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HUP0002777A1 - Kondenzált tiazolo-benzo-heterociklusos származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Kondenzált tiazolo-benzo-heterociklusos származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0002777A1
HUP0002777A1 HU0002777A HUP0002777A HUP0002777A1 HU P0002777 A1 HUP0002777 A1 HU P0002777A1 HU 0002777 A HU0002777 A HU 0002777A HU P0002777 A HUP0002777 A HU P0002777A HU P0002777 A1 HUP0002777 A1 HU P0002777A1
Authority
HU
Hungary
Prior art keywords
alk
thiazolobenzoheterocyclic
fused
derivatives
preparation
Prior art date
Application number
HU0002777A
Other languages
English (en)
Inventor
Jean Bouquerel
Jean-Claude Hardy
Patrick Nemecek
Jean-Francois Peyronel
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of HUP0002777A1 publication Critical patent/HUP0002777A1/hu
Publication of HUP0002777A3 publication Critical patent/HUP0002777A3/hu
Publication of HU226210B1 publication Critical patent/HU226210B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D517/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms
    • C07D517/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms in which the condensed system contains two hetero rings
    • C07D517/06—Peri-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány tárgyát az, (I) általános képletű vegyületek - ahol R1kén- vagy szelénatom; R2 hidrogénatom vagy alkilcsoport; -R3-R4-R5-R6-= -CH2-CH2-CH2-CH2-, -CH2-CH2-CH2-CO-, -CH2-CH2-CH2-CH(R8)-,-H2-CH2-CH2-Se-, -CH2-CH2-Se-CH2-, -CH2-CH2-CH2-S-, -CH2-CH2-CH2-SO-, -CH2-CH2-CH2-SO2, -CH2-CH2-CH2-O-,-CH2-CH2-CH2-N(R9) , -CH2-CH2-CO-CH2-, -CH2-CH2-CH(R8)-CH2-,-CH2-CH2-S-CH2-, -CH2-CH2-SO-CH2-, -CH2-CH2-SO2-CH2-, -CH2-C (alk) (alk') -S-CH2-, -CH2-C (alk) (alk') -SO-CH2-, -CH2-C (alk) (alk') -SO2-CH2-, -CH2-CH (R10) -S-CH2-, -CH2-CH (R10) -SO-CH2-, -CH2-CH (R10) -SO2-CH2-, -CH2-CH2-O-CH2-, -CH2-CH2-N (R9) -CH2-vagy -CH2-CO-N (R9) -CH2- képletű csoport; R7 polifluor-alkil- vagypolifluor-alkoxi-csoport; R8 hidroxilcsoport; R9 hidrogénatom, alkil-vagy benzilcsoport; R10 alkil-, -CH2-OH, -COOalk, karboxil- vagykarbamoilcsoport; alk és alk' alkilcsoport - és izomerjeik,racemátjaik, enantiomerjeik, sóik, az előállításukra szolgáló eljárásés ezeket tartalmazó gyógyszerkészítmények képezik. A vegyületekgörcsoldó hatásúak, és a glutamaterg transzmissziót gátolják. Ó
HU0002777A 1997-07-28 1998-07-24 Fused thiazolobenzoheterocyclic derivatives, process for their preparation and pharmaceutical compositions containing same HU226210B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9709556A FR2766487B1 (fr) 1997-07-28 1997-07-28 Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant
PCT/FR1998/001638 WO1999005147A1 (fr) 1997-07-28 1998-07-24 Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant

Publications (3)

Publication Number Publication Date
HUP0002777A1 true HUP0002777A1 (hu) 2001-07-30
HUP0002777A3 HUP0002777A3 (en) 2002-12-28
HU226210B1 HU226210B1 (en) 2008-06-30

Family

ID=9509694

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002777A HU226210B1 (en) 1997-07-28 1998-07-24 Fused thiazolobenzoheterocyclic derivatives, process for their preparation and pharmaceutical compositions containing same

Country Status (25)

Country Link
US (1) US6369221B1 (hu)
EP (1) EP1000067B1 (hu)
JP (1) JP4491131B2 (hu)
KR (1) KR100621703B1 (hu)
CN (1) CN1122670C (hu)
AT (1) ATE226585T1 (hu)
AU (1) AU746193B2 (hu)
BR (1) BR9811056A (hu)
CA (1) CA2298974C (hu)
CZ (2) CZ2000194A3 (hu)
DE (1) DE69808922T2 (hu)
DK (1) DK1000067T3 (hu)
ES (1) ES2187997T3 (hu)
FR (1) FR2766487B1 (hu)
HU (1) HU226210B1 (hu)
IL (4) IL158356A0 (hu)
NO (1) NO314630B1 (hu)
NZ (1) NZ502054A (hu)
PL (1) PL195758B1 (hu)
PT (1) PT1000067E (hu)
RU (1) RU2198889C2 (hu)
SK (1) SK285767B6 (hu)
TW (1) TW570923B (hu)
WO (1) WO1999005147A1 (hu)
ZA (1) ZA986680B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0307067D0 (en) 2002-12-17 2003-04-30 Aventis Pharma Inc Use of thiazolobenzoheterocycles for treating multiple sclerosis
US7179909B2 (en) 2003-12-12 2007-02-20 Aventis Pharma S.A. Process for the manufacture of a product of the thiazolo [3,4,5-de] [4,1]benzothiazepine type
FR2863612B1 (fr) * 2003-12-12 2006-03-03 Aventis Pharma Sa PROCEDE DE FABRICATION DE PRODUIT DE TYPE THIAZOLO[3,4,5-de] [4,1]BENZOTHIAZEPINE
FR2867187B1 (fr) * 2004-03-02 2007-10-12 Centre Nat Rech Scient Procede utile pour la preparation de benzazepines et derives de celles-ci.
DK3025584T3 (en) * 2013-07-22 2018-05-07 Sumitomo Chemical Co COMPOSITION FOR PLANT DISEASES AND APPLICATIONS
PL3025586T3 (pl) * 2013-07-22 2019-09-30 Sumitomo Chemical Company Limited Kompozycja do zwalczania chorób roślin i jej zastosowanie
CN105555139A (zh) 2013-07-22 2016-05-04 住友化学株式会社 植物病害防治组合物及其用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1173701A (en) * 1967-03-24 1969-12-10 Smith Kline French Lab 5-Substituted-1,4-Benzodiazepines
US3794646A (en) * 1970-04-14 1974-02-26 Robins Co Inc A H 5,7-disubstituted-1,9-tetramethylene-1,4-benzodiazepin-2-ones
US3857854A (en) * 1971-09-08 1974-12-31 Upjohn Co 6-phenyl-1h,4h-{8 1,2,4{9 oxadiazalo{8 4,3-2{9 {8 1,4{9 benzodiazepin-1-ones
US3850948A (en) * 1973-07-27 1974-11-26 Hoffmann La Roche Certain 3a,4-dihydro-8-chloro-6-phenyl-thiazolo(3,2-h)-1,4-benzodiazepin-1(2h)-ones
US3962440A (en) * 1973-12-26 1976-06-08 Eli Lilly And Company Quinoxaline compounds as hypnotic agents
US4218448A (en) * 1976-06-24 1980-08-19 E. I. Du Pont De Nemours And Company Antihypertensive polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils
US4107303A (en) * 1976-06-24 1978-08-15 E. I. Du Pont De Nemours And Company Antihypertensive hexafluorohydroxyisopropyl benzazepines and benzazocines
DE3990664T1 (de) * 1988-06-20 1991-04-25 Squibb & Sons Inc Benzazepin- und benzothiazepin-derivate
DK160941C (da) * 1988-06-28 1991-10-21 Novo Nordisk As Kondenserede 2,3-dihydroxypyraziner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar
US5248679A (en) * 1988-09-09 1993-09-28 Fujisawa Pharmaceutical Co., Ltd. Tricyclic compounds
FR2649701B2 (fr) * 1988-12-15 1991-11-22 Rhone Poulenc Sante Derives d'imino-2 benzothiazoline, leurs procedes de preparation et les medicaments les contenant
HU210264B (en) * 1989-06-09 1995-03-28 Upjohn Co Process for producing amines of condensed ring-systems containing nitrogen and pharmaceutical compositions containing them
EP0705835A1 (de) * 1994-09-01 1996-04-10 Ciba-Geigy Ag Oxa- oder thiaaliphatisch überbrückte Chinoxalin-2,3-dione

Also Published As

Publication number Publication date
TW570923B (en) 2004-01-11
CN1122670C (zh) 2003-10-01
AU746193B2 (en) 2002-04-18
EP1000067B1 (fr) 2002-10-23
NO314630B1 (no) 2003-04-22
CZ2000194A3 (cs) 2000-05-17
DK1000067T3 (da) 2003-02-24
ZA986680B (en) 1999-01-27
US6369221B1 (en) 2002-04-09
ES2187997T3 (es) 2003-06-16
EP1000067A1 (fr) 2000-05-17
JP4491131B2 (ja) 2010-06-30
KR100621703B1 (ko) 2006-09-13
IL158356A (en) 2006-04-10
HU226210B1 (en) 2008-06-30
CZ2000294A3 (cs) 2000-05-17
CN1265109A (zh) 2000-08-30
PT1000067E (pt) 2003-03-31
FR2766487A1 (fr) 1999-01-29
NO20000423L (no) 2000-03-22
JP2002520253A (ja) 2002-07-09
NZ502054A (en) 2002-05-31
PL195758B1 (pl) 2007-10-31
WO1999005147A1 (fr) 1999-02-04
CA2298974A1 (fr) 1999-02-04
SK1142000A3 (en) 2000-08-14
BR9811056A (pt) 2000-09-05
ATE226585T1 (de) 2002-11-15
HUP0002777A3 (en) 2002-12-28
PL338348A1 (en) 2000-10-23
RU2198889C2 (ru) 2003-02-20
KR20010022300A (ko) 2001-03-15
IL134192A0 (en) 2001-04-30
IL158356A0 (en) 2004-05-12
IL134192A (en) 2007-06-17
DE69808922D1 (de) 2002-11-28
FR2766487B1 (fr) 1999-08-27
NO20000423D0 (no) 2000-01-27
CA2298974C (fr) 2008-04-01
SK285767B6 (sk) 2007-07-06
AU8867698A (en) 1999-02-16
CZ289468B6 (cs) 2002-01-16
DE69808922T2 (de) 2003-08-14

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Legal Events

Date Code Title Description
FH91 Appointment of a representative

Free format text: FORMER REPRESENTATIVE(S): BELICZAY LASZLO, S.B.G. & K. BUDAPESTI NEMZETKOEZI SZABADALMI IRODA, HU

Representative=s name: RATHONYI ZOLTAN, S.B.G. & K. SZABADALMI UEGYVI, HU

FH92 Termination of representative

Representative=s name: BELICZAY LASZLO, S.B.G. & K. BUDAPESTI NEMZETK, HU

FH91 Appointment of a representative

Free format text: FORMER REPRESENTATIVE(S): RATHONYI ZOLTAN, S.B.G. & K. SZABADALMI UEGYVIVOEI IRODA, HU

Representative=s name: DANUBIA SZABADALMI ES JOGI IRODA KFT., HU

FH92 Termination of representative

Representative=s name: RATHONYI ZOLTAN, S.B.G. & K. SZABADALMI UEGYVI, HU

MM4A Lapse of definitive patent protection due to non-payment of fees