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IE44603L - 2-phenyl-5-(5-tetrazolyl)-pyrimidin - 4 (3h)-one derivatives - Google Patents

2-phenyl-5-(5-tetrazolyl)-pyrimidin - 4 (3h)-one derivatives

Info

Publication number
IE44603L
IE44603L IE770297A IE29777A IE44603L IE 44603 L IE44603 L IE 44603L IE 770297 A IE770297 A IE 770297A IE 29777 A IE29777 A IE 29777A IE 44603 L IE44603 L IE 44603L
Authority
IE
Ireland
Prior art keywords
compounds
tetrazolyl
pyrimidin
phenyl
derivatives
Prior art date
Application number
IE770297A
Other versions
IE44603B1 (en
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/748,851 external-priority patent/US4082751A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IE44603L publication Critical patent/IE44603L/en
Publication of IE44603B1 publication Critical patent/IE44603B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The compounds of the formula I, in which the substituents have the meaning mentioned in Patent Claim 1, are obtained by reacting equimolar amounts of an appropriately substituted benzamidine with ethylethoxymethylene cyanoacetate, sodium azide and ammonium chloride in an inert organic solvent. The compounds have anti-allergic activity and are therefore suitable as medicaments, in particular for the prophylactic treatment of allergic bronchial asthma by the oral route. <IMAGE> [GB1541351A]
IE297/77A 1976-02-13 1977-02-11 2-phenyl-5-(5-tetrazolyl)-pyrimidin-4(3h)-one derivatives IE44603B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65778776A 1976-02-13 1976-02-13
US05/748,851 US4082751A (en) 1976-02-13 1976-12-08 Therapeutic agents

Publications (2)

Publication Number Publication Date
IE44603L true IE44603L (en) 1977-08-13
IE44603B1 IE44603B1 (en) 1982-01-27

Family

ID=27097492

Family Applications (1)

Application Number Title Priority Date Filing Date
IE297/77A IE44603B1 (en) 1976-02-13 1977-02-11 2-phenyl-5-(5-tetrazolyl)-pyrimidin-4(3h)-one derivatives

Country Status (14)

Country Link
JP (1) JPS52118481A (en)
AU (1) AU508970B2 (en)
CA (1) CA1083152A (en)
CH (1) CH635339A5 (en)
DE (1) DE2705609A1 (en)
DK (1) DK149044C (en)
FI (1) FI62533C (en)
FR (1) FR2340943A1 (en)
GB (1) GB1541351A (en)
IE (1) IE44603B1 (en)
LU (1) LU76722A1 (en)
NL (1) NL173055C (en)
SE (1) SE433494B (en)
YU (1) YU41567B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419357A (en) * 1982-01-18 1983-12-06 The Dow Chemical Company 3-(1H-Tetrazol-5-yl)-4(3H)-quinazolinones
CN101747282A (en) * 2008-12-10 2010-06-23 上海特化医药科技有限公司 Phenyl pyrimidone compounds, pharmaceutical compositions and preparation methods and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883653A (en) * 1972-10-24 1975-05-13 Pfizer Method of preventing asthmatic symptoms

Also Published As

Publication number Publication date
FI62533B (en) 1982-09-30
YU35477A (en) 1982-10-31
JPS52118481A (en) 1977-10-04
AU508970B2 (en) 1980-04-17
JPS6139947B2 (en) 1986-09-06
FR2340943A1 (en) 1977-09-09
NL173055B (en) 1983-07-01
CH635339A5 (en) 1983-03-31
FR2340943B1 (en) 1981-01-09
NL173055C (en) 1983-12-01
DK149044B (en) 1985-12-30
FI770427A7 (en) 1977-08-14
DE2705609C2 (en) 1988-12-15
CA1083152A (en) 1980-08-05
NL7701483A (en) 1977-08-16
YU41567B (en) 1987-10-31
AU2189577A (en) 1978-08-10
LU76722A1 (en) 1977-08-18
IE44603B1 (en) 1982-01-27
FI62533C (en) 1983-01-10
DK149044C (en) 1986-06-02
GB1541351A (en) 1979-02-28
DK57377A (en) 1977-08-14
SE433494B (en) 1984-05-28
DE2705609A1 (en) 1977-08-25
SE7701552L (en) 1977-09-23

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