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HUP9700645A3 - Purification process for producing high purity ciklosporin a - Google Patents

Purification process for producing high purity ciklosporin a

Info

Publication number
HUP9700645A3
HUP9700645A3 HU9700645A HUP9700645A HUP9700645A3 HU P9700645 A3 HUP9700645 A3 HU P9700645A3 HU 9700645 A HU9700645 A HU 9700645A HU P9700645 A HUP9700645 A HU P9700645A HU P9700645 A3 HUP9700645 A3 HU P9700645A3
Authority
HU
Hungary
Prior art keywords
ciklosporin
high purity
purification process
producing high
producing
Prior art date
Application number
HU9700645A
Other languages
English (en)
Original Assignee
Teva Gyogyszergyar Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Gyogyszergyar Zrt filed Critical Teva Gyogyszergyar Zrt
Priority to HU9700645A priority Critical patent/HU223054B1/hu
Publication of HU9700645D0 publication Critical patent/HU9700645D0/hu
Priority to DK98913969T priority patent/DK0920447T3/da
Priority to CA002255062A priority patent/CA2255062C/en
Priority to PT98913969T priority patent/PT920447E/pt
Priority to AT98913969T priority patent/ATE223434T1/de
Priority to YU53598A priority patent/YU49468B/sh
Priority to PCT/HU1998/000029 priority patent/WO1998042734A1/en
Priority to NZ332718A priority patent/NZ332718A/xx
Priority to AU68482/98A priority patent/AU737260B2/en
Priority to UA98116251A priority patent/UA58511C2/uk
Priority to ES98913969T priority patent/ES2180159T3/es
Priority to SK1618-98A priority patent/SK283672B6/sk
Priority to RU98123499/04A priority patent/RU2182577C2/ru
Priority to DE69807635T priority patent/DE69807635T2/de
Priority to CZ19983814A priority patent/CZ293687B6/cs
Priority to SI9830241T priority patent/SI0920447T1/xx
Priority to EP98913969A priority patent/EP0920447B1/en
Priority to IL12687198A priority patent/IL126871A0/xx
Priority to HK99105786.9A priority patent/HK1020740B/en
Priority to JP10545312A priority patent/JP2000511939A/ja
Priority to PL98330142A priority patent/PL194252B1/pl
Priority to BG102911A priority patent/BG64215B1/bg
Priority to NO19985483A priority patent/NO322211B1/no
Publication of HUP9700645A2 publication Critical patent/HUP9700645A2/hu
Publication of HUP9700645A3 publication Critical patent/HUP9700645A3/hu
Priority to US10/144,841 priority patent/US6706192B2/en
Publication of HU223054B1 publication Critical patent/HU223054B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Saccharide Compounds (AREA)
  • Silicon Compounds (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
HU9700645A 1997-03-25 1997-03-25 Tisztítási eljárás nagytisztaságú ciklosporin A előállítására HU223054B1 (hu)

Priority Applications (24)

Application Number Priority Date Filing Date Title
HU9700645A HU223054B1 (hu) 1997-03-25 1997-03-25 Tisztítási eljárás nagytisztaságú ciklosporin A előállítására
PL98330142A PL194252B1 (pl) 1997-03-25 1998-03-23 Sposób oczyszczania w procesie wytwarzania cyklosporyny A i sposób na skalę przemysłową oczyszczania cyklosporyny A oraz cyklosporyna A o dużej czystości
RU98123499/04A RU2182577C2 (ru) 1997-03-25 1998-03-23 Способ получения циклоспорина a высокой чистоты из сырого продукта, содержащего циклоспориновый комплекс
CZ19983814A CZ293687B6 (cs) 1997-03-25 1998-03-23 Purifikační postup pro přípravu vysoce čistého cyklosporinu A a vysoce čistý cyklosporin A takto připravený
PT98913969T PT920447E (pt) 1997-03-25 1998-03-23 Processo para a purificacao de ciclosporinas
AT98913969T ATE223434T1 (de) 1997-03-25 1998-03-23 Verfahren zur reinigung vom cyclosporin
YU53598A YU49468B (sh) 1997-03-25 1998-03-23 Postupak za prečišćavanje ciklosporina
PCT/HU1998/000029 WO1998042734A1 (en) 1997-03-25 1998-03-23 Process of purification of cyclosporin
NZ332718A NZ332718A (en) 1997-03-25 1998-03-23 Process of purification of cyclosporin A using chromatography with a toluene containing solvent
AU68482/98A AU737260B2 (en) 1997-03-25 1998-03-23 Process of purification of cyclosporin
UA98116251A UA58511C2 (uk) 1997-03-25 1998-03-23 Способи очищення циклоспорину а та циклоспорин а високої чистоти
ES98913969T ES2180159T3 (es) 1997-03-25 1998-03-23 Procedimiento de purificacion de la ciclosporina a.
SK1618-98A SK283672B6 (sk) 1997-03-25 1998-03-23 Purifikačný postup na prípravu vysoko čistého cyklosporínu A
DK98913969T DK0920447T3 (da) 1997-03-25 1998-03-23 Fremgangsmåde til rensning af cyclosporin
DE69807635T DE69807635T2 (de) 1997-03-25 1998-03-23 Verfahren zur reinigung vom cyclosporin
CA002255062A CA2255062C (en) 1997-03-25 1998-03-23 Process of purification of cyclosporin
SI9830241T SI0920447T1 (en) 1997-03-25 1998-03-23 Process of purification of cyclosporin
EP98913969A EP0920447B1 (en) 1997-03-25 1998-03-23 Process of purification of cyclosporin
IL12687198A IL126871A0 (en) 1997-03-25 1998-03-23 Process of purification of cyclosporin
HK99105786.9A HK1020740B (en) 1997-03-25 1998-03-23 Process of purification of cyclosporin
JP10545312A JP2000511939A (ja) 1997-03-25 1998-03-23 シクロスポリンの精製方法
BG102911A BG64215B1 (bg) 1997-03-25 1998-11-10 Метод за пречистване на циклоспорин
NO19985483A NO322211B1 (no) 1997-03-25 1998-11-24 Fremgangsmate for rensing av syklosporin A, og syklosporin A med hoy renhet.
US10/144,841 US6706192B2 (en) 1997-03-25 2002-05-15 Purification process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9700645A HU223054B1 (hu) 1997-03-25 1997-03-25 Tisztítási eljárás nagytisztaságú ciklosporin A előállítására

Publications (4)

Publication Number Publication Date
HU9700645D0 HU9700645D0 (en) 1997-05-28
HUP9700645A2 HUP9700645A2 (hu) 1999-06-28
HUP9700645A3 true HUP9700645A3 (en) 2001-11-28
HU223054B1 HU223054B1 (hu) 2004-03-01

Family

ID=89994909

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700645A HU223054B1 (hu) 1997-03-25 1997-03-25 Tisztítási eljárás nagytisztaságú ciklosporin A előállítására

Country Status (21)

Country Link
EP (1) EP0920447B1 (hu)
JP (1) JP2000511939A (hu)
AT (1) ATE223434T1 (hu)
AU (1) AU737260B2 (hu)
BG (1) BG64215B1 (hu)
CA (1) CA2255062C (hu)
CZ (1) CZ293687B6 (hu)
DE (1) DE69807635T2 (hu)
DK (1) DK0920447T3 (hu)
ES (1) ES2180159T3 (hu)
HU (1) HU223054B1 (hu)
IL (1) IL126871A0 (hu)
NO (1) NO322211B1 (hu)
NZ (1) NZ332718A (hu)
PL (1) PL194252B1 (hu)
PT (1) PT920447E (hu)
RU (1) RU2182577C2 (hu)
SK (1) SK283672B6 (hu)
UA (1) UA58511C2 (hu)
WO (1) WO1998042734A1 (hu)
YU (1) YU49468B (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1154759T3 (da) 1998-12-30 2008-12-08 Dexcel Ltd Dispergerbart koncentrat til indgift af cyclosporin
RU2272643C2 (ru) * 2004-06-11 2006-03-27 Маргарита Васильевна Бибикова Высокоактивный кристаллический препарат циклоспорина а и способ его получения
EP2151450A1 (de) * 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
DE102009037551A1 (de) * 2009-08-17 2011-02-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Cyclosporinderivate
HUP1500502A2 (en) 2015-10-26 2017-04-28 Rotachrom Tech Kft Process for the purification of cyclosporin-a
CN114653350A (zh) * 2022-02-25 2022-06-24 江苏九阳生物制药有限公司 一种环孢素a层析硅胶的再生方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU201577B (en) * 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
ES2078374T3 (es) * 1991-04-06 1995-12-16 Dresden Arzneimittel Procedimiento para la produccion por fermentacion y aislamiento de ciclosporina a, y nuevas cepas formadoras de ciclosporina.
GB9208712D0 (en) * 1992-04-22 1992-06-10 Sandoz Ltd Pharmaceutical compositions containing cyclosporin derivates
HU213553B (en) * 1992-05-25 1997-07-28 Biogal Gyogyszergyar Process for isolating of cyclosporin-a
FI92334C (fi) * 1992-12-30 1994-10-25 Leiras Oy Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta
KR100304324B1 (ko) * 1994-10-13 2001-11-22 김용규 사이클로스포린a의제조방법

Also Published As

Publication number Publication date
PT920447E (pt) 2002-11-29
NO985483D0 (no) 1998-11-24
HK1020740A1 (en) 2000-05-19
HU9700645D0 (en) 1997-05-28
YU53598A (en) 1999-11-22
ES2180159T3 (es) 2003-02-01
CZ381498A3 (cs) 1999-02-17
IL126871A0 (en) 1999-09-22
BG102911A (en) 1999-09-30
WO1998042734A1 (en) 1998-10-01
HU223054B1 (hu) 2004-03-01
YU49468B (sh) 2006-05-25
NO985483L (no) 1998-11-24
JP2000511939A (ja) 2000-09-12
CA2255062C (en) 2008-06-17
HUP9700645A2 (hu) 1999-06-28
BG64215B1 (bg) 2004-05-31
ATE223434T1 (de) 2002-09-15
DK0920447T3 (da) 2002-12-16
CZ293687B6 (cs) 2004-07-14
RU2182577C2 (ru) 2002-05-20
DE69807635D1 (de) 2002-10-10
SK283672B6 (sk) 2003-11-04
PL330142A1 (en) 1999-04-26
NO322211B1 (no) 2006-08-28
PL194252B1 (pl) 2007-05-31
AU6848298A (en) 1998-10-20
EP0920447B1 (en) 2002-09-04
UA58511C2 (uk) 2003-08-15
CA2255062A1 (en) 1998-10-01
EP0920447A1 (en) 1999-06-09
NZ332718A (en) 2000-04-28
SK161898A3 (en) 1999-05-07
AU737260B2 (en) 2001-08-16
DE69807635T2 (de) 2003-08-07

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20031205

HC9A Change of name, address

Owner name: TEVA GYOGYSZERGYAR ZRT., HU

Free format text: FORMER OWNER(S): BIOGAL GYOGYSZERGYAR RT., HU

MM4A Lapse of definitive patent protection due to non-payment of fees