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HU913218D0 - Process for the production of hydroxy-alkyl-kinoline-ethers and of medical preparations containing them - Google Patents

Process for the production of hydroxy-alkyl-kinoline-ethers and of medical preparations containing them

Info

Publication number
HU913218D0
HU913218D0 HU913218A HU321891A HU913218D0 HU 913218 D0 HU913218 D0 HU 913218D0 HU 913218 A HU913218 A HU 913218A HU 321891 A HU321891 A HU 321891A HU 913218 D0 HU913218 D0 HU 913218D0
Authority
HU
Hungary
Prior art keywords
kinoline
ethers
hydroxy
alkyl
production
Prior art date
Application number
HU913218A
Other languages
Hungarian (hu)
Other versions
HUT61982A (en
Inventor
Michel L Belley
Marc Labelle
Yves Leblanc
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Publication of HU913218D0 publication Critical patent/HU913218D0/en
Publication of HUT61982A publication Critical patent/HUT61982A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Compounds having the formula I: <CHEM> are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.
HU913218A 1990-10-12 1991-10-10 Process for producing hydroxy alkylquinoline ether acids and pharmaceutical compositions comprising same HUT61982A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59688590A 1990-10-12 1990-10-12

Publications (2)

Publication Number Publication Date
HU913218D0 true HU913218D0 (en) 1992-01-28
HUT61982A HUT61982A (en) 1993-03-29

Family

ID=24389130

Family Applications (1)

Application Number Title Priority Date Filing Date
HU913218A HUT61982A (en) 1990-10-12 1991-10-10 Process for producing hydroxy alkylquinoline ether acids and pharmaceutical compositions comprising same

Country Status (18)

Country Link
EP (1) EP0480708B1 (en)
JP (1) JP2538154B2 (en)
KR (1) KR920008005A (en)
CN (1) CN1061594A (en)
AT (1) ATE128969T1 (en)
AU (1) AU639612B2 (en)
CA (1) CA2053208C (en)
CS (1) CS309491A3 (en)
DE (1) DE69113735T2 (en)
ES (1) ES2079586T3 (en)
FI (1) FI914795A7 (en)
HU (1) HUT61982A (en)
IE (1) IE913610A1 (en)
IL (1) IL99683A0 (en)
MX (1) MX9101556A (en)
NO (1) NO914003L (en)
PT (1) PT99211B (en)
ZA (1) ZA918115B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506227A (en) * 1992-04-13 1996-04-09 Merck Frosst Canada, Inc. Pyridine-substituted benzyl alcohols as leukotriene antagonists
US5358955A (en) * 1992-10-30 1994-10-25 Abbott Laboratories Aryl and heteroarylmethoxyphenyl inhibitors of leukotriene biosynthesis
US5438141A (en) * 1993-05-21 1995-08-01 Merck Frosst Canada, Inc. Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists
JPH09278653A (en) * 1996-04-05 1997-10-28 Santen Pharmaceut Co Ltd Retinal disease therapeutic agent
AU3868497A (en) * 1996-08-26 1998-03-19 Yamanouchi Pharmaceutical Co., Ltd. Benzenesulfone compounds and salts thereof
GB2356139A (en) * 1999-11-15 2001-05-16 Bayer Ag Use of substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphonamides and cyanamides for the treatment of diseases
EP1958936A1 (en) * 2007-02-14 2008-08-20 Inke, S.A. Process for obtaining montelukast
AU2012320010B2 (en) * 2011-07-26 2017-03-30 Sun Pharma Advanced Research Company Ltd. Quinoline-, quinoxaline or benzothiazole based cysteinyl leukotriene antagonists (LTD4)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62120365A (en) * 1985-11-16 1987-06-01 バイエル・アクチエンゲゼルシヤフト Substituted benzyl ethers, manufacture and use
IE59889B1 (en) * 1986-02-14 1994-04-20 Merck Frosst Canada Inc 2-substituted quinoline dioic acids
JPS62258369A (en) * 1986-05-02 1987-11-10 Nippon Soda Co Ltd Quinazolinone derivative and production thereof
EP0271287A3 (en) * 1986-12-11 1990-06-13 Merck Frosst Canada Inc. Quinoline dioic acids and amides
EP0318093A3 (en) * 1987-11-25 1990-12-05 Merck Frosst Canada Inc. Diarylquinoline diacids and their use as medicaments
EP0349062A1 (en) * 1988-06-27 1990-01-03 Merck Frosst Canada Inc. Quinoline ether alkanoic acid
NZ233752A (en) * 1989-05-24 1993-05-26 Merck Frosst Canada Inc Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
DE69113735T2 (en) 1996-06-13
FI914795L (en) 1992-04-13
CA2053208A1 (en) 1992-04-13
EP0480708B1 (en) 1995-10-11
IL99683A0 (en) 1992-08-18
FI914795A0 (en) 1991-10-11
ES2079586T3 (en) 1996-01-16
AU639612B2 (en) 1993-07-29
MX9101556A (en) 1994-01-31
PT99211A (en) 1992-09-30
JP2538154B2 (en) 1996-09-25
NO914003L (en) 1992-04-13
ATE128969T1 (en) 1995-10-15
CA2053208C (en) 2003-04-15
EP0480708A3 (en) 1992-05-20
FI914795A7 (en) 1992-04-13
ZA918115B (en) 1992-08-26
CN1061594A (en) 1992-06-03
IE913610A1 (en) 1992-04-22
KR920008005A (en) 1992-05-27
CS309491A3 (en) 1992-04-15
EP0480708A2 (en) 1992-04-15
HUT61982A (en) 1993-03-29
NO914003D0 (en) 1991-10-11
DE69113735D1 (en) 1995-11-16
JPH05105664A (en) 1993-04-27
AU8579791A (en) 1992-04-16
PT99211B (en) 1999-04-30

Similar Documents

Publication Publication Date Title
HU913217D0 (en) Process for the production of unsaturated hydroxy-alkyl-kinoline acids, and of medical preparations containing them
IL105193A0 (en) Fluorinated hydroxyalkylquinoline acids and pharmaceutical compositions containing them
IL100985A0 (en) Quinoline-containing ketoacids and pharmaceutical compositions containing them
HU913218D0 (en) Process for the production of hydroxy-alkyl-kinoline-ethers and of medical preparations containing them
PL309408A1 (en) Diaryl-5,6-condensed heterocyclic acids as leucotrenic antagonistic substances
MY107767A (en) Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists

Legal Events

Date Code Title Description
DFD9 Temporary protection cancelled due to non-payment of fee