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HUT77560A - Trombin inhibitort tartalmazó, tárolás közben stabil, vizes, infúziós törzsoldat és eljárás előállítására - Google Patents

Trombin inhibitort tartalmazó, tárolás közben stabil, vizes, infúziós törzsoldat és eljárás előállítására

Info

Publication number
HUT77560A
HUT77560A HU9800400A HU9800400A HUT77560A HU T77560 A HUT77560 A HU T77560A HU 9800400 A HU9800400 A HU 9800400A HU 9800400 A HU9800400 A HU 9800400A HU T77560 A HUT77560 A HU T77560A
Authority
HU
Hungary
Prior art keywords
pct
thrombin inhibitor
aqueous
stable
stock solution
Prior art date
Application number
HU9800400A
Other languages
English (en)
Other versions
HU217073B (hu
Inventor
Ulla Stjernfelt
Mats Sundgren
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of HUT77560A publication Critical patent/HUT77560A/hu
Publication of HU217073B publication Critical patent/HU217073B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU9800400A 1994-11-08 1995-10-19 Trombin inhibitort tartalmazó, tárolás közben stabil, vizes, infúziós törzsoldat és eljárás előállítására HU217073B (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9403831A SE504185C2 (sv) 1994-11-08 1994-11-08 Lagringsstabil vattenlösning för infusion av trombininhibitorer

Publications (2)

Publication Number Publication Date
HUT77560A true HUT77560A (hu) 1998-06-29
HU217073B HU217073B (hu) 1999-11-29

Family

ID=20395892

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9800400A HU217073B (hu) 1994-11-08 1995-10-19 Trombin inhibitort tartalmazó, tárolás közben stabil, vizes, infúziós törzsoldat és eljárás előállítására

Country Status (31)

Country Link
US (1) US5830865A (hu)
EP (1) EP0789585B1 (hu)
JP (1) JPH10508598A (hu)
KR (1) KR100416677B1 (hu)
CN (1) CN1090508C (hu)
AT (1) ATE205399T1 (hu)
AU (1) AU695719B2 (hu)
BR (1) BR9509634A (hu)
CA (1) CA2203396A1 (hu)
CZ (1) CZ287256B6 (hu)
DE (1) DE69522702T2 (hu)
DK (1) DK0789585T3 (hu)
EE (1) EE9700218A (hu)
ES (1) ES2163528T3 (hu)
FI (1) FI971949A7 (hu)
HU (1) HU217073B (hu)
IL (1) IL115879A (hu)
IS (1) IS4468A (hu)
MX (1) MX9703339A (hu)
MY (1) MY112593A (hu)
NO (1) NO322048B1 (hu)
NZ (1) NZ295492A (hu)
PL (1) PL320342A1 (hu)
PT (1) PT789585E (hu)
RU (1) RU2164803C2 (hu)
SE (1) SE504185C2 (hu)
SK (1) SK53597A3 (hu)
TR (1) TR199501391A2 (hu)
TW (1) TW407057B (hu)
WO (1) WO1996014084A1 (hu)
ZA (1) ZA959377B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US6984627B1 (en) * 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
AR005245A1 (es) 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
SE9802974D0 (sv) 1998-09-03 1998-09-03 Astra Ab New crystalline forms
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
US7345093B2 (en) * 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
US20110070293A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Preparation of Liposomes Comprising Docetaxel
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes
MX2021008557A (es) * 2021-01-13 2021-11-17 Grupo Ion Biotech S A P I De C V Sistema de suministro de ionoforos quimicos de membrana celular sintetica que comprende composiciones de ligandos hexa-acuaticos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2096415C1 (ru) * 1991-09-30 1997-11-20 Дзе Дюпон Мерк Фармасьютикал Компани Циклические пептиды или их фармацевтически приемлемые соли, фармацевтическая композиция
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
US5466131A (en) * 1994-03-22 1995-11-14 Micropump Corporation Multiple-chamber gear pump with hydraulically connected chambers

Also Published As

Publication number Publication date
EP0789585B1 (en) 2001-09-12
SK53597A3 (en) 1998-07-08
SE9403831D0 (sv) 1994-11-08
EP0789585A1 (en) 1997-08-20
ES2163528T3 (es) 2002-02-01
NO972065L (no) 1997-05-05
AU695719B2 (en) 1998-08-20
BR9509634A (pt) 1998-01-06
SE9403831L (sv) 1996-05-09
CA2203396A1 (en) 1996-05-17
SE504185C2 (sv) 1996-12-02
ATE205399T1 (de) 2001-09-15
EE9700218A (et) 1998-02-16
AU3884695A (en) 1996-05-31
NO322048B1 (no) 2006-08-07
IL115879A (en) 2001-08-08
NO972065D0 (no) 1997-05-05
MX9703339A (es) 1997-07-31
PT789585E (pt) 2002-01-30
JPH10508598A (ja) 1998-08-25
TR199501391A2 (tr) 1996-06-21
DK0789585T3 (da) 2001-11-12
IS4468A (is) 1997-04-21
ZA959377B (en) 1996-05-08
FI971949A0 (fi) 1997-05-07
KR100416677B1 (ko) 2004-06-16
CZ129497A3 (cs) 1998-02-18
FI971949L (fi) 1997-05-07
TW407057B (en) 2000-10-01
WO1996014084A1 (en) 1996-05-17
RU2164803C2 (ru) 2001-04-10
DE69522702D1 (de) 2001-10-18
FI971949A7 (fi) 1997-05-07
IL115879A0 (en) 1996-01-31
CN1090508C (zh) 2002-09-11
DE69522702T2 (de) 2002-07-11
KR970706844A (ko) 1997-12-01
US5830865A (en) 1998-11-03
MY112593A (en) 2001-07-31
CN1162921A (zh) 1997-10-22
NZ295492A (en) 1998-06-26
CZ287256B6 (en) 2000-10-11
HU217073B (hu) 1999-11-29
PL320342A1 (en) 1997-09-29

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee