IE43028L - PYRIMIDO [1,2-a] QUINOLINE DERIVATIVES - Google Patents
PYRIMIDO [1,2-a] QUINOLINE DERIVATIVESInfo
- Publication number
- IE43028L IE43028L IE760714A IE71476A IE43028L IE 43028 L IE43028 L IE 43028L IE 760714 A IE760714 A IE 760714A IE 71476 A IE71476 A IE 71476A IE 43028 L IE43028 L IE 43028L
- Authority
- IE
- Ireland
- Prior art keywords
- alkoxy
- pyrimido
- formula
- quinoline
- quinoline derivatives
- Prior art date
Links
- APEJRAFJAXCCER-UHFFFAOYSA-N 1h-pyrimido[1,2-a]quinoline Chemical class C1=CC=C2N3CC=CN=C3C=CC2=C1 APEJRAFJAXCCER-UHFFFAOYSA-N 0.000 title abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001408 amides Chemical class 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 methylenedioxy Chemical group 0.000 abstract 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 abstract 2
- SRJXKPVAILSTMB-UHFFFAOYSA-N 2-ethoxycarbonyl-3-(quinolin-2-ylamino)prop-2-enoic acid Chemical class CCOC(=O)C(=CNC1=NC2=CC=CC=C2C=C1)C(=O)O SRJXKPVAILSTMB-UHFFFAOYSA-N 0.000 abstract 1
- ULRPISSMEBPJLN-UHFFFAOYSA-N 2h-tetrazol-5-amine Chemical compound NC1=NN=NN1 ULRPISSMEBPJLN-UHFFFAOYSA-N 0.000 abstract 1
- 239000000150 Sympathomimetic Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- OQJVRQCUJFRMJU-UHFFFAOYSA-N pyrido[2,3-f]quinazoline-2-carboxylic acid Chemical compound C1=NC=C2C3=NC(C(=O)O)=CC=C3C=CC2=N1 OQJVRQCUJFRMJU-UHFFFAOYSA-N 0.000 abstract 1
- 229960000278 theophylline Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1500666 Pyrimido[1,2-a]quinoline - derived amides PFIZER Inc 14 July 1976 [1 Aug 1975] 29181/76 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable cationic salts, wherein R 1 and R 2 are each H, Cl, F or C 1-5 alkyl or alkoxy, or R 1 -R 2 is methylenedioxy or ethylenedioxy, and R 3 is Cl, Br or C 1-5 alkoxy. In examples, the amide link is formed from 5-aminotetrazole and the analogous pyrimidoquinolinecarboxylic acid; the latter is made by hydrolysing the ethyl ester, which is in turn prepared by cyclizing a correspondingly substituted ethyl 2-quinolylaminomethylenemalonate. Additionally, the product in which R 3 is halogen may be converted to one in which R 3 is alkoxy, by reaction with an alkanol. Therapeutic compositions having antiallergy activity comprise compounds of the above formula, and may contain additional active agents such as theophylline or sympathomimetic amines.
[GB1500666A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60103975A | 1975-08-01 | 1975-08-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE43028L true IE43028L (en) | 1977-02-01 |
| IE43028B1 IE43028B1 (en) | 1980-12-03 |
Family
ID=24406004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE714/76A IE43028B1 (en) | 1975-08-01 | 1976-04-06 | Substituted pyrimido-quinoline derivatives and pharmaceutical compositions containing them |
Country Status (31)
| Country | Link |
|---|---|
| JP (1) | JPS5231098A (en) |
| AR (1) | AR213099A1 (en) |
| AT (1) | AT351028B (en) |
| AU (1) | AU497412B2 (en) |
| BE (1) | BE843952A (en) |
| BG (1) | BG31229A3 (en) |
| CA (1) | CA1060441A (en) |
| CH (1) | CH616679A5 (en) |
| CS (1) | CS195731B2 (en) |
| DD (1) | DD126735A5 (en) |
| DE (1) | DE2630469C2 (en) |
| DK (1) | DK311276A (en) |
| EG (1) | EG12424A (en) |
| ES (1) | ES449777A1 (en) |
| FI (1) | FI59409C (en) |
| FR (1) | FR2319363A1 (en) |
| GB (1) | GB1500666A (en) |
| GR (1) | GR60549B (en) |
| HU (1) | HU172063B (en) |
| IE (1) | IE43028B1 (en) |
| IL (1) | IL49924A (en) |
| LU (1) | LU75369A1 (en) |
| NL (1) | NL163514C (en) |
| NO (1) | NO139786C (en) |
| NZ (1) | NZ181317A (en) |
| PH (1) | PH12132A (en) |
| PT (1) | PT65349B (en) |
| SE (1) | SE414175B (en) |
| SU (1) | SU685156A3 (en) |
| YU (1) | YU185076A (en) |
| ZA (1) | ZA763876B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2720085A1 (en) * | 1977-05-05 | 1978-11-16 | Hoechst Ag | PYRIMIDO (6.1-A) ISOCHINOLIN-2-ON DERIVATIVES |
| US4127720A (en) * | 1977-09-21 | 1978-11-28 | Bristol-Myers Company | Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity |
| US4192944A (en) * | 1978-04-03 | 1980-03-11 | Bristol-Myers Company | Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents |
| JPS55138593U (en) * | 1979-03-27 | 1980-10-02 | ||
| WO1997037999A1 (en) * | 1996-04-04 | 1997-10-16 | University Of Nebraska Board Of Regents | Synthetic triple helix-forming compounds |
-
1976
- 1976-03-12 SU SU762379567A patent/SU685156A3/en active
- 1976-04-06 IE IE714/76A patent/IE43028B1/en unknown
- 1976-06-21 SE SE7607099A patent/SE414175B/en unknown
- 1976-06-28 IL IL49924A patent/IL49924A/en unknown
- 1976-06-28 NZ NZ181317A patent/NZ181317A/en unknown
- 1976-06-28 GR GR51134A patent/GR60549B/en unknown
- 1976-06-29 ZA ZA763876A patent/ZA763876B/en unknown
- 1976-06-29 CA CA255,988A patent/CA1060441A/en not_active Expired
- 1976-07-01 PH PH18640A patent/PH12132A/en unknown
- 1976-07-07 DE DE2630469A patent/DE2630469C2/en not_active Expired
- 1976-07-09 BG BG033712A patent/BG31229A3/en unknown
- 1976-07-09 NO NO762411A patent/NO139786C/en unknown
- 1976-07-09 FR FR7621101A patent/FR2319363A1/en active Granted
- 1976-07-09 DK DK311276A patent/DK311276A/en not_active Application Discontinuation
- 1976-07-09 HU HU76PI00000528A patent/HU172063B/en unknown
- 1976-07-09 NL NL7607618.A patent/NL163514C/en not_active IP Right Cessation
- 1976-07-09 AU AU15784/76A patent/AU497412B2/en not_active Expired
- 1976-07-09 PT PT65349A patent/PT65349B/en unknown
- 1976-07-09 BE BE1007495A patent/BE843952A/en not_active IP Right Cessation
- 1976-07-09 FI FI762016A patent/FI59409C/en not_active IP Right Cessation
- 1976-07-12 ES ES449777A patent/ES449777A1/en not_active Expired
- 1976-07-12 EG EG426/76A patent/EG12424A/en active
- 1976-07-12 CH CH891276A patent/CH616679A5/en not_active IP Right Cessation
- 1976-07-12 AT AT512676A patent/AT351028B/en not_active IP Right Cessation
- 1976-07-12 CS CS764616A patent/CS195731B2/en unknown
- 1976-07-12 DD DD193810A patent/DD126735A5/xx unknown
- 1976-07-12 JP JP51082862A patent/JPS5231098A/en active Pending
- 1976-07-12 LU LU75369A patent/LU75369A1/xx unknown
- 1976-07-14 GB GB29181/76A patent/GB1500666A/en not_active Expired
- 1976-07-19 AR AR263987A patent/AR213099A1/en active
- 1976-07-27 YU YU01850/76A patent/YU185076A/en unknown
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