IE39516B1 - Corticoid-containing inhalant preparations - Google Patents
Corticoid-containing inhalant preparationsInfo
- Publication number
- IE39516B1 IE39516B1 IE1292/74A IE129274A IE39516B1 IE 39516 B1 IE39516 B1 IE 39516B1 IE 1292/74 A IE1292/74 A IE 1292/74A IE 129274 A IE129274 A IE 129274A IE 39516 B1 IE39516 B1 IE 39516B1
- Authority
- IE
- Ireland
- Prior art keywords
- corticoid
- compositions
- june
- carrier
- containing inhalant
- Prior art date
Links
- 239000003470 adrenal cortex hormone Substances 0.000 title abstract 2
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- -1 isopropylidene-dioxy group Chemical group 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Natural products O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- 229930189077 Rifamycin Natural products 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960005091 chloramphenicol Drugs 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
- BTVYFIMKUHNOBZ-QXMMDKDBSA-N rifamycin s Chemical class O=C1C(C(O)=C2C)=C3C(=O)C=C1NC(=O)\C(C)=C/C=C\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C(C)C(OC)\C=C/OC1(C)OC2=C3C1=O BTVYFIMKUHNOBZ-QXMMDKDBSA-N 0.000 abstract 1
- 229940081192 rifamycins Drugs 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 229940040944 tetracyclines Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1479488 Inhalant compositions SCHERING AG 24 June 1974 [23 June 1973] 27902/74 Heading A5B Inhalant compositions suitable for treatment of allergic disorders of the respiratory tract comprise a corticoid of formula:- in which -B-A- represents -CH 2 -CH 2 -, -CH=CH-, or -CCl=CH-; X is H, F or CH 3 ; Y is H, F or Cl; Z is -CH 3 -, -C(OH)H-, -CFH-, -CClH-, or -C(O)-; R 1 is H or CH 3 ; R 2 is H, or R 1 and R 2 together are an isopropylidene-dioxy group: and R 3 is a C 1 -C 12 hydrocarbon residue, in admixture or conjunction with a suitable carrier. The compositions may be in a capsule and contain dextran, mannitol, glucose or lactose as carrier. Antibodies such as chloramphenicol tetracyclines, penicillins cephalosporins. lincomycins, erythromycins and rifamycins, may also be present.
[GB1479488A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2332663A DE2332663C2 (en) | 1973-06-23 | 1973-06-23 | Use of corticosteroid active ingredients for inhalation therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE39516L IE39516L (en) | 1974-12-23 |
| IE39516B1 true IE39516B1 (en) | 1978-10-25 |
Family
ID=5885228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1292/74A IE39516B1 (en) | 1973-06-23 | 1974-06-20 | Corticoid-containing inhalant preparations |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS6245846B2 (en) |
| BE (1) | BE816709A (en) |
| DD (1) | DD112437A5 (en) |
| DE (1) | DE2332663C2 (en) |
| DK (1) | DK337574A (en) |
| ES (1) | ES427480A1 (en) |
| FR (1) | FR2233987B1 (en) |
| GB (1) | GB1479488A (en) |
| IE (1) | IE39516B1 (en) |
| IL (1) | IL45087A (en) |
| NL (1) | NL184724C (en) |
| SE (1) | SE7408091L (en) |
| ZA (1) | ZA744022B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX3864E (en) | 1975-05-27 | 1981-08-26 | Syntex Corp | A PROCESS TO PREPARE THE CRYSTALLINE COMPOUND 6-FLUIRO-11B 21-DIHIROXI-16 17-ISOPROPILIDENDIOXIPREGNA-1 4-DIEN-3 20-DIONA |
| DE2829953A1 (en) * | 1978-07-03 | 1980-01-24 | Schering Ag | PHARMACEUTICAL PREPARATION FOR TREATING THE KOLITIS ULCEROSA AND KOLITIS GRANULOMATOSA |
| US5215979A (en) * | 1985-12-19 | 1993-06-01 | Aktiebolaget Draco | 16,17-acetalsubstituted pregnane 21-oic acid derivatives |
| US7858650B2 (en) | 2004-10-22 | 2010-12-28 | Ono Pharmaceutical Co., Ltd. | Medicinal composition for inhalation |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB799902A (en) * | 1954-08-11 | 1958-08-13 | Merck & Co Inc | Therapeutic preparations |
| US3320125A (en) * | 1964-04-28 | 1967-05-16 | Merck & Co Inc | Inhalation aerosol composition |
| GB1242211A (en) * | 1967-08-08 | 1971-08-11 | Fisons Pharmaceuticals Ltd | Pharmaceutical composition |
| GB1381872A (en) * | 1971-06-22 | 1975-01-29 | Fisons Ltd | Pharmaceutical compositions for inhalation |
| BE787100A (en) * | 1971-08-06 | 1973-02-02 | Beecham Group Ltd | COMPOSITION FOR THE TREATMENT OF ASTHMA |
| DE2150268C3 (en) * | 1971-10-04 | 1980-11-06 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Pregnanic acid derivatives, processes for their preparation and pharmaceuticals containing them |
| YU35148B (en) * | 1971-10-04 | 1980-09-25 | Schering Ag | Process for obtaining pregnane acid derivatives |
| DE2264003C2 (en) * | 1972-12-22 | 1982-11-04 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | New pregnanic acid derivatives, processes for their production and pharmaceutical preparations containing them |
| DE2319479C2 (en) * | 1973-04-14 | 1982-10-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Pregnanic acid derivatives, processes for their production and pharmaceutical preparations containing them |
-
1973
- 1973-06-23 DE DE2332663A patent/DE2332663C2/en not_active Expired
-
1974
- 1974-06-19 SE SE7408091A patent/SE7408091L/ not_active Application Discontinuation
- 1974-06-20 ES ES427480A patent/ES427480A1/en not_active Expired
- 1974-06-20 IE IE1292/74A patent/IE39516B1/en unknown
- 1974-06-21 IL IL45087A patent/IL45087A/en unknown
- 1974-06-21 BE BE145751A patent/BE816709A/en not_active IP Right Cessation
- 1974-06-21 NL NLAANVRAGE7408421,A patent/NL184724C/en not_active IP Right Cessation
- 1974-06-21 ZA ZA00744022A patent/ZA744022B/en unknown
- 1974-06-24 GB GB27902/74A patent/GB1479488A/en not_active Expired
- 1974-06-24 JP JP49072169A patent/JPS6245846B2/ja not_active Expired
- 1974-06-24 DK DK337574A patent/DK337574A/da unknown
- 1974-06-24 DD DD179417A patent/DD112437A5/xx unknown
- 1974-06-24 FR FR7421859A patent/FR2233987B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2233987B1 (en) | 1977-07-08 |
| AU7042174A (en) | 1976-01-08 |
| DK337574A (en) | 1975-03-17 |
| IL45087A0 (en) | 1974-09-10 |
| SE7408091L (en) | 1974-12-23 |
| GB1479488A (en) | 1977-07-13 |
| ES427480A1 (en) | 1976-07-16 |
| FR2233987A1 (en) | 1975-01-17 |
| BE816709A (en) | 1974-12-23 |
| DE2332663A1 (en) | 1975-01-16 |
| DD112437A5 (en) | 1975-04-12 |
| JPS5047967A (en) | 1975-04-28 |
| JPS6245846B2 (en) | 1987-09-29 |
| NL184724B (en) | 1989-05-16 |
| IL45087A (en) | 1978-04-30 |
| ZA744022B (en) | 1975-06-25 |
| DE2332663C2 (en) | 1986-07-31 |
| NL184724C (en) | 1989-10-16 |
| IE39516L (en) | 1974-12-23 |
| NL7408421A (en) | 1974-12-30 |
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