[go: up one dir, main page]

HU900861D0 - Process for preparation of 2-(1-piperidinyl)-4-phenyl-cycloalkane-pyrimidine derivatives and producing pharmaceutical products comprising this compounds - Google Patents

Process for preparation of 2-(1-piperidinyl)-4-phenyl-cycloalkane-pyrimidine derivatives and producing pharmaceutical products comprising this compounds

Info

Publication number
HU900861D0
HU900861D0 HU90861A HU86190A HU900861D0 HU 900861 D0 HU900861 D0 HU 900861D0 HU 90861 A HU90861 A HU 90861A HU 86190 A HU86190 A HU 86190A HU 900861 D0 HU900861 D0 HU 900861D0
Authority
HU
Hungary
Prior art keywords
cycloalkane
piperidinyl
phenyl
compounds
preparation
Prior art date
Application number
HU90861A
Other languages
Hungarian (hu)
Other versions
HUT53098A (en
HU204815B (en
Inventor
Katsuhiko Hino
Naoki Kai
Masato Sakamoto
Tatsuya Kon
Makoto Oka
Kiyoshi Furukawa
Joshiaki Ochi
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Publication of HU900861D0 publication Critical patent/HU900861D0/en
Publication of HUT53098A publication Critical patent/HUT53098A/en
Publication of HU204815B publication Critical patent/HU204815B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU90861A 1989-02-21 1990-02-20 Process for producing 2-(1-piperazinyl)-4-phenyl-cycloalkanepyrimidine derivatives and pharmaceutical compositions comprising such compounds HU204815B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4072989 1989-02-21

Publications (3)

Publication Number Publication Date
HU900861D0 true HU900861D0 (en) 1990-05-28
HUT53098A HUT53098A (en) 1990-09-28
HU204815B HU204815B (en) 1992-02-28

Family

ID=12588717

Family Applications (1)

Application Number Title Priority Date Filing Date
HU90861A HU204815B (en) 1989-02-21 1990-02-20 Process for producing 2-(1-piperazinyl)-4-phenyl-cycloalkanepyrimidine derivatives and pharmaceutical compositions comprising such compounds

Country Status (9)

Country Link
US (1) US5041443A (en)
EP (2) EP0484988A1 (en)
KR (1) KR910015562A (en)
AU (1) AU622976B2 (en)
CA (1) CA2010477A1 (en)
DD (1) DD297819A5 (en)
FI (1) FI900833A7 (en)
HU (1) HU204815B (en)
NO (1) NO900795L (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007893A1 (en) * 1993-09-15 1995-03-23 Merck Sharp & Dohme Limited Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands
JP6067226B2 (en) 2009-03-13 2017-01-25 アジオス ファーマシューティカルズ， インコーポレイテッド Methods and compositions for cell proliferation related diseases
JP5856052B2 (en) 2009-06-29 2016-02-09 アジオス ファーマシューティカルズ， インコーポレイテッド Therapeutic compounds and compositions
CA2793835C (en) 2009-10-21 2021-07-20 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
CA2793836C (en) 2009-10-21 2020-03-24 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
PH12017501176B1 (en) 2011-05-03 2023-03-08 Agios Pharmaceuticals Inc Pyruvate kinase activators for use in therapy
CN102827073A (en) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 Therapeutically active compositions and application methods thereof
CN102827170A (en) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 Active treatment compositions and use method thereof
RS57401B1 (en) 2012-01-06 2018-09-28 Agios Pharmaceuticals Inc Therapeutically active compounds and their methods of use
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
NZ706999A (en) 2012-10-15 2018-12-21 Agios Pharmaceuticals Inc Inhibitors of mutant isocitrate dehydrogenase and therapeutical uses thereof
AU2014287121B2 (en) 2013-07-11 2018-11-15 Agios Pharmaceuticals, Inc. 2,4- or 4,6-diaminopyrimidine compounds as IDH2 mutants inhibitors for the treatment of cancer
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
WO2015003355A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
US9968595B2 (en) 2014-03-14 2018-05-15 Agios Pharmaceuticals, Inc. Pharmaceutical compositions of therapeutically active compounds
HUE063541T2 (en) 2015-06-11 2024-01-28 Agios Pharmaceuticals Inc Methods of using pyruvate kinase activators
IL258684B2 (en) 2015-10-15 2023-04-01 Agios Pharmaceuticals Inc Combination therapy comprising isocitrate dehydrogenase 1 (idh1) inhibitor for use in treating acute myelogenous leukemia (aml) characterized by the presence of a mutant allele of idh1
CN108697698B (en) 2015-10-15 2021-12-03 阿吉奥斯制药公司 Combination therapy for the treatment of malignant tumors
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
AU2022252182B2 (en) * 2021-03-29 2025-02-20 Gilead Sciences, Inc. Khk inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3305553A (en) * 1965-10-18 1967-02-21 Parke Davis & Co 2-aminoquinazoline derivatives
US3915976A (en) * 1972-09-01 1975-10-28 Sandoz Ag Substituted-4-phenyl-5h-cycloalkano(d)pyrimidines
US4133884A (en) * 1977-02-25 1979-01-09 Eli Lilly And Company Substituted pyrroloquinoxalinones and diones used in treating inflammation in warm blooded mammals
EP0022481A1 (en) * 1979-06-21 1981-01-21 Mitsubishi Yuka Pharmaceutical Co., Ltd. 5,6-Alkylenepyrimidine derivatives, processes for preparing the same and pharmaceutical compositions
DE3609596A1 (en) * 1986-03-21 1987-10-01 Hoechst Ag 2-AZOLYLMETHYL-2-ARYL-1,3-DIOXOLANE AND THE SALTS THEREOF, METHOD FOR THE PRODUCTION THEREOF, MEANS CONTAINING IT AND THEIR USE
JPS6442472A (en) * 1987-08-10 1989-02-14 Kanebo Ltd Quinazoline derivative, production thereof and brain function disorder improving agent containing said derivative as active ingredient
DE69010232T2 (en) * 1989-03-03 1994-12-01 Dainippon Pharmaceutical Co 2- (1-piperazinyl) -4-phenylcycloalkane pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them.

Also Published As

Publication number Publication date
AU622976B2 (en) 1992-04-30
US5041443A (en) 1991-08-20
HUT53098A (en) 1990-09-28
NO900795D0 (en) 1990-02-20
HU204815B (en) 1992-02-28
NO900795L (en) 1990-08-22
EP0484988A1 (en) 1992-05-13
CA2010477A1 (en) 1990-08-21
AU4912290A (en) 1990-08-30
DD297819A5 (en) 1992-01-23
FI900833A7 (en) 1990-08-22
FI900833A0 (en) 1990-02-20
EP0384228A1 (en) 1990-08-29
KR910015562A (en) 1991-09-30

Similar Documents

Publication Publication Date Title
HU900861D0 (en) Process for preparation of 2-(1-piperidinyl)-4-phenyl-cycloalkane-pyrimidine derivatives and producing pharmaceutical products comprising this compounds
HU905917D0 (en) Process for producing sulfinic and sulfonamidic derivatives of dioles and pharmaceutical preparatives containing these compounds
HU906006D0 (en) Process for the preparation of medical products
HUT58326A (en) Process for producing pipeidine derivatives and pharmaceutical compositions containing them
HU906501D0 (en) Process for producing pyrimidine derivatives and pharmaceutical preparatives containing these compounds
HUT53885A (en) Process for producing piridazinon derivatives of 2-hydroxy-n-propyl-amines and pharmaceutical compositions containing them
HU904169D0 (en) Process for producing new hetrazepines of paf-antagonistic effect and pharmaceutical preparations containing these compounds
HUT54129A (en) Process for producing thiazole derivatives and pharmaceutical compositions comprising same
HUT54139A (en) Process for producing n-heteroaryl-4-quinolineamine derivatives and pharmaceutical compositions comprising such compounds
HU903196D0 (en) Process for producing benzocycloalkane derivatives and pharmaceutical preparatives containing these compounds
HU907116D0 (en) Process for producing n-substituted derivatives and pharmaceutical preparatives containing these compounds
HUT56078A (en) Process for producing piridazine derivatives and pharmaceutical compositions containing them
HUT48869A (en) Process for producing indan derivatives and pharmaceutical compositions comprising same
HU904924D0 (en) Process for producing derivatives of human trombomoduline
HU900658D0 (en) Process for preparation of naphtaline derivatives
HU904594D0 (en) Process for producing chromane derivatives and pharmaceutical preparations containing these compounds
HUT54703A (en) Process for producing epypodophyllotoxin-altroside derivatives and pharmaceutical preparatives containing these compounds
HU907176D0 (en) Process for producing 3-amino-pyrrhole derivatives and pharmaceutical preparatives containing these compounds
HU904114D0 (en) Process for producing chromane derivatives and pharmaceutical preparatives containing these compounds
HU901382D0 (en) Process for preparation of indole derivatives and manufacturing of pharmaceutical compositions thereof
HU902047D0 (en) Process for the preparation of pharmaceutical product
HUT53620A (en) Process for producing new thiouracyl derivatives and pharmaceutical compositions comprising same
HUT55758A (en) Process for producing pyridine derivatives and pharmaceutical compositions comprising such compounds
HU906325D0 (en) Process for producing new penicillin derivatives and pharmaceutical preparatives containing these compounds
HUT54165A (en) Process for producing cefalosporin derivatives and pharmaceutical compositions comprising same

Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee