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HUS1600044I1 - Eljárások mielóma multiplex kezelésére, anti-CS1 ellenanyagokon alapuló terápiák kombinációjának alkalmazásával - Google Patents

Eljárások mielóma multiplex kezelésére, anti-CS1 ellenanyagokon alapuló terápiák kombinációjának alkalmazásával

Info

Publication number
HUS1600044I1
HUS1600044I1 HUS1600044C HUS1600044C HUS1600044I1 HU S1600044 I1 HUS1600044 I1 HU S1600044I1 HU S1600044 C HUS1600044 C HU S1600044C HU S1600044 C HUS1600044 C HU S1600044C HU S1600044 I1 HUS1600044 I1 HU S1600044I1
Authority
HU
Hungary
Prior art keywords
antibodies
methods
multiple myeloma
combination therapies
treating multiple
Prior art date
Application number
HUS1600044C
Other languages
English (en)
Original Assignee
Abbvie Biotherapeutics Inc
Dana-Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38831279&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUS1600044(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Biotherapeutics Inc, Dana-Farber Cancer Institute Inc filed Critical Abbvie Biotherapeutics Inc
Publication of HUS1600044I1 publication Critical patent/HUS1600044I1/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2806Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061Blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/542Mucosal route oral/gastrointestinal
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
HUS1600044C 2006-08-07 2016-10-20 Eljárások mielóma multiplex kezelésére, anti-CS1 ellenanyagokon alapuló terápiák kombinációjának alkalmazásával HUS1600044I1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83618506P 2006-08-07 2006-08-07
US94426207P 2007-06-15 2007-06-15
EP07840746.7A EP2068874B1 (en) 2006-08-07 2007-08-07 Methods of treating multiple myeloma using combination therapies based on anti-cs1 antibodies

Publications (1)

Publication Number Publication Date
HUS1600044I1 true HUS1600044I1 (hu) 2016-12-28

Family

ID=38831279

Family Applications (4)

Application Number Title Priority Date Filing Date
HUE13168383A HUE029027T2 (hu) 2006-08-07 2007-08-07 Eljárások myeloma multiplex kezelésére HuLuc63 és bortezomib alapú kombinációs terápiák alkalmazásával
HUS1600045C HUS1600045I1 (hu) 2006-08-07 2016-10-20 Eljárások mielóma multiplex kezelésére, anti-CS1 ellenanyagokon alapuló terápiák kombinációjának alkalmazásával
HUS1600044C HUS1600044I1 (hu) 2006-08-07 2016-10-20 Eljárások mielóma multiplex kezelésére, anti-CS1 ellenanyagokon alapuló terápiák kombinációjának alkalmazásával
HUS1600043C HUS1600043I1 (hu) 2006-08-07 2016-10-20 Eljárások mielóma multiplex kezelésére, anti-CS1 ellenanyagokon alapuló terápiák kombinációjának alkalmazásával

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HUE13168383A HUE029027T2 (hu) 2006-08-07 2007-08-07 Eljárások myeloma multiplex kezelésére HuLuc63 és bortezomib alapú kombinációs terápiák alkalmazásával
HUS1600045C HUS1600045I1 (hu) 2006-08-07 2016-10-20 Eljárások mielóma multiplex kezelésére, anti-CS1 ellenanyagokon alapuló terápiák kombinációjának alkalmazásával

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUS1600043C HUS1600043I1 (hu) 2006-08-07 2016-10-20 Eljárások mielóma multiplex kezelésére, anti-CS1 ellenanyagokon alapuló terápiák kombinációjának alkalmazásával

Country Status (23)

Country Link
US (4) US8632772B2 (hu)
EP (5) EP2641601B8 (hu)
JP (1) JP5340935B2 (hu)
CN (1) CN101686971B (hu)
AU (1) AU2007281684C1 (hu)
BR (1) BRPI0716647A2 (hu)
CA (1) CA2660356C (hu)
CY (5) CY1116247T1 (hu)
DK (2) DK2641601T3 (hu)
ES (2) ES2589302T3 (hu)
HR (2) HRP20150449T1 (hu)
HU (4) HUE029027T2 (hu)
IL (2) IL196919A (hu)
LT (4) LT2641601T (hu)
LU (3) LU93277I2 (hu)
MX (1) MX2009001441A (hu)
NL (1) NL300840I2 (hu)
NO (1) NO346835B1 (hu)
NZ (1) NZ574978A (hu)
PL (2) PL2641601T3 (hu)
PT (2) PT2641601T (hu)
SI (2) SI2068874T1 (hu)
WO (1) WO2008019378A1 (hu)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8632772B2 (en) 2006-08-07 2014-01-21 Dana-Farber Cancer Institute Methods of treating multiple myeloma using combination therapies based on anti-CS1 antibodies
NZ574979A (en) 2006-08-07 2012-06-29 Abbott Biotherapeutics Corp Compositions and methods using anti-cs1 antibodies to treat multiple myeloma
EP3384919A1 (en) 2008-06-02 2018-10-10 Dana Farber Cancer Institute, Inc. Cs1 peptides
AU2009271401A1 (en) * 2008-06-16 2010-01-21 Immunogen Inc. Novel synergistic effects
US20110236428A1 (en) * 2008-10-21 2011-09-29 Onyx Therapeutics, Inc. Combination therapy with peptide epoxyketones
EP2476438B1 (en) 2009-09-10 2014-07-23 Kyowa Hakko Kirin Co., Ltd. Medicament including antibody composition specifically bound to human cc chemokine receptor 4 (ccr4)
CA2780998C (en) * 2009-11-24 2016-07-12 Celgene Corporation Immunomodulatory compounds for the restoration of vitamin d sensitivity in vitamin d resistant tumor cells
CN102241773B (zh) * 2010-05-13 2014-05-14 四川大学 抗骨髓瘤细胞多克隆抗体及其制备方法
US9950047B2 (en) 2012-11-05 2018-04-24 Dana-Farber Cancer Institute, Inc. XBP1, CD138, and CS1 peptides, pharmaceutical compositions that include the peptides, and methods of using such peptides and compositions
ES2707057T3 (es) 2013-11-06 2019-04-02 Bristol Myers Squibb Co Combinación de anticuerpos anti-KIR y anti-CS1 para tratar el mieloma múltiple
WO2015069703A1 (en) 2013-11-06 2015-05-14 Bristol-Myers Squibb Company Immunotherapeutic dosing regimens and combinations thereof
SI3071597T1 (sl) * 2013-11-21 2020-11-30 F. Hoffmann-La Roche Ag Anti alfa-sinukleinska protitelesa in postopki uporabe
US10034872B2 (en) 2014-08-22 2018-07-31 Celgene Corporation Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
WO2016049022A1 (en) * 2014-09-23 2016-03-31 Board Of Trustees Of Michigan State University Compositions and methods for modulating an immune response
US10365280B2 (en) 2014-10-02 2019-07-30 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating malignancies
JP2017537893A (ja) 2014-10-31 2017-12-21 アッヴィ・バイオセラピューティクス・インコーポレイテッド 抗cs1抗体および抗体薬結合体
US10302644B2 (en) 2014-11-04 2019-05-28 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating multiple myeloma
MX2017007097A (es) 2014-12-04 2017-09-05 Bristol Myers Squibb Co Combinacion de anticuerpos anti-cs1 y anti-muerte programada 1 (pd1) para tratar cancer (mieloma).
SMT202100202T1 (it) 2015-05-13 2021-05-07 Morphosys Ag Trattamento per il mieloma multiplo
CA2990478A1 (en) 2015-06-29 2017-01-05 Bristol-Myers Squibb Company Immunotherapeutic dosing regimens comprising pomalidomide and an anti-cs1 antibody for treating cancer
CN109432398A (zh) * 2016-03-13 2019-03-08 曹帅 一种用于治疗骨髓增生、骨癌的药物组合物及其用途
CN110382546B (zh) * 2017-03-29 2024-08-09 新加坡科技研究局 抗寡糖抗体
WO2019104001A1 (en) * 2017-11-22 2019-05-31 Hillstream Biopharma Inc. Polymeric nanoparticles comprising bortezomib
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone
US20220390455A1 (en) 2019-11-05 2022-12-08 Bristol-Myers Squibb Company M-protein assays and uses thereof
CN115368462B (zh) * 2022-07-19 2026-01-02 合肥天港免疫药物有限公司 双特异性抗体及其应用

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Publication number Priority date Publication date Assignee Title
IL112969A (en) 1994-03-17 2001-05-20 Baxter Int Pharmaceutical compositions for the treatment of cancer comprising allogenic lymphocytes or their combination with a t-cell activator
EP0831860B1 (en) 1995-05-25 2004-10-20 Baxter International Inc. Allogeneic cell therapy for cancer following allogeneic stem cell transplantation
US7968569B2 (en) * 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
EP2272513A1 (en) * 2002-05-17 2011-01-12 Celgene Corporation Pharmaceutical compositions for treating cancer
US7709610B2 (en) * 2003-05-08 2010-05-04 Facet Biotech Corporation Therapeutic use of anti-CS1 antibodies
US20050025763A1 (en) * 2003-05-08 2005-02-03 Protein Design Laboratories, Inc. Therapeutic use of anti-CS1 antibodies
CA2595398A1 (en) * 2004-11-04 2006-05-11 Fibron Limited Treatment of b-cell malignancies
NZ574979A (en) * 2006-08-07 2012-06-29 Abbott Biotherapeutics Corp Compositions and methods using anti-cs1 antibodies to treat multiple myeloma
US8632772B2 (en) 2006-08-07 2014-01-21 Dana-Farber Cancer Institute Methods of treating multiple myeloma using combination therapies based on anti-CS1 antibodies
US20080095768A1 (en) 2006-08-07 2008-04-24 Pdl Biopharma, Inc. Use of allogeneic effector cells and anti-cs1 antibodies for selective killing of multiple myeloma cells

Also Published As

Publication number Publication date
LTPA2016030I1 (lt) 2016-11-10
PT2068874E (pt) 2015-05-21
LT2641601T (lt) 2016-10-10
CA2660356A1 (en) 2008-02-14
ES2535437T3 (es) 2015-05-11
US20170342150A1 (en) 2017-11-30
EP2942057A1 (en) 2015-11-11
LTPA2016031I1 (lt) 2016-11-10
HRP20161284T1 (hr) 2016-12-16
CY2016036I1 (el) 2017-07-12
SI2068874T1 (sl) 2015-06-30
AU2007281684A1 (en) 2008-02-14
CN101686971A (zh) 2010-03-31
LTC2068874I2 (lt) 2018-11-12
HRP20150449T1 (xx) 2015-06-05
PT2641601T (pt) 2016-10-14
HUE029027T2 (hu) 2017-01-30
SI2641601T1 (sl) 2016-11-30
US20140322201A1 (en) 2014-10-30
LU93277I2 (fr) 2016-12-27
EP2068874A1 (en) 2009-06-17
IL243933A0 (en) 2016-04-21
DK2068874T3 (da) 2015-04-27
WO2008019378A1 (en) 2008-02-14
EP2641601A1 (en) 2013-09-25
EP2641600A1 (en) 2013-09-25
CA2660356C (en) 2016-04-05
IL196919A0 (en) 2009-11-18
US8632772B2 (en) 2014-01-21
LU93276I2 (fr) 2016-12-27
BRPI0716647A2 (pt) 2017-05-16
NL300840I2 (hu) 2017-01-03
EP3115049A1 (en) 2017-01-11
AU2007281684B2 (en) 2013-05-16
CY1117992T1 (el) 2017-05-17
HK1129853A1 (en) 2009-12-11
NO346835B1 (no) 2023-01-23
LU93275I2 (fr) 2016-12-27
HUS1600045I1 (hu) 2016-12-28
NZ574978A (en) 2012-08-31
PL2068874T3 (pl) 2015-06-30
MX2009001441A (es) 2009-07-06
EP2641601B8 (en) 2016-09-21
US20080152646A1 (en) 2008-06-26
CN101686971B (zh) 2013-09-11
CY2016038I1 (el) 2017-07-12
LTPA2016029I1 (lt) 2016-11-10
EP2068874B1 (en) 2015-01-28
NO20090968L (no) 2009-04-30
AU2007281684C1 (en) 2013-12-19
JP5340935B2 (ja) 2013-11-13
IL196919A (en) 2016-03-31
ES2589302T3 (es) 2016-11-11
DK2641601T3 (en) 2016-08-22
JP2010500371A (ja) 2010-01-07
CY2016037I1 (el) 2017-07-12
EP2641601B1 (en) 2016-07-06
HUS1600043I1 (hu) 2016-12-28
US20160137735A1 (en) 2016-05-19
CY1116247T1 (el) 2017-02-08
CY2016036I2 (el) 2017-07-12
PL2641601T3 (pl) 2017-01-31

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