HUP0100950A2 - Ciklusos aminovegyületek, alkalmazásuk gyógyászati készítmények előállítására és a vegyületeket tartalmazó gyógyászati készítmények - Google Patents
Ciklusos aminovegyületek, alkalmazásuk gyógyászati készítmények előállítására és a vegyületeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP0100950A2 HUP0100950A2 HU0100950A HUP0100950A HUP0100950A2 HU P0100950 A2 HUP0100950 A2 HU P0100950A2 HU 0100950 A HU0100950 A HU 0100950A HU P0100950 A HUP0100950 A HU P0100950A HU P0100950 A2 HUP0100950 A2 HU P0100950A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- general formula
- optionally substituted
- compounds
- alkyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 2
- 125000003277 amino group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 125000001424 substituent group Chemical class 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000005189 Embolism Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005117 dialkylcarbamoyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Cosmetics (AREA)
- Lubricants (AREA)
Abstract
A találmány az (I) általános képletű gyűrűs aminovegyületekre és ezekgyógyászatilag elfogadható sóira, továbbá ilyen vegyületekettartalmazó gyógyászati készítményekre, valamint a vegyületekelőállítására szolgáló eljárásra vonatkozik. Az (I) általánosképletben R1 jelentése halogénatommal vagy alkil-, fluoralkil-,alkoxi-, fluoralkoxi-, ciano- vagy nitrocsoporttal adott esetbenszubsztituált fenilcsoport; R2 jelentése halogénatommal vagy alkoxi-,vagy cianocsoporttal adott esetben szubsztituált alifás acilcsoport,halogénatommal vagy alkil- vagy alkoxicsoporttal adott esetbenszubsztituált benzoilcsoport, vagy pedig alkoxikarbonilcsoport; és R3jelentése szubsztituált, 3-7-tagú telített gyűrűs aminocsoport, amelyadott esetben kondenzált gyűrű része lehet, mimellett ez a gyűrűsaminocsoport szubsztituálva lehet -S-XR4 általános képletű csoporttal[ebben a csoportban R4 jelentése halogénatommal vagy alkil-, alkoxi-,nitro- vagy cianocsoporttal adott esetben szubsztituált fenilcsoport,adott esetben szubsztituált alkilcsoport[ennek szubsztituense akövetkező csoportok valamelyike lehet: aminocsoport, hidroxilcsoport,karboxilcsoport, alkoxikarbonilcsoport, -NH-A1 általános képletűcsoport (ebben a képletben A1 jelentése a-aminosavból leszármaztathatómaradék) vagy -CO-A2 általános képletű csoport (ebben a képletben A2jelentése a-aminosavból leszármaztatható maradék)] vagycikloalkilcsoport, és X jelentése kénatom, szulfinilcsoport vagyszulfonilcsoport], továbbá ez a gyűrűs aminocsoport adott esetbentovábbi szubsztituensként valamely =CR5R6 általános képletű csoporttallehet helyettesítve[ebben az általános képletben R5 és R6 egymástólfüggetlenül hidrogénatomot vagy alkil-, karboxi-, alkoxikarbonil-,karbamoil-, alkilkarbamoil- vagy dialkilkarbamoilcsoportot jelent]. Az(I) általános képletű vegyületek vérlemezke-aggregációt inhibitálóhatással rendelkeznek. A találmány szerinti gyógyászati készítményekalkalmasak embólia, trombózis vagy érelmeszedés kezelésére vagymegelőzésére. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4692198 | 1998-02-27 | ||
| PCT/JP1999/000924 WO1999043648A1 (en) | 1998-02-27 | 1999-02-26 | Cyclic amino compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0100950A2 true HUP0100950A2 (hu) | 2001-08-28 |
| HUP0100950A3 HUP0100950A3 (en) | 2002-12-28 |
| HU225741B1 HU225741B1 (en) | 2007-07-30 |
Family
ID=12760807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100950A HU225741B1 (en) | 1998-02-27 | 1999-02-26 | Cyclic amino compounds, use of them for producing pharmaceutical compositions and pharmaceutical compositions containing them |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6610708B1 (hu) |
| EP (1) | EP1063230B1 (hu) |
| KR (1) | KR100567950B1 (hu) |
| CN (1) | CN100369896C (hu) |
| AT (1) | ATE238279T1 (hu) |
| AU (1) | AU737303B2 (hu) |
| BR (1) | BRPI9908319B8 (hu) |
| CA (1) | CA2322171C (hu) |
| CZ (1) | CZ300821B6 (hu) |
| DE (1) | DE69907166T2 (hu) |
| DK (1) | DK1063230T3 (hu) |
| ES (1) | ES2196772T3 (hu) |
| HU (1) | HU225741B1 (hu) |
| ID (1) | ID25589A (hu) |
| IL (1) | IL138068A (hu) |
| MX (1) | MXPA00008439A (hu) |
| NO (1) | NO317882B1 (hu) |
| NZ (1) | NZ506574A (hu) |
| PL (1) | PL200666B1 (hu) |
| PT (1) | PT1063230E (hu) |
| RU (1) | RU2203887C2 (hu) |
| TR (1) | TR200002505T2 (hu) |
| WO (1) | WO1999043648A1 (hu) |
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| EP1773773A4 (en) * | 2004-06-24 | 2009-07-29 | Incyte Corp | AMID COMPOUNDS AND THEIR USE AS MEDICAMENTS |
| CA2609852A1 (en) * | 2005-05-27 | 2006-11-30 | Daiichi Sankyo Company, Limited | Cyclic amine derivative having substituted alkyl group |
| RU2312660C2 (ru) * | 2005-07-25 | 2007-12-20 | Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Федерального агентства по здравоохранению и социальному развитию (ГОУ ВПО ПГФА Росздрава) | 4-ацетил-3-гидрокси-1-(2-гидроксиэтиламиноэтил)-5-фенил-3-пирролин-2-он, проявляющий антикоагулянтную активность |
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| US11642335B2 (en) * | 2019-09-26 | 2023-05-09 | Board Of Regents, The University Of Texas System | Chemical synthesis of clopidogrel active metabolites and disulfide conjugate prodrugs |
| CN111484446A (zh) * | 2020-04-02 | 2020-08-04 | 北京翼方生物科技有限责任公司 | 氯吡格雷代谢活性体二硫衍生物、其制备方法及医药用途 |
| CN111848497A (zh) * | 2020-07-28 | 2020-10-30 | 内蒙古医科大学 | 氯吡格雷活性代谢物衍生物、其前药及其制备方法与应用 |
| CN112851570A (zh) * | 2021-01-13 | 2021-05-28 | 北京沃邦医药科技有限公司 | 不饱和环胺半胱氨酸二硫衍生物制备方法及其医药用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US555854A (en) * | 1896-03-03 | Brush-handle attachment | ||
| US3647796A (en) * | 1968-12-23 | 1972-03-07 | Parke Davis & Co | Cyclicamino alkylaminothioacridine |
| FR2215948B1 (hu) | 1973-02-01 | 1976-05-14 | Centre Etd Ind Pharma | |
| FR2495156A1 (fr) * | 1980-11-28 | 1982-06-04 | Sanofi Sa | Derives de la thieno-pyridinone, leur procede de preparation et leur application therapeutique |
| FR2530247B1 (fr) * | 1982-07-13 | 1986-05-16 | Sanofi Sa | Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique |
| FR2576901B1 (fr) * | 1985-01-31 | 1987-03-20 | Sanofi Sa | Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique |
| US4845121A (en) * | 1986-06-13 | 1989-07-04 | The Ohio State University Research Foundation | Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-dihydro benzopyan-2H-one class having antiaggregatory properties |
| JPH04334358A (ja) * | 1991-05-02 | 1992-11-20 | Ono Pharmaceut Co Ltd | 縮合ベンゼンオキシ酢酸誘導体 |
| FI101150B (fi) | 1991-09-09 | 1998-04-30 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi |
| WO1993014077A1 (en) * | 1992-01-21 | 1993-07-22 | Glaxo Group Limited | Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation |
| WO1994022440A1 (en) * | 1993-03-29 | 1994-10-13 | Smithkline Beecham Corporation | Bicyclic compounds which inhibit platelet aggregation |
| ES2134284T3 (es) | 1993-04-23 | 1999-10-01 | Hoechst Ag | Pirido-pirimidindionas, procedimiento para su preparacion y su empleo como medicamentos. |
| JPH09504274A (ja) * | 1993-09-17 | 1997-04-28 | ブリガム アンド ウィメンズ ホスピタル | 人工表面および血管面の血栓を予防する酸化窒素付加物の利用 |
| NZ334389A (en) * | 1996-08-28 | 2001-05-25 | Ube Industries | Cyclic amine derivatives |
-
1999
- 1999-02-26 IL IL13806899A patent/IL138068A/xx not_active IP Right Cessation
- 1999-02-26 WO PCT/JP1999/000924 patent/WO1999043648A1/ja not_active Ceased
- 1999-02-26 HU HU0100950A patent/HU225741B1/hu unknown
- 1999-02-26 DK DK99906508T patent/DK1063230T3/da active
- 1999-02-26 NZ NZ506574A patent/NZ506574A/xx not_active IP Right Cessation
- 1999-02-26 CA CA002322171A patent/CA2322171C/en not_active Expired - Lifetime
- 1999-02-26 ID IDW20001635A patent/ID25589A/id unknown
- 1999-02-26 TR TR2000/02505T patent/TR200002505T2/xx unknown
- 1999-02-26 EP EP99906508A patent/EP1063230B1/en not_active Expired - Lifetime
- 1999-02-26 BR BRPI9908319-1 patent/BRPI9908319B8/pt not_active IP Right Cessation
- 1999-02-26 KR KR1020007009485A patent/KR100567950B1/ko not_active Expired - Lifetime
- 1999-02-26 DE DE69907166T patent/DE69907166T2/de not_active Expired - Lifetime
- 1999-02-26 ES ES99906508T patent/ES2196772T3/es not_active Expired - Lifetime
- 1999-02-26 PL PL342573A patent/PL200666B1/pl unknown
- 1999-02-26 AU AU26413/99A patent/AU737303B2/en not_active Expired
- 1999-02-26 AT AT99906508T patent/ATE238279T1/de active
- 1999-02-26 CZ CZ20003119A patent/CZ300821B6/cs not_active IP Right Cessation
- 1999-02-26 CN CNB998055786A patent/CN100369896C/zh not_active Expired - Lifetime
- 1999-02-26 RU RU2000122434/04A patent/RU2203887C2/ru active
- 1999-02-26 MX MXPA00008439A patent/MXPA00008439A/es active IP Right Grant
- 1999-02-26 PT PT99906508T patent/PT1063230E/pt unknown
-
2000
- 2000-08-24 US US09/622,849 patent/US6610708B1/en not_active Expired - Lifetime
- 2000-08-25 NO NO20004279A patent/NO317882B1/no not_active IP Right Cessation
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