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HUP9700885A2 - Eljárás tieno[3,2-c]piridin-származékok előállítására - Google Patents

Eljárás tieno[3,2-c]piridin-származékok előállítására

Info

Publication number
HUP9700885A2
HUP9700885A2 HU9700885A HUP9700885A HUP9700885A2 HU P9700885 A2 HUP9700885 A2 HU P9700885A2 HU 9700885 A HU9700885 A HU 9700885A HU P9700885 A HUP9700885 A HU P9700885A HU P9700885 A2 HUP9700885 A2 HU P9700885A2
Authority
HU
Hungary
Prior art keywords
novel process
pyridine derivatives
general formula
thieno
producing
Prior art date
Application number
HU9700885A
Other languages
English (en)
Inventor
Mária Bakonyi
Nagy Marianna Csatáriné
Antal Gajáry
Leventéné Molnár
Edit Alattyáni
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Priority to HU9700885A priority Critical patent/HU222283B1/hu
Publication of HUP9700885D0 publication Critical patent/HUP9700885D0/hu
Priority to HR980240A priority patent/HRP980240B1/xx
Priority to ZA983921A priority patent/ZA983921B/xx
Priority to PL336693A priority patent/PL194859B1/pl
Priority to KR10-1999-7010466A priority patent/KR100428238B1/ko
Priority to TR1999/02783T priority patent/TR199902783T2/xx
Priority to US09/423,549 priority patent/US6180793B1/en
Priority to CA002289623A priority patent/CA2289623C/en
Priority to AU74448/98A priority patent/AU735702B2/en
Priority to EP98921670A priority patent/EP0981529B1/en
Priority to DE69803176T priority patent/DE69803176T2/de
Priority to MEP-1999-587A priority patent/ME01636B/me
Priority to EEP199900488A priority patent/EE03925B1/xx
Priority to JP1998548956A priority patent/JP4256478B6/ja
Priority to NZ501577A priority patent/NZ501577A/en
Priority to RU99126506/04A priority patent/RU2172315C1/ru
Priority to IL13277498A priority patent/IL132774A0/xx
Priority to ES98921670T priority patent/ES2172141T3/es
Priority to PCT/HU1998/000048 priority patent/WO1998051689A1/en
Priority to CN98805036A priority patent/CN1109036C/zh
Priority to DK98921670T priority patent/DK0981529T3/da
Priority to PT98921670T priority patent/PT981529E/pt
Priority to YUP-587/99A priority patent/RS49626B/sr
Priority to HK00106408.3A priority patent/HK1027350B/xx
Priority to BRPI9809112-3A priority patent/BR9809112B1/pt
Priority to SK1516-99A priority patent/SK283700B6/sk
Priority to CZ19993939A priority patent/CZ292820B6/cs
Priority to AT98921670T priority patent/ATE212025T1/de
Priority to DZ980098A priority patent/DZ2487A1/xx
Priority to EG52098A priority patent/EG21973A/xx
Priority to MYPI98002116A priority patent/MY121299A/en
Priority to ARP980102220A priority patent/AR014349A1/es
Priority to CO98026855A priority patent/CO4950564A1/es
Priority to TW087109424A priority patent/TW552263B/zh
Priority to SA98190583A priority patent/SA98190583B1/ar
Priority to IDW991592A priority patent/ID23018A/id
Priority to UA99126785A priority patent/UA66359C2/uk
Publication of HUP9700885A2 publication Critical patent/HUP9700885A2/hu
Priority to IS5244A priority patent/IS1883B/is
Priority to NO19995533A priority patent/NO325419B1/no
Publication of HUP9700885A3 publication Critical patent/HUP9700885A3/hu
Publication of HU222283B1 publication Critical patent/HU222283B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

A találmány tárgya új eljárás a (VI) általánős képletű metil-[2-(2-tienil)-etilaminő]-2-halőgénfenil)-acetátők előállítására a (VII)általánős képletű acetamid-származékőkból. A (VI) általánős képletűvegyületek között értékes antitrőmbőtikűs hatású gyógyszerhatóanyagőkvannak. ŕ
HU9700885A 1997-05-13 1997-05-13 Eljárás tieno[3,2-c]piridin-származékok előállítására HU222283B1 (hu)

Priority Applications (39)

Application Number Priority Date Filing Date Title
HU9700885A HU222283B1 (hu) 1997-05-13 1997-05-13 Eljárás tieno[3,2-c]piridin-származékok előállítására
HR980240A HRP980240B1 (en) 1997-05-13 1998-05-06 A new process for the preparation of a pharmacologically ve substance
ZA983921A ZA983921B (en) 1997-05-13 1998-05-08 A new process for the preparation of a pharmacologically active substance
AT98921670T ATE212025T1 (de) 1997-05-13 1998-05-11 Verfahren zur herstellung von einer pharmacologisch aktiven substanz
DK98921670T DK0981529T3 (da) 1997-05-13 1998-05-11 Hidtil ukendt fremgangsmåde til fremstilling af farmakologisk aktivt stof
YUP-587/99A RS49626B (sr) 1997-05-13 1998-05-11 Novi postupak za dobijanje farmakološki aktivne supstance
TR1999/02783T TR199902783T2 (xx) 1997-05-13 1998-05-11 Bir farmakolojik a��dan aktif maddenin haz�rlanmas� i�in yeni bir i�lem.
US09/423,549 US6180793B1 (en) 1997-05-13 1998-05-11 Process for the preparation of a pharmacologically active substance
CA002289623A CA2289623C (en) 1997-05-13 1998-05-11 A new process for the preparation of a pharmacologically active substance
AU74448/98A AU735702B2 (en) 1997-05-13 1998-05-11 A new process for the preparation of a pharmacologically active substance
EP98921670A EP0981529B1 (en) 1997-05-13 1998-05-11 A new process for the preparation of a pharmacologically active substance
DE69803176T DE69803176T2 (de) 1997-05-13 1998-05-11 Verfahren zur herstellung von einer pharmacologisch aktiven substanz
MEP-1999-587A ME01636B (me) 1997-05-13 1998-05-11 Novi postupak za dobijanje farmakološki aktivne supstance
EEP199900488A EE03925B1 (et) 1997-05-13 1998-05-11 Farmakoloogiliselt aktiivse aine valmistamise meetod
JP1998548956A JP4256478B6 (ja) 1997-05-13 1998-05-11 薬理学的に活性な物質の新規調製方法
NZ501577A NZ501577A (en) 1997-05-13 1998-05-11 Method for making (+)-(S)-(2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester and salts thereof, process characterised by use of methyl hydrogen sulfate
RU99126506/04A RU2172315C1 (ru) 1997-05-13 1998-05-11 Способ получения рацемических или оптически активных метил(2-галогенофенил)(6,7-дигидро-4н-тиено[3,2-с]пиридин-5-ил)ацетатов или их солей
IL13277498A IL132774A0 (en) 1997-05-13 1998-05-11 A new process for preparation of a pharmacologically active substance
ES98921670T ES2172141T3 (es) 1997-05-13 1998-05-11 Nuevo procedimiento para la preparacion de una sustancia farmacologicamente activa.
PCT/HU1998/000048 WO1998051689A1 (en) 1997-05-13 1998-05-11 A new process for the preparation of a pharmacologically active substance
CN98805036A CN1109036C (zh) 1997-05-13 1998-05-11 制备药理活性物质的新方法
PL336693A PL194859B1 (pl) 1997-05-13 1998-05-11 Sposób wytwarzania racemicznych lub optycznie czynnych związków
PT98921670T PT981529E (pt) 1997-05-13 1998-05-11 Um novo processo para a preparacao de uma substancia farmacologicamente activa
KR10-1999-7010466A KR100428238B1 (ko) 1997-05-13 1998-05-11 약리학적 활성 물질의 제조 방법
HK00106408.3A HK1027350B (en) 1997-05-13 1998-05-11 A new process for the preparation of a pharmacologically active substance
BRPI9809112-3A BR9809112B1 (pt) 1997-05-13 1998-05-11 processo para preparação de clopidogrel.
SK1516-99A SK283700B6 (sk) 1997-05-13 1998-05-11 Spôsob prípravy farmakologicky účinných racemických alebo opticky aktívnych zlúčenín
CZ19993939A CZ292820B6 (cs) 1997-05-13 1998-05-11 Způsob přípravy clopidogrelu a jeho analogů
DZ980098A DZ2487A1 (fr) 1997-05-13 1998-05-12 Un nouveau procédé de fabrication d'une substance active sur le plan pharmacologique.
MYPI98002116A MY121299A (en) 1997-05-13 1998-05-12 A new process for the preparation of a pharmacologically active substance
EG52098A EG21973A (en) 1997-05-13 1998-05-12 A new process for the preparation of a pharmacolgically active substance
ARP980102220A AR014349A1 (es) 1997-05-13 1998-05-13 Proceso para la preparacion de [2-(2-tienil)etilamino](2-halogenofenil) acetatos de metilo racemicos u opticamente activos.
CO98026855A CO4950564A1 (es) 1997-05-13 1998-05-13 Nuevo proceso para la preparacion de una sustancia farmaco- logimante activa
TW087109424A TW552263B (en) 1997-05-13 1998-06-12 A process for the preparation of a racemic or optically active thieno [3,2-c] pyridine derivative or their salts
SA98190583A SA98190583B1 (ar) 1997-05-13 1998-09-27 عملية لتحضير مادة فعالة دوائياً
IDW991592A ID23018A (id) 1997-05-13 1998-11-05 Proses baru untuk pembuatan zat-zat yang aktif secara farmakologi
UA99126785A UA66359C2 (uk) 1997-05-13 1998-11-05 Спосіб одержання рацемічних або оптично активних сполук
IS5244A IS1883B (is) 1997-05-13 1999-11-11 Ný aðferð við að framleiða lyfjafræðilega virkar útskiptar-(6,7-díhýdró-4H-þíenó[3,2-C]pýridín-5-ýl)ediksýruafleiður
NO19995533A NO325419B1 (no) 1997-05-13 1999-11-12 Ny fremgangsmate for fremstilling av en farmakologisk aktiv substans

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9700885A HU222283B1 (hu) 1997-05-13 1997-05-13 Eljárás tieno[3,2-c]piridin-származékok előállítására

Publications (4)

Publication Number Publication Date
HUP9700885D0 HUP9700885D0 (en) 1997-07-28
HUP9700885A2 true HUP9700885A2 (hu) 1999-09-28
HUP9700885A3 HUP9700885A3 (en) 2000-06-28
HU222283B1 HU222283B1 (hu) 2003-05-28

Family

ID=90014236

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700885A HU222283B1 (hu) 1997-05-13 1997-05-13 Eljárás tieno[3,2-c]piridin-származékok előállítására

Country Status (37)

Country Link
US (1) US6180793B1 (hu)
EP (1) EP0981529B1 (hu)
KR (1) KR100428238B1 (hu)
CN (1) CN1109036C (hu)
AR (1) AR014349A1 (hu)
AT (1) ATE212025T1 (hu)
AU (1) AU735702B2 (hu)
BR (1) BR9809112B1 (hu)
CA (1) CA2289623C (hu)
CO (1) CO4950564A1 (hu)
CZ (1) CZ292820B6 (hu)
DE (1) DE69803176T2 (hu)
DK (1) DK0981529T3 (hu)
DZ (1) DZ2487A1 (hu)
EE (1) EE03925B1 (hu)
EG (1) EG21973A (hu)
ES (1) ES2172141T3 (hu)
HR (1) HRP980240B1 (hu)
HU (1) HU222283B1 (hu)
ID (1) ID23018A (hu)
IL (1) IL132774A0 (hu)
IS (1) IS1883B (hu)
ME (1) ME01636B (hu)
MY (1) MY121299A (hu)
NO (1) NO325419B1 (hu)
NZ (1) NZ501577A (hu)
PL (1) PL194859B1 (hu)
PT (1) PT981529E (hu)
RS (1) RS49626B (hu)
RU (1) RU2172315C1 (hu)
SA (1) SA98190583B1 (hu)
SK (1) SK283700B6 (hu)
TR (1) TR199902783T2 (hu)
TW (1) TW552263B (hu)
UA (1) UA66359C2 (hu)
WO (1) WO1998051689A1 (hu)
ZA (1) ZA983921B (hu)

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FR2769313B1 (fr) * 1997-10-06 2000-04-21 Sanofi Sa Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese
HU226421B1 (en) 1998-11-09 2008-12-29 Sanofi Aventis Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides
IN191030B (hu) * 2001-01-24 2003-09-13 Cadila Healthcare Ltd
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
ITMI20020933A1 (it) * 2002-05-03 2003-11-03 Danimite Dipharma S P A Procedimento per la sintesi di clopidogrel
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
US6812363B2 (en) * 2002-10-15 2004-11-02 Usv Limited Racemization of optically active 2-substituted phenyl glycine esters
RU2231527C1 (ru) * 2003-02-19 2004-06-27 Кубанский государственный технологический университет Замещенные 3-(1н)-1-пирролил)тиено[2,3-b]пиридины, проявляющие рострегулирующую и антистрессовую активность
WO2004081015A1 (en) * 2003-03-10 2004-09-23 Hetero Drugs Limited Amorphous clopidogrel hydrogen sulfate
AU2003238664A1 (en) 2003-03-12 2004-09-30 Cadila Healthcare Limited Polymorphs and amorphous form of (s) - (+) -clopidogrel bisulfate
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
DE602004025267D1 (de) 2003-11-03 2010-03-11 Cadila Healthcare Ltd Verfahren zur herstellung form i von (s)-(+)- clopidogrelbisulfat
CA2457459A1 (en) * 2004-02-11 2005-08-11 Brantford Chemicals Inc. Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate
KR100553398B1 (ko) * 2004-03-12 2006-02-16 한미약품 주식회사 티에노[3,2-ｃ]피리딘 유도체의 제조 방법 및 이에사용되는 중간체
CA2562532C (en) * 2004-04-09 2010-02-16 Hanmi Pharm. Co., Ltd. Crystalline clopidogrel naphthalenesulfonate or hydrate thereof, method for preparing same and pharmaceutical composition containing same
DK1589019T3 (da) * 2004-04-20 2008-11-17 Ratiopharm Gmbh Stereoselektiv fremgangsmåde til fremstilling af clopidogrel
US20060154957A1 (en) * 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof
JP2008526896A (ja) * 2005-02-24 2008-07-24 テバ ファーマシューティカル インダストリーズ リミティド 医薬製剤に適したグロピドグレル塩基及びその調製
KR100681512B1 (ko) 2005-03-08 2007-02-09 주식회사 한서켐 클로피도그렐의 신규한 제조 중간체 및 이를 이용한 클로피도그렐의 제조방법
KR101235117B1 (ko) 2005-12-26 2013-02-20 에스케이케미칼주식회사 광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
US20090099363A1 (en) * 2006-04-27 2009-04-16 Saxena Rahul Process for the preparation of polymorphic forms of clopidogrel hydrogen sulfate
CA2655844A1 (en) * 2006-08-03 2008-02-14 Teva Pharmaceutical Industries Ltd. Process for preparing clopidogrel bisulphate
ATE496055T1 (de) 2006-09-04 2011-02-15 Ranbaxy Lab Ltd Verbessertes verfahren zur herstellung von clopidogrel und pharmazeutisch unbedenklichen salzen davon
EP1980563A1 (en) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
US20090264460A1 (en) * 2008-04-21 2009-10-22 Mamta Mishra Clopidogrel pharmaceutical formulations
KR100990949B1 (ko) 2008-06-09 2010-10-29 엔자이텍 주식회사 클로피도그렐 및 그의 유도체의 제조방법
WO2010046476A1 (en) * 2008-10-24 2010-04-29 Sandoz Ag A process for the preparation of s-clopidogrel
US8563690B2 (en) * 2008-11-03 2013-10-22 The Board Of Trustees Of The University Of Illinois Modulation of platelet aggregation
CN101544655B (zh) * 2009-05-05 2012-07-04 上海医药集团股份有限公司 噻吩并[3，2-c]吡啶衍生物的制备方法
CN101863899B (zh) * 2010-06-21 2013-03-20 常州制药厂有限公司 一种提高氯吡格雷樟脑磺酸盐拆分收率的方法
KR20170004283A (ko) 2015-07-02 2017-01-11 류종렬 그립부가 개선된 쉐이크 핸드형 탁구 라켓
KR20170004282A (ko) 2015-07-02 2017-01-11 류종렬 수도 지지부가 구비된 쉐이크 핸드형 탁구 라켓

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FR2664596B1 (fr) 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.

Also Published As

Publication number Publication date
JP2001525819A (ja) 2001-12-11
ZA983921B (en) 1998-11-09
HUP9700885D0 (en) 1997-07-28
DZ2487A1 (fr) 2004-07-30
NO325419B1 (no) 2008-04-21
TW552263B (en) 2003-09-11
NO995533L (no) 1999-12-13
RS49626B (sr) 2007-08-03
HU222283B1 (hu) 2003-05-28
US6180793B1 (en) 2001-01-30
BR9809112A (pt) 2000-08-01
IS1883B (is) 2003-08-15
RU2172315C1 (ru) 2001-08-20
HUP9700885A3 (en) 2000-06-28
MY121299A (en) 2006-01-28
SK151699A3 (en) 2000-07-11
CN1109036C (zh) 2003-05-21
EP0981529A1 (en) 2000-03-01
EP0981529B1 (en) 2002-01-16
CO4950564A1 (es) 2000-09-01
DE69803176D1 (de) 2002-02-21
IL132774A0 (en) 2001-03-19
PL194859B1 (pl) 2007-07-31
HRP980240A2 (en) 1999-02-28
KR20010012511A (ko) 2001-02-15
EE03925B1 (et) 2002-12-16
CA2289623A1 (en) 1998-11-19
JP4256478B2 (ja) 2009-04-22
ME01636B (me) 2007-08-03
CZ292820B6 (cs) 2003-12-17
CZ393999A3 (cs) 2000-04-12
AU7444898A (en) 1998-12-08
DK0981529T3 (da) 2002-04-22
KR100428238B1 (ko) 2004-04-30
ES2172141T3 (es) 2002-09-16
YU58799A (sh) 2002-06-19
PT981529E (pt) 2002-06-28
PL336693A1 (en) 2000-07-03
UA66359C2 (uk) 2004-05-17
NZ501577A (en) 2001-10-26
HRP980240B1 (en) 2003-02-28
AU735702B2 (en) 2001-07-12
WO1998051689A1 (en) 1998-11-19
CN1255924A (zh) 2000-06-07
HK1027350A1 (en) 2001-01-12
CA2289623C (en) 2007-01-30
SA98190583B1 (ar) 2006-08-19
IS5244A (is) 1999-11-11
DE69803176T2 (de) 2002-08-22
ID23018A (id) 1999-12-30
TR199902783T2 (xx) 2000-04-21
EE9900488A (et) 2000-06-15
AR014349A1 (es) 2001-02-28
NO995533D0 (no) 1999-11-12
EG21973A (en) 2002-05-31
SK283700B6 (sk) 2003-12-02
ATE212025T1 (de) 2002-02-15
BR9809112B1 (pt) 2010-10-05

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