toluene. The mixture is concentrated and the residue is distilled.
Yields 20.8 g (87.2% of theory) Boiling point: 105-112*0/0.12 mbar b) 1,4-Diazatricyclo [6.4.0.02,6 ] decane .7 g (86.8 mmol) of ethyl 1,4-diazatricyclo[6.4.0.02,e]dodecane-4-carboxylate are heated under reflux overnight with 250 ml of concentrated hydrochloric acid.
The mixture is concentrated, the residue is taken up in LeAJ26_.6$$ 50 ml of water and the mixture is rendered alkaline with potassium carbonate. It is extracted ten times using 50 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Yields 8.5 g (58.9% of theory) Boiling points 108C/8 mbar Example 15 -Thia-1,4-diazatricyclo[6.3.0.02,s]undecane ,0 -;-a) Ethyl 10-thia-l,4-diazatricyclo [6.3.0.02*"]undecane4-carboxvlate I cooc2h5 17.2 g (0.1 mol) of ethyl N-allyl-N-(2-oxoethyl)15 carbamate are heated under reflux overnight with 13.5 g (0.1 mol) of thiazolidine-4-carboxylic acid in 300 ml of toluene. The mixture is concentrated and the residue is distilled.
Yield: 20 g (82.5% of theory) Boiling point: 155-156C/0.5 mbar Le A 26 686 - 46 b) 10-Thia-1,4-diazatricyclo[6.3.0.02,6]undecane H I 12.5 g (50 mmol) of ethyl 10-thia-l,4-diazatri5 cyclo [6.3.0.02,6] undecane-4-carboxylate are heated under reflux overnight with 32 of Ba(OH)2.8H2O in 225 ml of water. Potassium carbonate is added to the mixture, barium carbonate is filtered off with suction and the filtrate is extracted ten times using 100 ml of chloro10 form each time. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled. Yield: 6.2 g (72.8% of theory) Boiling point: 90-94°C/0<05 mbar Example 16 9,9-Dimethyl-10-thia-l,4-diazatricyclo[ 6.3.0.02,e]undecane a) Ethyl 9r9-dimethyl-10-thia-l,4-diazatricyclo [6.3.0.02,6] -undecane-4-carboxylate Le A 26 686 - 47 8.6 g (50 nmol) of ethyl N-allyl-N-(2-oxoethyl)carbamate are heated under reflux overnight with 8.1 g (50 mmol) of 5,5-dimethylthiazolidine-4-carboxylic acid in 200 ml of toluene. The mixture is concentrated and the residue is distilled.
Yields 8.4 g (62.2% of theory) Boiling points 141-155°C/0.03-0.05 mbar b) 9,9-Dimethyl-10-thia-l, 4-diazatricyclo [6.3.0.02’6] undecane_t_ .. g (22.2 mmol) of ethyl 9,9-dimethyl-10-thia1,4-diazatricyclo [6.3.0.02,6]undecane-4-carboxylate are heated under reflux overnight with 12 g of Ba(OH)2.8H2O in 100 ml of water. Potassium carbonate is added, barium carbonate is filtered off with suction and the filtrate is extracted ten times using 100 ml of chloroform each time. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Yields 2.25 g (51% of theory) Boiling point: 83*C/0.02 mbar Le A 2_6_6.Qj6 Example 17 7-Methvl-2,7-diazabicvclor3.3.0 Ίoctane a) 2-Benzvl-7-methvl-2,7-diazabicvclo Γ 3.3.0loctane 13.7 g (50 mmol) of ethyl 2-benzyldiazabicyclo[3.3.0]octane-7-carboxylate in 20 ml of absolute tetrahydrofuran are added dropwise to 3.8 g (0.1 mol) of lithium aluminium hydride in 100 ml of absolute tetrahydrofuran. The mixture is heated under reflux overnight and decomposed successively with 4 ml each of water, 15% strength potassium hydroxide solution and water. The inorganic salts are filtered off with suction and boiled three times with 50 ml of tetrahydrofuran each time. The organic solutions are concentrated and the residue is distilled.
Yield: 10.4 g (96% of theory) Boiling point: 90-100°C/0.1 mbar b) 7-Methvl-2,7-diazabicvclor 3.3.0loctane .3 g (47.6 mmol) of 2-benzyl-7-methyl-2,7Le A 26 ¢66 - 49 diazabicyclo[3.3.Ο]octane in 200 ml of ethanol are hydrogenated at 100*C and 100 bar on 2.5 g of palladiumactive carbon (10% Pd). The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.
Yield: 4.2 g (69.9% of theory) Boiling point: 50-53*0/6 mbar Example 18 2-Benzvl-8-methvl-2.7-diazabicvcloΓ 3.3.01octane 10 a) Ethyl 2-benzyl-8-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate cooc2h5 g (0.2 mol) of ethyl N-allyl-N-(l-oxo-2propyl)-carbamate are heated under reflux overnight in a water separator with 33 g (0.2 mol) of N-benzylglycine in 500 ml of toluene. The mixture is concentrated and the residue is distilled.
Yield: 48.5 g (84% of theory) Boiling point: 140-145*0/0.2 mbar The product is a homogeneous stereoisomer by gas chromatography. be A 26 686 - 50 b) 2-Benzvl-8-methvl-2,7-diazabicvcloΓ 3.3.0 Ίoctane H g (55 mmol) of ethyl 2-benzyl-8-methyl-2,7diazabicyclo[3.3.0]octane-7-carboxylate axe heated under reflux overnight with 50 ml of concentrated hydrochloric acid. The mixture is concentrated, and the residue is dissolved in 50 ml of water and rendered alkaline with potassium carbonate. The mixture is extracted five times using 50 ml of chloroform each time, the extracts are dried over K2CO3 and concentrated, and the residue is distilled.
Yield: 7.9 g (66.4% of theory) Boiling point: 108-113*C/0.17 mbar Example 19 8-Methvl-2.7-diazabicvcloΓ3.3.01octane CH7.8 g (36 mmol) of 2-benzyl-8-methyl-2,7-diazabicyclo[3.3.0]octane in 200 ml of ethanol are hydrogenated at 100 *C and 100 bar on 2 g of palladium-active carbon (10% Pd). The catalyst is filtered off with Le A 26 686 - 51 suction, the filtrate is concentrated and the residue is distilled. The distillate crystallises.
Yield: 3.3 g (72.7% of theory) Boiling point: 110°C/30 mbar Melting point: 72-75°C Example 20 Ethyl 8-methyl-2,7-diazabicyclo[3.3.0]octane-7qarboxvlate; g (55 mmol) of ethyl 2-benzyl-8-methyl-2,7 diazabicyclo[3.3.0]octane-7-carboxylate In 300 ml of ethanol are hydrogenated at 100°C and 100 bar on 3 g of palladium-active carbon (10% Pd). The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.
Yield: 9.7 g (89% of theory) Boiling point: 100"C/0.1 mbar Example 21 7.8-Pimethvl-2.7-dlazabicvclor 3.3.0 loctane a) 2-Bensvl-7.8-dimethvl-2.7-dlazabicvclor 3.3.01 octane Le A 26 686 - 52 14.4 g (50 mmol) of ethyl 2-benzyl-8-methyl-2,7diazabicyclo[3.3.0]octane-7-carboxylate in 20 ml of absolute tetrahydrofuran are added dropwise to 3.8 g (0.1 mol) of lithium aluminium hydride in 100 ml of absolute tetrahydrofuran and the mixture is then heated under reflux overnight. It is decomposed successively .using 4 ml each of water, 15% strength potassium hydroxide solution and water, and the inorganic salts are filtered off with suction and boiled three times with 50 ml of tetrahydrofuran each time. The organic solutions are concentrated and the residue is distilled.
Yield: 10.9 g (94.6% of theory) Boiling point: 105*C/0.08 mbar b) 7,8-Dimethvl-2.7-diazabicyclo Γ 3.3.01octane .8 g (46.9 mmol) of 2-benzyl-7,8-dimethyl-2,7diazabicyclo[3.3.0]octane in 200 ml of ethanol are hydrogenated at 100°C and 100 bar on 2.5 g of palladiumactive carbon. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.
Yield: 4.3 g (65.4% of theory) Boiling point: 60-62C/6 mbar Le A 26 686 Example 22 4-Methvl-2.7-diazabicvclo Γ 3.3.0 loctane a) N- (2-Buten-l-vl) -N- f 2.2-dimethoxvethvl 1 -amine 200 g of molecular sieve are initially introduced into 1,000 ml of ethanol and 105 g (1 mol) of aminoacetaldehyde dimethyl acetal and 70 g (1 mol) of crotonaldehyde are added. The mixture is allowed to stand at room temperature overnight, decanted off from molecular sieve and cooled to 0°C, and 40 g of sodium borohydride are added in 1 g portions. The mixture is then stirred overnight at room temperature and concentrated, the residue is taken up in 500 ml of water and potassium carbonate is added until an organic phase separates. This is extracted using chloroform, dried over potassium carbonate and concentrated, and the residue is distilled. Yield: 69.5 g (41.5% of theory) Boiling point: 85*C/12 mbar b) Ethyl N-(2-buten-l-yl)-N-(2,2-dimethoxyethyl)20 carbamate_ g (0.41 mol) of N-(2-buten-l-yl)-N-(2,2dimethoxyethyl)-amine are dissolved in 200 ml of toluene, 30 ml of 45% strength sodium hydroxide solution are added and 43 g (0.44 mol) of ethyl chloroformate are added dropwise with ice-cooling. The mixture is stirred for a further three hours at room temperature, and the aqueous phase is separated off and extracted with 100 ml of toluene. The extract is dried over potassium carbonate and concentrated, and the residue is distilled.
Yields 92 g (94% of theory) Boiling points 72C/0.08 mbar g (0.5 mol) of ethyl N-(2,2-dimethoxyethyl)carbamate are dissolved in 500 ml of toluene, 100 g of powdered potassium hydroxide and 1.5 g of triethylbenzylammonium chloride are added and 80 g (0.6 mol) of crotyl bromide (isomer mixture) are added dropwise. The mixture is stirred overnight at room temperature, the salts are dissolved in water, and the aqueous phase is separated off and extracted once using 100 ml of toluene. The extract is dried over potassium carbonate and concentrated, and the residue is distilled.
Yields 112 g (96.8% of theory) Boiling points 65eC/0.1 mbar c) Ethvl N-(2-buten-l-vl)-N-(2-oxoethvl)-carbamate I COOC H 2 5 Le A 26 686 - 55 10 111 g (0.48 mol) of ethyl N-(2-buten-l-yl)-N(2,2-dimethoxyethyl)-carbamate are heated under reflux for three hours with 50 g of formic acid in 950 ml of water. The mixture is saturated with sodium chloride and extracted three times using 200 ml of methylene chloride each time. The organic phases are washed with sodium hydrogen carbonate solution until neutral, dried over magnesium sulphate and concentrated, and the residue is distilled.
Yield: 77 g (86.6% of theory) Boiling point: 94 to 100’C/0.15 mbar d) Ethyl 2-benzyl-4-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate__ 18.5 g (0.1 mol) of ethyl N-(2-buten-l-yl)-N-(2oxoethyl)-carbamate are heated under reflux overnight in a water separator with 16.5 g (0.1 mol) of N-benzylglycine in 300 ml of toluene. The mixture is concentrated and the residue is distilled.
Yield: 10 g (25% of theory) Boiling point: 135 to 142’C/0.1 mbar The product is 76% pure by gas chromatography. - 56 e) 2-Benzvl-4-methvl-2.7-diazabicvcloΓ 3.3.0loctane H3 H g (26.3 nmol) of ethyl 2-benzyl-4-methyl-2,7diazabicyclo[3.3.0]octanc>-7-carboxylate are heated under reflux overnight with 100 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 20 ml of water, the mixture is rendered alkaline with potassium carbonate and extracted five times using 50 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Yield: 4.6 g (81% of theory) Boiling point: 87 to 95*C/0.13 mbar The product is 76% pure by gas chromatography. f) 4-Methyl-2.7-diazabicvclo Γ 3.3.01 octane h3cxxz^n-h Sr ι H 4.1 g (19 mmol) of 2-benzyl-4-methyl-2,7-diazabicyclo[3.3.0)octane in 80 ml of methanol are hydrogenated at 100 *C and 100 bar on 1 g of palladium-active Le A 26 686 - 57 carbon (10% Pd). The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.
Yields 1.2 g (50% of theory) Boiling point: 76C/8 mbar Example 23 -Fluoromethvl-2-methvl-2.7-diazabicvcloΓ 3.3.01octane a) Ethyl N-(2-fluoromethylallyl)-N-(2,2-dimethoxyethvlI-carbamate g (0.26 mol) of sodium hydride (80% pure) are initially introduced into 200 ml of toluene and 35.8 g (0.2 mol) of ethyl N-(2,2-dimethoxyethyl)-carbamate are added dropwise at 90*C. The mixture is then stirred for one hour at 90C and 32.6 g (0.3 mol) of l-chloro-2fluoromethylprop-2-ene are then added dropwise. The mixture is stirred overnight at 90 "C, salts are dissolved in water, and the aqueous phase is separated off and extracted with toluene. The organic phases are dried over potassium carbonate and concentrated, and the residue is distilled.
Yields 28.2 g (56.6% of theory) Boiling points 71 to 79*C/0.07 mbar mi ii ¢88 - SB b) Ethyl Nt (2-fluoromethylallyl) -N- (2-oxoethyl) carbamate CHO I cooc H 2 5 g (0.1 mol) of ethyl N-(2-fluoromethylallyl)N-(2,2-dimethoxyethyl)carbamate are heated under reflux for two hours with 5 g of formic acid in 100 ml of water. The mixture is saturated with sodium chloride and extracted with methylene chloride, and the organic phases are washed with sodium hydrogen carbonate solution until neutral. They are dried over magnesium sulphate and concentrated, and the residue is distilled.
Yield: 18.5 g (87% of theory) Boiling point: 84*C/0.18 mbar c) Ethyl 5-fluoromethyl-2-methyl-2,7-diazabicycloΓ 3.3.0 Ί octane-7-carboxylate; f-ch2 I COOC H 2 5 9.1 g (43 mmol) of ethyl N-(2-fluoromethylallyl)N-(2-oxoethyl)-carbamate are heated under reflux overnight in a water separator with 3.9 g (43 mmol) of powdered sarcosine in 170 ml of toluene. The mixture is Le A76-6S6 concentrated and the residue is distilled.
Yield: 7.5 g (75.8% of theory) Boiling point: 80 to 100°C/0.25 to 0.35 mbar d) 5-Fluoromethyl-2-methyl-2,7-diazabicyclo[ 3.3.0 ] octane' fX^N-CH3 f-ch2-I H 7.1 g (26 mmol) of ethyl 5-fluoromethyl-2-methyl2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight in 100 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 20 ml of water, the mixture is rendered alkaline with potassium carbonate and extracted ten times using 50 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Yield: 0.8 g (20% of theory) Boiling point: 34’C/0.07 mbar 3^e-A.2.6—6-Rfe Example 24 -Fluoro-7-methvl-2.7-diazabicvcloΓ 3.3.0loctane a) Ethyl N-(2,2-dimethoxyethyl)-N-(2-fluoroallyl,carbamate 0CH3 och3 cooc2h5 11.6 g (65.5 mmol) of ethyl N-(2,2-dimethoxyethyl)-carbamate, 15 g of powdered potassium hydroxide and 0.25 g of triethylbenzylammonium chloride are initially introduced into 65 ml of toluene and 10 g (72 mmol) of 2-fluoroallyl bromide are added dropwise at room temperature. The mixture is stirred overnight at room temperature, 100 ml of water are added, and the aqueous phase is separated off and extracted using 30 ml of toluene. The organic solutions are dried over magnesium sulphate and concentrated, and the residue is distilled.
Yield: 14.1 g (91.5% of theory) Boiling point: 72°C/0.3 mbar b) Ethvl N-l2-fluoroallvlI-N-(2-oxoethvlI-carbamate I cooc2h5 14.1 g (60 mmol) of ethyl N-(2,2-dimethoxyethyl)Le A 26 686 N-(2-fluoroallyl) -carbamate are heated under reflux for three hours with 6.3 ml of formic acid in 120 ml of water. The solution is saturated with sodium chloride and extracted several times with methylene chloride, the organic solutions are washed with saturated sodium hydrogen carbonate solution, dried over magnesium sulphate and concentrated, and the residue is distilled. Yields 9.8 g (86% of theory) Boiling points 80"C/0.25 mbar c) Ethyl 2-benzyl-5-fluoro-2,7-diazabicyclo[ 3.3.0 ]octane-7-carboxylate___ COOC2H5 .8 g (0.11 mol) of ethyl N-( 2-f luoroallyl )-11(2-oxoethyl)-carbamate are heated under reflux with 19 g (0.115 mol) of N-benzylglycine in 300 ml of toluene until evolution of CO2 is complete. The mixture is concentrated and the residue is distilled.
Yields 16.4 g (44.8% of theory) Boiling point: 148-152C/0.1 mbar The product is 88% pure by gas chromatography.
Le A 26 686 - 62 d) 2-Benzyl-5-f luoro-7-methyl-2,7-diazabicyclo [ 3.3.0]octane A solution of 16 ;4 g (49.4 mmol, 88% pure) of 5 ethyl 2-benzyl-5-fluoro-2,7-diazabicyclo [3.3.0]octane-7carboxylate in 25 ml of absolute tetrahydrofuran is added dropwise to 4.3 g (0.11 mol) of lithium aluminium hydride in 125 ml of absolute tetrahydrofuran and the mixture is then heated overnight under reflux. It is decomposed successively with 4.5 ml each of water, 15% strength potassium hydroxide solution and water, and the inorganic salts are filtered off with suction and boiled three times with 50 ml of tetrahdrofuran each time. The organic solutions are concentrated and the residue is distilled.
Yield: 11 g (88% of theory) Boiling point: 98-108*0/0.08 bar The product is 93% pure by gas chromatography, e) 5-Fluoro-7-methvl-2.7-diazablcvclo Γ 3.3.0 7octane F-I ch3 Le_A_J2g_g8g — 63 — g (43.7 mmol, 93% pure) of 2-benzyl-5-fluoro7-methyl-2,7-diazabicyclo[3.3.0]octane in 100 ml of ethanol are hydrogenated at 100 *C and 100 bar on 2 g of palladium-active carbon (10% Pd). The catalyst is fil5 tered off with suction, the filtrate is concentrated and the residue is distilled.
Yields 4.4 g (69.8% of theory) Boiling points 85-90’C/25 mbar Example 25 Ethyl 6-methyl-2,7-diazabicyclo[3.3.0]octane-7carboxvlate a) Ethyl N-(l-buten-3-yl)-N-(2,2-dimethoxyethyl)carbamate CH(OCH3)2 .5 g (0.2 mol) of ethyl N-(2,2-dimethoxyethyl)-carbamate and 26 g of powdered potassium hydroxide in 400 ml of dimethylformamide and the mixture is warmed overnight to 40°C. The salts are dissolved with water and the mixture is extracted several times with methylene chloride. The organic extracts are dried over potassium carbonate and concentrated, and the residue is distilled. Yields 28.5 g (61.6% of theory) Boiling points 60C/0.08 mbar Le A 26 686 - 64 b) Ethvl N-(l-buten-3-vl)-N-(2-oxoethvl)-carbamate H2C5S5s CHO h3cA< Aooc2h5 28.3 g (0.122 mol) of ethyl N-(l-buten-3-yl)-N2,2-dime thoxye thyl) -carbamate are heated at 100 *C for one hour with 65 ml of formic acid. The mixture is poured onto 200 g of ice and extracted using methylene chloride, the organic extracts are washed with saturated sodium hydrogen carbonate solution, dried over magnesium sulphate and concentrated, and the residue is distilled. Yield: 11.6 g (51.3% of theory) Boiling point: 62-65*0/0.03 mbar c) Ethyl 2-benzyl-6-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxvlate 11.6 g (62.6 mmol) of ethyl N-(l-buten-3-yl)-N(2-oxoethyl)-carbamate and 10.4 g (62.6 mmol) of Nbenzylglycine in 170 ml of toluene are heated under reflux overnight in a water separator. The aixture is concentrated and the residue is distilled.
Yield: 13.7 g (75.9% of theory) Le A 26 686 - 65 Boiling point: 140-153*0/0.1 mbar. d) Ethyl 6-methyl-2,7-diazabicyclo[3.3.0]octane-7 carboxylate cooc2h5 g (44.9 mmol) of ethyl 2-benzyl-6-methyl-2,7 diazabicyclo [3.3.0] octane-7-carboxylate in 150 ml of ethanol are hydrogenated at 100 *C and 100 bar on 2 g of palladium-active carbon (10% Pd). The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.
Yield: 6.8 g (76.4% of theory) Boiling point: 81*C/0.09 mbar Example 26 Diethvl 2.7-diazabicvcloΓ3.3.01octane-3.7-dicarboxvlate a) Diethyl 2-benzyl-2,7-diazabicyclo[3.3.0]octane-3,7dicarboxvlate C00C2H5 cooc2h5 g (0.25 mol) of Ν-benzylglycine ethyl ester in 1 1 of toluene are heated under reflux in a water separate A 26686 - 66 tor and 43 g (0.25 mol) of ethyl N-allyl-N-(2-oxoethyl)carbamate are added dropwise during the course of two hours. The mixture is heated under reflux until water no longer separates and concentrated, and the residue is distilled.
Yield: 82.1 g (94.8% of theory) Boiling point: 160-165*0/0.05 mbar b) Diethyl 2,7-diazabicyclo[3.3.0)octane-3,7"dicarboxylate C00C2H5 jC I cooc2h5 96.5 g (0.279 mol) of diethyl 2-benzyl-2,7diazabicyclo[3.3.0]octane-3,7-dicarboxylate in 1 1 of ethanol are hydrogenated at 100C and 100 bar on 5 g of palladium-active carbon (10% Pd). The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.
Yield: 63.3 g (84.6% of theory) Bolling point: 137-140*0/0.18-0.2 mbar fte. A.2J 685 Example 27 ίfinal product! 1.7 g (15 mmol) of l,4-diazabicyclo[2.2.2]octane and 1.4 g (11 mmol) of 2-methyl-2,7-diazabicyclo[3.3.0]5 octane are added to 3 g (10 mmol) of 8-chloro-l-cyclopropyl-6,7-dif luoro-1,4-dihydro~4-oxo-3-quinolinecarboxylic acid in a mixture of 30 ml of acetonitrile and 15 ml of dimethylformamide and the mixture is heated under reflux for 1 hour. The mixture is evaporated, the residue is stirred with water and the undissolved precipitate is filtered off with suction, washed with water and dried at 120C in vacuo.
Yields 2.4 g (59% of theory) of 8-chloro-l-cyclopropyl6-fluoro-1,4-dihydro-7-(2-methyl-2,7-diazabicyclo[ 3.3.0]15 oct-7-yl)-4-oxo-3-quinolinecarboxylic acid, melting point: 208-213*C (with decomposition) (from glycol monomethyl ether).
Claims (5)
1. Process for the preparation of 2,7-diazabicyclo [3.3.0]octanes of the formula (I) R 3 rK/Ln-r 2 R 5 x^NX t XR 7 where R 1 , R 3 , R 4 , R 5 , R 7 and R 8 may be identical or 10 different and in each case denote H, q-C 5 alkyl (optionally substituted by halogen, hydroxyl or q-q-alkoxy), q-C 3 -alkoxycarbonyl or q-C-jj-aryl, preferably H, q-q-alkyl, q-qalkoxycarbonyl or phenyl, particularly 15 preferably H and methyl, R 4 additionally denotes halogen, preferably fluorine, chlorine or bromine, particularly preferably chlorine and bromine, R 2 and R c may be identical or different and denote 20 H, q-q-alkyl, benzyl,. q-q 2 -aryl, q-qalkanoyl, benzoyl or q-C 5 -alkoxycarbonyl and, if appropriate, R 2 and R 3 together denote a bridge of the structure (CH 2 ) a , CH 2 -CHOH-CH 2 , CH 2 -S-CH 2 or 25 C(CH 3 ) 2 -S-CH 2 , in which n represents 2-4, - 70 characterized in that unsaturated carbonyl compounds of the formula (II) are reacted with amino acid derivatives of the formula (III) in an intramolecular 1,3-dipolar cycloaddition R 8 ♦ R 2 -NH-CH-COOR* R 3 (I) + C0 2 + H 2 0 (III) (II) in which R' represents H or Cj-C 3 -alkyl and in which R 1 -R 8 have the abovementioned meaning, and the substituents R 2 or R c , in so far as they have a 10 protective group function, are then removed.
2. Compounds of the formula (II) R®-CH R 4 -C-CH-N-CH-CO-R 1 ( 11 ) L U f 7 r5 r 6 r 7 in which R 1 , R 4 , R s , R 7 and R 8 may be identical or different 15 and in each case denote H, Cj-Cj-alkyl (optionally substituted by halogen, hydroxyl or Ci-C 3 -alkoxy), C 1 -C 3 -alkoxycarbonyl or C 6 -C 12 aryl, preferably H, C 3 -C 3 -alkyl, C 3 -C 3 alkoxycarbonyl or phenyl, particularly 20 preferably H and methyl, R 4 additionally denotes halogen, preferably florine, chlorine or bromine, particularly preferably chlorine and bromine, R* denotes H, C 3 -C e -alkyl, benzyl, C 4 -C 12 -aryl, C 1 -C 3 -alkanoyl, benzoyl or Cj-C 5 -alkoxycarbonyl, preferably H, Cj-C 3 -alkyl, benzyl, C 4 -C 12 -aryl, 5 Cj-Cj-alkanoyl, benzoyl or C 1 -C 4 -alkoxycarbonyl, particularly preferably H, methyl, phenyl, acetyl or C 2 -C 4 -alkoxycarbonyl.
3. A process according to Claim 1 for the preparation , of 2,7-diazabicyclo[3.3.0]octanes of the formula given and defined therein, substantially as 10 hereinbefore described and exemplified.
4. 2,7-diazabicyclo[3.3.0]octanes of the formula given and defined in Claim 1 whenever prepared by a process claimed in Claim 1 .
5. A compound according to Claim 2, substantially as 15 hereinbefore described and exemplified.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3912509 | 1989-04-17 | ||
| DE3932903 | 1989-10-03 |
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| IE68591B1 true IE68591B1 (en) | 1996-06-26 |
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|---|---|
| US (1) | US5071999A (en) |
| EP (1) | EP0393424B1 (en) |
| JP (1) | JPH02292288A (en) |
| KR (1) | KR0166963B1 (en) |
| AT (1) | ATE128466T1 (en) |
| CA (1) | CA2014478A1 (en) |
| DE (1) | DE59009705D1 (en) |
| DK (1) | DK0393424T3 (en) |
| ES (1) | ES2079391T3 (en) |
| GR (1) | GR3017384T3 (en) |
| IE (1) | IE68591B1 (en) |
| PT (1) | PT93702B (en) |
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| US5177210A (en) * | 1989-04-17 | 1993-01-05 | Bayer Aktiengesellschaft | Preparation of 2,7-diazabicyclo(3.3.0)octanes |
| KR960003611B1 (en) * | 1992-07-23 | 1996-03-20 | 재단법인 한국화학연구소 | New diazabicyclo alkene derivatives and the preparation process thereof |
| CA2389553C (en) | 1999-12-14 | 2010-06-22 | Neurosearch A/S | Heteroaryl-diazabicycloalkanes |
| US6809105B2 (en) * | 2000-04-27 | 2004-10-26 | Abbott Laboratories | Diazabicyclic central nervous system active agents |
| MY137020A (en) | 2000-04-27 | 2008-12-31 | Abbott Lab | Diazabicyclic central nervous system active agents |
| WO2002070523A1 (en) * | 2001-03-07 | 2002-09-12 | Pfizer Products Inc. | Modulators of chemokine receptor activity |
| ATE418555T1 (en) | 2003-04-09 | 2009-01-15 | Biogen Idec Inc | A2A ADENOSIN RECEPTOR ANTAGONISTS |
| US20050065178A1 (en) | 2003-09-19 | 2005-03-24 | Anwer Basha | Substituted diazabicycloakane derivatives |
| US7728031B2 (en) | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
| US8735411B2 (en) * | 2006-10-02 | 2014-05-27 | Abbvie Inc. | Macrocyclic benzofused pyrimidine derivatives |
| US7985745B2 (en) * | 2006-10-02 | 2011-07-26 | Abbott Laboratories | Method for pain treatment |
| US20080159958A1 (en) * | 2006-12-27 | 2008-07-03 | Abbott Laboratories | Determination of histamine-3 bioactivity |
| WO2009036132A1 (en) | 2007-09-11 | 2009-03-19 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole n-oxides |
| US8278313B2 (en) * | 2008-03-11 | 2012-10-02 | Abbott Laboratories | Macrocyclic spiro pyrimidine derivatives |
| MX350575B (en) | 2012-09-27 | 2017-09-11 | Bayer Cropscience Ag | Process for the preparation of optionally substituted phenyl and pyridyl pyrrolidines. |
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| HU198372B (en) * | 1984-07-18 | 1989-10-30 | Sandoz Ag | Insecticide compositions containing carbaminic acid derivatives as active components and process for producing th the active components |
| JPH0676400B2 (en) * | 1987-08-25 | 1994-09-28 | 大日本製薬株式会社 | Novel pyridonecarboxylic acid derivative, its ester and its salt |
| DE3906365A1 (en) * | 1988-07-15 | 1990-01-18 | Bayer Ag | 7- (1-PYRROLIDINYL) -3-CHINOLONE AND NAPHTHYRIDONE CARBOXYLIC ACID DERIVATIVES, METHOD AND SUBSTITUTED (OXA) DIAZABICYCLOOCTANES AND NONANESE AS INTERMEDIATE PRODUCTS, AND ANTIBACTERIAL AGENTS AND FOOD ADDITIVES CONTAINING THEM |
| DE3910663A1 (en) * | 1989-04-03 | 1990-10-04 | Bayer Ag | 5-ALKYLCHINOLON CARBONIC ACIDS |
-
1990
- 1990-04-04 DK DK90106459.2T patent/DK0393424T3/en active
- 1990-04-04 AT AT90106459T patent/ATE128466T1/en not_active IP Right Cessation
- 1990-04-04 DE DE59009705T patent/DE59009705D1/en not_active Expired - Fee Related
- 1990-04-04 ES ES90106459T patent/ES2079391T3/en not_active Expired - Lifetime
- 1990-04-04 EP EP90106459A patent/EP0393424B1/en not_active Expired - Lifetime
- 1990-04-09 PT PT93702A patent/PT93702B/en not_active IP Right Cessation
- 1990-04-10 US US07/507,938 patent/US5071999A/en not_active Expired - Fee Related
- 1990-04-10 JP JP2093304A patent/JPH02292288A/en active Pending
- 1990-04-12 IE IE134390A patent/IE68591B1/en not_active IP Right Cessation
- 1990-04-12 CA CA002014478A patent/CA2014478A1/en not_active Abandoned
- 1990-04-17 KR KR1019900005297A patent/KR0166963B1/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| PT93702A (en) | 1990-11-20 |
| KR900016215A (en) | 1990-11-12 |
| KR0166963B1 (en) | 1999-01-15 |
| DK0393424T3 (en) | 1996-02-05 |
| GR3017384T3 (en) | 1995-12-31 |
| PT93702B (en) | 1996-08-30 |
| CA2014478A1 (en) | 1990-10-17 |
| ATE128466T1 (en) | 1995-10-15 |
| EP0393424A3 (en) | 1991-10-16 |
| US5071999A (en) | 1991-12-10 |
| EP0393424A2 (en) | 1990-10-24 |
| IE901343L (en) | 1990-10-17 |
| EP0393424B1 (en) | 1995-09-27 |
| JPH02292288A (en) | 1990-12-03 |
| DE59009705D1 (en) | 1995-11-02 |
| ES2079391T3 (en) | 1996-01-16 |
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