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HUP0001118A2 - N-szubsztituált pirrolidinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

N-szubsztituált pirrolidinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP0001118A2
HUP0001118A2 HU0001118A HUP0001118A HUP0001118A2 HU P0001118 A2 HUP0001118 A2 HU P0001118A2 HU 0001118 A HU0001118 A HU 0001118A HU P0001118 A HUP0001118 A HU P0001118A HU P0001118 A2 HUP0001118 A2 HU P0001118A2
Authority
HU
Hungary
Prior art keywords
pyrrolidine derivatives
substituted pyrrolidine
preparing
same
pharmaceutical compositions
Prior art date
Application number
HU0001118A
Other languages
English (en)
Inventor
Naoki Ando
Masato Hoshino
Fumiyoshi Kobayashi
Hiroyuki Miyachi
Original Assignee
Kyorin Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co., Ltd. filed Critical Kyorin Pharmaceutical Co., Ltd.
Publication of HUP0001118A2 publication Critical patent/HUP0001118A2/hu
Publication of HUP0001118A3 publication Critical patent/HUP0001118A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

A találmány új, (1) általános képletű N-szubsztituáltpirrolidinszármazékokra - a képletben R jelentése hidrogén-, vagyhalogénatom vagy rövid szénláncú alkoxicsoport -, valamint ezekelőállítására, illetve ilyen vegyületeket tartalmazó gyógyászatikészítményekre vonatkozik. A találmány szerinti vegyületek nagymértékben szelektív és hatékony antagonista hatást fejtenek ki asimaizomzat muszkarinreceptorjai vonatkozásában, ezért felhaználhatókpéldául irritábilis bélszindróma kezelésére. Ó
HU0001118A 1996-12-02 1997-11-26 N-substituted pyrrolidine derivatives, process for preparing the same and pharmaceutical compositions containing them HUP0001118A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33635396 1996-12-02
PCT/JP1997/004306 WO1998024431A1 (en) 1996-12-02 1997-11-26 Novel n-substituted pyrrolidine derivatives and process for preparing the same

Publications (2)

Publication Number Publication Date
HUP0001118A2 true HUP0001118A2 (hu) 2000-10-28
HUP0001118A3 HUP0001118A3 (en) 2001-06-28

Family

ID=18298258

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001118A HUP0001118A3 (en) 1996-12-02 1997-11-26 N-substituted pyrrolidine derivatives, process for preparing the same and pharmaceutical compositions containing them

Country Status (12)

Country Link
US (1) US6071950A (hu)
EP (1) EP0948964B1 (hu)
JP (1) JP4167302B2 (hu)
KR (1) KR100483221B1 (hu)
CN (1) CN1104239C (hu)
AT (1) ATE235903T1 (hu)
AU (1) AU733209B2 (hu)
CA (1) CA2273253C (hu)
DE (1) DE69720518T2 (hu)
HU (1) HUP0001118A3 (hu)
TW (1) TW429249B (hu)
WO (1) WO1998024431A1 (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20104880B (en) * 2005-09-21 2010-01-11 Pfizer Ltd Carboxamide derivatives as muscarinic receptor antagonists
WO2008035157A1 (en) * 2006-09-22 2008-03-27 Pfizer Limited Azetidine derivatives as muscarinic receptor antagonists
KR101120227B1 (ko) 2007-03-16 2012-03-20 화이자 리미티드 5-［3-（3-하이드록시페녹시）아제티딘-1-일］-5-메틸-2,2-다이페닐-헥산아마이드의 염산염

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
WO1991006536A1 (en) * 1989-10-25 1991-05-16 The Regents Of The University Of California Method of inhibiting the transport of l-glutamate
GB8928042D0 (en) * 1989-12-12 1990-02-14 Pfizer Ltd Muscarinic receptor antagonists
SE9203318D0 (sv) * 1992-11-06 1992-11-06 Kabi Pharmacia Ab Novel 3,3-diphenylpropylamines, their use and preparation
IL117440A0 (en) * 1995-03-31 1996-07-23 Pfizer Pyrrolidinyl hydroxamic acid compounds and their production process
DE19523502A1 (de) * 1995-06-28 1997-01-02 Merck Patent Gmbh Kappa-Opiatagonisten für entzündliche Darmerkrankungen
AU746126B2 (en) * 1997-09-08 2002-04-18 Georgetown University Substituted 2-pyrrolidinone activators of PKC
JPH11100366A (ja) * 1997-09-29 1999-04-13 Kyorin Pharmaceut Co Ltd 新規ｎ−置換環状アミン誘導体及びその製造法

Also Published As

Publication number Publication date
EP0948964A4 (en) 2001-04-04
TW429249B (en) 2001-04-11
EP0948964A1 (en) 1999-10-13
WO1998024431A1 (en) 1998-06-11
AU733209B2 (en) 2001-05-10
CN1239428A (zh) 1999-12-22
US6071950A (en) 2000-06-06
DE69720518D1 (de) 2003-05-08
KR20000069260A (ko) 2000-11-25
EP0948964B1 (en) 2003-04-02
CA2273253C (en) 2003-09-16
CN1104239C (zh) 2003-04-02
JP4167302B2 (ja) 2008-10-15
KR100483221B1 (ko) 2005-04-15
DE69720518T2 (de) 2004-02-26
HUP0001118A3 (en) 2001-06-28
AU5066998A (en) 1998-06-29
CA2273253A1 (en) 1998-06-11
ATE235903T1 (de) 2003-04-15

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees