HU908122D0 - Process for producing nitrogen containing spirocycles - Google Patents
Process for producing nitrogen containing spirocyclesInfo
- Publication number
- HU908122D0 HU908122D0 HU908122A HU812290A HU908122D0 HU 908122 D0 HU908122 D0 HU 908122D0 HU 908122 A HU908122 A HU 908122A HU 812290 A HU812290 A HU 812290A HU 908122 D0 HU908122 D0 HU 908122D0
- Authority
- HU
- Hungary
- Prior art keywords
- spirocycles
- nitrogen containing
- producing nitrogen
- producing
- chem
- Prior art date
Links
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Fats And Perfumes (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Dental Preparations (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44795089A | 1989-12-08 | 1989-12-08 | |
| US61209190A | 1990-11-16 | 1990-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU908122D0 true HU908122D0 (en) | 1991-06-28 |
Family
ID=27035165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU908122A HU908122D0 (en) | 1989-12-08 | 1990-12-07 | Process for producing nitrogen containing spirocycles |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0431943B1 (hu) |
| JP (1) | JPH0747576B2 (hu) |
| KR (1) | KR910011859A (hu) |
| CN (2) | CN1053613A (hu) |
| AT (1) | ATE168377T1 (hu) |
| AU (2) | AU6787390A (hu) |
| CA (1) | CA2031633A1 (hu) |
| DE (1) | DE69032480T2 (hu) |
| ES (1) | ES2118715T3 (hu) |
| FI (1) | FI906045A7 (hu) |
| HU (1) | HU908122D0 (hu) |
| IE (1) | IE904430A1 (hu) |
| IL (1) | IL96507A0 (hu) |
| NO (1) | NO905306L (hu) |
| NZ (1) | NZ236315A (hu) |
| PT (1) | PT96126A (hu) |
| YU (1) | YU231790A (hu) |
Families Citing this family (69)
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| IE911192A1 (en) * | 1990-04-12 | 1991-10-23 | Merck & Co Inc | Substituted aromatic sulfonamides as antiglaucoma agents |
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| HUT72076A (en) * | 1992-12-11 | 1996-03-28 | Merck & Co Inc | Process for preparing spiro piperidines and homologs which promote release of growth hormone and pharmaceutical compositions containing them |
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| JPH08511522A (ja) * | 1993-06-07 | 1996-12-03 | メルク エンド カンパニー インコーポレーテッド | ニューロキニンアンタゴニストとしてのスピロ置換アザ環 |
| US5484923A (en) * | 1993-06-10 | 1996-01-16 | Merck & Co., Inc. | Process of making spirocycles and analogs thereof |
| US5439914A (en) * | 1994-02-18 | 1995-08-08 | Merck & Co., Inc. | Spirocycles |
| US5464788A (en) * | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| WO1995028389A1 (en) * | 1994-04-15 | 1995-10-26 | Yamanouchi Pharmaceutical Co., Ltd. | Spiro compound and medicinal composition thereof |
| US5434158A (en) * | 1994-04-26 | 1995-07-18 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin-3 antagonists |
| US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
| US5679706A (en) * | 1994-09-30 | 1997-10-21 | Bristol-Myers Squibb Company | Combination of a potassium channel activator and an antiarrhythmic agent |
| HUP9600928A3 (en) | 1996-04-10 | 1999-03-29 | Richter Gedeon Vegyeszet | Use of spiro[2h-1-benzopyran-2,4'-piperidin]-4(3h)-one derivatives for the preparation of pharmaceutical compositions treating dementia, novel derivatives and process for their preparation |
| US6156783A (en) * | 1996-04-30 | 2000-12-05 | Smithkline Beecham P.L.C. | Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use |
| US6110935A (en) * | 1997-02-13 | 2000-08-29 | The Regents Of The University Of California | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
| TW526195B (en) | 1997-06-10 | 2003-04-01 | Novartis Ag | Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use |
| US6013652A (en) * | 1997-12-04 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin antagonists |
| BR0011427A (pt) * | 1999-06-07 | 2002-03-26 | Warner Lambert Co | Analgésicos tricìclicos |
| SK822002A3 (en) * | 1999-07-21 | 2002-09-10 | Astrazeneca Ab | New compounds |
| MXPA02002283A (es) * | 1999-09-03 | 2002-07-30 | Asahi Chemical Ind | Proceso para preparar derivados triciclicos de amino alcoholes. |
| JPWO2003095427A1 (ja) * | 2002-05-10 | 2005-09-15 | 大正製薬株式会社 | スピロ環化合物 |
| EP1601674B1 (en) | 2002-09-09 | 2012-08-08 | Janssen Pharmaceutica NV | Hydroxyalkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
| BRPI0409078A (pt) | 2003-04-04 | 2006-04-18 | Merck & Co Inc | composto, métodos para o tratamento ou prevenção de distúrbios, doenças ou condições responsivas à ativação do receptor de melanocortina-4, para o tratamento ou prevenção de obesidade, para o tratamento ou prevenção de um distúrbio relacionado com a obesidade, para o tratamento ou prevenção de diabete melito, para o tratamento ou prevenção da disfunção sexual masculina ou feminina e para o tratamento ou prevenção de disfunção erétil, composição farmacêutica, métodos para o tratamento de disfução erétil em um mamìfero, para o tratamento de diabete em um mamìfero e para o tratamento de obesidade em um mamìfero, e, uso de um composto |
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| US20060079566A1 (en) | 2003-10-03 | 2006-04-13 | Ching-Shih Chen | PDK-1/Akt signaling inhibitors |
| BRPI0509307A (pt) | 2004-03-29 | 2007-09-04 | Pfizer | compostos de alfa aril ou heteroaril metil beta piperidino propanamida como antagonistas do receptor orl1 |
| SE0401539D0 (sv) * | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
| PT1781619E (pt) | 2004-08-27 | 2011-11-04 | Esteve Labor Dr | Inibidores do recetor sigma |
| PT1781618E (pt) | 2004-08-27 | 2012-12-18 | Esteve Labor Dr | Inibidores do receptor sigma |
| EP1634873A1 (en) | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
| EP1781618B1 (en) | 2004-08-27 | 2012-10-03 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
| AU2006252781A1 (en) * | 2005-06-02 | 2006-12-07 | Janssen Pharmaceutica, N.V. | Novel 3-spirocyclic indolyl derivatives useful as ORL-1 receptor modulators |
| CA2614963C (en) * | 2005-07-19 | 2014-10-07 | Merck & Co., Inc. | Spirochromanone derivatives as acetyl coenzyme a carboxylase (acc) inhibitors |
| AR057570A1 (es) | 2005-11-14 | 2007-12-05 | Solvay Pharm Gmbh | Derivados de n-sulfamoil-n'-benzopiranopiperidinas espirocondensadas, composiciones farmaceuticas que los comprenden, un procedimiento para su preparacion y su uso en la preparacion de medicamentos para el tratamiento de enfermedades mediadas por las isoenzimas anhidrasas carbonicas subtipos ii y/o |
| WO2007063385A2 (en) * | 2005-12-01 | 2007-06-07 | Pfizer Products Inc. | Spirocyclic amine histamine-3 receptor antagonists |
| EP1829875A1 (en) | 2006-03-01 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Pyrazole derivatives as sigma receptor inhibitors |
| EP1829866A1 (en) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
| EP1829867A1 (en) | 2006-03-03 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Imidazole compounds having pharmaceutical activity towards the sigma receptor |
| CA2670422C (en) * | 2006-11-29 | 2011-09-06 | Pfizer Products Inc. | Spiroketone acetyl-coa carboxylase inhibitors |
| AU2008205642B2 (en) * | 2007-01-12 | 2013-06-06 | Msd K.K. | Spirochromanon derivatives |
| PE20081559A1 (es) * | 2007-01-12 | 2008-11-20 | Merck & Co Inc | DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA |
| CN101679430B (zh) | 2007-04-09 | 2013-12-25 | 詹森药业有限公司 | 用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物 |
| EP2160187B1 (en) * | 2007-05-16 | 2013-05-22 | Merck Sharp & Dohme Corp. | Spiroindalones |
| US8039502B2 (en) | 2007-07-24 | 2011-10-18 | The Ohio State University Research Foundation | Anti-infective agents against intracellular pathogens |
| CN102016590A (zh) * | 2008-02-28 | 2011-04-13 | 生命技术公司 | 荧光偏振hERG试验 |
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| US10412788B2 (en) | 2008-06-13 | 2019-09-10 | Lg Chem, Ltd. | Heating element and manufacturing method thereof |
| US20120108823A1 (en) | 2009-04-22 | 2012-05-03 | The Ohio State University Research Foundation | Anti-francisella agents |
| UA107943C2 (xx) | 2009-11-16 | 2015-03-10 | Lilly Co Eli | Сполуки спіропіперидину як антагоністи рецептора orl-1 |
| EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
| EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
| WO2011140425A1 (en) | 2010-05-06 | 2011-11-10 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
| EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2395003A1 (en) | 2010-05-27 | 2011-12-14 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazole compounds as sigma receptor inhibitors |
| TWI543984B (zh) | 2010-07-09 | 2016-08-01 | 艾伯維公司 | 作為s1p調節劑的螺-哌啶衍生物 |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| AR085893A1 (es) | 2011-02-02 | 2013-11-06 | Vertex Pharma | Pirrolopirazina-amidas de piperidina espirociclica como moduladores de los canales ionicos |
| CA2827311A1 (en) | 2011-02-18 | 2012-08-23 | Vertex Pharmaceuticals Incorporated | Chroman-spirocyclic piperidine amides as modulators of ion channels |
| US8828996B2 (en) | 2011-03-14 | 2014-09-09 | Vertex Pharmaceuticals Incorporated | Morpholine-spirocyclic piperidine amides as modulators of ion channels |
| EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
| CA2899957A1 (en) * | 2013-02-04 | 2014-08-07 | Merck Patent Gmbh | Spiro-quinazolinone derivatives useful for the treatment of neurological diseases and conditions |
| CN105873578A (zh) | 2013-12-17 | 2016-08-17 | 埃斯蒂维实验室股份有限公司 | 血清素-去甲肾上腺素再摄取抑制剂(SNRIs)和σ受体配体组合物 |
| WO2018108627A1 (de) | 2016-12-12 | 2018-06-21 | Bayer Cropscience Aktiengesellschaft | Verwendung substituierter indolinylmethylsulfonamide oder deren salze zur steigerung der stresstoleranz in pflanzen |
| CN108752360B (zh) * | 2018-04-12 | 2019-10-29 | 牡丹江医学院 | 一种治疗小儿腹泻的化合物及其制备方法 |
| JP7349491B2 (ja) | 2018-07-12 | 2023-09-22 | ユーシービー バイオファルマ エスアールエル | Il-17モジュレーターとしてのスピロ環状インダン類似体 |
| CA3159378A1 (en) | 2019-10-31 | 2021-05-06 | ESCAPE Bio, Inc. | Solid forms of an s1p-receptor modulator |
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|---|---|---|---|---|
| US3301857A (en) | 1963-08-26 | 1967-01-31 | Hoffmann La Roche | Spiro |
| US3649635A (en) * | 1969-10-24 | 1972-03-14 | Warner Lambert Co | Spiropyranopyridines |
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| JPS4867287A (hu) * | 1971-12-20 | 1973-09-13 | ||
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| DE3308554A1 (de) * | 1983-03-10 | 1984-09-13 | Hoechst Ag, 6230 Frankfurt | 1-/1,3-dioxolan-2-ylmethyl)-azole, ihre salze, verfahren zu ihrer herstellung und ihre verwendung |
| DK139684A (da) * | 1983-04-11 | 1984-10-12 | Janssen Pharmaceutica Nv | N-aryl-alpha-amino-carboxamider |
| US4452802A (en) | 1983-08-25 | 1984-06-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Antihypertensive spiro[benzofuran-azalkanes] |
| JPS60158190A (ja) * | 1984-01-30 | 1985-08-19 | Eisai Co Ltd | ヒダントイン誘導体およびその製法ならびにそれを含有する医薬 |
-
1990
- 1990-11-29 IL IL96507A patent/IL96507A0/xx unknown
- 1990-12-03 NZ NZ236315A patent/NZ236315A/en unknown
- 1990-12-06 CA CA002031633A patent/CA2031633A1/en not_active Abandoned
- 1990-12-06 AT AT90313262T patent/ATE168377T1/de not_active IP Right Cessation
- 1990-12-06 DE DE69032480T patent/DE69032480T2/de not_active Expired - Fee Related
- 1990-12-06 EP EP90313262A patent/EP0431943B1/en not_active Expired - Lifetime
- 1990-12-06 ES ES90313262T patent/ES2118715T3/es not_active Expired - Lifetime
- 1990-12-07 CN CN90110421A patent/CN1053613A/zh active Pending
- 1990-12-07 FI FI906045A patent/FI906045A7/fi not_active Application Discontinuation
- 1990-12-07 PT PT96126A patent/PT96126A/pt unknown
- 1990-12-07 HU HU908122A patent/HU908122D0/hu unknown
- 1990-12-07 YU YU231790A patent/YU231790A/sh unknown
- 1990-12-07 AU AU67873/90A patent/AU6787390A/en not_active Abandoned
- 1990-12-07 JP JP2419271A patent/JPH0747576B2/ja not_active Expired - Lifetime
- 1990-12-07 KR KR1019900020064A patent/KR910011859A/ko not_active Ceased
- 1990-12-07 NO NO90905306A patent/NO905306L/no unknown
- 1990-12-07 IE IE443090A patent/IE904430A1/en unknown
-
1994
- 1994-05-24 AU AU63297/94A patent/AU6329794A/en not_active Abandoned
-
1995
- 1995-01-06 CN CN95100709A patent/CN1110685A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NO905306L (no) | 1991-06-10 |
| FI906045A0 (fi) | 1990-12-07 |
| NZ236315A (en) | 1994-09-27 |
| FI906045L (fi) | 1991-06-09 |
| CA2031633A1 (en) | 1991-06-09 |
| PT96126A (pt) | 1991-09-30 |
| YU231790A (sh) | 1993-05-28 |
| IE904430A1 (en) | 1991-06-19 |
| CN1110685A (zh) | 1995-10-25 |
| AU6787390A (en) | 1991-06-13 |
| CN1053613A (zh) | 1991-08-07 |
| EP0431943B1 (en) | 1998-07-15 |
| IL96507A0 (en) | 1991-08-16 |
| JPH04217960A (ja) | 1992-08-07 |
| EP0431943A3 (en) | 1992-03-25 |
| JPH0747576B2 (ja) | 1995-05-24 |
| DE69032480D1 (de) | 1998-08-20 |
| KR910011859A (ko) | 1991-08-07 |
| DE69032480T2 (de) | 1999-05-06 |
| FI906045A7 (fi) | 1991-06-09 |
| ES2118715T3 (es) | 1998-10-01 |
| NO905306D0 (no) | 1990-12-07 |
| EP0431943A2 (en) | 1991-06-12 |
| AU6329794A (en) | 1994-07-21 |
| ATE168377T1 (de) | 1998-08-15 |
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