IE40886B1 - 3-substituted quinoxaline-2-carboxamide-1,4-dioxides - Google Patents
3-substituted quinoxaline-2-carboxamide-1,4-dioxidesInfo
- Publication number
- IE40886B1 IE40886B1 IE621/75A IE62175A IE40886B1 IE 40886 B1 IE40886 B1 IE 40886B1 IE 621/75 A IE621/75 A IE 621/75A IE 62175 A IE62175 A IE 62175A IE 40886 B1 IE40886 B1 IE 40886B1
- Authority
- IE
- Ireland
- Prior art keywords
- lower alkyl
- piperazino
- group
- carbamyl
- hydroxy
- Prior art date
Links
- GLLHZHAFSZJULJ-UHFFFAOYSA-N 1-oxido-4-oxoquinoxalin-4-ium-2-carboxamide Chemical class C1=CC=CC2=[N+]([O-])C(C(=O)N)=C[N+]([O-])=C21 GLLHZHAFSZJULJ-UHFFFAOYSA-N 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 20
- -1 alkyl sulphide Chemical compound 0.000 abstract 14
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
- 125000001589 carboacyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 244000000010 microbial pathogen Species 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001174 sulfone group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
1450518 3-Substituted quinoxaline-2-carboxamide-1,4-dioxides PFIZER Ine 6 May 1975 [7 May 1974] 19058/75 Heading C2C Novel 3-substituted quinoxaline-2-carboxamide-1,4-dioxides having the general formula wherein X is a hydrogen atom or a substituent in the 6- or 7-position which is a halogen atom or a lower alkoxy, trifluoromethyl, methyl, lower alkyl sulphide, lower alkyl sulphoxide or lower alkyl sulphone group; Y is S, SO or SO 2 ; R 1 is a lower alkyl group substituted with a halogen atom or a hydroxy, lower alkoxy, amino, mono (lower alkyl) amino, di-(lower alkyl(amino, lower alkoxycarbonyl, carbamyl, mono- (lower alkyl)carbamyl, di-(lower alkyl)carbamyl, mercapto, sulpho, lower alkyl sulphide, lower alkyl sulphoxide, lower alkyl sulphone, acetoxy, pyrrolidino, piperidino, morpholino, thiomorpholino, piperazino, N-(lower alkyl) piperazino, N-hydroxy-(lower alkyl)piperazino, N-(lower alkanoyl) piperazino or N-carbo (lower alkoxy) piperazino group; R 2 is a hydrogen atom or a lower alkyl group; R 3 is a hydrogen atom or a phenyl, lower alkyl or substituted lower alkyl group wherein the substituent is ammo, mono-(lower alkyl)amino, di-(lower alkyl)amino, pyrrolidino, piperidino, morpholino, N-(lower alkyl)piperazino, N- hydroxy (lower alkyl)piperazino, N-(lower alkanoyl)piperazino, N-carbo (lower alkoxy)piperazino, pyrrolo, piperazino, imidazolidino, hydroxy, lower alkoxy, thio-(lower alkyl), carboxy, carbo (lower alkoxy), carbamyl, mono- (lower alkyl)carbamyl, di-(lower alkyl)carbamyl, lower alkanoyloxy or lower alkanoylamino, or R 2 and R 3 , when taken together with the nitrogen atom to which they are attached, form a pyrrolo, pyrrolidino, piperidino, morpholino, thiomorpholino, piperazino, N-(lower alkyl) piperazino, N - hydroxy(lower alkyl piperazino, N-(lower alkanoyl)piperazino or N-carbo-(lower alkoxy)piperazino group, and the pharmaceutically-acceptable acid addition salts of those compounds wherein at least one of R 1 and R 3 is a substituted lower alkyl group wherein the substituent is a basic group. The novel compounds may be used as antibacterial agents for the control of various pathogenic microorganisms and as animal growth promotants.
[GB1450518A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46771874A | 1974-05-07 | 1974-05-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40886L IE40886L (en) | 1975-11-07 |
| IE40886B1 true IE40886B1 (en) | 1979-09-12 |
Family
ID=23856860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE621/75A IE40886B1 (en) | 1974-05-07 | 1975-03-20 | 3-substituted quinoxaline-2-carboxamide-1,4-dioxides |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS50160286A (en) |
| AR (1) | AR210328A1 (en) |
| AT (1) | ATA351075A (en) |
| AU (1) | AU8053075A (en) |
| BE (1) | BE828745A (en) |
| DE (1) | DE2520545A1 (en) |
| DK (1) | DK140940B (en) |
| ES (1) | ES437053A1 (en) |
| FI (1) | FI751328A7 (en) |
| FR (1) | FR2269949B1 (en) |
| GB (1) | GB1450518A (en) |
| IE (1) | IE40886B1 (en) |
| IT (1) | IT1052135B (en) |
| LU (1) | LU72415A1 (en) |
| NL (1) | NL7505292A (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3644360A (en) * | 1970-05-05 | 1972-02-22 | Pfizer | 3-substituted methylquinoxaline-2-carboxamide-1 4-dioxides |
-
1975
- 1975-03-20 IE IE621/75A patent/IE40886B1/en unknown
- 1975-04-21 DK DK171275AA patent/DK140940B/en active IP Right Grant
- 1975-04-24 AU AU80530/75A patent/AU8053075A/en not_active Expired
- 1975-04-26 ES ES437053A patent/ES437053A1/en not_active Expired
- 1975-05-05 BE BE1006643A patent/BE828745A/en unknown
- 1975-05-06 JP JP50054193A patent/JPS50160286A/ja active Pending
- 1975-05-06 FI FI751328A patent/FI751328A7/fi not_active Application Discontinuation
- 1975-05-06 NL NL7505292A patent/NL7505292A/en not_active Application Discontinuation
- 1975-05-06 DE DE19752520545 patent/DE2520545A1/en not_active Withdrawn
- 1975-05-06 GB GB1905875A patent/GB1450518A/en not_active Expired
- 1975-05-06 LU LU72415A patent/LU72415A1/xx unknown
- 1975-05-07 AT AT351075A patent/ATA351075A/en not_active IP Right Cessation
- 1975-05-07 IT IT49476/75A patent/IT1052135B/en active
- 1975-05-07 AR AR258662A patent/AR210328A1/en active
- 1975-05-07 FR FR7514453A patent/FR2269949B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK171275A (en) | 1975-11-08 |
| LU72415A1 (en) | 1976-03-17 |
| ES437053A1 (en) | 1977-01-16 |
| IT1052135B (en) | 1981-06-20 |
| DE2520545A1 (en) | 1975-11-20 |
| AR210328A1 (en) | 1977-07-29 |
| FR2269949A1 (en) | 1975-12-05 |
| DK140940B (en) | 1979-12-10 |
| AU8053075A (en) | 1976-10-28 |
| NL7505292A (en) | 1975-11-11 |
| FI751328A7 (en) | 1975-11-08 |
| BE828745A (en) | 1975-11-05 |
| ATA351075A (en) | 1977-07-15 |
| JPS50160286A (en) | 1975-12-25 |
| IE40886L (en) | 1975-11-07 |
| FR2269949B1 (en) | 1978-07-21 |
| GB1450518A (en) | 1976-09-22 |
| DK140940C (en) | 1980-05-19 |
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