IE38550B1 - Method of making tablets - Google Patents
Method of making tabletsInfo
- Publication number
- IE38550B1 IE38550B1 IE2147/73A IE214773A IE38550B1 IE 38550 B1 IE38550 B1 IE 38550B1 IE 2147/73 A IE2147/73 A IE 2147/73A IE 214773 A IE214773 A IE 214773A IE 38550 B1 IE38550 B1 IE 38550B1
- Authority
- IE
- Ireland
- Prior art keywords
- lithium carbonate
- sustained release
- tablets
- mixture
- mesh
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 abstract 7
- 229910052808 lithium carbonate Inorganic materials 0.000 abstract 7
- 239000000203 mixture Substances 0.000 abstract 4
- 238000013268 sustained release Methods 0.000 abstract 4
- 239000012730 sustained-release form Substances 0.000 abstract 4
- 239000003826 tablet Substances 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 3
- 239000000945 filler Substances 0.000 abstract 2
- 239000008187 granular material Substances 0.000 abstract 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- 235000006491 Acacia senegal Nutrition 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 244000165918 Eucalyptus papuana Species 0.000 abstract 1
- 229920000084 Gum arabic Polymers 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 235000010489 acacia gum Nutrition 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 208000028683 bipolar I disease Diseases 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 125000005908 glyceryl ester group Chemical group 0.000 abstract 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 125000005472 straight-chain saturated fatty acid group Chemical group 0.000 abstract 1
- 239000007939 sustained release tablet Substances 0.000 abstract 1
- 150000005691 triesters Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1450536 Sustained release tablets containing lithium carbonate DELANDALE LABORATORIES Ltd 20 Nov 1973 54671/72 Addition to 1209093 Heading A5B Sustained release pharmaceutical tablets for the treatment of manic depressive states, comprising powdered lithium carbonate; a sustained release agent comprising a mixture of glyceryl mono-, di- and tri-esters of one or mere C 16-18 straight chain saturated fatty acids and one or more excipients, are prepared by coating a mixture of powdered lithium carbonate and one or more excipients with the sustained release agent, granulating the mixture using about (11.55 to 24.5 p) litres of water per 100 kg lithium carbonate where p is the bulk density of the lithium carbonate in grams per c.c., screening to form a granulate whose particles are all less than 12 BS Mesh, from 20 to 30% of which have particle sizes in the range of from 12 BS to 60 BS Mesh and from 70 to 80% of which have a particle size below 60 BS Mesh, and compressing the granulate into tablets. The tablets may comprise a filler e.g. mannitol, a binding agent e.g. gum acacia and a lubricant e.g. magnesium stearate. The tablets preferably contain 9.5 to 11.4 parts by weight of the mixture of glyceryl esters per 100 parts by weight of lithium carbonate. Preferably the sustained release agent is added in alcohol solution and at 68C or higher, the powdered lithium carbonate and filler being pre-heated to about this temperature before adding the solution.
[GB1450536A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5467172A GB1450536A (en) | 1972-11-27 | 1972-11-27 | Method of making tablets |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38550L IE38550L (en) | 1974-05-27 |
| IE38550B1 true IE38550B1 (en) | 1978-04-12 |
Family
ID=10471737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2147/73A IE38550B1 (en) | 1972-11-27 | 1973-11-27 | Method of making tablets |
Country Status (9)
| Country | Link |
|---|---|
| BE (1) | BE807801R (en) |
| CA (1) | CA1012887A (en) |
| CY (1) | CY914A (en) |
| DE (1) | DE2358906C2 (en) |
| GB (1) | GB1450536A (en) |
| IE (1) | IE38550B1 (en) |
| MT (1) | MTP755B (en) |
| NL (1) | NL7316079A (en) |
| ZA (1) | ZA738856B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MTP930B (en) * | 1982-04-30 | 1984-04-10 | Delandale Labs Ltd | Substained release lithium-containing tablets and method for their manufacture |
| CN113521024A (en) * | 2017-04-17 | 2021-10-22 | 上海葆隆生物科技有限公司 | Lithium carbonate sustained release tablet |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1209093A (en) * | 1968-07-16 | 1970-10-14 | Delandale Lab Ltd | Pharmaceutical preparation |
-
1972
- 1972-11-27 GB GB5467172A patent/GB1450536A/en not_active Expired
-
1973
- 1973-11-20 CY CY914A patent/CY914A/en unknown
- 1973-11-20 ZA ZA738856A patent/ZA738856B/en unknown
- 1973-11-23 NL NL7316079A patent/NL7316079A/xx not_active Application Discontinuation
- 1973-11-26 BE BE138166A patent/BE807801R/en active
- 1973-11-26 MT MT755A patent/MTP755B/en unknown
- 1973-11-26 CA CA186,637A patent/CA1012887A/en not_active Expired
- 1973-11-27 IE IE2147/73A patent/IE38550B1/en unknown
- 1973-11-27 DE DE2358906A patent/DE2358906C2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA738856B (en) | 1974-10-30 |
| BE807801R (en) | 1974-03-15 |
| IE38550L (en) | 1974-05-27 |
| CA1012887A (en) | 1977-06-28 |
| AU6290173A (en) | 1975-05-29 |
| MTP755B (en) | 1974-05-09 |
| GB1450536A (en) | 1976-09-22 |
| NL7316079A (en) | 1974-05-29 |
| CY914A (en) | 1977-12-23 |
| DE2358906C2 (en) | 1983-12-22 |
| DE2358906A1 (en) | 1974-06-06 |
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