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HUP0102714A2 - Matrix metalloproteináz inhibitor hatású triciklusos szulfonamidszármazékok és azokat tartalmazó gyógyszerkészítmények - Google Patents

Matrix metalloproteináz inhibitor hatású triciklusos szulfonamidszármazékok és azokat tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0102714A2
HUP0102714A2 HU0102714A HUP0102714A HUP0102714A2 HU P0102714 A2 HUP0102714 A2 HU P0102714A2 HU 0102714 A HU0102714 A HU 0102714A HU P0102714 A HUP0102714 A HU P0102714A HU P0102714 A2 HUP0102714 A2 HU P0102714A2
Authority
HU
Hungary
Prior art keywords
integer
value
derivatives
tricyclic
sulfonamid
Prior art date
Application number
HU0102714A
Other languages
English (en)
Inventor
Patrick Michael O'brien
Joseph Armand Picard
Drago Robert Sliskovic
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of HUP0102714A2 publication Critical patent/HUP0102714A2/hu
Publication of HUP0102714A3 publication Critical patent/HUP0102714A3/hu

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/76—Dibenzothiophenes
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
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    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M15/00—Arrangements for metering, time-control or time indication ; Metering, charging or billing arrangements for voice wireline or wireless communications, e.g. VoIP
    • H04M15/28—Arrangements for metering, time-control or time indication ; Metering, charging or billing arrangements for voice wireline or wireless communications, e.g. VoIP with meter at substation or with calculation of charges at terminal
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M15/00—Arrangements for metering, time-control or time indication ; Metering, charging or billing arrangements for voice wireline or wireless communications, e.g. VoIP
    • H04M15/28—Arrangements for metering, time-control or time indication ; Metering, charging or billing arrangements for voice wireline or wireless communications, e.g. VoIP with meter at substation or with calculation of charges at terminal
    • H04M15/30—Arrangements for metering, time-control or time indication ; Metering, charging or billing arrangements for voice wireline or wireless communications, e.g. VoIP with meter at substation or with calculation of charges at terminal the meter or calculation of charges not being controlled from an exchange
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M15/00—Arrangements for metering, time-control or time indication ; Metering, charging or billing arrangements for voice wireline or wireless communications, e.g. VoIP
    • H04M15/31—Distributed metering or calculation of charges
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M15/00—Arrangements for metering, time-control or time indication ; Metering, charging or billing arrangements for voice wireline or wireless communications, e.g. VoIP
    • H04M15/49—Connection to several service providers
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M15/00—Arrangements for metering, time-control or time indication ; Metering, charging or billing arrangements for voice wireline or wireless communications, e.g. VoIP
    • H04M15/80—Rating or billing plans; Tariff determination aspects
    • H04M15/8044—Least cost routing
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    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M15/00—Arrangements for metering, time-control or time indication ; Metering, charging or billing arrangements for voice wireline or wireless communications, e.g. VoIP
    • H04M15/83—Notification aspects
    • H—ELECTRICITY
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    • H04M—TELEPHONIC COMMUNICATION
    • H04M2215/00—Metering arrangements; Time controlling arrangements; Time indicating arrangements
    • H04M2215/01—Details of billing arrangements
    • H04M2215/0168—On line or real-time flexible customization or negotiation according to wishes of subscriber
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    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
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    • H04M2215/42—Least cost routing, i.e. provision for selecting the lowest cost tariff
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    • H04—ELECTRIC COMMUNICATION TECHNIQUE
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    • H04M2215/46—Connection to several service providers
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    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M2215/00—Metering arrangements; Time controlling arrangements; Time indicating arrangements
    • H04M2215/74—Rating aspects, e.g. rating parameters or tariff determination apects
    • H04M2215/745—Least cost routing, e.g. Automatic or manual, call by call or by preselection
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    • H04M—TELEPHONIC COMMUNICATION
    • H04M2215/00—Metering arrangements; Time controlling arrangements; Time indicating arrangements
    • H04M2215/92—Autonomous calculations of charges in terminal, i.e. meter not controlled from exchange
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    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M2215/00—Metering arrangements; Time controlling arrangements; Time indicating arrangements
    • H04M2215/96—Distributed calculation of charges, e.g. in different nodes like for mobiles between HLR and VLR, or between the terminal and the billing function

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
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Abstract

A találmány tárgya (I) általános képletű új triciklusos szulfonamid-származékok - ahol n jelentése 0 vagy egész szám, melynek értéke 1-2,X jelentése -O-, -NR2-, -CH2- vagy =CO csoport, R jelentésehidrogénatom vagy alifás, vagy adott esetben szubsztituált aromásszénhidrogén gyök, D jelentése 0 vagy egész szám, melynek értéke 1-3,L jelentése 0 vagy egész szám, melynek értéke 1-3, R1 jelentésehidrogénatom vagy egy természetes, vagy nem természetes aminosavoldallánca, Y jelentése OR3 , vagy NH-OR4 csoport, - és megfelelőizomerjeik, valamint gyógyászailag alkalmazható sóik, az ezeket avegyületeket tartalmazó gyógyszerkészítmények, továbbá eljárás az újvegyületek előállítására. A találmány szerinti vegyületek mátrixmetalloproteináz gátló hatásúak, így számos betegség gyógyításábanalkalmazhatók. Ó
HU0102714A 1998-07-30 1999-06-02 Tricyclic sulfonamid derivatives as inhibitors of matrix metalloproteinases and medicaments containing the same HUP0102714A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9500698P 1998-07-30 1998-07-30
PCT/US1999/012273 WO2000006561A1 (en) 1998-07-30 1999-06-02 Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases

Publications (2)

Publication Number Publication Date
HUP0102714A2 true HUP0102714A2 (hu) 2002-01-28
HUP0102714A3 HUP0102714A3 (en) 2003-01-28

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Family Applications (1)

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HU0102714A HUP0102714A3 (en) 1998-07-30 1999-06-02 Tricyclic sulfonamid derivatives as inhibitors of matrix metalloproteinases and medicaments containing the same

Country Status (32)

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US (2) US6420408B1 (hu)
EP (1) EP1100792B1 (hu)
JP (1) JP2002521478A (hu)
KR (1) KR20010072089A (hu)
CN (1) CN1310716A (hu)
AP (1) AP2001002037A0 (hu)
AT (1) ATE261954T1 (hu)
AU (1) AU758619B2 (hu)
BG (1) BG105185A (hu)
BR (1) BR9912600A (hu)
CA (1) CA2335077A1 (hu)
DE (1) DE69915634T2 (hu)
DK (1) DK1100792T3 (hu)
EA (1) EA200100158A1 (hu)
EE (1) EE200100063A (hu)
ES (1) ES2216614T3 (hu)
GE (1) GEP20033052B (hu)
HR (1) HRP20010078A2 (hu)
HU (1) HUP0102714A3 (hu)
ID (1) ID27192A (hu)
IL (1) IL140746A0 (hu)
IS (1) IS5810A (hu)
NO (1) NO20010479D0 (hu)
NZ (1) NZ509439A (hu)
OA (1) OA11589A (hu)
PL (1) PL345776A1 (hu)
PT (1) PT1100792E (hu)
SK (1) SK1192001A3 (hu)
TR (1) TR200100239T2 (hu)
WO (1) WO2000006561A1 (hu)
YU (1) YU6701A (hu)
ZA (1) ZA200100455B (hu)

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DE60232276D1 (de) * 2001-12-20 2009-06-18 Bristol Myers Squibb Co Alpha-(n-sulfonamid)acetamidderivate als beta-amyloidinhibitoren
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ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
ES2537514T3 (es) 2003-04-04 2015-06-09 Incyte Corporation Composiciones, métodos y kits relacionados con la escisión de HER-2
EP2330132B1 (en) 2003-04-04 2013-08-14 Yeda Research and Development Co. Ltd. Antibodies against MMP2 or MMP9 and pharmaceutical compositions containing same useful for inhibiting activity of said metalloproteins
WO2005061448A1 (en) * 2003-12-24 2005-07-07 Monash University Compositions and methods for treating vascular conditions
US20060112494A1 (en) * 2004-12-01 2006-06-01 David Oppong Method of protecting an animal skin product from metalloproteinase activity
CN101702906B (zh) * 2007-02-23 2014-02-12 耶达研究及发展有限公司 用于抑制金属蛋白活性的抗体和含有所述抗体的药物组合物
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MX2013003362A (es) 2010-09-24 2013-06-05 Ranbaxy Lab Ltd Inhibidores de metaloproteinasa de matriz.
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WO2021147882A1 (zh) * 2020-01-21 2021-07-29 深圳信立泰药业股份有限公司 一种二苯并呋喃类衍生物组织蛋白酶k抑制剂及其制备方法和医药用途

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NZ509439A (en) 2002-10-25
IL140746A0 (en) 2002-02-10
OA11589A (en) 2004-07-30
AU4329299A (en) 2000-02-21
US6420408B1 (en) 2002-07-16
ES2216614T3 (es) 2004-10-16
YU6701A (sh) 2003-12-31
HRP20010078A2 (en) 2002-02-28
US6492422B2 (en) 2002-12-10
EP1100792A1 (en) 2001-05-23
NO20010479L (no) 2001-01-29
US20020169164A1 (en) 2002-11-14
PT1100792E (pt) 2004-08-31
ATE261954T1 (de) 2004-04-15
EE200100063A (et) 2002-06-17
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WO2000006561A1 (en) 2000-02-10
DK1100792T3 (da) 2004-07-05
DE69915634T2 (de) 2004-08-12
PL345776A1 (en) 2002-01-02
CN1310716A (zh) 2001-08-29
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CA2335077A1 (en) 2000-02-10
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