HUP0500736A3 - (s)-2-amino-4-(2-ethanimidoylamino-ethylthio)-butyric acid phosphate salt as nitric oxide synthase inhibitor, process for its preparation and pharmaceutical composition containing it - Google Patents
(s)-2-amino-4-(2-ethanimidoylamino-ethylthio)-butyric acid phosphate salt as nitric oxide synthase inhibitor, process for its preparation and pharmaceutical composition containing itInfo
- Publication number
- HUP0500736A3 HUP0500736A3 HU0500736A HUP0500736A HUP0500736A3 HU P0500736 A3 HUP0500736 A3 HU P0500736A3 HU 0500736 A HU0500736 A HU 0500736A HU P0500736 A HUP0500736 A HU P0500736A HU P0500736 A3 HUP0500736 A3 HU P0500736A3
- Authority
- HU
- Hungary
- Prior art keywords
- ethanimidoylamino
- ethylthio
- amino
- preparation
- pharmaceutical composition
- Prior art date
Links
- CNNHVSBCHOIDCA-FJXQXJEOSA-N (2s)-2-amino-4-[2-(1-aminoethylideneamino)ethylsulfanyl]butanoic acid;phosphoric acid Chemical compound OP(O)(O)=O.CC(N)=NCCSCC[C@H](N)C(O)=O CNNHVSBCHOIDCA-FJXQXJEOSA-N 0.000 title 1
- 229940123921 Nitric oxide synthase inhibitor Drugs 0.000 title 1
- 239000000236 nitric oxide synthase inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0031179.5A GB0031179D0 (en) | 2000-12-21 | 2000-12-21 | Nitric oxide synthase inhibitors |
| PCT/GB2001/005596 WO2002050021A1 (en) | 2000-12-21 | 2001-12-17 | Nitric oxide synthase inhibitor phosphate salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0500736A2 HUP0500736A2 (hu) | 2005-11-28 |
| HUP0500736A3 true HUP0500736A3 (en) | 2009-12-28 |
Family
ID=9905536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0500736A HUP0500736A3 (en) | 2000-12-21 | 2001-12-17 | (s)-2-amino-4-(2-ethanimidoylamino-ethylthio)-butyric acid phosphate salt as nitric oxide synthase inhibitor, process for its preparation and pharmaceutical composition containing it |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7317040B2 (hu) |
| EP (1) | EP1351929A1 (hu) |
| JP (1) | JP3971704B2 (hu) |
| KR (1) | KR100853049B1 (hu) |
| CN (1) | CN100369894C (hu) |
| AR (1) | AR031944A1 (hu) |
| AU (2) | AU2002222252B2 (hu) |
| BR (1) | BR0116369A (hu) |
| CA (1) | CA2432121C (hu) |
| CZ (1) | CZ301458B6 (hu) |
| GB (1) | GB0031179D0 (hu) |
| HU (1) | HUP0500736A3 (hu) |
| IL (1) | IL156305A0 (hu) |
| MX (1) | MXPA03005698A (hu) |
| NO (1) | NO328982B1 (hu) |
| NZ (1) | NZ526563A (hu) |
| PL (1) | PL207158B1 (hu) |
| WO (1) | WO2002050021A1 (hu) |
| ZA (1) | ZA200304683B (hu) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0214147D0 (en) * | 2002-06-19 | 2002-07-31 | Glaxo Group Ltd | Formulations |
| NZ538184A (en) * | 2002-08-23 | 2008-02-29 | Pharmacia Corp | Crystalline solid form of (2S-5Z)-2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid 1.5 hydrochloride |
| TWI328009B (en) | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
| GB0316290D0 (en) | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
| PE20060272A1 (es) | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
| TWI307630B (en) | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
| GB0418045D0 (en) | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
| WO2006072599A2 (en) | 2005-01-10 | 2006-07-13 | Glaxo Group Limited | Androstane 17-alpha carbonate derivatives for use in the treatment of allergic and inflammatory conditions |
| UY29440A1 (es) | 2005-03-25 | 2006-10-02 | Glaxo Group Ltd | Nuevos compuestos |
| PE20061193A1 (es) | 2005-03-25 | 2006-12-02 | Glaxo Group Ltd | DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38 |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| AR058109A1 (es) | 2005-12-20 | 2008-01-23 | Glaxo Group Ltd | Acido 3 - (4 - {[4 -(4 -{[3 - (3, 3 - dimetil - 1 - piperidinil)propil]oxi}fenil) - 1 - piperidinil]carbonil} - 1 - naftalenil)propanoico como antagonistas de los receptotres de histamina h1/h3, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamie |
| MX2008013411A (es) | 2006-04-20 | 2008-11-04 | Glaxo Group Ltd | Nuevos compuestos. |
| GB0611587D0 (en) | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
| EP2046787B1 (en) | 2006-08-01 | 2011-04-06 | Glaxo Group Limited | Pyrazolo[3,4-b]pyridine compounds, and their use as pde4 inhibitors |
| AU2007354255A1 (en) * | 2006-11-09 | 2008-12-04 | University Of Maryland, Baltimore | Use of 5,6-dimethylxanthenone-4-acetic acid as an antimicrobial agent |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| MX2010012814A (es) | 2008-05-23 | 2010-12-20 | Amira Pharmaceuticals Inc | Inhibidor de proteina activadora de 5-lipoxigenasa. |
| WO2009147190A1 (en) | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | Novel compounds |
| WO2009147187A1 (en) | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | 4-carboxamide indazole derivatives useful as inhibitors of p13-kinases |
| WO2010094643A1 (en) | 2009-02-17 | 2010-08-26 | Glaxo Group Limited | Quinoline derivatives and their uses for rhinitis and urticaria |
| WO2010102958A1 (en) | 2009-03-09 | 2010-09-16 | Glaxo Group Limited | 4-oxadiazol-2 -yl- indazoles as inhibitors of p13 kinases |
| US8354539B2 (en) | 2009-03-10 | 2013-01-15 | Glaxo Group Limited | Indole derivatives as IKK2 inhibitors |
| US20120058984A1 (en) | 2009-03-17 | 2012-03-08 | Catherine Mary Alder | Pyrimidine derivatives used as itk inhibitors |
| US20120029054A1 (en) | 2009-03-19 | 2012-02-02 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of GATA Binding Protein 3 (GATA3) Gene Expression Using Short Intefering Nucleic Acid (siNA) |
| US20120035247A1 (en) | 2009-03-19 | 2012-02-09 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 6 (STAT6) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| WO2010107952A2 (en) | 2009-03-19 | 2010-09-23 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF CONNECTIVE TISSUE GROWTH FACTOR (CTGF) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US20120016010A1 (en) | 2009-03-19 | 2012-01-19 | Merck Sharp & Dohme Corp | RNA Interference Mediated Inhibition of BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| KR20110138223A (ko) | 2009-03-27 | 2011-12-26 | 머크 샤프 앤드 돔 코포레이션 | 짧은 간섭 핵산 (ｓｉＮＡ)을 사용한 세포간 부착 분자 1 (ＩＣＡＭ-1) 유전자 발현의 ＲＮＡ 간섭 매개 억제 |
| WO2010111468A2 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF THE NERVE GROWTH FACTOR BETA CHAIN (NGFß) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) |
| EP2411019A2 (en) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 (STAT1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US20120022143A1 (en) | 2009-03-27 | 2012-01-26 | Merck Sharp & Dohme Corp | RNA Interference Mediated Inhibition of the Thymic Stromal Lymphopoietin (TSLP) Gene Expression Using Short Interfering Nucliec Acid (siNA) |
| WO2010111464A1 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| JP2012524754A (ja) | 2009-04-24 | 2012-10-18 | グラクソ グループ リミテッド | Ｃｒａｃチャネル阻害剤としてのピラゾールおよびトリアゾ−ルカルボキサミド |
| AR076373A1 (es) | 2009-04-24 | 2011-06-08 | Glaxo Group Ltd | N-pirazolil carboxamidas como inhibidores de canales de calcio |
| PL2899191T3 (pl) | 2009-04-30 | 2018-01-31 | Glaxo Group Ltd | Indazole podstawione oksazolem jako inhibitory kinazy PI3 |
| EP2507231A1 (en) | 2009-12-03 | 2012-10-10 | Glaxo Group Limited | Indazole derivatives as pi 3 - kinase inhibitors |
| WO2011067365A1 (en) | 2009-12-03 | 2011-06-09 | Glaxo Group Limited | Benzpyrazole derivatives as inhibitors of p13 kinases |
| US20120238559A1 (en) | 2009-12-03 | 2012-09-20 | Glaxo Group Limited | Novel compounds |
| EP2512438B1 (en) | 2009-12-16 | 2017-01-25 | 3M Innovative Properties Company | Formulations and methods for controlling mdi particle size delivery |
| TWI375671B (en) * | 2010-03-01 | 2012-11-01 | Univ China Medical | Pharmaceutical compositions containing brazilin for inhibiting expression of cytokines of t helper cell type ii and/or inhibiting expression of chemokines and uses of the same |
| WO2011110575A1 (en) | 2010-03-11 | 2011-09-15 | Glaxo Group Limited | Derivatives of 2-[2-(benzo- or pyrido-) thiazolylamino]-6-aminopyridine, useful in the treatment of respiratoric, allergic or inflammatory diseases |
| GB201007203D0 (en) | 2010-04-29 | 2010-06-16 | Glaxo Group Ltd | Novel compounds |
| HUE026059T2 (hu) | 2010-09-08 | 2016-05-30 | Glaxosmithkline Ip Dev Ltd | N-[5-[4-(5-{[(2R,6S)-2,6-dimetil-4-morfolinil]metil}-1,3-oxazol-2-il)-1H-indazol-6-il]-2-(metiloxi)-3-piridinil]metánszulfonamid polimorfjai és sói |
| US9326987B2 (en) | 2010-09-08 | 2016-05-03 | Glaxo Group Limited | Indazole derivatives for use in the treatment of influenza virus infection |
| WO2012035055A1 (en) | 2010-09-17 | 2012-03-22 | Glaxo Group Limited | Novel compounds |
| WO2012052458A1 (en) | 2010-10-21 | 2012-04-26 | Glaxo Group Limited | Pyrazole compounds acting against allergic, immune and inflammatory conditions |
| US9149462B2 (en) | 2010-10-21 | 2015-10-06 | Glaxo Group Limited | Pyrazole compounds acting against allergic, inflammatory and immune disorders |
| GB201018124D0 (en) | 2010-10-27 | 2010-12-08 | Glaxo Group Ltd | Polymorphs and salts |
| JP2012140390A (ja) * | 2011-01-06 | 2012-07-26 | Sumitomo Chemical Co Ltd | α−アミノ−γ−ブチロラクトンの製造方法 |
| EP2683716A1 (en) | 2011-03-11 | 2014-01-15 | Glaxo Group Limited | Pyrido[3,4-b]pyrazine derivatives as syk inhibitors |
| GB201104153D0 (en) | 2011-03-11 | 2011-04-27 | Glaxo Group Ltd | Novel compounds |
| CN102344397B (zh) * | 2011-08-23 | 2013-09-04 | 浙江升华拜克生物股份有限公司 | 一种伐奈莫林盐酸盐的提纯方法 |
| JP6494634B2 (ja) | 2013-09-22 | 2019-04-03 | キャリター・サイエンシーズ・リミテッド・ライアビリティ・カンパニーＣａｌｉｔｏｒ Ｓｃｉｅｎｃｅｓ， Ｌｌｃ | 置換されているアミノピリミジン化合物および使用方法 |
| EP3312164B1 (en) | 2014-03-28 | 2020-12-09 | Calitor Sciences, LLC | Substituted heteroaryl compounds and methods of use |
| TW201625247A (zh) | 2014-05-12 | 2016-07-16 | 葛蘭素史密斯克藍智慧財產權有限公司 | 用於治療傳染性疾病之醫藥組合物 |
| JP2018527362A (ja) | 2015-09-11 | 2018-09-20 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | 置換されたヘテロアリール化合物および使用方法 |
| WO2017214159A1 (en) * | 2016-06-06 | 2017-12-14 | The Regents Of The University Of California | A host cell modified to produce lactams |
| US10683297B2 (en) | 2017-11-19 | 2020-06-16 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| US10751339B2 (en) | 2018-01-20 | 2020-08-25 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine compounds and methods of use |
| CN109369432B (zh) * | 2018-11-02 | 2021-06-25 | 永农生物科学有限公司 | (s)-4-氯-2-氨基丁酸酯的制备方法 |
| WO2021191875A1 (en) | 2020-03-26 | 2021-09-30 | Glaxosmithkline Intellectual Property Development Limited | Cathepsin inhibitors for preventing or treating viral infections |
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| ATE191470T1 (de) | 1994-06-15 | 2000-04-15 | Wellcome Found | Enzymhemmer |
| DE59508647D1 (de) | 1994-07-04 | 2000-09-21 | Schering Ag | Niedrig dosierte steroidtabletten, die gallussäureester als antioxidans enthalten, verfahren zur herstellung und die verwendung |
| MY117948A (en) * | 1997-01-13 | 2004-08-30 | Glaxo Group Ltd | Nitride oxide synthase inhibitors. |
| CA2322873A1 (en) | 1998-03-11 | 1999-09-16 | G.D. Searle & Co. | Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors |
| GB9810299D0 (en) * | 1998-05-15 | 1998-07-15 | Glaxo Group Ltd | Use of nitric oxide synthase inhibitors |
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2000
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- 2001-12-17 WO PCT/GB2001/005596 patent/WO2002050021A1/en not_active Ceased
- 2001-12-17 AU AU2002222252A patent/AU2002222252B2/en not_active Ceased
- 2001-12-17 CZ CZ20031744A patent/CZ301458B6/cs not_active IP Right Cessation
- 2001-12-17 IL IL15630501A patent/IL156305A0/xx unknown
- 2001-12-17 US US10/451,299 patent/US7317040B2/en not_active Expired - Fee Related
- 2001-12-17 JP JP2002551520A patent/JP3971704B2/ja not_active Expired - Fee Related
- 2001-12-17 NZ NZ526563A patent/NZ526563A/en unknown
- 2001-12-17 PL PL364833A patent/PL207158B1/pl not_active IP Right Cessation
- 2001-12-17 BR BR0116369-8A patent/BR0116369A/pt not_active Application Discontinuation
- 2001-12-17 KR KR1020037008395A patent/KR100853049B1/ko not_active Expired - Fee Related
- 2001-12-17 CA CA002432121A patent/CA2432121C/en not_active Expired - Fee Related
- 2001-12-17 HU HU0500736A patent/HUP0500736A3/hu unknown
- 2001-12-17 EP EP01271352A patent/EP1351929A1/en not_active Withdrawn
- 2001-12-17 CN CNB018227066A patent/CN100369894C/zh not_active Expired - Fee Related
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2003
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| ZA200304683B (en) | 2004-09-17 |
| MXPA03005698A (es) | 2003-10-06 |
| CN100369894C (zh) | 2008-02-20 |
| BR0116369A (pt) | 2003-10-28 |
| CA2432121A1 (en) | 2002-06-27 |
| AR031944A1 (es) | 2003-10-08 |
| NZ526563A (en) | 2004-11-26 |
| JP3971704B2 (ja) | 2007-09-05 |
| NO328982B1 (no) | 2010-07-05 |
| PL207158B1 (pl) | 2010-11-30 |
| JP2004516278A (ja) | 2004-06-03 |
| GB0031179D0 (en) | 2001-01-31 |
| AU2002222252B2 (en) | 2005-02-24 |
| CZ301458B6 (cs) | 2010-03-10 |
| US20040087654A1 (en) | 2004-05-06 |
| AU2225202A (en) | 2002-07-01 |
| EP1351929A1 (en) | 2003-10-15 |
| CZ20031744A3 (cs) | 2004-01-14 |
| KR100853049B1 (ko) | 2008-08-19 |
| NO20032835D0 (no) | 2003-06-20 |
| KR20030066737A (ko) | 2003-08-09 |
| NO20032835L (no) | 2003-08-15 |
| CA2432121C (en) | 2009-12-01 |
| WO2002050021A1 (en) | 2002-06-27 |
| US7317040B2 (en) | 2008-01-08 |
| IL156305A0 (en) | 2004-01-04 |
| PL364833A1 (en) | 2004-12-27 |
| CN1527814A (zh) | 2004-09-08 |
| HUP0500736A2 (hu) | 2005-11-28 |
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