IE43551L - Naphthyridine derivatives - Google Patents
Naphthyridine derivativesInfo
- Publication number
- IE43551L IE43551L IE762064A IE206476A IE43551L IE 43551 L IE43551 L IE 43551L IE 762064 A IE762064 A IE 762064A IE 206476 A IE206476 A IE 206476A IE 43551 L IE43551 L IE 43551L
- Authority
- IE
- Ireland
- Prior art keywords
- reacting
- prepared
- compound
- trifluoromethyl
- anhydride
- Prior art date
Links
- 150000005054 naphthyridines Chemical class 0.000 title abstract 2
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000008064 anhydrides Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- NQTLZJODEOHALT-UHFFFAOYSA-N 2-amino-4-(trifluoromethyl)benzoic acid Chemical compound NC1=CC(C(F)(F)F)=CC=C1C(O)=O NQTLZJODEOHALT-UHFFFAOYSA-N 0.000 abstract 1
- VNLYHYHJIXGBFX-UHFFFAOYSA-N 4-(trifluoromethyl)phthalic acid Chemical compound OC(=O)C1=CC=C(C(F)(F)F)C=C1C(O)=O VNLYHYHJIXGBFX-UHFFFAOYSA-N 0.000 abstract 1
- AKAAHMXNWDUFTD-UHFFFAOYSA-N 5-(trifluoromethyl)-2-benzofuran-1,3-dione Chemical compound FC(F)(F)C1=CC=C2C(=O)OC(=O)C2=C1 AKAAHMXNWDUFTD-UHFFFAOYSA-N 0.000 abstract 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 150000008049 diazo compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 150000003949 imides Chemical class 0.000 abstract 1
- FVVIVIPXASZNGB-UHFFFAOYSA-N methyl 2-cyano-4-(trifluoromethyl)benzoate Chemical compound COC(=O)C1=CC=C(C(F)(F)F)C=C1C#N FVVIVIPXASZNGB-UHFFFAOYSA-N 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/54—Preparation of carboxylic acid anhydrides
- C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1498348 Naphthyridine derivatives RHONEPOULENC SA 17 Sept 1976 [22 Sept 1975] 38671/76 Addition to 1417935 Heading C2C Novel compounds II in which Y is H, halogen, C 1-4 alkyl, C 1-4 alkoxy, CN or NO 2 and R is H, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 hydroxyalkyl or phenyl, and acid addition salts thereof, are prepared by (a) reacting a compound IV with a 1-R-2-chlorocarbonyl-piperazine, or (b) reacting a mixed carbonate of a compound IV with a 1-R-piperazine. Compounds IV are prepared by partial reduction of corresponding imides which are themselves prepared by reacting a trifluoromethyl-substituted anhydride with a 2-amino- 7-Y-naphthyridine. 4 - Trifluoromethyl - phthalic anhydride is prepared by converting 2-amino-4-trifluoromethylbenzoic acid to the methyl ester, diazotizing the ester and reacting the diazo compound with KCN to form methyl 2-cyano-4-trifluoromethylbenzoate, hydrolysing this to form 4-trifluoromethyl-phthalic acid and cyclizing this to form the desired anhydride. Pharmaceutical compositions useful as tranquillizers and anticonvulsants comprise a compound II or a non-toxic acid addition salt thereof, together with a pharmaceutical carrier. The compositions may be in a form suitable for oral, parenteral, rectal or topical administration.
[GB1498348A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7528951A FR2324305A2 (en) | 1975-09-22 | 1975-09-22 | NEW DERIVATIVES OF ISOINDOLINE, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE43551L true IE43551L (en) | 1977-03-22 |
| IE43551B1 IE43551B1 (en) | 1981-03-25 |
Family
ID=9160275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2064/76A IE43551B1 (en) | 1975-09-22 | 1976-09-17 | Naphthyridine derivatives |
Country Status (26)
| Country | Link |
|---|---|
| JP (2) | JPS5239700A (en) |
| AR (1) | AR209515A1 (en) |
| AT (1) | AT349024B (en) |
| AU (1) | AU502308B2 (en) |
| BE (1) | BE846409R (en) |
| CH (2) | CH617696A5 (en) |
| CS (1) | CS196323B2 (en) |
| DD (1) | DD126905A6 (en) |
| DE (1) | DE2642598A1 (en) |
| DK (1) | DK142365B (en) |
| ES (1) | ES451741A2 (en) |
| FI (1) | FI59595C (en) |
| FR (1) | FR2324305A2 (en) |
| GB (1) | GB1498348A (en) |
| HU (1) | HU176005B (en) |
| IE (1) | IE43551B1 (en) |
| LU (1) | LU75838A1 (en) |
| MX (1) | MX3641E (en) |
| NL (1) | NL7610201A (en) |
| NO (1) | NO145098C (en) |
| PH (1) | PH12289A (en) |
| PL (2) | PL111060B1 (en) |
| SE (1) | SE423391B (en) |
| SU (1) | SU671724A3 (en) |
| YU (1) | YU230476A (en) |
| ZA (1) | ZA765589B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1282532C (en) * | 1986-08-22 | 1991-04-02 | Myron Timothy Maxson | Organosiloxane inhibitors for hydrosilation reactions and polyorganosiloxane compositions containing same |
| US6739238B2 (en) | 2000-11-20 | 2004-05-25 | Nissan Motor Co., Ltd. | Sliding structure for a reciprocating internal combustion engine and a reciprocating internal combustion engine using the sliding structure |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| OA04700A (en) * | 1973-05-15 | 1980-07-31 | Rhone Poulenc Sa | New derivatives of naphthyridine and their preparation process. |
-
1975
- 1975-09-22 FR FR7528951A patent/FR2324305A2/en active Granted
-
1976
- 1976-08-24 PH PH18826A patent/PH12289A/en unknown
- 1976-09-14 NL NL7610201A patent/NL7610201A/en not_active Application Discontinuation
- 1976-09-17 GB GB38671/76A patent/GB1498348A/en not_active Expired
- 1976-09-17 JP JP51110948A patent/JPS5239700A/en active Pending
- 1976-09-17 ZA ZA765589A patent/ZA765589B/en unknown
- 1976-09-17 IE IE2064/76A patent/IE43551B1/en unknown
- 1976-09-17 SU SU762403396A patent/SU671724A3/en active
- 1976-09-17 AU AU17893/76A patent/AU502308B2/en not_active Expired
- 1976-09-20 PL PL1976192537A patent/PL111060B1/en unknown
- 1976-09-20 MX MX764932U patent/MX3641E/en unknown
- 1976-09-20 YU YU02304/76A patent/YU230476A/en unknown
- 1976-09-20 PL PL1976209687A patent/PL110655B1/en unknown
- 1976-09-20 AR AR264772A patent/AR209515A1/en active
- 1976-09-21 HU HU76RO900A patent/HU176005B/en unknown
- 1976-09-21 CS CS766117A patent/CS196323B2/en unknown
- 1976-09-21 CH CH1196276A patent/CH617696A5/en not_active IP Right Cessation
- 1976-09-21 BE BE170795A patent/BE846409R/en not_active IP Right Cessation
- 1976-09-21 DK DK425076AA patent/DK142365B/en not_active IP Right Cessation
- 1976-09-21 NO NO763225A patent/NO145098C/en unknown
- 1976-09-21 LU LU75838A patent/LU75838A1/xx unknown
- 1976-09-21 DD DD194904A patent/DD126905A6/xx unknown
- 1976-09-21 SE SE7610477-7A patent/SE423391B/en not_active IP Right Cessation
- 1976-09-22 AT AT702476A patent/AT349024B/en not_active IP Right Cessation
- 1976-09-22 DE DE19762642598 patent/DE2642598A1/en not_active Ceased
- 1976-09-22 ES ES451741A patent/ES451741A2/en not_active Expired
- 1976-09-22 FI FI762699A patent/FI59595C/en not_active IP Right Cessation
-
1979
- 1979-09-04 CH CH796279A patent/CH617935A5/en not_active IP Right Cessation
-
1984
- 1984-10-09 JP JP59210605A patent/JPS6038392B2/en not_active Expired
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1432576A (en) | Substituted phenylacetic acids | |
| GB1358680A (en) | Pyrrolo-3,4-b-pyrazine derivatives | |
| GB1418822A (en) | Imidazo-and pyrimido-2,1-b-quinazolin-2-ones and a process for the preparation thereof | |
| AU537819B2 (en) | 2-alkoxyphenyl-imidazo (4,5-b) pyridines | |
| IE42216L (en) | Benzomorphane derivatives | |
| IE41528L (en) | Furfuryl-benzomorphane derivatives. | |
| JPS5587771A (en) | 1-phenylisoquinoline derivative | |
| IE41648L (en) | BENZ [de] ISOQUINOLINE DERIVATIVES | |
| IE43551L (en) | Naphthyridine derivatives | |
| ES8105330A1 (en) | Thiazolo (2,3-b) benzo (and azabenzo) thiazole derivatives, process for their preparation and pharmaceutical compositions containing them. | |
| CA2117340A1 (en) | Synthesis of homochiral 2-hydroxy acids | |
| GB1438260A (en) | Sulphoxides and sulphones processes for their preparation and compositions containing them | |
| JPS55380A (en) | Preparation of dibenzoxepin derivative | |
| IE42711L (en) | THIENO (3,2-c) PYRIDINE DERIVATIVES | |
| JPS5473797A (en) | Pyride 3.2.1-jk carbazole derivative | |
| JPS5690067A (en) | Novel heterocyclic ring substituted phenylacetic acid derivative | |
| GB1511475A (en) | Hydrazinopyridazine derivatives having antihypertensive activity | |
| GB1446833A (en) | Hydroxamic acid derivatives of substituted a-aminooxycarboxylic acids and a process for the preparation thereof | |
| JPS55102561A (en) | 2-aroylformyl-substituted pyrrole derivative and its preparation | |
| JPS5412393A (en) | Novel phenylacetic acid derivative and its salt | |
| GB1363640A (en) | Esters of 2,2-diphenyl - cyclopropane - carboxylic acids | |
| ES8602782A1 (en) | 1,6-Naphthyridin derivatives useful as cardiotonics and preparation thereof. | |
| GB1413407A (en) | Dihydropyrido-pyrimidine derivatives their preparation and therapeutical use | |
| JPS55136293A (en) | Thiazolo 3,2-a pyrimidine derivative and its preparation | |
| JPS5283360A (en) | (e)-5-(beta-substituted vinyl)-2-thienylacetic acids |