IE39546L - Quinazoline derivatives - Google Patents
Quinazoline derivativesInfo
- Publication number
- IE39546L IE39546L IE40074A IE40074A IE39546L IE 39546 L IE39546 L IE 39546L IE 40074 A IE40074 A IE 40074A IE 40074 A IE40074 A IE 40074A IE 39546 L IE39546 L IE 39546L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- alkoxy
- meo
- halogen
- compounds
- Prior art date
Links
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 2
- GVRRXASZZAKBMN-UHFFFAOYSA-N 4-chloroquinazoline Chemical compound C1=CC=C2C(Cl)=NC=NC2=C1 GVRRXASZZAKBMN-UHFFFAOYSA-N 0.000 abstract 1
- -1 N- methyl - 2 - (2 - pyridyl)ethyl Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 239000000496 cardiotonic agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1417029 Quinazoline - derived amines PFIZER Ltd 5 March 1974 [7 March 1973] 11018/73 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable acid addition salts, wherein n is 1-3; R<SP>1</SP> is halogen, OH, PhCH 2 O, NH 2 or C 1-6 alkyl or alkoxy, provided that (R<SP>1</SP>) n contains at least one alkoxy group; R<SP>2</SP> is H, halogen or C 1-6 alkyl (optionally HO- or C 1-6 -alkoxy-substituted); R<SP>3</SP> is H, C 1-6 alkyl, PhCH 2 or Ph (optionally substituted by halogen or C 1-6 alkyl or alkoxy); R<SP>4</SP> is a C- attached N-containing aromatic heterocyclic group; and "alk" is C 1-4 alkylene. In examples, these compounds are prepared by reacting the appropriate 4-chloroquinazoline with R<SP>3</SP>NH-alk-R<SP>4</SP>, or by converting functional groups, by known procedures, in similarly prepared intermediates, in particular those of the above formula where the 4-substituent is N- methyl - 2 - (2 - pyridyl)ethyl and (i) R<SP>2</SP>= AcOCH 2 , (R<SP>1</SP>) n =6,7-(MeO) 2 , (ii) R<SP>2</SP>=H, (R<SP>1</SP>) n = 7-MeO-6-NO 2 , and (iii) R<SP>3</SP>=H, (R<SP>1</SP>) n = 6-EtOCO 2 -7-MeO. Therapeutic compositions having cardiac stimulant activity comprise compounds of the above formula, and may be administered orally or parenterally.
[GB1417029A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1101873A GB1417029A (en) | 1973-03-07 | 1973-03-07 | Quinazoline-derived amines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE39546L true IE39546L (en) | 1974-09-07 |
| IE39546B1 IE39546B1 (en) | 1978-11-08 |
Family
ID=9978541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE40074A IE39546B1 (en) | 1973-03-07 | 1974-02-27 | Quinazoline-derived amines |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5029582A (en) |
| BE (1) | BE811856A (en) |
| DE (1) | DE2410938A1 (en) |
| DK (1) | DK132892C (en) |
| FR (1) | FR2220265B1 (en) |
| GB (1) | GB1417029A (en) |
| IE (1) | IE39546B1 (en) |
| LU (1) | LU69561A1 (en) |
| NL (1) | NL7403075A (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1460389A (en) * | 1974-07-25 | 1977-01-06 | Pfizer Ltd | 4-substituted quinazoline cardiac stimulants |
| JPS52126939A (en) * | 1976-04-19 | 1977-10-25 | Stanley Electric Co Ltd | Method of filtering regenerative drain water treating device |
| IT1229237B (en) * | 1989-05-08 | 1991-07-26 | Prodotti Formenti | SALTS OF (2- (PYRIDYL) ETHYL) METHYLAMINE |
| EP0669324A4 (en) * | 1993-09-10 | 1996-04-03 | Eisai Co Ltd | Quinazoline compound. |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| AU705229B2 (en) | 1994-08-09 | 1999-05-20 | Eisai R&D Management Co., Ltd. | Fused pyridazine compound |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| JP4533534B2 (en) | 1998-06-19 | 2010-09-01 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | Inhibitor of glycogen synthase kinase 3 |
| NZ537635A (en) * | 2002-07-17 | 2006-11-30 | Lek Pharmaceuticals D | Novel derivatives of pyridylethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, processes for their preparation, and pharmaceutical compositions containing them |
| WO2007030582A2 (en) * | 2005-09-09 | 2007-03-15 | Bristol-Myers Squibb Company | Acyclic ikur inhibitors |
| EP2014662A1 (en) * | 2007-07-12 | 2009-01-14 | Bayer Schering Pharma Aktiengesellschaft | Indolyl alkyl thieno-pyrimidyl amines as modulators of EP2 receptors |
-
1973
- 1973-03-07 GB GB1101873A patent/GB1417029A/en not_active Expired
-
1974
- 1974-02-27 IE IE40074A patent/IE39546B1/en unknown
- 1974-03-04 BE BE141633A patent/BE811856A/en unknown
- 1974-03-05 LU LU69561A patent/LU69561A1/xx unknown
- 1974-03-06 FR FR7407621A patent/FR2220265B1/fr not_active Expired
- 1974-03-06 DK DK120174A patent/DK132892C/en active
- 1974-03-07 NL NL7403075A patent/NL7403075A/xx not_active Application Discontinuation
- 1974-03-07 DE DE19742410938 patent/DE2410938A1/en active Pending
- 1974-03-07 JP JP2578274A patent/JPS5029582A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2220265B1 (en) | 1977-11-10 |
| JPS5029582A (en) | 1975-03-25 |
| BE811856A (en) | 1974-09-04 |
| DK132892C (en) | 1976-07-19 |
| IE39546B1 (en) | 1978-11-08 |
| NL7403075A (en) | 1974-09-10 |
| GB1417029A (en) | 1975-12-10 |
| LU69561A1 (en) | 1976-02-04 |
| FR2220265A1 (en) | 1974-10-04 |
| DE2410938A1 (en) | 1974-09-19 |
| DK132892B (en) | 1976-02-23 |
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