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HUP0100431A2 - Adamantánszármazékok, ezeket tartalmazó gyógyászati készítmények és előállításuk - Google Patents

Adamantánszármazékok, ezeket tartalmazó gyógyászati készítmények és előállításuk

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Publication number
HUP0100431A2
HUP0100431A2 HU0100431A HUP0100431A HUP0100431A2 HU P0100431 A2 HUP0100431 A2 HU P0100431A2 HU 0100431 A HU0100431 A HU 0100431A HU P0100431 A HUP0100431 A HU P0100431A HU P0100431 A2 HUP0100431 A2 HU P0100431A2
Authority
HU
Hungary
Prior art keywords
group
phenyl
ortho
amino
different
Prior art date
Application number
HU0100431A
Other languages
English (en)
Inventor
Andrew Baxter
Stephen Brough
David Cladingboel
Thomas Mcinally
Michael Mortimore
Original Assignee
Astrazeneca Uk Limited
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Publication date
Application filed by Astrazeneca Uk Limited filed Critical Astrazeneca Uk Limited
Publication of HUP0100431A2 publication Critical patent/HUP0100431A2/hu
Publication of HUP0100431A3 publication Critical patent/HUP0100431A3/hu

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    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/08—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
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    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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    • C07C233/26—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

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  • Chemical & Material Sciences (AREA)
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  • Transplantation (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)

Abstract

A találmány adamantánszármazékokra, azok előállítási eljárására, azazokat tartalmazó gyógyászati készítményekre, a gyógyászatikészítmények előállítására, végül a készítmények gyógyászatban valófelhasználására vonatkozik. A vegyületek P2X7 receptor antgonistahatásuk révén többek között gyulladásellenes hatásúak. A találmányszerinti vegyületek az (I) általános képletnek felelnek meg - aképletben A -CH2- csoportot vagy oxigénatomot jelent, B hidrogénatomotvagy halogénatomot jelent, D -CH2-, -OCH2-, -NHCH2- vagy -CH2CH2-csoportot jelent, és R fenil-, benzotiazolil-, indolil-, indazolil-,purinil-, piridil-, pirimidinil- vagy tiofenil-csoportot jelent,amelyekhez adott esetben egy vagy több azonos vagy eltérőszubsztituens kapcsolódhat, azzal a feltétellel, hogy (i) ha A -CH2-csoportot és ugyanakkor B hidrogénatomot és D -CH2- csoportot jelent,akkor R jelentése csak fenil-, orto-karboxi-fenil-, orto-nitro-fenil-,orto-amino-fenil-, orto-(dimetil-amino-etil)- fenil-, metil-fenil-vagy para-fenoxi-fenil-csoporttól eltérő lehet, (ii) ha A -CH2-csoportot és ugyanakkor B brómatomot és D -CH2- csoportot jelent,akkor R jelentése csak orto-karboxi-fenil-csoporttól eltérő lehet,(iii) ha A -CH2- csoportot és ugyanakkor B hidrogénatomot és D -CH2CH2- csoportot jelent, akkor R jelentése csak fenilcsoporttóleltérő lehet, és (iv) ha A -CH2- csoportot és ugyanakkor D -CH2- vagy-CH2- -CH2- csoportot és R szubsztituált fenilcsoportot jelent, akkora fenilcsoport az orto-helyzetben csak amino-, di-(1-6 szénatomosalkil)-amino-, imidazolil-, morfolinil-, piperidinil- vagypirrolidinilcsoporttal szubsztituált 1-6 szénatomos alkoxicsoporttóleltérő szubsztituenst hordozhat. Ó
HU0100431A 1997-12-05 1998-12-01 Adamantana derivatives, pharmaceutical compositions comprising them and process for preparing them HUP0100431A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704545A SE9704545D0 (sv) 1997-12-05 1997-12-05 Novel compounds
PCT/SE1998/002189 WO1999029660A1 (en) 1997-12-05 1998-12-01 Adamantane derivatives

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HUP0100431A2 true HUP0100431A2 (hu) 2001-07-30
HUP0100431A3 HUP0100431A3 (en) 2002-12-28

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US (1) US6242470B1 (hu)
EP (1) EP1036058B1 (hu)
JP (1) JP2001525391A (hu)
KR (1) KR20010032708A (hu)
CN (1) CN1280560A (hu)
AT (1) ATE234274T1 (hu)
AU (1) AU746716B2 (hu)
BR (1) BR9813368A (hu)
CA (1) CA2312889A1 (hu)
DE (1) DE69812159T2 (hu)
DK (1) DK1036058T3 (hu)
EE (1) EE200000320A (hu)
ES (1) ES2195433T3 (hu)
HU (1) HUP0100431A3 (hu)
IL (1) IL136503A0 (hu)
NO (1) NO20002785L (hu)
NZ (1) NZ504375A (hu)
PL (1) PL340890A1 (hu)
PT (1) PT1036058E (hu)
RU (1) RU2197477C2 (hu)
SE (1) SE9704545D0 (hu)
SK (1) SK8412000A3 (hu)
TR (1) TR200001558T2 (hu)
WO (1) WO1999029660A1 (hu)

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Publication number Priority date Publication date Assignee Title
WO2000061569A1 (en) * 1999-04-09 2000-10-19 Astrazeneca Ab Adamantane derivatives
SE9904505D0 (sv) 1999-12-09 1999-12-09 Astra Pharma Prod Novel compounds
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