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IE45692L - 1-amino-2-hydroxy-3-heterocyclyloxypropanes. - Google Patents

1-amino-2-hydroxy-3-heterocyclyloxypropanes.

Info

Publication number
IE45692L
IE45692L IE771938A IE193877A IE45692L IE 45692 L IE45692 L IE 45692L IE 771938 A IE771938 A IE 771938A IE 193877 A IE193877 A IE 193877A IE 45692 L IE45692 L IE 45692L
Authority
IE
Ireland
Prior art keywords
cyanopyridine
dimethoxyphenyl
heterocyclyloxypropanes
hydroxy
amino
Prior art date
Application number
IE771938A
Other versions
IE45692B1 (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IE45692L publication Critical patent/IE45692L/en
Publication of IE45692B1 publication Critical patent/IE45692B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Novel 2-[3'-(2-(3,4-dimethoxyphenyl)ethylamino)- 2'-hydroxypropoxy]-3-cyanopyridine of the formula <IMAGE> and its acid addition salts are prepared by hydrolysis of [3'-(2-(3,4-dimethoxyphenyl)ethyl)-2'-phenyloxazolidin-5'-yl]methoxy-3 -cyanopyridine. The compound and its salts are cardioselective beta receptor blockers having additional alpha receptor-blocking and hypertensive properties, by virtue of which they can be used in the treatment of the indications known for beta receptor blockers, e.g. angina pectoris and cardiac arrhythmias, in particular hypertension. [GB1591723A]
IE1938/77A 1976-10-05 1977-09-22 1-amino-2-hydroxy-3-heterocyclyloxy-propanes IE45692B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1263576A CH607585A5 (en) 1976-10-05 1976-10-05 Process for the preparation of 2-[3'-(2-(3,4-dimethoxy-phenyl)ethylamino)-2'-hydroxypropoxy]-3-cyanop yridine

Publications (2)

Publication Number Publication Date
IE45692L true IE45692L (en) 1978-04-05
IE45692B1 IE45692B1 (en) 1982-10-20

Family

ID=4384944

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1938/77A IE45692B1 (en) 1976-10-05 1977-09-22 1-amino-2-hydroxy-3-heterocyclyloxy-propanes

Country Status (21)

Country Link
JP (1) JPS5350177A (en)
AT (1) AT358037B (en)
AU (1) AU514676B2 (en)
BE (1) BE858867A (en)
CA (1) CA1105021A (en)
CH (1) CH607585A5 (en)
DE (1) DE2740678A1 (en)
DK (1) DK402877A (en)
ES (1) ES462389A1 (en)
FI (1) FI772681A7 (en)
FR (1) FR2367065A1 (en)
GB (1) GB1591723A (en)
GR (1) GR71677B (en)
IE (1) IE45692B1 (en)
IL (1) IL53013A (en)
NL (1) NL7710394A (en)
NO (1) NO773125L (en)
NZ (1) NZ185267A (en)
PT (1) PT67048B (en)
SE (1) SE7710250L (en)
ZA (1) ZA775698B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208416A (en) * 1978-06-27 1980-06-17 Merck & Co., Inc. N-Aralkyl containing cyanopyridines
DK267779A (en) * 1978-06-27 1979-12-28 Merck & Co Inc PROCEDURE FOR THE PREPARATION OF N-ARALKYLAMINO-PROPOXYCYANOPYRIDINES
US4210653A (en) * 1978-06-27 1980-07-01 Merck & Co., Inc. Pyridyloxypropanolamines
GB8510146D0 (en) * 1985-04-20 1985-05-30 Smith Kline French Lab Chemical compounds & processes
EP0252670B1 (en) * 1986-06-30 1992-01-15 Toyo Jozo Kabushiki Kaisha 2-substituted alkoxy-3-substituted-pyrazines
WO2001036412A1 (en) * 1999-11-15 2001-05-25 Eli Lilly And Company Process for the preparation of aryloxy propanolamines

Also Published As

Publication number Publication date
BE858867A (en) 1978-03-20
FR2367065A1 (en) 1978-05-05
SE7710250L (en) 1978-04-06
AT358037B (en) 1980-08-11
IE45692B1 (en) 1982-10-20
PT67048B (en) 1979-02-16
DE2740678A1 (en) 1978-04-06
IL53013A0 (en) 1977-11-30
ES462389A1 (en) 1978-07-01
NZ185267A (en) 1979-07-11
ZA775698B (en) 1978-05-30
PT67048A (en) 1977-10-01
FR2367065B1 (en) 1980-10-10
FI772681A7 (en) 1978-04-06
IL53013A (en) 1981-09-13
NL7710394A (en) 1978-04-07
CA1105021A (en) 1981-07-14
AU2912577A (en) 1979-04-05
ATA648777A (en) 1980-01-15
GB1591723A (en) 1981-06-24
AU514676B2 (en) 1981-02-19
GR71677B (en) 1983-06-21
NO773125L (en) 1978-04-06
DK402877A (en) 1978-04-06
JPS5350177A (en) 1978-05-08
CH607585A5 (en) 1978-09-15

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