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HUP0400387A2 - A tobramicin aeroszol kialakítására optimalizált készítménye és eljárás az előállítására - Google Patents

A tobramicin aeroszol kialakítására optimalizált készítménye és eljárás az előállítására

Info

Publication number
HUP0400387A2
HUP0400387A2 HU0400387A HUP0400387A HUP0400387A2 HU P0400387 A2 HUP0400387 A2 HU P0400387A2 HU 0400387 A HU0400387 A HU 0400387A HU P0400387 A HUP0400387 A HU P0400387A HU P0400387 A2 HUP0400387 A2 HU P0400387A2
Authority
HU
Hungary
Prior art keywords
tobramycin
aerosolization
preparation
subject
sodium chloride
Prior art date
Application number
HU0400387A
Other languages
English (en)
Inventor
Chiara Malvolti
Raffaella Garzia
Original Assignee
Chiesi Farmaceutici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8177921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0400387(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farmaceutici S.P.A. filed Critical Chiesi Farmaceutici S.P.A.
Publication of HUP0400387A2 publication Critical patent/HUP0400387A2/hu
Publication of HU230807B1 publication Critical patent/HU230807B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A találmány tárgya aeroszol készítmény, amely 75 mg/ml tobramicinttartalmaz 0,45%-os nátrium-kloridban oldva, ahol az oldat pH-ja 4,0 és5,5 között van és az ozmolaritása 250-450 mOsm/l tartományba esik. Atalálmány tárgya továbbá eljárás az aeroszolkészítmény előállítására,amely a következő lépésekből áll: elkészítik a 0,45 tömeg%-os nátrium-kloridot tartalmazó vizes oldatot, beállítják a pH-t tömény erőssavval, hozzáadják a hatóanyagot, és addig keverik míg teljesenfeloldódik, újra beállítják a pH-t a kívánt értékre, majd az oldatotmegfelelő tartályokba töltik, előnyösen szűréssel elősterilizálva. Ó
HU0400387A 2001-07-02 2002-06-14 A tobramicin aeroszol kialakítására optimalizált készítménye HU230807B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01116071.0 2001-07-02
EP01116071A EP1273292B1 (en) 2001-07-02 2001-07-02 Optimised formulation of tobramycin for aerosolization
PCT/EP2002/006544 WO2003004005A1 (en) 2001-07-02 2002-06-14 Optimised formulation of tobramycin for aerosolization

Publications (2)

Publication Number Publication Date
HUP0400387A2 true HUP0400387A2 (hu) 2004-09-28
HU230807B1 HU230807B1 (hu) 2018-06-28

Family

ID=8177921

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400387A HU230807B1 (hu) 2001-07-02 2002-06-14 A tobramicin aeroszol kialakítására optimalizált készítménye

Country Status (26)

Country Link
US (5) US6987094B2 (hu)
EP (1) EP1273292B1 (hu)
JP (1) JP4262086B2 (hu)
KR (1) KR100910888B1 (hu)
CN (1) CN1234346C (hu)
AT (1) ATE267591T1 (hu)
AU (1) AU2002319226B2 (hu)
BG (1) BG66328B1 (hu)
BR (1) BRPI0211320B8 (hu)
CA (1) CA2452638C (hu)
CZ (1) CZ299348B6 (hu)
DE (1) DE60103527T2 (hu)
DK (1) DK1273292T3 (hu)
EA (1) EA006068B1 (hu)
EE (1) EE05392B1 (hu)
EG (1) EG24019A (hu)
ES (1) ES2222294T3 (hu)
HU (1) HU230807B1 (hu)
PL (1) PL202598B1 (hu)
PT (1) PT1273292E (hu)
SI (1) SI1273292T1 (hu)
SK (1) SK285806B6 (hu)
TN (1) TNSN03149A1 (hu)
TR (1) TR200401980T4 (hu)
WO (1) WO2003004005A1 (hu)
ZA (1) ZA200400026B (hu)

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Also Published As

Publication number Publication date
WO2003004005A1 (en) 2003-01-16
DE60103527T2 (de) 2005-06-16
AU2002319226B2 (en) 2006-07-06
US20120184502A1 (en) 2012-07-19
ZA200400026B (en) 2005-03-30
CA2452638A1 (en) 2003-01-16
EP1273292A1 (en) 2003-01-08
US20110212912A1 (en) 2011-09-01
KR100910888B1 (ko) 2009-08-05
DE60103527D1 (de) 2004-07-01
PL202598B1 (pl) 2009-07-31
US8168598B2 (en) 2012-05-01
CA2452638C (en) 2010-10-05
US7696178B2 (en) 2010-04-13
BRPI0211320B1 (pt) 2015-08-18
US20050163722A1 (en) 2005-07-28
CZ20033580A3 (cs) 2004-10-13
BG66328B1 (bg) 2013-06-28
BRPI0211320B8 (pt) 2021-05-25
CN1529589A (zh) 2004-09-15
SI1273292T1 (en) 2004-12-31
SK16432003A3 (sk) 2004-06-08
TR200401980T4 (tr) 2004-09-21
CZ299348B6 (cs) 2008-06-25
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