HUP0401225A3 - Azabicyclo derivatives bridged with aromatic ring and pharmaceutical compositions containing them and process for their use - Google Patents

Azabicyclo derivatives bridged with aromatic ring and pharmaceutical compositions containing them and process for their use

Info

Publication number: HUP0401225A3
Authority: HU; Hungary
Prior art keywords: pharmaceutical compositions; aromatic ring; compositions containing; azabicyclo derivatives; bridged
Prior art date: 2000-08-04

Application number

HU0401225A

Other languages

English (en)

Original Assignee

Targacept Inc Winston Salem

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-04

Filing date

2001-07-13

Publication date

2005-07-28

2001-07-13 Application filed by Targacept Inc Winston Salem filed Critical Targacept Inc Winston Salem

2004-12-28 Publication of HUP0401225A2 publication Critical patent/HUP0401225A2/hu

2005-07-28 Publication of HUP0401225A3 publication Critical patent/HUP0401225A3/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HU0401225A 2000-08-04 2001-07-13 Azabicyclo derivatives bridged with aromatic ring and pharmaceutical compositions containing them and process for their use HUP0401225A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/633,156 US6624167B1 (en)	2000-08-04	2000-08-04	Pharmaceutical compositions and methods for use
PCT/US2001/022170 WO2002012245A2 (en)	2000-08-04	2001-07-13	Azabicyclic derivatives and their therapeutic use

Publications (2)

Publication Number	Publication Date
HUP0401225A2 HUP0401225A2 (hu)	2004-12-28
HUP0401225A3 true HUP0401225A3 (en)	2005-07-28

Family

ID=24538497

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0401225A HUP0401225A3 (en)	2000-08-04	2001-07-13	Azabicyclo derivatives bridged with aromatic ring and pharmaceutical compositions containing them and process for their use

Country Status (14)

Country	Link
US (2)	US6624167B1 (hu)
EP (1)	EP1305316A2 (hu)
JP (1)	JP2004536019A (hu)
CN (1)	CN1447811A (hu)
AU (1)	AU2001276911A1 (hu)
BR (1)	BR0113033A (hu)
CA (1)	CA2417967A1 (hu)
HU (1)	HUP0401225A3 (hu)
IL (1)	IL153897A0 (hu)
NO (1)	NO20030547D0 (hu)
NZ (1)	NZ523728A (hu)
PL (1)	PL363048A1 (hu)
WO (1)	WO2002012245A2 (hu)
ZA (1)	ZA200300571B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005524712A (ja) *	2002-05-07	2005-08-18	ニューロサーチ、アクティーゼルスカブ	新規アザシクロエチニル誘導体
AU2002313690A1 (en) *	2002-07-19	2004-02-09	Targacept, Inc.	Five-membered heteroaromatic olefinic azacyclic compounds, pharmaceutical compositions containing them and their use as inhibitors of ncotinic cholinergic receptors
US7098331B2 (en)	2003-03-05	2006-08-29	Targacept, Inc.	Arylvinylazacycloalkane compounds and methods of preparation and use thereof
US7235688B1 (en)	2004-11-04	2007-06-26	University Of Notre Dame Du Lac	Process for preparing histone deacetylase inhibitors and intermediates thereof
US20070021612A1 (en) *	2004-11-04	2007-01-25	University Of Notre Dame Du Lac	Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof
PE20061162A1 (es) *	2004-12-06	2006-10-14	Smithkline Beecham Corp	Compuestos derivados olefinicos de 8-azoniabiciclo[3.2.1]octanos
US20090239901A1 (en) *	2008-03-19	2009-09-24	Merouane Bencherif	Method and compositions for treatment of cerebral malaria
TW201031664A (en)	2009-01-26	2010-09-01	Targacept Inc	Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
US8802694B2 (en)	2009-12-07	2014-08-12	Targacept, Inc.	3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetycholine receptor ligands

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6060473A (en)	1993-04-01	2000-05-09	Ucb S.A. - Dtb	7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands
US5817679A (en)	1993-04-01	1998-10-06	University Of Virginia	7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
US5852041A (en)	1993-04-07	1998-12-22	Sibia Neurosciences, Inc.	Substituted pyridines useful as modulators of acethylcholine receptors
JP3637973B2 (ja)	1993-06-17	2005-04-13	エーザイ株式会社	アザビシクロヘプタン誘導体
US5510355A (en)	1994-09-06	1996-04-23	Bencherif; Merouane	Depolarizing skeletal muscle relaxants
US5583140A (en)	1995-05-17	1996-12-10	Bencherif; Merouane	Pharmaceutical compositions for the treatment of central nervous system disorders
WO1997001556A1 (en)	1995-06-29	1997-01-16	Novo Nordisk A/S	Novel substituted azacyclic or azabicyclic compounds
WO1997011072A1 (en)	1995-09-22	1997-03-27	Novo Nordisk A/S	Novel substituted azacyclic or azabicyclic compounds
BR9610960A (pt)	1995-10-13	1999-03-02	Neurosearch As	Derivados de 8-azabiciclo [3.2.1] oct -2- eno sua preparação e uso
AU736798B2 (en)	1997-05-30	2001-08-02	Neurosearch A/S	9-Azabicyclo(3.3.1)non-2-ene and nonane derivatives as cholinergic ligands at nicotinic ACh receptors
US5952339A (en)	1998-04-02	1999-09-14	Bencherif; Merouane	Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
CZ20012716A3 (cs)	1999-01-29	2001-11-14	Abbott Laboratories	Diazabicyklické deriváty jako ligandy nikotinového receptoru acetylcholinu
FR2791678B1 (fr)	1999-03-30	2001-05-04	Synthelabo	Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique
AU780492B2 (en)	1999-11-01	2005-03-24	Targacept, Inc.	Aryl olefinic azacyclic, and aryl acetylenic azacyclic compounds, pharmaceutical compositions containing them and their use as inhibitors of nicotinic cholinergic receptors
GB0000257D0 (en)	2000-01-07	2000-03-01	Univ Bristol	9-Azabicyclo[4.2.1]non-2-ene derivatives as ligands for nicotinic acetylcholine receptors

2000
- 2000-08-04 US US09/633,156 patent/US6624167B1/en not_active Expired - Fee Related
2001
- 2001-07-13 JP JP2002518220A patent/JP2004536019A/ja not_active Withdrawn
- 2001-07-13 WO PCT/US2001/022170 patent/WO2002012245A2/en not_active Ceased
- 2001-07-13 AU AU2001276911A patent/AU2001276911A1/en not_active Abandoned
- 2001-07-13 PL PL01363048A patent/PL363048A1/xx not_active Application Discontinuation
- 2001-07-13 NZ NZ523728A patent/NZ523728A/en unknown
- 2001-07-13 CN CN01813738A patent/CN1447811A/zh active Pending
- 2001-07-13 EP EP01954684A patent/EP1305316A2/en not_active Ceased
- 2001-07-13 IL IL15389701A patent/IL153897A0/xx unknown
- 2001-07-13 CA CA002417967A patent/CA2417967A1/en not_active Abandoned
- 2001-07-13 HU HU0401225A patent/HUP0401225A3/hu unknown
- 2001-07-13 BR BR0113033-1A patent/BR0113033A/pt not_active IP Right Cessation
2003
- 2003-01-21 ZA ZA200300571A patent/ZA200300571B/en unknown
- 2003-02-04 NO NO20030547A patent/NO20030547D0/no unknown
- 2003-09-23 US US10/668,692 patent/US7022706B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1305316A2 (en)	2003-05-02
ZA200300571B (en)	2004-04-21
NZ523728A (en)	2004-09-24
JP2004536019A (ja)	2004-12-02
NO20030547L (no)	2003-02-04
CN1447811A (zh)	2003-10-08
WO2002012245A3 (en)	2002-06-13
WO2002012245B1 (en)	2003-03-20
WO2002012245A2 (en)	2002-02-14
US20040152723A1 (en)	2004-08-05
US6624167B1 (en)	2003-09-23
US7022706B2 (en)	2006-04-04
AU2001276911A1 (en)	2002-02-18
CA2417967A1 (en)	2002-02-14
NO20030547D0 (no)	2003-02-04
IL153897A0 (en)	2003-07-31
BR0113033A (pt)	2003-07-15
HUP0401225A2 (hu)	2004-12-28
PL363048A1 (en)	2004-11-15

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