HUP0000965A3 - Pyrrolidine derivatives having phospolipase a2 inhibitory activity and pharmaceutical compositions containing the same - Google Patents
Pyrrolidine derivatives having phospolipase a2 inhibitory activity and pharmaceutical compositions containing the sameInfo
- Publication number
- HUP0000965A3 HUP0000965A3 HU0000965A HUP0000965A HUP0000965A3 HU P0000965 A3 HUP0000965 A3 HU P0000965A3 HU 0000965 A HU0000965 A HU 0000965A HU P0000965 A HUP0000965 A HU P0000965A HU P0000965 A3 HUP0000965 A3 HU P0000965A3
- Authority
- HU
- Hungary
- Prior art keywords
- phospolipase
- same
- pharmaceutical compositions
- compositions containing
- inhibitory activity
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003235 pyrrolidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Cosmetics (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1796297 | 1997-01-31 | ||
| PCT/JP1998/000307 WO1998033797A1 (en) | 1997-01-31 | 1998-01-27 | Pyrrolidine derivatives having phospholipase a2 inhibitory activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0000965A2 HUP0000965A2 (hu) | 2001-04-28 |
| HUP0000965A3 true HUP0000965A3 (en) | 2001-11-28 |
Family
ID=11958379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000965A HUP0000965A3 (en) | 1997-01-31 | 1998-01-27 | Pyrrolidine derivatives having phospolipase a2 inhibitory activity and pharmaceutical compositions containing the same |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6147100A (hu) |
| EP (1) | EP0976748B1 (hu) |
| JP (1) | JP3850450B2 (hu) |
| KR (1) | KR100354358B1 (hu) |
| CN (1) | CN1217942C (hu) |
| AT (1) | ATE255579T1 (hu) |
| AU (1) | AU719210B2 (hu) |
| BR (1) | BR9807132A (hu) |
| CA (1) | CA2277947C (hu) |
| DE (1) | DE69820248T2 (hu) |
| DK (1) | DK0976748T3 (hu) |
| ES (1) | ES2210710T3 (hu) |
| HU (1) | HUP0000965A3 (hu) |
| NO (1) | NO313881B1 (hu) |
| PL (1) | PL334915A1 (hu) |
| PT (1) | PT976748E (hu) |
| RU (1) | RU2198174C2 (hu) |
| TR (1) | TR199901847T2 (hu) |
| TW (1) | TW577875B (hu) |
| WO (1) | WO1998033797A1 (hu) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| KR20020069183A (ko) | 1999-07-26 | 2002-08-29 | 시오노기세이야쿠가부시키가이샤 | 트롬보포이에틴 작동성을 나타내는 의약 조성물 |
| JP5420128B2 (ja) | 1999-10-13 | 2014-02-19 | ジョンズ ホプキンス ユニバーシティ スクール オブ メディシン | ヘッジホッグ経路の調節物質、並びにそれに関する組成物及び利用法 |
| US6552016B1 (en) | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| AU780612C (en) * | 1999-10-14 | 2005-10-20 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| EP1240906A4 (en) | 1999-10-22 | 2004-04-14 | Shionogi & Co | PROPHYLACTICS AND THERAPEUTICS AGAINST ARRHYTHMIA |
| AU2155001A (en) * | 1999-11-10 | 2001-06-06 | Aventis Pharma Deutschland Gmbh | N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor xa |
| US7361663B2 (en) * | 1999-11-10 | 2008-04-22 | Aventis Pharmaceuticals Inc. | N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa |
| MX259234B (es) * | 2000-08-07 | 2008-08-01 | Akzo Nobel Nv | Un proceso para apresto de papel. |
| JP4145655B2 (ja) * | 2001-01-26 | 2008-09-03 | 塩野義製薬株式会社 | トロンボポエチン受容体アゴニスト作用を有するハロゲン化合物 |
| US20030073945A1 (en) * | 2001-10-17 | 2003-04-17 | Liang-Kuang Diang | Ozone hemodiafiltration device |
| US6867320B2 (en) * | 2002-02-21 | 2005-03-15 | Asahi Kasei Pharma Corporation | Substituted phenylalkanoic acid derivatives and use thereof |
| US20040018533A1 (en) * | 2002-06-04 | 2004-01-29 | Adam Gail Isabel Reid | Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| AU2003248793A1 (en) * | 2002-06-27 | 2004-01-19 | Sequenom, Inc | Diagnosing predisposition to fat deposition and associated condition |
| AU2003248794B2 (en) * | 2002-06-27 | 2007-10-04 | Harkness Pharmaceuticals, Inc. | Therapeutic methods for reducing fat deposition and treating associated conditions |
| EP1597255A1 (en) * | 2002-11-13 | 2005-11-23 | Rigel Pharmaceuticals, Inc. | Rhodanine derivatives and pharmaceutical compositions containing them |
| AU2003302645A1 (en) * | 2002-11-29 | 2004-06-23 | Shionogi And Co., Ltd. | Synthesis of pyrrolidine compound and salt thereof |
| US7781464B2 (en) * | 2003-01-17 | 2010-08-24 | Bexel Pharmaceuticals, Inc. | Heterocyclic diphenyl ethers |
| US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
| US7521465B2 (en) * | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
| WO2004089368A1 (ja) * | 2003-04-08 | 2004-10-21 | Shionogi & Co. Ltd. | 皮膚炎の治療または予防剤 |
| CN101031539A (zh) * | 2003-08-14 | 2007-09-05 | 旭化成制药株式会社 | 取代的芳基链烷酸衍生物及其用途 |
| US7087576B2 (en) * | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
| US7207652B2 (en) * | 2003-10-17 | 2007-04-24 | Lexmark International, Inc. | Balanced satellite distributions |
| US20090215857A1 (en) * | 2005-09-13 | 2009-08-27 | Pfizer Products Inc. | Therapeutic Pyrrolidines |
| TWI461423B (zh) | 2008-07-02 | 2014-11-21 | Astrazeneca Ab | 用於治療Pim激酶相關病狀及疾病之噻唑啶二酮化合物 |
| EP2348856B1 (en) * | 2008-10-21 | 2013-08-14 | Merck Sharp & Dohme Corp. | 2,4-disubstituted pyrrolidine orexin receptor antagonists |
| EP2583099B1 (en) | 2010-06-18 | 2016-11-02 | Whitehead Institute for Biomedical Research | Pla2g16 as a target for antiviral compounds |
| WO2013018929A1 (en) | 2011-08-04 | 2013-02-07 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
| USD804651S1 (en) | 2017-01-10 | 2017-12-05 | Howard Loonan | Syringe |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986002073A1 (fr) * | 1984-10-03 | 1986-04-10 | Takeda Chemical Industries, Ltd. | Derives de thiazolidinedione, procede de preparation et composition pharmaceutique les contenant |
| US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| JP2826379B2 (ja) * | 1990-01-22 | 1998-11-18 | 三共株式会社 | チアゾリジン誘導体を有効成分とする肥満性高血圧症治療剤 |
| FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5317016A (en) * | 1991-08-20 | 1994-05-31 | Shionogi Seiyaku Kabushiki Kaisha | Pyrrolidylthiocarbapenem derivative |
| JPH05306224A (ja) * | 1992-04-24 | 1993-11-19 | Wakamoto Pharmaceut Co Ltd | ドーパミン β−ヒドロキシラーゼ阻害剤 |
| EP0586229A1 (en) * | 1992-09-01 | 1994-03-09 | Zeneca Limited | 3-Hydroxy-3-(subst-akyl)-pyrrolidines as 5-lipoxygenase inhibitors |
| TW245716B (hu) * | 1992-12-28 | 1995-04-21 | Takeda Pharm Industry Co | |
| AU684316B2 (en) * | 1993-10-15 | 1997-12-11 | Shionogi & Co., Ltd. | Oxazolinone derivative having intracellular phospholipase A2 inhibitor activity |
| JPH07138258A (ja) * | 1993-11-16 | 1995-05-30 | Taiho Yakuhin Kogyo Kk | チアゾリジンジオン誘導体又はその塩 |
| CA2145257A1 (en) * | 1994-03-23 | 1995-09-24 | Takashi Fujita | Thiazolidine and oxazolidine derivatives, their preparation and their medical use |
| CA2227829A1 (en) * | 1995-07-31 | 1997-02-13 | Shionogi & Co., Ltd. | Pyrrolidine derivatives having phospholipase a2 inhibitory activity |
| JPH09176162A (ja) * | 1995-12-22 | 1997-07-08 | Toubishi Yakuhin Kogyo Kk | チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物 |
| AU2995497A (en) * | 1996-07-26 | 1997-11-19 | Dr. Reddy's Research Foundation | Thiazolidinedione compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions thereof |
| DE69716592T2 (de) * | 1997-05-02 | 2003-06-26 | Dr. Reddy's Laboratories Ltd., Hyderabad | Neue heterozyklische verbindungen mit antidiabetischen, hypolipiddaemischen und blutdrucksenkenden eigenschaften, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die diese enthalten |
| WO1997041119A1 (en) * | 1997-05-02 | 1997-11-06 | Dr. Reddy's Research Foundation | Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
-
1998
- 1998-01-26 TW TW087101064A patent/TW577875B/zh not_active IP Right Cessation
- 1998-01-27 US US09/355,008 patent/US6147100A/en not_active Expired - Fee Related
- 1998-01-27 ES ES98900741T patent/ES2210710T3/es not_active Expired - Lifetime
- 1998-01-27 AT AT98900741T patent/ATE255579T1/de not_active IP Right Cessation
- 1998-01-27 JP JP53270898A patent/JP3850450B2/ja not_active Expired - Fee Related
- 1998-01-27 PT PT98900741T patent/PT976748E/pt unknown
- 1998-01-27 AU AU55775/98A patent/AU719210B2/en not_active Ceased
- 1998-01-27 BR BR9807132-7A patent/BR9807132A/pt not_active Application Discontinuation
- 1998-01-27 CA CA002277947A patent/CA2277947C/en not_active Expired - Fee Related
- 1998-01-27 DE DE69820248T patent/DE69820248T2/de not_active Expired - Lifetime
- 1998-01-27 KR KR1019997006741A patent/KR100354358B1/ko not_active Expired - Fee Related
- 1998-01-27 EP EP98900741A patent/EP0976748B1/en not_active Expired - Lifetime
- 1998-01-27 TR TR1999/01847T patent/TR199901847T2/xx unknown
- 1998-01-27 DK DK98900741T patent/DK0976748T3/da active
- 1998-01-27 WO PCT/JP1998/000307 patent/WO1998033797A1/ja not_active Ceased
- 1998-01-27 HU HU0000965A patent/HUP0000965A3/hu unknown
- 1998-01-27 CN CN988038021A patent/CN1217942C/zh not_active Expired - Fee Related
- 1998-01-27 RU RU99119481/04A patent/RU2198174C2/ru not_active IP Right Cessation
- 1998-01-27 PL PL98334915A patent/PL334915A1/xx not_active Application Discontinuation
-
1999
- 1999-07-29 NO NO19993706A patent/NO313881B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2198174C2 (ru) | 2003-02-10 |
| CA2277947C (en) | 2004-09-21 |
| EP0976748A1 (en) | 2000-02-02 |
| DE69820248D1 (de) | 2004-01-15 |
| NO993706L (no) | 1999-09-30 |
| ES2210710T3 (es) | 2004-07-01 |
| CN1217942C (zh) | 2005-09-07 |
| AU719210B2 (en) | 2000-05-04 |
| TR199901847T2 (xx) | 2000-06-21 |
| BR9807132A (pt) | 2000-01-25 |
| EP0976748A4 (en) | 2001-08-08 |
| PL334915A1 (en) | 2000-03-27 |
| NO313881B1 (no) | 2002-12-16 |
| WO1998033797A1 (en) | 1998-08-06 |
| CA2277947A1 (en) | 1998-08-06 |
| HUP0000965A2 (hu) | 2001-04-28 |
| DE69820248T2 (de) | 2004-09-23 |
| PT976748E (pt) | 2004-03-31 |
| US6147100A (en) | 2000-11-14 |
| JP3850450B2 (ja) | 2006-11-29 |
| AU5577598A (en) | 1998-08-25 |
| KR20000070497A (ko) | 2000-11-25 |
| CN1251587A (zh) | 2000-04-26 |
| DK0976748T3 (da) | 2004-03-22 |
| KR100354358B1 (ko) | 2002-09-28 |
| TW577875B (en) | 2004-03-01 |
| EP0976748B1 (en) | 2003-12-03 |
| ATE255579T1 (de) | 2003-12-15 |
| NO993706D0 (no) | 1999-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: ANTHERA PHARMACEUTICALS, INC., US Free format text: FORMER OWNER(S): SHIONOGI & CO. LTD., JP |
|
| FD9A | Lapse of provisional protection due to non-payment of fees |