HUP0001395A3 - Novel screening methods to identify agents that selectively inhibit hepatitis c virus replication - Google Patents
Novel screening methods to identify agents that selectively inhibit hepatitis c virus replicationInfo
- Publication number
- HUP0001395A3 HUP0001395A3 HU0001395A HUP0001395A HUP0001395A3 HU P0001395 A3 HUP0001395 A3 HU P0001395A3 HU 0001395 A HU0001395 A HU 0001395A HU P0001395 A HUP0001395 A HU P0001395A HU P0001395 A3 HUP0001395 A3 HU P0001395A3
- Authority
- HU
- Hungary
- Prior art keywords
- screening methods
- virus replication
- selectively inhibit
- identify agents
- novel screening
- Prior art date
Links
- 241000711549 Hepacivirus C Species 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3859697P | 1997-03-05 | 1997-03-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0001395A1 HUP0001395A1 (en) | 2000-07-28 |
| HUP0001395A3 true HUP0001395A3 (en) | 2001-09-28 |
Family
ID=21900807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0001395A HUP0001395A3 (en) | 1997-03-05 | 1998-03-05 | Novel screening methods to identify agents that selectively inhibit hepatitis c virus replication |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US6030785A (hu) |
| EP (1) | EP0975809A4 (hu) |
| JP (1) | JP2001514508A (hu) |
| KR (1) | KR20000075983A (hu) |
| CN (1) | CN1268980A (hu) |
| AU (1) | AU726374B2 (hu) |
| CA (1) | CA2283379A1 (hu) |
| HU (1) | HUP0001395A3 (hu) |
| IL (1) | IL131730A (hu) |
| NO (1) | NO994295L (hu) |
| NZ (1) | NZ337703A (hu) |
| PL (1) | PL335721A1 (hu) |
| TR (1) | TR199902561T2 (hu) |
| WO (1) | WO1998039487A1 (hu) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9712900A (pt) | 1996-11-06 | 2000-11-28 | Univ California | Enzima liberadora de receptor de fator de necrose de tumor isolado, composições que compreendem a enzima e métodos de utilização da mesma |
| US6593456B1 (en) * | 1996-11-06 | 2003-07-15 | The Regents Of The University Of California | Tumor necrosis factor receptor releasing enzyme |
| US20050191661A1 (en) * | 1996-11-06 | 2005-09-01 | Tetsuya Gatanaga | Treatment of inflammatory disease by cleaving TNF receptors |
| PL335721A1 (en) * | 1997-03-05 | 2000-05-08 | Ribogene | Novel methods of screening serving the purpose of identifying the factors of selective hepatitis c virus replication inhibition |
| CA2334895C (en) | 1998-06-12 | 2016-01-19 | Mount Sinai School Of Medicine | Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals |
| WO2001053355A1 (en) * | 2000-01-24 | 2001-07-26 | The Trustees Of Columbia University In The City Of New York | An in vivo screen using chemical inducers of dimerization |
| AU2001257001A1 (en) * | 2000-04-10 | 2001-10-23 | Mount Sinai School Of Medicine Of New York University | Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| US20020061579A1 (en) * | 2000-08-09 | 2002-05-23 | Farrand Stephen K. | Counter selection strategy for Gram-negative bacteria |
| WO2002022880A1 (en) * | 2000-09-13 | 2002-03-21 | University Of Chicago | Compositions and methods for the identification of viral inhibitors of host cell protein synthesis shut-off |
| US20020168737A1 (en) * | 2001-01-24 | 2002-11-14 | Cornish Virginia W. | Binding and catalysis screen for high throughput determination of protein function using chemical inducers of dimerization |
| EP1360276A4 (en) * | 2001-01-31 | 2004-12-15 | Bristol Myers Squibb Pharma Co | IN VITRO SYSTEM FOR REPLICATION OF RNA-DEPENDENT RNA POLYMERASE VIRUSES |
| US7326536B2 (en) * | 2001-05-03 | 2008-02-05 | Eli Lilly And Company | Agents for treatment of HCV and methods of use |
| WO2003025209A1 (en) * | 2001-09-21 | 2003-03-27 | Ortho-Clinical Diagnostics, Inc. | Use of hcv core antigen assay for screening of anti-viral compounds |
| US7138376B2 (en) * | 2001-09-28 | 2006-11-21 | Idenix Pharmaceuticals, Inc. | Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides |
| KR100447578B1 (ko) * | 2001-11-01 | 2004-09-07 | 주식회사 이매진 | Hcv 자가 복제 효소 활성의 세포내 측정용 키트 및측정 방법 |
| HUE047557T2 (hu) | 2002-01-18 | 2020-04-28 | Biogen Ma Inc | Polialkilén polimervegyületek és felhasználásuk |
| US7083918B2 (en) * | 2002-04-24 | 2006-08-01 | The Trustees Of Columbia University In The City Of New York | Bacterial small-molecule three-hybrid system |
| US20040180438A1 (en) * | 2002-04-26 | 2004-09-16 | Pachuk Catherine J. | Methods and compositions for silencing genes without inducing toxicity |
| AU2003241335A1 (en) * | 2002-05-09 | 2003-11-11 | The Regents Of The University Of California | Method of analyzing ataxia-telangiectasia protein |
| US6690975B2 (en) * | 2002-05-17 | 2004-02-10 | Bistner Co., Ltd. | Methods for treating hepatitis C |
| AU2003237889A1 (en) * | 2002-06-11 | 2003-12-22 | Idaho Research Foundation | Type i interferon-inducible proteins to detect viral infection |
| EP1539786A4 (en) * | 2002-07-10 | 2006-09-06 | Stratagene California | HUMANIZED, GREEN FLUORESCENT RENILLA RENIFORMIS PROTEIN AS FRUIT |
| US20050069522A1 (en) * | 2002-08-12 | 2005-03-31 | Richard Colonno | Combination pharmaceutical agents as inhibitors of HCV replication |
| JP2007501185A (ja) | 2003-07-25 | 2007-01-25 | イデニクス(ケイマン)リミテツド | C型肝炎を含むフラビウイルス関連疾患を治療するためのプリンヌクレオシド類似体 |
| DE602005002673T2 (de) * | 2004-04-29 | 2008-07-24 | F. Hoffmann-La Roche Ag | Nukleotidsequenzvariation im Gen NS5A als Marker |
| DK2497492T3 (en) * | 2004-06-01 | 2018-11-26 | Icahn School Med Mount Sinai | Genetically modified swine influenza virus and its applications |
| US7781478B2 (en) * | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US8013006B2 (en) * | 2004-07-14 | 2011-09-06 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7772271B2 (en) * | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7868037B2 (en) * | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| JP2008507518A (ja) * | 2004-07-22 | 2008-03-13 | ピーティーシー セラピューティクス,インコーポレーテッド | C型肝炎を治療するためのチエノピリジン |
| ATE474587T1 (de) * | 2004-09-29 | 2010-08-15 | Univ Tulane | Inhibitoren des hepatitis-c-virus |
| WO2006121468A1 (en) * | 2004-11-22 | 2006-11-16 | Genelabs Technologies, Inc. | 5-nitro-nucleoside compounds for treating viral infections |
| WO2006088481A2 (en) * | 2005-02-15 | 2006-08-24 | Mount Sinai School Of Medicine Of New York University | Genetically engineered equine influenza virus and uses thereof |
| CA2597683A1 (en) * | 2005-02-28 | 2006-09-08 | Genelabs Technologies, Inc. | Tricyclic-nucleoside prodrugs for treating viral infections |
| US7405204B2 (en) * | 2005-04-25 | 2008-07-29 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
| KR20080040677A (ko) * | 2005-06-24 | 2008-05-08 | 제네랩스 테크놀로지스, 인코포레이티드 | 바이러스를 치료하기 위한 헤테로아릴 유도체 |
| WO2007058384A1 (en) * | 2005-11-17 | 2007-05-24 | Osaka University | Method of suppressing replication of hepatitis c virus, inhibitor of replication of the virus and method of screening for the same |
| EP3431602A1 (en) * | 2006-04-03 | 2019-01-23 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| AU2007234191B2 (en) * | 2006-04-03 | 2012-07-12 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-miRNA antisense oligonucleotides |
| WO2008002165A2 (en) * | 2006-06-30 | 2008-01-03 | Krzysztof Kucharczyk | A method, assay and kit for prediction and treatment of a human subject infected with a virus |
| AR062827A1 (es) * | 2006-07-20 | 2008-12-10 | Genelabs Tech Inc | Inhibidores virales policiclicos, una composicion farmaceutica que los comprende y su uso en la preparacion de medicamentos para el tratamiento de una infeccion viral mediada porl el virus de la hepatitis c |
| KR100783287B1 (ko) * | 2006-08-09 | 2007-12-06 | 한국생명공학연구원 | 텔로미어 전사 비활성화에 관여하는 화합물의 동정을 위한균주의 제조 |
| WO2008043753A2 (en) * | 2006-10-09 | 2008-04-17 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of pcsk9 |
| US8470791B2 (en) * | 2007-03-22 | 2013-06-25 | Santaris Pharma A/S | RNA antagonist compounds for the inhibition of Apo-B100 expression |
| US8580756B2 (en) * | 2007-03-22 | 2013-11-12 | Santaris Pharma A/S | Short oligomer antagonist compounds for the modulation of target mRNA |
| US20110054011A1 (en) * | 2007-08-30 | 2011-03-03 | Mccullagh Keith | RNA Antagonist Compounds for the Modulation of FABP4/AP2 |
| WO2009029729A1 (en) * | 2007-08-31 | 2009-03-05 | Genelabs Technologies, Inc. | Amino tricyclic-nucleoside compounds, compositions, and methods of use |
| US20090162858A1 (en) * | 2007-09-18 | 2009-06-25 | Cornish Virginia W | Orthogonal chemical inducer of dimerization |
| CN101821391B (zh) * | 2007-10-04 | 2016-04-27 | 桑塔里斯制药公司 | 微小聚体 |
| WO2009109665A1 (en) * | 2008-03-07 | 2009-09-11 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microrna related diseases |
| CN101314614B (zh) * | 2008-06-16 | 2011-03-23 | 南开大学 | 与pkr激酶结构域特异性结合的多肽及其应用 |
| EP2315832B1 (en) | 2008-08-01 | 2015-04-08 | Roche Innovation Center Copenhagen A/S | Micro-rna mediated modulation of colony stimulating factors |
| JP5773535B2 (ja) * | 2009-04-24 | 2015-09-02 | ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブRoche Innovation Center Copenhagen A/S | インターフェロンに非応答性のhcv患者の治療のための医薬組成物 |
| EP2456870A1 (en) | 2009-07-21 | 2012-05-30 | Santaris Pharma A/S | Antisense oligomers targeting pcsk9 |
| AR082453A1 (es) | 2010-04-21 | 2012-12-12 | Novartis Ag | Compuestos de furopiridina, composiciones farmaceuticas que los contienen y usos de los mismos |
| EA201300160A1 (ru) | 2010-07-22 | 2013-06-28 | Новартис Аг | 2,3,5-тризамещенные тиофены и их применение |
| EP2658857B1 (en) | 2010-12-29 | 2016-11-02 | Inhibitex, Inc. | Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections |
| WO2013103829A1 (en) * | 2012-01-05 | 2013-07-11 | Viracine Therapeutics Corporation | Compositions and methods for screening antiviral agents |
| US9879265B2 (en) | 2013-06-27 | 2018-01-30 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugates |
| AU2016222962B2 (en) | 2015-02-26 | 2020-05-21 | Boehringer Ingelheim Vetmedica Gmbh | Bivalent swine influenza virus vaccine |
| WO2016196324A1 (en) | 2015-05-29 | 2016-12-08 | University Of Floridia Research Foundation, Inc. | Methods for diagnosing huntington's disease |
| WO2017176813A1 (en) | 2016-04-04 | 2017-10-12 | University Of Florida Research Foundation, Incorporated | Manipulation of eif3 to modulate repeat associated non-atg (ran) translation |
| EP3612190A4 (en) * | 2017-04-17 | 2021-01-20 | University of Florida Research Foundation, Incorporated | REGULATION OF RAN TRANSLATION THROUGH PKR AND EIF2A-P WAYS |
| AU2020348916A1 (en) | 2019-09-20 | 2022-04-07 | University Of Florida Research Foundation, Incorporated | Detection of antibodies against RAN proteins from serum and tissue lysates |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5679342A (en) * | 1987-11-18 | 1997-10-21 | Chiron Corporation | Hepatitis C virus infected cell systems |
| WO1994023041A2 (en) * | 1993-04-02 | 1994-10-13 | Ribogene, Inc. | Method for selective inactivation of viral replication |
| PL335721A1 (en) | 1997-03-05 | 2000-05-08 | Ribogene | Novel methods of screening serving the purpose of identifying the factors of selective hepatitis c virus replication inhibition |
-
1998
- 1998-03-05 PL PL98335721A patent/PL335721A1/xx unknown
- 1998-03-05 IL IL13173098A patent/IL131730A/en not_active IP Right Cessation
- 1998-03-05 AU AU66840/98A patent/AU726374B2/en not_active Ceased
- 1998-03-05 JP JP53875498A patent/JP2001514508A/ja not_active Ceased
- 1998-03-05 CN CN98804841A patent/CN1268980A/zh active Pending
- 1998-03-05 WO PCT/US1998/004226 patent/WO1998039487A1/en not_active Ceased
- 1998-03-05 EP EP98908928A patent/EP0975809A4/en not_active Withdrawn
- 1998-03-05 NZ NZ337703A patent/NZ337703A/en unknown
- 1998-03-05 TR TR1999/02561T patent/TR199902561T2/xx unknown
- 1998-03-05 US US09/035,619 patent/US6030785A/en not_active Expired - Lifetime
- 1998-03-05 KR KR1019997008068A patent/KR20000075983A/ko not_active Ceased
- 1998-03-05 CA CA002283379A patent/CA2283379A1/en not_active Abandoned
- 1998-03-05 HU HU0001395A patent/HUP0001395A3/hu unknown
-
1999
- 1999-09-03 NO NO994295A patent/NO994295L/no not_active Application Discontinuation
-
2000
- 2000-02-25 US US09/514,006 patent/US6326151B1/en not_active Expired - Fee Related
-
2001
- 2001-10-05 US US09/972,756 patent/US7148006B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL335721A1 (en) | 2000-05-08 |
| US6030785A (en) | 2000-02-29 |
| NO994295L (no) | 1999-11-02 |
| NO994295D0 (no) | 1999-09-03 |
| EP0975809A4 (en) | 2002-10-30 |
| IL131730A0 (en) | 2001-03-19 |
| CN1268980A (zh) | 2000-10-04 |
| NZ337703A (en) | 2001-05-25 |
| IL131730A (en) | 2004-06-20 |
| AU726374B2 (en) | 2000-11-02 |
| CA2283379A1 (en) | 1998-09-11 |
| KR20000075983A (ko) | 2000-12-26 |
| TR199902561T2 (xx) | 2000-02-21 |
| HUP0001395A1 (en) | 2000-07-28 |
| US6326151B1 (en) | 2001-12-04 |
| US7148006B2 (en) | 2006-12-12 |
| US20020155431A1 (en) | 2002-10-24 |
| WO1998039487A1 (en) | 1998-09-11 |
| EP0975809A1 (en) | 2000-02-02 |
| AU6684098A (en) | 1998-09-22 |
| JP2001514508A (ja) | 2001-09-11 |
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