HUP0105282A3 - Acetylenic sulfonamide thiol tace inhibitors process for their preparation and pharmaceutical compositions containing the same - Google Patents

Acetylenic sulfonamide thiol tace inhibitors process for their preparation and pharmaceutical compositions containing the same

Info

Publication number: HUP0105282A3
Authority: HU; Hungary
Prior art keywords: preparation; pharmaceutical compositions; same; compositions containing; tace inhibitors
Prior art date: 1999-01-27

Application number

HU0105282A

Other languages

Hungarian (hu)

Original Assignee

Wyeth Holdings Corp Madison

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-27

Filing date

2000-01-27

Publication date

2005-04-28

2000-01-27 Application filed by Wyeth Holdings Corp Madison filed Critical Wyeth Holdings Corp Madison

2002-05-29 Publication of HUP0105282A2 publication Critical patent/HUP0105282A2/en

2005-04-28 Publication of HUP0105282A3 publication Critical patent/HUP0105282A3/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Transplantation (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Psychiatry (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Biochemistry (AREA)

HU0105282A 1999-01-27 2000-01-27 Acetylenic sulfonamide thiol tace inhibitors process for their preparation and pharmaceutical compositions containing the same HUP0105282A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US23839399A	1999-01-27	1999-01-27

Publications (2)

Publication Number	Publication Date
HUP0105282A2 HUP0105282A2 (en)	2002-05-29
HUP0105282A3 true HUP0105282A3 (en)	2005-04-28

Family

ID=22897697

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0105282A HUP0105282A3 (en)	1999-01-27	2000-01-27	Acetylenic sulfonamide thiol tace inhibitors process for their preparation and pharmaceutical compositions containing the same

Country Status (21)

Country	Link
EP (1)	EP1149074B1 (en)
JP (1)	JP2002535386A (en)
KR (1)	KR20010101691A (en)
CN (1)	CN1224612C (en)
AT (1)	ATE280152T1 (en)
AU (1)	AU766192B2 (en)
BR (1)	BR0007727A (en)
CA (1)	CA2356480A1 (en)
CZ (1)	CZ20012545A3 (en)
DE (1)	DE60015079T2 (en)
DK (1)	DK1149074T3 (en)
EA (1)	EA200100811A1 (en)
ES (1)	ES2230064T3 (en)
HK (1)	HK1038915A1 (en)
HU (1)	HUP0105282A3 (en)
IL (1)	IL144347A0 (en)
NO (1)	NO20013638L (en)
NZ (1)	NZ512306A (en)
PL (1)	PL350420A1 (en)
WO (1)	WO2000044716A1 (en)
ZA (1)	ZA200105069B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003033477A1 (en) *	2001-10-12	2003-04-24	Warner-Lambert Company Llc	Alkynlated fused ring pyrimidine compounds as matrix metalloprotease-13 inhibitor
US6962922B2 (en)	2001-10-12	2005-11-08	Warner-Lambert Company Llc	Alkynylated quinazoline compounds
PE20030701A1 (en)	2001-12-20	2003-08-21	Schering Corp	COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
PT1465861E (en)	2001-12-20	2009-07-08	Bristol Myers Squibb Co	Alpha-(n-sulphonamido)acetamide derivatives as beta-amyloid inhibitors
US6747147B2 (en)	2002-03-08	2004-06-08	Warner-Lambert Company	Oxo-azabicyclic compounds
US6894057B2 (en)	2002-03-08	2005-05-17	Warner-Lambert Company	Oxo-azabicyclic compounds
AU2003304456A1 (en)	2002-12-23	2005-03-16	Wyeth Holdings Corporation	Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors
US8084477B2 (en)	2007-10-31	2011-12-27	Bristol-Myers Squibb Company	Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
US8093276B2 (en)	2007-10-31	2012-01-10	Bristol-Myers Squibb Company	Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
US8044077B2 (en)	2009-03-19	2011-10-25	Bristol-Myers Squibb Company	Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production
US7977362B2 (en)	2009-03-20	2011-07-12	Bristol-Myers Squibb Company	Alpha-(N-benzenesulfonamido)cycloalkyl derivatives
US8252821B2 (en)	2009-04-14	2012-08-28	Bristol-Myers Squibb Company	Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound
EP3860608A1 (en)	2018-10-04	2021-08-11	INSERM (Institut National de la Santé et de la Recherche Médicale)	Egfr inhibitors for treating keratodermas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ333825A (en) *	1996-07-22	2000-10-27	Monsanto Co	Metalloprotease inhibitors particularly MMP-13
NZ333824A (en) *	1996-07-22	2000-08-25	Monsanto Co	Thiol sulfone metalloprotease inhibitors

2000
- 2000-01-27 JP JP2000595972A patent/JP2002535386A/en active Pending
- 2000-01-27 WO PCT/US2000/002143 patent/WO2000044716A1/en not_active Ceased
- 2000-01-27 HU HU0105282A patent/HUP0105282A3/en unknown
- 2000-01-27 CZ CZ20012545A patent/CZ20012545A3/en unknown
- 2000-01-27 BR BR0007727-5A patent/BR0007727A/en not_active IP Right Cessation
- 2000-01-27 AU AU27417/00A patent/AU766192B2/en not_active Ceased
- 2000-01-27 ES ES00905787T patent/ES2230064T3/en not_active Expired - Lifetime
- 2000-01-27 NZ NZ512306A patent/NZ512306A/en unknown
- 2000-01-27 DK DK00905787T patent/DK1149074T3/en active
- 2000-01-27 DE DE60015079T patent/DE60015079T2/en not_active Expired - Fee Related
- 2000-01-27 KR KR1020017009365A patent/KR20010101691A/en not_active Withdrawn
- 2000-01-27 EP EP00905787A patent/EP1149074B1/en not_active Expired - Lifetime
- 2000-01-27 CA CA002356480A patent/CA2356480A1/en not_active Abandoned
- 2000-01-27 HK HK02100417.3A patent/HK1038915A1/en unknown
- 2000-01-27 AT AT00905787T patent/ATE280152T1/en not_active IP Right Cessation
- 2000-01-27 IL IL14434700A patent/IL144347A0/en unknown
- 2000-01-27 EA EA200100811A patent/EA200100811A1/en unknown
- 2000-01-27 CN CNB008030286A patent/CN1224612C/en not_active Expired - Fee Related
- 2000-01-27 PL PL00350420A patent/PL350420A1/en not_active Application Discontinuation
2001
- 2001-06-20 ZA ZA200105069A patent/ZA200105069B/en unknown
- 2001-07-24 NO NO20013638A patent/NO20013638L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
EA200100811A1 (en)	2002-12-26
DK1149074T3 (en)	2005-01-10
NO20013638D0 (en)	2001-07-24
DE60015079T2 (en)	2005-03-03
CZ20012545A3 (en)	2002-04-17
JP2002535386A (en)	2002-10-22
CN1224612C (en)	2005-10-26
EP1149074A1 (en)	2001-10-31
DE60015079D1 (en)	2004-11-25
CA2356480A1 (en)	2000-08-03
KR20010101691A (en)	2001-11-14
PL350420A1 (en)	2002-12-16
HK1038915A1 (en)	2002-04-04
NO20013638L (en)	2001-07-24
WO2000044716A1 (en)	2000-08-03
EP1149074B1 (en)	2004-10-20
ATE280152T1 (en)	2004-11-15
ZA200105069B (en)	2002-09-20
IL144347A0 (en)	2002-05-23
BR0007727A (en)	2001-10-30
NZ512306A (en)	2003-10-31
HUP0105282A2 (en)	2002-05-29
ES2230064T3 (en)	2005-05-01
AU766192B2 (en)	2003-10-09
AU2741700A (en)	2000-08-18
CN1337947A (en)	2002-02-27

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