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IE39253B1 - Cephalosporin cleavage process - Google Patents

Cephalosporin cleavage process

Info

Publication number
IE39253B1
IE39253B1 IE963/74A IE96374A IE39253B1 IE 39253 B1 IE39253 B1 IE 39253B1 IE 963/74 A IE963/74 A IE 963/74A IE 96374 A IE96374 A IE 96374A IE 39253 B1 IE39253 B1 IE 39253B1
Authority
IE
Ireland
Prior art keywords
cleavage process
cephalosporin
cephalosporin cleavage
mixed anhydride
us3905966a
Prior art date
Application number
IE963/74A
Other versions
IE39253L (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IE39253L publication Critical patent/IE39253L/en
Publication of IE39253B1 publication Critical patent/IE39253B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A 7-(amic acid) cephalosporin is cleaved by conversion to the corresponding mixed anhydride and cleavage of the mixed anhydride to the corresponding 7-aminocephalosporin or to a corresponding 7-acylamidocephalosporin. [US3905966A]
IE963/74A 1973-06-18 1974-05-07 Cephalosporin cleavage process IE39253B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US371011A US3905966A (en) 1973-06-18 1973-06-18 Cephalosporin cleavage process

Publications (2)

Publication Number Publication Date
IE39253L IE39253L (en) 1974-12-18
IE39253B1 true IE39253B1 (en) 1978-08-30

Family

ID=23462129

Family Applications (1)

Application Number Title Priority Date Filing Date
IE963/74A IE39253B1 (en) 1973-06-18 1974-05-07 Cephalosporin cleavage process

Country Status (12)

Country Link
US (1) US3905966A (en)
JP (1) JPS61352B2 (en)
BE (1) BE816408A (en)
CA (1) CA1018155A (en)
CH (1) CH601313A5 (en)
DE (1) DE2429166A1 (en)
ES (2) ES427388A1 (en)
FR (1) FR2233328B1 (en)
GB (1) GB1474544A (en)
IE (1) IE39253B1 (en)
IL (1) IL44791A (en)
NL (1) NL7408170A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001239A (en) * 1973-06-18 1977-01-04 Eli Lilly And Company Cephalosporin cleavage process
US3994888A (en) * 1973-06-18 1976-11-30 Eli Lilly And Company Cephalosporin cleavage process
US4039535A (en) * 1973-12-10 1977-08-02 Eli Lilly And Company 7-[α-(GUANYL-1-UREIDO)PHENYLACETAMIDO]-3-SUBSTITUTED CEPHALOSPORIN ANTIBIOTICS
JPS52124221A (en) * 1976-04-10 1977-10-19 Toshizou Miyai Water tpa with selffclosing valve
US5239069A (en) * 1990-05-14 1993-08-24 Eli Lilly And Company Amino protecting group
US5169945A (en) * 1990-05-14 1992-12-08 Eli Lilly And Company Amino protecting group
IL98072A0 (en) * 1990-05-14 1992-06-21 Lilly Co Eli Azetidinone analogs and process for their preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3487074A (en) * 1966-01-14 1969-12-30 Bristol Myers Co Derivatives of 6-amino-3-penamylcarboxylic acid and 7-amino-2,2-dimethyl-cephalosporanic acid
US3487070A (en) * 1966-01-14 1969-12-30 Bristol Myers Co 3-blocked amino-4-sulfhydryl-2-azetidinones
US3769281A (en) * 1970-07-09 1973-10-30 Lilly Co Eli Deblocking process for cephalosporin antibiotics

Also Published As

Publication number Publication date
CA1018155A (en) 1977-09-27
NL7408170A (en) 1974-12-20
US3905966A (en) 1975-09-16
IL44791A (en) 1976-09-30
CH601313A5 (en) 1978-07-14
JPS5036488A (en) 1975-04-05
ES427388A1 (en) 1976-09-16
JPS61352B2 (en) 1986-01-08
BE816408A (en) 1974-12-17
DE2429166A1 (en) 1975-01-09
IL44791A0 (en) 1974-07-31
FR2233328A1 (en) 1975-01-10
IE39253L (en) 1974-12-18
FR2233328B1 (en) 1977-10-07
GB1474544A (en) 1977-05-25
ES448016A1 (en) 1977-07-01

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