[go: up one dir, main page]

HU210815A9 - Therapeutic nucleosides - Google Patents

Therapeutic nucleosides

Info

Publication number
HU210815A9
HU210815A9 HU95P/P00072P HU9500072P HU210815A9 HU 210815 A9 HU210815 A9 HU 210815A9 HU 9500072 P HU9500072 P HU 9500072P HU 210815 A9 HU210815 A9 HU 210815A9
Authority
HU
Hungary
Prior art keywords
therapeutic nucleosides
nucleosides
therapeutic
Prior art date
Application number
HU95P/P00072P
Other languages
English (en)
Inventor
Lilia Maria Beuchamp
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10622363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HU210815(A9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of HU210815A9 publication Critical patent/HU210815A9/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU95P/P00072P 1987-08-15 1995-02-07 Therapeutic nucleosides HU210815A9 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878719367A GB8719367D0 (en) 1987-08-15 1987-08-15 Therapeutic compounds

Publications (1)

Publication Number Publication Date
HU210815A9 true HU210815A9 (en) 1995-08-28

Family

ID=10622363

Family Applications (1)

Application Number Title Priority Date Filing Date
HU95P/P00072P HU210815A9 (en) 1987-08-15 1995-02-07 Therapeutic nucleosides

Country Status (13)

Country Link
US (1) US4957924A (hu)
AP (1) AP9000238A0 (hu)
AT (1) ATE116648T1 (hu)
CA (1) CA1340083C (hu)
DD (1) DD282229A5 (hu)
DE (2) DE19575021I2 (hu)
ES (1) ES2065914T3 (hu)
GB (1) GB8719367D0 (hu)
HK (1) HK39595A (hu)
HU (1) HU210815A9 (hu)
LT (1) LT2063B (hu)
PH (2) PH29942A (hu)
ZA (1) ZA885995B (hu)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) * 1909-10-07 2002-10-01 Medivir Ab Prodrugs
GB8725939D0 (en) * 1987-11-05 1987-12-09 Wellcome Found Therapeutic compounds
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
US5677308A (en) * 1996-12-19 1997-10-14 Lerner; A. Martin Method for alleviating spasmodic torticollis
US6399622B1 (en) 1997-02-18 2002-06-04 A. Martin Lerner Method for diagnosing and alleviating the symptoms of chronic fatigue syndrome
US5872123A (en) * 1997-02-18 1999-02-16 Lerner; A. Martin Method for diagnosing and alleviating the symptoms of chronic fatigue syndrome
US6537997B1 (en) 1997-02-18 2003-03-25 A. Martin Lerner Method for diagnosing and alleviating the symptoms of chronic fatigue syndrome
CN1130362C (zh) * 1997-08-15 2003-12-10 美迪维尔公司 核苷类似物,这些化合物作为包括乙型肝炎病毒(hbv)的逆转录病毒的逆转录酶及dna聚合酶抑制剂的抗病毒药
US20020128301A1 (en) * 1998-02-13 2002-09-12 Medivir AB Non-nucleoside reverse transcriptase inhibitors
US6444652B1 (en) 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
SG132498A1 (en) 1998-08-10 2007-06-28 Idenix Pharmaceuticals Inc Beta-l-2æ-deoxy-nucleosides for the treatment of hepatitis b
US6107303A (en) * 1999-03-15 2000-08-22 Demarco; Charlene C. Treatment of Epstein Barr infection
US6448256B1 (en) 1999-05-24 2002-09-10 University Of Massachusetts Antibiotic prodrugs
GB0010446D0 (en) * 2000-04-28 2000-06-14 Glaxo Wellcome Kk Pharmaceutical formulation
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
NZ547204A (en) 2000-05-26 2008-01-31 Idenix Cayman Ltd Methods and compositions for treating flaviviruses and pestiviruses
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en) * 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
US20030212051A1 (en) * 2001-04-06 2003-11-13 Polli James E Bile acid containing prodrugs with enhanced bioavailabilty
CA2457835A1 (en) * 2001-09-07 2003-03-20 Teva Pharmaceutical Industries Ltd. Crystalline forms of valacyclovir hydrochloride
US7138376B2 (en) * 2001-09-28 2006-11-21 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
US20040197396A1 (en) * 2001-11-05 2004-10-07 Fain Helen S Anhydrous crystal form of valaciclovir hydrochloride
CN1307177C (zh) 2001-11-14 2007-03-28 特瓦制药工业有限公司 伐昔洛韦的合成与纯化
JP2005519916A (ja) * 2001-12-14 2005-07-07 フアーマセツト・リミテツド ウィルス感染治療用n4−アシルシトシンヌクレオシド類
CA2470938A1 (en) * 2001-12-20 2003-07-03 Raymond F. Schinazi Treatment of ebv and khsv infection and associated abnormal cellular proliferation
SE521676C2 (sv) * 2002-01-02 2003-11-25 Dilafor Ab Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet
NZ534811A (en) * 2002-02-14 2007-07-27 Pharmasset Inc Modified fluorinated nucleoside analogues
AU2003217676B2 (en) 2002-02-22 2009-06-11 Takeda Pharmaceutical Company Limited Active agent delivery systems and methods for protecting and administering active agents
AU2003240213A1 (en) * 2002-06-24 2004-01-06 Ranbaxy Laboratories Limited Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
MY140819A (en) 2002-06-28 2010-01-29 Idenix Caymans Ltd Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae
AU2003248748A1 (en) 2002-06-28 2004-01-19 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
AU2003263412A1 (en) 2002-06-28 2004-01-19 Centre National De La Recherche Scientifique (Cnrs) 1'-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
TWI244393B (en) 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
BR0314259A (pt) * 2002-09-13 2005-07-26 Idenix Cayman Ltd ß-l-2'-desoxinucleosìdeos para o tratamento de cepas de hbv resistentes e terapias combinadas
WO2004035583A1 (en) * 2002-10-16 2004-04-29 Teva Pharmaceutical Industries Ltd. Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
CN1319972C (zh) * 2002-10-16 2007-06-06 特瓦制药工业有限公司 在盐酸伐昔洛韦结晶中减少残留醇类物质的方法
US20050059684A1 (en) * 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
EP1575953A1 (en) * 2002-12-09 2005-09-21 Texcontor Etablissement Anhydrous crystalline form of valacyclovir hydrochloride
AU2003296601A1 (en) * 2002-12-10 2004-06-30 F. Hoffmann-La Roche Ag Antiviral nucleoside derivatives
KR20050109918A (ko) 2002-12-12 2005-11-22 이데닉스 (케이만) 리미티드 2'-분지형 뉴클레오시드의 제조 방법
NZ540913A (en) * 2002-12-23 2008-02-29 Idenix Cayman Ltd Process for the production of 3'-nucleoside prodrugs
AU2004206821C1 (en) 2003-01-14 2009-10-01 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
US7582748B2 (en) * 2003-03-20 2009-09-01 Microbiologica Quimica E Farmaceutical Ltd. Methods of manufacture of 2′-deoxy-β-L-nucleosides
WO2004096149A2 (en) * 2003-04-28 2004-11-11 Idenix (Cayman) Limited Industrially scalable nucleoside synthesis
AU2003232719A1 (en) * 2003-05-30 2005-01-21 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Novel crystalline forms of valacyclovir hydrochloride
CA2734052A1 (en) 2003-05-30 2005-01-13 Pharmasset, Inc. Modified fluorinated nucleoside analogues
WO2005000850A2 (en) 2003-06-02 2005-01-06 Teva Pharmaceutical Industries, Ltd. Novel crystalline forms of valacyclovir hydrochloride
RU2361875C2 (ru) * 2003-06-30 2009-07-20 Айденикс (Кайман) Лимитед СИНТЕЗ β-L-2'-ДЕЗОКСИНУКЛЕОЗИДОВ
US20050025839A1 (en) * 2003-07-28 2005-02-03 Polli James Edward Formulation approach to enhance transporter-mediated drug uptake
US20050137141A1 (en) * 2003-10-24 2005-06-23 John Hilfinger Prodrug composition
US20070167353A1 (en) * 2003-10-24 2007-07-19 John Hilfinger Prodrug composition
US7253175B2 (en) * 2003-11-13 2007-08-07 Barnet Liberman Method for treating athlete's foot
CN1980657A (zh) 2004-05-05 2007-06-13 耶鲁大学 新颖的抗病毒赛菊宁黄质类似物
BRPI0512360A (pt) * 2004-06-23 2008-03-11 Idenix Cayman Ltd derivados de 5-aza-7-deazapurina para o tratamento de flaviviridae
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
JP2007513074A (ja) * 2004-09-04 2007-05-24 テバ ファーマシューティカル インダストリーズ リミティド 単離されたバラシクロビル不純物、バラシクロビル不純物の調製方法および参照標準としての使用
BRPI0515279A (pt) 2004-09-14 2008-07-15 Pharmasset Inc preparação de ribofuranosil pirimidinas e purinas 2'fluoro-2'-alquil- substituìdas ou outras opcionalmente substituìdas e seus derivados
US20060178512A1 (en) * 2005-02-04 2006-08-10 Cheruthur Govindan Method for preparing amino acid esters of nucleoside analogues
WO2006127217A2 (en) 2005-05-25 2006-11-30 Eli Lilly And Company Cyclopropanecarboxylate esters of acyclovir
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) * 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
EP1746098A1 (en) * 2005-07-21 2007-01-24 SOLMAG S.p.A. Valacyclovir polymorphs and a process for the preparation thereof
US20070112193A1 (en) * 2005-11-14 2007-05-17 Khunt Mayur D Valacyclovir process
WO2007075876A2 (en) 2005-12-23 2007-07-05 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
GB0605344D0 (en) * 2006-03-17 2006-04-26 Pliva Istrazivanje I Razvoj D Pharmaceutically acceptable salts and polymorphic forms
EP2068906B1 (en) 2006-09-19 2012-08-01 Sungkyunkwan University Foundation for Corporate Collaboration Antiviral agent against animal viruses
US20080167325A1 (en) * 2006-12-27 2008-07-10 Bs Praveen Kumar Valacyclovir compositions
WO2008089008A2 (en) * 2007-01-12 2008-07-24 Biomarin Pharmaceutical Inc. Tetrahydrobiopterin prodrugs
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US20080281099A1 (en) * 2007-05-07 2008-11-13 Mayur Devjibhai Khunt Process for purifying valacyclovir hydrochloride and intermediates thereof
US20090076039A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched valacyclovir
CN101969953B (zh) * 2008-01-03 2013-01-09 生物马林药物股份有限公司 用于治疗bh4反应性疾病的喋呤类似物
TW200946541A (en) * 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
US20110059921A1 (en) * 2008-03-27 2011-03-10 Ektar Therapeutics Oligomer-Nitrogenous Base Conjugates
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US8716262B2 (en) * 2008-12-23 2014-05-06 Gilead Pharmasset Llc Nucleoside phosphoramidates
EP2376514A2 (en) * 2008-12-23 2011-10-19 Pharmasset, Inc. Nucleoside analogs
WO2010075554A1 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Synthesis of purine nucleosides
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI583692B (zh) * 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 核苷磷醯胺
RS54368B1 (sr) 2010-03-31 2016-04-28 Gilead Pharmasset Llc Kristalni (s)-izopropil 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-diokso-3,4-dihidropirimidin-1-(2h)-il)-4-fluoro-3-hidroksi-4-metiltetrahidrofuran-2-il)metoksi)(fenoksi)fosforil)amino)propanoat
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
CA2818853A1 (en) 2010-11-30 2012-06-07 Gilead Pharmasset Llc 2'-spirocyclo-nucleosides for use in therapy of hcv or dengue virus
CN102584825B (zh) * 2011-01-17 2014-04-02 四川科伦药物研究有限公司 一种合成盐酸伐昔洛韦的方法
WO2013076688A1 (en) * 2011-11-25 2013-05-30 Piramal Enterprises Limited A process for the preparation of valacyclovir hydrochloride
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US20140100238A1 (en) 2012-10-04 2014-04-10 Ohio State University Method of diagnosing and treating epstein barr virus-based myalgic encephalomyelitis chronic fatigue syndrome patients
US20140213600A1 (en) * 2013-01-29 2014-07-31 Lily Hsiao Medicament for treating peripheral neuropathies
TW201429475A (zh) * 2013-01-29 2014-08-01 Li-Ly Hsiao 使用抗病毒藥治療末稍神經病變之疾病
SG11201600919UA (en) 2013-08-27 2016-03-30 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
CN115745997A (zh) * 2022-11-30 2023-03-07 湖北省宏源药业科技股份有限公司 一种高纯度伐昔洛韦杂质h制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
GB1561380A (en) * 1976-03-01 1980-02-20 Wellcome Found Esters of hydroxyalkoxyalkyl purines their preparation and pharmaceutical compositions containing them
US4287188A (en) * 1977-02-24 1981-09-01 Burroughs Wellcome Co. Purine derivatives
US4457919A (en) * 1980-03-14 1984-07-03 Newport Pharmaceutical International, Inc. Method of imparting immunomodulating, antiviral or antitumor activity
AU564576B2 (en) * 1981-09-24 1987-08-20 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Purine derivatives
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
US4695570A (en) * 1982-10-14 1987-09-22 Burroughs Wellcome Co. Antiviral compound use
US4745119A (en) * 1982-10-14 1988-05-17 Burroughs Wellcome Co. Method for using purine derivatives

Also Published As

Publication number Publication date
PH29942A (en) 1996-09-16
LT2063B (lt) 1993-06-15
ZA885995B (en) 1990-04-25
DE3852682D1 (de) 1995-02-16
CA1340083C (en) 1998-10-13
HK39595A (en) 1995-03-24
DD282229A5 (de) 1990-09-05
AP9000238A0 (en) 1991-01-31
DE3852682T2 (de) 1995-06-22
PH29943A (en) 1996-09-16
DE19575021I2 (de) 2003-05-22
GB8719367D0 (en) 1987-09-23
ES2065914T3 (es) 1995-03-01
ATE116648T1 (de) 1995-01-15
US4957924A (en) 1990-09-18

Similar Documents

Publication Publication Date Title
HU210815A9 (en) Therapeutic nucleosides
EP0308065A3 (en) Therapeutic nucleosides
CY2018A (en) Therapeutic nucleosides
ZA9010365B (en) Therapeutic nucleosides
EP0286425A3 (en) Therapeutic nucleosides
EP0356166A3 (en) Therapeutic nucleosides
EP0287215A3 (en) Therapeutic nucleosides
ZA881842B (en) Therapeutic nucleosides
GB8712691D0 (en) Therapeutic nucleosides
GB8823353D0 (en) Therapeutic nucleosides
GB8912972D0 (en) Therapeutic nucleosides
PH29941A (en) Therapeutic nucleosides
ZA882477B (en) Therapeutic nucleosides
GB8723793D0 (en) Therapeutic nucleosides
GB8723747D0 (en) Therapeutic nucleosides
GB8723746D0 (en) Therapeutic nucleosides
GB8723013D0 (en) Therapeutic nucleosides
IE862454L (en) therapeutic nucleosides
IE861273L (en) Therapeutic nucleosides
IE880748L (en) Therapeutic nucleosides
GB8819732D0 (en) Therapeutic nucleosides
GB8824899D0 (en) Therapeutic nucleosides
GB8816284D0 (en) Therapeutic nucleosides
IE883328L (en) Therapeutic nucleosides
IE881047L (en) Therapeutic nucleosides