HUP0400997A3 - Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy - Google Patents

Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy

Info

Publication number: HUP0400997A3
Authority: HU; Hungary
Prior art keywords: diagnostics; therapy; metal ions; complex metal; aza ligands
Prior art date: 2001-07-17

Application number

HU0400997A

Other languages

Hungarian (hu)

Original Assignee

Bracco Imaging Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-17

Filing date

2002-07-10

Publication date

2010-03-29

2002-07-10 Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa

2004-09-28 Publication of HUP0400997A2 publication Critical patent/HUP0400997A2/en

2010-03-29 Publication of HUP0400997A3 publication Critical patent/HUP0400997A3/en

2013-05-28 Publication of HU228830B1 publication Critical patent/HU228830B1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Radiology & Medical Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Magnetic Resonance Imaging Apparatus (AREA)

HU0400997A 2001-07-17 2002-07-10 Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy HU228830B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2001MI001518A ITMI20011518A1 (en)	2001-07-17	2001-07-17	MULTIDENTATED NITROGEN BINDERS CAPABLE OF COMPLEXING METAL IONS AND THEIR USE IN DIAGNOSTICS AND THERAPY
PCT/EP2002/007658 WO2003008390A1 (en)	2001-07-17	2002-07-10	Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy

Publications (3)

Publication Number	Publication Date
HUP0400997A2 HUP0400997A2 (en)	2004-09-28
HUP0400997A3 true HUP0400997A3 (en)	2010-03-29
HU228830B1 HU228830B1 (en)	2013-05-28

Family

ID=11448069

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0400997A HU228830B1 (en)	2001-07-17	2002-07-10	Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy

Country Status (21)

Country	Link
US (1)	US7186400B2 (en)
EP (2)	EP1417183B1 (en)
JP (1)	JP4249610B2 (en)
KR (1)	KR100890471B1 (en)
CN (1)	CN100443476C (en)
AT (2)	ATE362921T1 (en)
AU (1)	AU2002331348B2 (en)
CA (1)	CA2453845C (en)
DE (1)	DE60220282T2 (en)
DK (1)	DK1417183T3 (en)
ES (1)	ES2286278T3 (en)
HU (1)	HU228830B1 (en)
IL (2)	IL159874A0 (en)
IT (1)	ITMI20011518A1 (en)
MX (1)	MXPA04000408A (en)
NO (1)	NO328840B1 (en)
PL (1)	PL202690B1 (en)
PT (1)	PT1417183E (en)
SI (1)	SI1417183T1 (en)
WO (1)	WO2003008390A1 (en)
ZA (1)	ZA200400318B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7893223B2 (en) *	2001-07-17	2011-02-22	Bracco Imaging S.P.A.	Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
US8420050B2 (en)	2003-01-13	2013-04-16	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7226577B2 (en)	2003-01-13	2007-06-05	Bracco Imaging, S. P. A.	Gastrin releasing peptide compounds
US7850947B2 (en)	2003-01-13	2010-12-14	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7922998B2 (en) *	2003-01-13	2011-04-12	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7611692B2 (en)	2003-01-13	2009-11-03	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
CN101090739B (en)	2004-07-02	2012-10-10	伯拉考成像股份公司	1,4-Bis(carboxymethyl)amino-6-methyl-perhydro-1,4-diazepine* (AAZTA) derivatives as ligands for high-relaxation contrast agents in magnetic resonance imaging
FR2883562B1 (en)	2005-03-24	2009-02-27	Guerbet Sa	LIPOPHILIC CHELATES AND THEIR USE IN IMAGING
US8986650B2 (en)	2005-10-07	2015-03-24	Guerbet	Complex folate-NOTA-Ga68
JP5368099B2 (en)	2005-10-07	2013-12-18	ゲルベ	A compound comprising a moiety for recognition of a biological target coupled to a signal moiety capable of complexing with gallium
FR2891830B1 (en)	2005-10-07	2011-06-24	Guerbet Sa	SHORT AMINOALCOHOL COMPOUNDS AND METAL COMPLEXES FOR MEDICAL IMAGING
US9333272B2 (en)	2006-12-11	2016-05-10	Bracco Imaging Spa	Fibrin binding peptide conjugates for diagnostic and therapeutic applications
EP2476703A1 (en)	2011-01-14	2012-07-18	Bracco Imaging S.p.A	Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
EP2147684A1 (en)	2008-07-22	2010-01-27	Bracco Imaging S.p.A	Diagnostic Agents Selective Against Metalloproteases
JP5376130B2 (en) *	2009-03-24	2013-12-25	独立行政法人日本原子力研究開発機構	Separation and purification of carrier-free 177Lu capable of antibody labeling
WO2012095516A1 (en)	2011-01-14	2012-07-19	Bracco Imaging Spa	Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
JP2015513551A (en)	2012-03-05	2015-05-14	ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏＩｍａｇｉｎｇＳ．Ｐ．Ａ．	Dynamic contrast-enhanced MRI methods and agents for assessing macromolecular transport into pathological tissues
EP2639227A1 (en)	2012-03-14	2013-09-18	Bracco Imaging S.p.A	A new class of diazepine derivative chelating agents and complexes with paramagnetic metals as MRI contrast agents
JP6251744B2 (en) *	2012-09-07	2017-12-20	ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏＩｍａｇｉｎｇＳ．Ｐ．Ａ．	Paramagnetic solid lipid nanoparticles (pSLN) containing amphiphilic complexes for MRI
DE102013106066A1 (en)	2013-06-11	2014-12-11	Johannes-Gutenberg-Universität Mainz	Bifunctional chelating agents based on the 1,4-diazepine scaffold (DAZA) for non-invasive molecular imaging
US9259725B2 (en) *	2013-10-10	2016-02-16	Lawrence Livermore National Security, Llc	Acyclic aza-containing ligands for use as catalytic carbon capture systems
JP6991148B2 (en)	2016-02-09	2022-01-12	ブラッコ・スイス・ソシエテ・アノニム	Recombinant chimeric protein for selectin targeting
DE102017129405A1 (en) *	2017-12-11	2019-06-13	Universitätsklinikum Jena	New DAZA chelators as ligands in liver imaging
JP7744240B2 (en)	2018-11-12	2025-09-25	ブラッコ・イメージング・ソシエタ・ペル・アチオニ	Chelated AAZTA conjugates and complexes thereof
CN114262351B (en) *	2022-03-01	2022-05-13	宜宾锂宝新材料有限公司	Prussian blue positive electrode material, preparation method and application thereof, and battery

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3107260A (en) *	1960-11-29	1963-10-15	Geigy Chem Corp	Triaminopropane hexa-acetic acid and metal chelates thereof
DE3938992A1 (en) *	1989-11-21	1991-05-23	Schering Ag	Cascade polymer-bound complex formers, their complexes and conjugates, process for their preparation and pharmaceutical compositions containing them
WO1992009283A1 (en) *	1990-11-26	1992-06-11	Warner-Lambert Company	Stabilized hexahydro-5-pyrimidinamine compounds in aqueous solution and methods for preparing same
US6403055B1 (en) *	1996-08-02	2002-06-11	Dibra S.P.A.	Diagnostic imaging contrast agent with improved in serum relaxivity
IT1283650B1 (en) *	1996-08-02	1998-04-23	Bracco Spa	HIGH RELAXATION PARAMAGNETIC CHELATES IN SERUM

2001
- 2001-07-17 IT IT2001MI001518A patent/ITMI20011518A1/en unknown
2002
- 2002-07-10 JP JP2003513950A patent/JP4249610B2/en not_active Expired - Fee Related
- 2002-07-10 IL IL15987402A patent/IL159874A0/en unknown
- 2002-07-10 MX MXPA04000408A patent/MXPA04000408A/en active IP Right Grant
- 2002-07-10 EP EP02767192A patent/EP1417183B1/en not_active Expired - Lifetime
- 2002-07-10 ES ES02767192T patent/ES2286278T3/en not_active Expired - Lifetime
- 2002-07-10 AT AT02767192T patent/ATE362921T1/en active
- 2002-07-10 EP EP07003558A patent/EP1803711B1/en not_active Expired - Lifetime
- 2002-07-10 US US10/484,111 patent/US7186400B2/en not_active Expired - Lifetime
- 2002-07-10 PT PT02767192T patent/PT1417183E/en unknown
- 2002-07-10 AT AT07003558T patent/ATE529414T1/en not_active IP Right Cessation
- 2002-07-10 DE DE60220282T patent/DE60220282T2/en not_active Expired - Lifetime
- 2002-07-10 HU HU0400997A patent/HU228830B1/en not_active IP Right Cessation
- 2002-07-10 AU AU2002331348A patent/AU2002331348B2/en not_active Ceased
- 2002-07-10 SI SI200230566T patent/SI1417183T1/en unknown
- 2002-07-10 CA CA2453845A patent/CA2453845C/en not_active Expired - Lifetime
- 2002-07-10 WO PCT/EP2002/007658 patent/WO2003008390A1/en not_active Ceased
- 2002-07-10 PL PL367007A patent/PL202690B1/en unknown
- 2002-07-10 DK DK02767192T patent/DK1417183T3/en active
- 2002-07-10 KR KR1020047000593A patent/KR100890471B1/en not_active Expired - Fee Related
- 2002-07-10 CN CNB028142020A patent/CN100443476C/en not_active Expired - Fee Related
2004
- 2004-01-15 ZA ZA200400318A patent/ZA200400318B/en unknown
- 2004-01-15 IL IL159874A patent/IL159874A/en active IP Right Grant
- 2004-01-15 NO NO20040179A patent/NO328840B1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE362921T1 (en)	2007-06-15
AU2002331348B2 (en)	2008-04-10
HK1061031A1 (en)	2004-09-03
MXPA04000408A (en)	2004-03-18
KR100890471B1 (en)	2009-03-26
CA2453845A1 (en)	2003-01-30
NO328840B1 (en)	2010-05-25
US20040156786A1 (en)	2004-08-12
PT1417183E (en)	2007-07-31
DE60220282D1 (en)	2007-07-05
CN100443476C (en)	2008-12-17
NO20040179L (en)	2004-03-15
ZA200400318B (en)	2006-04-26
WO2003008390A1 (en)	2003-01-30
JP2005504027A (en)	2005-02-10
ITMI20011518A0 (en)	2001-07-17
CN1533381A (en)	2004-09-29
DE60220282T2 (en)	2008-01-24
EP1803711B1 (en)	2011-10-19
US7186400B2 (en)	2007-03-06
HU228830B1 (en)	2013-05-28
EP1417183B1 (en)	2007-05-23
HUP0400997A2 (en)	2004-09-28
DK1417183T3 (en)	2007-10-01
PL202690B1 (en)	2009-07-31
SI1417183T1 (en)	2007-10-31
ITMI20011518A1 (en)	2003-01-17
EP1417183A1 (en)	2004-05-12
ES2286278T3 (en)	2007-12-01
ATE529414T1 (en)	2011-11-15
JP4249610B2 (en)	2009-04-02
IL159874A0 (en)	2004-06-20
KR20040018461A (en)	2004-03-03
CA2453845C (en)	2011-07-05
PL367007A1 (en)	2005-02-07
EP1803711A1 (en)	2007-07-04
IL159874A (en)	2008-11-03

Publication	Publication Date	Title
HUP0400997A3 (en)	2010-03-29	Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy
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IL159291A0 (en)	2004-06-01	Conjugates of macrocyclic metal complexes with biomolecules and the utilization thereof for producing agents for use in nmr diagnosis and radiodiagnosis and radiotherapy
AU2002355333A1 (en)	2003-06-19	Conjugates of macrocyclic metal complexes with biomolecules and the utilization thereof for producing agents for use in NMR diagnosis and radiodiagnosis and radiotherapy
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GB0128431D0 (en)	2002-01-16	Improvements in and relating to portable defibrillators
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GB2379153B (en)	2004-10-27	Improvements in or relating to cooking
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AUPR624401A0 (en)	2001-08-02	Metal complexes for use in boron neutron capture therapy
PL349955A1 (en)	2002-10-21	Radioactive cisplatin in the treatment of cancer

Legal Events

Date	Code	Title	Description
2022-04-28	MM4A	Lapse of definitive patent protection due to non-payment of fees