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HUP9800744A2 - Fas-antigén elleni antitestek - Google Patents

Fas-antigén elleni antitestek

Info

Publication number
HUP9800744A2
HUP9800744A2 HU9800744A HUP9800744A HUP9800744A2 HU P9800744 A2 HUP9800744 A2 HU P9800744A2 HU 9800744 A HU9800744 A HU 9800744A HU P9800744 A HUP9800744 A HU P9800744A HU P9800744 A2 HUP9800744 A2 HU P9800744A2
Authority
HU
Hungary
Prior art keywords
fas
antibodies
subject
humanized antibodies
prevention
Prior art date
Application number
HU9800744A
Other languages
English (en)
Inventor
Hideyuki Haruyama
Kimihisa Ichikawa
Jun Ohsumi
Masahiko Ohtsuki
Nobufusa Serizawa
Akio Shiraishi
Tohru Takahashi
Shin Yonehara
Hiroko Yoshida
Original Assignee
Sankyo Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Company Limited filed Critical Sankyo Company Limited
Publication of HU9800744D0 publication Critical patent/HU9800744D0/hu
Publication of HUP9800744A2 publication Critical patent/HUP9800744A2/hu
Publication of HUP9800744A3 publication Critical patent/HUP9800744A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A találmány tárgyát Fas-antigént felismerő antitestek (elsősőrbanhűmanizált antitestek) és azők fragmensei képezik, tővábbá az ilyenantitestek egészét vagy részét kódőló DNS-ek, a DNS-eket tartalmazórekőmbináns DNS-vektőrők, valamint az ilyen rekőmbináns vektőrőkkaltranszfőrmált gazdasejtek. A találmány tárgyát képezik tővábbá a találmány szerinti antitestekettartalmazó hatóanyagők, amlyek a Fas/Fas-ligandűm rendszerrendellenességeiből adódó betegségek megelőzésére és/vagy kezelésérealkalmazhatók. Szintén a találmány tárgyát képezik a találmányszerinti antitestek előállítási eljárásai. A találmány tárgya, Fas-antigén elleni hűmanizált antitestekalkalmasak a Fas/Fas-ligandűm rendszer rendellenességei őkőztabetegségek kezelésére és/vagy megelőzésére. A találmány szerintihűmanizált antitestek alkalmazása a HAMA-reakció indűkálódásánakminimális kőckázatával jár. ŕ
HU9800744A 1997-04-01 1998-04-01 Antibodies against fas-antigene HUP9800744A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8295397 1997-04-01
JP16908897 1997-06-25
JP27606497 1997-10-08

Publications (3)

Publication Number Publication Date
HU9800744D0 HU9800744D0 (en) 1998-05-28
HUP9800744A2 true HUP9800744A2 (hu) 1999-02-01
HUP9800744A3 HUP9800744A3 (en) 2001-04-28

Family

ID=27304060

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9800744A HUP9800744A3 (en) 1997-04-01 1998-04-01 Antibodies against fas-antigene

Country Status (17)

Country Link
EP (1) EP0909816A1 (hu)
KR (1) KR19980080993A (hu)
CN (1) CN1207395A (hu)
AR (1) AR010139A1 (hu)
AU (1) AU734758B2 (hu)
BR (1) BR9803296A (hu)
CA (1) CA2233783A1 (hu)
CZ (1) CZ294340B6 (hu)
HU (1) HUP9800744A3 (hu)
ID (1) ID20117A (hu)
IL (1) IL123888A0 (hu)
NO (1) NO981454L (hu)
NZ (1) NZ330095A (hu)
PL (1) PL325667A1 (hu)
RU (1) RU2212412C2 (hu)
TR (1) TR199800604A2 (hu)
TW (1) TW526205B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6972323B1 (en) 1997-04-01 2005-12-06 Sankyo Company, Limited Anti-Fas antibodies
JP4481489B2 (ja) * 1998-01-23 2010-06-16 エフ．ホフマン−ラ ロシュ アーゲー ヒトｉｌ−１２に対する抗体
WO1999065935A2 (en) * 1998-06-18 1999-12-23 Karolinska Innovations Ab Fas peptides and antibodies for modulating apoptosis
AU757961B2 (en) * 1998-09-30 2003-03-13 Sankyo Company Limited Anti-Fas antibodies
NZ515598A (en) 1999-05-24 2004-05-28 Sankyo Co Synergistic medicinal compositions containing anti-Fas antibody and a compound having a folate antagonistic activity or a dihydrofolate reductase inhibiting activity
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
EP1418935A1 (en) * 2001-08-01 2004-05-19 Genset S.A. Genobix agonists and antagonists for use in the treatment of metabolic disorders
CN101799476B (zh) 2001-08-23 2013-01-02 Rsr有限公司 筛选针对tsh受体的自身抗体的试剂盒
ES2357225T3 (es) 2001-11-01 2011-04-20 Uab Research Foundation Combinaciones de anticuerpos anti-dr5 y anticuerpos anti-dr4 y otros agentes terapéuticos.
RU2401277C2 (ru) 2004-01-07 2010-10-10 Чирон Корпорейшн Не мышиное анти-m-csf-антитело (варианты), его получение и использование
EP2322220B1 (en) * 2008-08-01 2014-01-01 Axis, Inc. Therapeutic agent or preventive agent for osteoarthritis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991010448A1 (en) * 1990-01-19 1991-07-25 German Cancer Research Center A cell surface antigen associated with cellular apoptosis
WO1994008454A1 (en) * 1992-10-14 1994-04-28 Uab Research Foundation Methods, compositions and screening assays relating to autoimmune disease
CA2174132A1 (en) * 1993-10-14 1995-04-20 Immunex Corporation Fas antagonists and uses thereof
NZ279108A (en) * 1994-01-07 1997-06-24 Immunex Corp Human fas (tgf/ngf receptor) ligand proteins coding sequences and production
WO1996040041A2 (en) * 1995-06-07 1996-12-19 Chiron Corporation Antibodies to fas antigen capable of inhibiting apoptosis
GB9523469D0 (en) * 1995-11-16 1996-01-17 Sandoz Ltd Organic compounds

Also Published As

Publication number Publication date
HU9800744D0 (en) 1998-05-28
CA2233783A1 (en) 1998-10-01
AU5970198A (en) 1998-10-08
RU2212412C2 (ru) 2003-09-20
CZ98598A3 (cs) 1998-10-14
CN1207395A (zh) 1999-02-10
EP0909816A1 (en) 1999-04-21
BR9803296A (pt) 2000-01-11
AR010139A1 (es) 2000-05-17
TR199800604A3 (tr) 1999-10-21
IL123888A0 (en) 1998-10-30
NO981454L (no) 1998-10-02
KR19980080993A (ko) 1998-11-25
NZ330095A (en) 1998-12-23
HUP9800744A3 (en) 2001-04-28
ID20117A (id) 1998-10-01
TW526205B (en) 2003-04-01
AU734758B2 (en) 2001-06-21
NO981454D0 (no) 1998-03-31
PL325667A1 (en) 1998-10-12
TR199800604A2 (xx) 1999-10-21
CZ294340B6 (cs) 2004-12-15

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees