HU203973B - Process for producing medicinal ointment composition suitable for treating diseases of hoof and ulcerous, inflamed wounds - Google Patents

Abstract

The present invention relates to a method for the production of a therapeutic ointment composition for the treatment of pancreatic and patella disorders and ulcerative inflammatory wounds. According to the present invention, a propolis extract of 1.50000 to 22000 IU of vitamin A per 1.5 g of dry matter, 0.9 to 1.1 g of acriflavin, 8 to 22 g of zinc oxide, 9 to 35 g of pharmaceutically acceptable is acceptable. with vegetable oil or mineral oil, preferably castor oil, linseed oil, sunflower oil, paraffin oil, or any mixture thereof, and 0-0.11 g of borax, and ointment prepared with the usual excipients, excipients, emulsifiers, antioxidants and / or preservatives. The medicated ointment composition obtainable by the method of the invention can be used to cure the listed ghosts in a short time. The composition is particularly advantageous for the treatment of larger wounds. Scope of the description: 4 pages EN 203 973 A -1-

Description

FIELD OF THE INVENTION The present invention relates to a process for the preparation of a medicated ointment for the treatment of foot and hoof diseases, in particular sheep stink, cattle foot ulcer, porcine ragweed and ulcerative inflammatory wounds.

The lameness of sheep caused by a disorder around the knuckle was first described by Chabert in 1791, followed by Tátray (1890), Hasenkamp (1909), Aynand (1921), Berrár (1927), Marék, Manninger and Mócsy (1945). Oláh (1953), Kovács (1968), etc. they dealt with the pathology, symptoms, prevention and treatment of the disease. The pathophysiological studies of stinking lameness have been ongoing for decades, yet the etiology of the disease has not been satisfactorily clarified. However, all researchers agree that other pathogens they have identified (Sperophonis necrophorus, Bang necrobacillus, virus, Fusifomvis nodosus, Corynebacterium pyogenes, Bacteroides nodosus, etc.) play a role in the development of the disease. Meteorological conditions (precipitation, temperature), neglect of knuckle care, inadequate littering, lack of training, disease introduction, malnutrition (vitamin A and C, low calcium, primary or secondary trace elements) permanently damp (loose) hamstrings, yellow ball wedged in the cilia, overly dry hernia, blockage of the nail opening, etc. The development of the disorder usually takes longer and is polyfactorial in origin.

To date, this disease has been treated with preparations containing zinc and copper, most often their sulfates, and my forms. Known formulations have the disadvantage that they do not adhere well, have a relatively short duration of action, do not form a film-like coating on the damaged surface, and thus allow further bacterial activity. Due to poor adhesion, an attempt was made to use a bandage, but this did not result in a free surface for evaporation of the badly damaged parts.

Similar problems are encountered in porcine ragweed, so far no satisfactory therapy for this disease has been developed.

According to the current knowledge, the treatment of bovine foot ulcers is possible only with surface treatment with bandage. Of course, this type of treatment on a large scale cannot be considered.

Attempts have been made to use antibiotics to treat all the diseases listed. The active compounds are applied as ointments or solutions to the diseased surface. The attempts were unsuccessful because of litter and other infectious conditions that developed antibiotic resistance in a very short time.

It is also known to use iodine tincture for the treatment of these diseases, which is based on the disinfectant effect of this drug. However, the use of iodine tincture is limited by iodine sensitivity, which often results in an allergy to this drug.

Thus, for the treatment of the listed foot and foot disorders and ulcerative inflammatory wounds, a composition is required which provides an easily applied, risk-free and satisfactory effect on the treated surface.

It is an object of the present invention to provide a process for preparing such a composition.

SUMMARY OF THE INVENTION It is an object of the present invention to provide a process for the preparation of a composition which primarily heals larger wounds.

It has been found that the combination of propolis extract with vitamin A, acriflavin and zinc oxide in appropriate proportions and the addition of the above active ingredients with pharmaceutically acceptable vegetable or mineral oils and optionally borax provides a composition that satisfies the above requirements.

Based on this discovery, the present invention provides a process for preparing propolis extract as a dry substance

Per 1.5 g, 80000-220000 IU of vitamin A, 0.9-1.1 g of acriflavin, 8-22 g of zinc oxide, 9-35 g of a pharmaceutically acceptable vegetable or mineral oil, preferably castor oil, linseed oil, sunflower oil, paraffin oil or any mixture thereof and 0 to 0.11 g of borax and adjuvants, adjuvants, emulsifiers, antioxidants and / or preservatives conventional in ointment preparation.

Propolis extract in the context of the present invention is understood to mean an extract of organic or inorganic solvent extracted from crude propolis collected by beekeepers and then evaporated in vacuo, which may be a dry extract or a extract having a different density. For the preparation of the extract, the extraction agent may be, for example, ethyl alcohol 70% or more concentrated, and a two or more component solvent mixture of ethyl alcohol, methyl alcohol, dichloromethane, dichloroethane, diethyl ether, petroleum ether, acetone and acetic acid. Thus, for example, the propolis can be extracted with a 1: 1 mixture of petroleum ether and diethyl ether or a 1: 1 mixture of methyl alcohol and water. As the inorganic extractant, water or an alkali such as ammonium hydroxide may be used. Propolis extract has anti-inflammatory, anesthetic, antibacterial and antiviral properties.

The propolis extract used is preferably the extract produced and marketed by the Finontvegszer-Hungaronektár Cooperative with a dry matter content of about 50% and a total polyphenol content of about 38%. However, other extracts may also be used, for example, propolis extract which has been evaporated to dryness and has a substantially dry content of 100%.

For propolis extract, its dry matter content

Based on 1.5 g, 80000-220000 IU Vitamin A is administered in a pharmaceutical formulation such as Vitamin A acetate concentrate. This active ingredient promotes skin formation.

It is also the dry matter of the propolis extract

For each 1.5 g, 0.9-1.1 g of acriflavin is also added to the composition. This is the active ingredient in the propolis extract

Together, it has an optimal antibacterial effect for the therapeutic purposes mentioned in the introduction.

As further active ingredients, 8 to 22 g of zinc oxide per 1.5 g of dry matter of the propolis extract are added to the composition. It has a mild antiseptic effect and a wound-drying effect to help heal the treated areas.

The above active ingredients are supplemented with 9 to 35 g of a pharmaceutically acceptable vegetable or mineral oil, preferably castor oil, linseed oil, sunflower oil or paraffin oil, per 1.5 g of dry matter of the propolis extract. Preferably, a mixture of several oils is used. These oils inhibit the progress of the inflammatory process and promote the action of propolis extract and acriflavin.

If desired, the dry matter of the propolis extract

An amount of borax up to 0.11 g per 1.5 g is added to the above components of the composition. It has an antiseptic effect as well as an emulsifying effect.

The aforementioned components are formulated with ointments, excipients, emulsifiers, antioxidants and preservatives conventional in ointment preparation. The carrier is preferably white petroleum jelly. As an excipient, a emollient such as lanolin or a tackifier may be added, preferably white beeswax. Emulsifiers which may be used are any conventional emulsifier, such as polyoxyethylene solybitan monooleate (Tween 80). Preferably the antioxidant is butylhydroxytoluene and the preservative is preferably methyl paraoxybenzoate.

The composition is prepared by simply mixing the ingredients. Preferably, the harder fat-like components are melted by gentle heating and then mixed with the oil components. The propolis extract and vitamin A are dissolved in one of these before mixing. The water-soluble components are dissolved in a little water, if necessary with stirring and gentle heating, and the solution is mixed with the acriflavine in the oily components. The pH of the aqueous shake of the finished composition is checked and, if necessary, adjusted to the desired pH of about 6.5-7.5 with a dilute acid or base.

The ointment thus prepared can be used very effectively to cure foot and foot disorders and ulcerative inflammatory wounds. The composition is particularly preferred for the treatment of larger wounds.

The ointment composition of the present invention has analgesic, anti-inflammatory, ulcer and wound healing and epithelial properties.

After stinging a knuckle of a stinky lump of sheep, it heals the rudimentary forms of panarithium after 2 treatments. During treatment, animals should be kept on dry soil (litter), but no limb cover is required. Similar results can be achieved in the treatment of other hamstrings and hoof diseases.

The invention is illustrated by the following examples.

Example 1

An ointment is prepared according to the following examples. Propolis extract (Product of the Fine-Hungaronectar Cooperative, dry matter storage:

50%, total polyphenol content: 38%) 3.0 g

Vitamin A (Vitamin A Acetate Conc. Oil 10000000-100mg) 100,000 IU

Zinc oxide 15.00g

Sunflower oil 10.00 g

Wool fat (lanolin) 15.00 g

White beeswax 3.00 g

Cetyl alcohol 1.00 g

Butylhydroxytoluene 0.01 g

Borax 0.10 g

Acriflavin 1.00 g

Distilled water 20.00 g

Methyl paraoxybenzoate 0.10 g

White petroleum jelly gives 100.00 g

The pH of the aqueous ointment ointment should be between 6.5 and 7.5.

The propolis extract and vitamin A are fused with wool fat at 50-55 ° C. The zinc oxide is rubbed with sunflower oil heated to 40 ° C. The white beeswax, cetyl alcohol, butylhydroxytoluene oil and white petroleum jelly are thawed at 75-80 ° C, and after cooling at 40-45 ° C are added to the sunflower oil and zinc oxide suspension. Then add propolis and vitamin A in wool grease.

Dissolve borax in 60 ml of water at 60-65 ° C and then cool to 40 ° C and mix with the oily phase. Dissolve methyl paraoxybenzoate in 10 ml of water at 80 ° C, sprinkle with acriflavin at 40 ° C after cooling, and mix with ointment at 30 ° C. The ointment is stirred until cool. Check the pH of the aqueous ripple. Adjust the pH with 0.1 M citric acid and 0.1 M sodium hydroxide.

Example 2

Propolis extract (dry substance content: 50%, total polyphenol content: 38%) 3.00 g

Vitamin A (Vitamin A acetate conc. Oil

200,000 IU = 200 mg) 200,000 IU

Zinc oxide 10.00 g

Sunflower oil 10.00 g

Castor oil 10.00 g

Linseed oil 10.00 g

Wool fat (lanolin) 10.00 g

Butylhydroxytoluene 0.02 g

White beeswax 1.00 g

Cetyl alcohol 1.00 g

Tween 80 1.00 g

Acriflavin 0.10 g

Methyl paraoxybenzoate 0.10 g

Distilled water 10.00 g

White petroleum jelly gives 100.00 g

HU 203 973 A

The pH of the aqueous ointment ointment should be between 6.5 and 7.5.

The propolis extract and vitamin A are dissolved in castor oil at 50-55 ° C. The mixture of wool fat, linseed oil, butylhydroxytoluene, white beeswax, cetyl alcohol, then Tween 80 and white petroleum jelly is thawed at 75-80 ° C and then mixed at 50 ° C with propolis in castor oil and vitamin A.

The zinc oxide was triturated with sunflower oil heated to 40 ° C, and the oil phase cooled to 40-45 ° C was added in portions and mixed.

Methyl paraoxybenzoate is dissolved in distilled water at 80 ° C and, after cooling, acriflavin is sprayed onto the surface at 40 ° C. After dissolution, the aqueous phase is added in portions and mixed at 40 ° C with the oil phase.

The ointment is stirred until cool.

Check the pH of the aqueous flash and adjust with 0.1 M citric acid and 0.1 M sodium hydroxide.

Example 3

Propolis extract (dry matter;

50%, total polyphenol content: 38%) 3.00 g

Vitamin A (Vitamin A acetate conc. Oil

150000 IU = 150 mg) 150000 IU

Zinc oxide 15.00 g

Paraffin oil 10.00 g

Castor oil 10.00 g

Methyl paraoxybenzoate 0.10 g

Wool fat (lanolin) 15.00 g

Cetyl alcohol 1.00 g

White beeswax 2.00 g

Tween 80 1.00 g

Acriflavin 1.00 g

Distilled water 10.00 g

White petroleum jelly gives 100.00 g

The pH of the aqueous ripple should be between 6.5 and 7.5.

Dissolve the propolis extract and vitamin A in castor oil at 50-55 ° C.

The zinc oxide is triturated with paraffin oil heated to 40 ° C and the castor oil phase cooled to 40-45 ° C is mixed.

The mixture of wool fat, cetyl alcohol, white beeswax, Tween 80 and white petroleum jelly is thawed at 75-80 ° C. After cooling to 40-45 ° C, it is mixed in portions with the previous phase.

Methyl paraoxy 15 benzoate is dissolved in distilled water at 80 ° C, and after cooling, acriflavin is sprayed onto its surface at 40 ° C. After dissolution, add to the oily phase and stir until cool. Finally, the pH is adjusted as in the previous examples.

Claims (1)

²⁰ PATENT CLAIMS A process for the preparation of a medicated ointment composition for the treatment of hamstrings and hoof diseases and ulcerative inflammatory wounds comprising: 25 propolis extracts, based on 1.5 g of dry matter, 80000-220000 IU of vitamin A, 0.9-1.1 g of acriflavin, 8-22 g of zinc oxide, 9-35 g of a pharmaceutically acceptable vegetable or mineral oil, preferably castor oil, linseed oil, sunflower oil, pa30 raffin oil or any mixture thereof and 00.11 g of borax and adjuvants, excipients, emulsifiers, antioxidants and / or preservatives customary for ointment preparation.