HU205005B - Process for producing cough releiving and catarrh easing breast ointment - Google Patents

Abstract

Cough soothing and congestion relieving chest ointment contains oils of anise, eucalyptus, thyme, rosemary, juniper, pine, peppermint, sweet-fennel, camphor, methyl-salycilate, tincture of valerian in a simple ointment base (unguent simplex). - The ointment is rubbed on the chest (percutim therapy) and exerts a beneficial penetrant effect both on the lower and upper part of the respiratory system

Description

BACKGROUND OF THE INVENTION The present invention relates to a process for the manufacture of a cough suppressant and an antitussive, and a secretory ointment to reduce inflammation in the lungs.

Its active ingredients are: anise oil, eucalyptus oil, thyme oil, rosemary oil, juniper oil, pine oil, peppermint oil, fennel oil, camphor, methyl salicylate (prepared from gaultheril), known as a tincture - a recipe like a man. dispersed in a simple ointment (unguentum sinaplex), formulated as a pharmaceutical composition, they are capable of acting in a complex manner, enhancing the effects of each other, to produce cataract and cough suppression.

This effect develops quickly and effectively by rubbing 2-3 grams of the ointment into the skin of the chest (breast and back) and applying a thicker cloth (eg towel) around the torso. The procedure can be repeated after bathing.

Outpatient (and hospital) internal and pediatric patient traffic accounts for a large proportion of cataract, cough patients - from autumn to spring, especially during the epidemic period.

Mucosal lesions also occur in the upper respiratory tract or in the lower respiratory tract. In more severe cases, bronchitis - inflammation of the bronchial mucosa or pneumonia - pneumonia can occur.

A common feature of variable severity is that the patient coughs heavily.

Coughing is a useful activity for the body, when it eliminates the secretion of inflamed mucous membranes, this function can be helped by the so-called cough. expectorants.

The production of reproducible secretions is difficult to control. If the mucus is dense, cough does not occur - mucolitica is needed.

Frequent coughing exhausts the body (heart), and coughing at night does not produce sleep. Strong cough - especially at night - should be reduced with cough suppressants, which in turn may expose the exudate to blocking the airways.

With irritable, unproductive cough, no secretions (krupp - pseudokrupp, dry pleurisy, etc.) are excreted; The most important thing here is to reduce cough (with codeine preparations which, however, have a negative effect on the respiratory center and can get used to).

To reduce swelling of the mucous membranes, so-called antihistamines. Their side effects include drowsiness, decreased reflexes, and possibly also blood disorders.

In therapeutic practice, a number of pharmaceutical compositions are used simultaneously for the above diseases. Synthetic manholes can also have serious side effects. Prescribing multiple medications can cause a number of problems, cause unwanted reactions, or cause the patient to lose nutrition due to the many pills and “spoonfuls”. Healing is relatively slow.

The aim of the present invention has therefore been to find a composition which can effectively control inflammation of the airways mucosa.

Another goal was to reduce the cough reflex, thereby preventing the body from becoming exhausted and saving the heart.

A further aim was to dilute the producing mucus to aid in emptying.

Another object of the present invention was to inhibit coughing by reducing the exudate fluid in the airways.

A further aim is to alleviate the course of the disease and thereby reduce treatment time.

It was a further object of the present invention to find natural substances for healing as a complex pharmaceutical composition having a number of therapeutic benefits over the co-administration of compositions commonly used today.

Another goal was to avoid strain on the stomach. The fast and lasting effect should go hand in hand, and the durability can mean a night's sleep.

Another aim of the invention was to obtain an ointment dosage form, thereby implementing the state-of-the-art soap formulation. percutaneous drug delivery.

Some of the ointments applied to the skin have shown that, for some active substances, not only the local effect but also the remote and / or the topical application. a general effect is also available. (Kedvessy: Pharmaceutical Technology.)

Surprisingly, it has been found that especially those suffering from acute but chronic cataract can be effectively treated with a prescription drug. The onset of action is rapid, and the coughing incidence, which otherwise increases in the lying patient, is significantly reduced or even eliminated for a few hours. The effect is probably lasting because the slow but steady penetration (flow) of the essential oils is achieved from the oily ointment to the bronchi.

Although the active ingredient components individually or individually have anti-inflammatory or anti-inflammatory properties, the combined effect is far more than their sum. Their effect is likely to be so-called "mutual". synergist, with many examples in medicine.

It is therefore an object of the present invention to provide a process for the preparation of an antitussive and cataract bust ointment, which is derived from the known amounts of anise oil, eucalyptus oil, thyme oil, juniper oil, pine oil, peppermint oil, fennel oil, camphor, methyl salicylate, making an ointment, converting it into a pharmaceutical composition.

Factors known to those skilled in the art about the individual components play a role in the mechanism of action of the drug.

Essential oils reduce the cataract state of the mucous membranes, enhance the active transport of ciliary hairs, due to their surface activity they liquefy the sticky mucus, because of their antispasmodic effect, they facilitate breathing, slightly conquer the central nervous system.

HU 205 005 Β

Because of all of these, as well as the reduction of the reflex mechanism, the cough suppressant and the antitussive / antitussive effect co-occur during percutaneous administration.

Enlarging the bronchi, causing some degree of seizure relief, helps to temporarily improve the patient's condition by reducing the cough reflex. The reduction of mucosal inflammation, its mild antiseptic effect and its secretion-reducing effect, initiates a healing process during its application.

By moderating or eliminating the cough stimulus while preventing the production of new secretions, it does not exacerbate the cataract condition during treatment.

However, with less frequent coughing, effective removal of diluted secretions is possible.

Due to its complex effect, it can be applied to upper respiratory tract, applied to a smaller area of skin (neck), but plays a major role in deeper lower respiratory tract diseases, where it is necessary to thin the entire chest.

At this point, there is a complex effect that can be replaced only by 4-5 different formulations with different modes of action. Particularly in the treatment of these cases, breast ointment can play a major role.

Effects:

1. Cough suppression by reducing the cough reflex.

2. Effect of effervescence by liquefying dense mucus.

3. Inhibitory secretion effect - thus eliminates the irritant agent gradually.

4. Bronchodilator effect, which in itself can bring about significant improvement, as the catarrhal condition is often aggravated by bronchospasm.

5. Soothing effect, as it slightly conquers the central nervous system, promotes night sleep.

6. It has a positive effect on the heart and improving the health of the body by providing rest and reducing cough.

Even the ancient Egyptians used essential oils. In addition to their good scent, many oils have been shown to inhibit bacterial growth.

The pharmacological effects of essential oils are varied, since each oil is composed of many different constituents, and is excreted and accumulated in other organ systems. Essential oils that are excreted in the bronchi of the lungs fluidise the secretions in the respiratory tract and promote its clearance.

Essential oils that act directly on the mucous membranes of the respiratory tract through increased bronchial secretion and fluid secretion.

Direct acting expectorants can enhance not only secretion but also the transport of produced mucus. The epithelial cells of the airways, the movement of the ciliary hair, and the peristalsis of the bronchial muscles play a major role in the transport of bronchial secretions.

Essential oils are excreted internally to a small extent in the bronchi, where they are slightly excited and increase secretion, resulting in a broader but more dilute secretion.

In chronic cataract, essential oils cause healing inflammation, thereby reducing the production of secretions, deodorizing the secretions and inhibiting the growth of bacteria. Some relieve the onset of pertussis, likely to reduce the cough-causing reflex. They are also used in bronchitis putridia, emphysema (Issekutz B.).

Percutimeter therapy is essentially a parenteral drug administration or administration. One of the possible routes of administration is the penetration of a pharmaceutical ointment or using the appropriate starting material.

Some foreign pharmaceutical companies have recently introduced drug ointments with vasodilator effects. patches - for the treatment and prevention of angina pectoris, preecordial pain - (Nitroderm TTS patch).

Abroad, rubbing the chest with essential oils was known.

Unguentum broncho-resorbent, which is included in the Praescriptiones Magistrales of Switzerland, has a beneficial effect on the respiratory system by rubbing into the skin of the breasts with the essential oils absorbed and excreted in the bronchi.

The D.R.P. prescription sample collection contains the recipe for Balsamum contra pertussim (DRF), which involves rubbing 10 drops of a mixture of four types of essential oil into the skin of the chest to produce a good antitussive and respiratory effect.

However, this effect is not permanent but lasts for a short time after rubbing.

Currently, the use of natural substances in medicine is increasing worldwide, so we have turned our attention to essential oils.

Known formulas for some recipes:

Unguentum broncho-resorbent PM

The Camphora 3.0 g B Guaiacolum 3.0 g C Oleum Eucalypti 2.0 g D Methylium salicylicum 3.0 g E Oleum Pini Pumilionis 2.0 g F Oleum Thymi 1.0 g G Oleum Hyoscyami compositum H Unguentum Polyaethylenglycoli 5.0 g (MollePM) MDS. Zum Einrei. Pour frictions. Balsamum contra pertussim DRF 81.0 g 100.0 g 01. pini pumilionis 2.5 g 01. eucalypti 2.5 g 01. terebinthinae 10.0 g 01. camphorati fort ad. 30.0 g Dosage: Rub with 10 drops on the chest. Contratussivum, antiasthmaticum. Pinimenthol ®-S Ointment (Spitzner) 100 g content: 01. eucalypti 10.8 g 01. pini silvestris 10.8 g 01. Pini Pumil 1.4 g 01. Terebinth. 2.0g

Application: for acute, chronic and spastic bronchitis, laryngitis, Pleuritis. Adjuvant pertussis and upper respiratory tract disease.

HU 205 005 Β

The object of the invention, that is, the recipe for breast ointment we recommend:

“Unguentum. contratussicum "

Aetheroleum eucalypti 2.5 g

Aetheroleum thymi 2.0 g

Aetheroleum anisi 0.1 g

Aetheroleum rosmarini 0.1 g

Aetheroleum juniperi 0.3 g

Aethoroleum pini silvestris 0.3 g

Aetheroleum menthae piperitae 0.2 g

Aetheroleum foenlculi 1.0 g

Camphora 2.2 g

Methylium salicylicum 0.1 g

Tinctura valerianae alcoholica 0.1 g

Unguentum sipmlex ad gta 100.0 g

M.D.S

Expedition: Tube

Signature: Externally, Breast Antitussiva, Broncholyticum.

Note: For children and adults, apply 4-5 cm of ointment (about 2x more for adults) in the chest around the chest. With soft, thick textiles eg. towel, wrap it. The effect is evident after a few minutes and the constipation of the cough can be felt throughout the night. It provides relatively restful sleep, even with coughing as you lie down. Its respiratory effect is immediately apparent and no other cough suppressant is needed. You can treat less severe bronchitis on your own by helping the exudate to be absorbed.

Its effect is multi-directional. In mild cases, cataracts may be given as monotherapy and in more severe cases as adjuvants, antibiotic treatment

The properties of the ingredients, active ingredients, which make them useful in colds, catarrhal diseases:

1. Eucalyptus oil: Due to its antiseptic and expectorant effect, it is used to treat asthma and bronchitis.

2. Thyme oil: Due to its secretomotor effect, it is beneficial for cough and bronchitis.

3. Anise: It facilitates the elimination of secretions in the respiratory system, and inhibits bacterial growth with its secretolytic effect.

4. Rosemary Oil: There are countless preparations and combinations abroad for official use. It is high in essential oils such as eucalyptol, pinene, camphene, camphor, etc. contain.

5. Juniper oil: very good expectorant and anti-mucus effect.

6. Pine oil: widespread due to its antiseptic and antihypertensive effect. Due to its expectorant properties it is an ingredient of inhalants.

7. Peppermint Oil: Used for its antispasmodic and antiseptic properties against colds. It is not recommended for young children. Our product contains only a very small amount. The currently official FONO VI. (Ung. nasale), regardless of age.

8. Fennel Oil: Expectorant due to its secretolytic and antibacterial properties.

9. Camphor: has antiseptic properties and is a component of many recipes. The Ung. bronchial resorbable PM and Balsamum contra pertussim DRF are also present in significant percentages.

10. Methyl salicylate: anti-inflammatory and therefore a component of rheumatic rubbing.

11. Valerian tincture: the drug has a sedative and antispasmodic effect. Many drug combinations contain the drug or its extracts. Increases the effect of other active substances. The essential oil combination is preferably supplemented in the present composition.

In the literary work, Pharmacies and

In addition to prescription sample collections and textbooks, Dr Verzárné dr. Petri Gizella, dr. Nyirediné dr. Klára Mikita, dr. Szabolcs Nyiredy: Medicinal herbs in medicine The work of Medicina (1984) gave, and confirms the proven effect and the legitimacy of the composition, the possibility of a good combination.

The Ung. Broncho-resorbent beneficial effect of dr.

Gy. Kedvessy mentions it in his textbook and taught in his lectures. In the light of the experience gained in trying some of the ointments described, it is said that the ointment we recommend contains a solid amount of herbal active ingredients, but these are sufficient to cure a small child. Adults have a larger body surface anyway, so a higher dose of ointment used will produce a good therapeutic effect.

The prescription breast ointment in mild cataract may be administered as a single agent as monotherapy.

It has been shown to be an effective adjuvant in addition to antibiotics in more severe bacterial infections. Helps to heal the underlying disease and reduce symptoms. This will shorten the healing time.

There are still few ways to combat viral diseases today. The most we do is to improve the body's immune status, helping to activate macrophages and T-lymphocytes.

In addition to synthetic immunomodulators, oral administration of more recently killed cultures (eg Broncho-Vaxom capsule) enhances the body's defense mechanism.

In the case of respiratory viral diseases, the administration of antibiotics is clearly not a causal therapy, but only prevents over-infections, so we cannot expect and experience the spectacular improvement and healing that we often experience with targeted antibiotic treatment of bacterial diseases.

Therefore, for the treatment of viral respiratory diseases as a symptomatic therapy - but to avoid complications, it may be useful in addition to the administration of other non-specific drugs.

As all components of the product are recognized in the Hungarian and / or European Pharmacopoeias or in the prescription sample collections, the safety of the product is certain.

HU 205 005 Β

The ingredients provide a beneficial complex effect that has been proven.

An essential oil rubbed into the skin of the chest provides an extremely gentle and effective adjuvant treatment option for respiratory diseases, particularly in the treatment of fallen, febrile, malnourished or vomiting patients.

Percutaneous therapy does not cause any discomfort to the patient, while the effervescent effect of orally administered essential oils is caused by the induction of mild nausea by stimulation of the stomach and the salivary secretion of the saliva (Issekutz B.).

This nausea or nausea does not occur with percutaneous administration. Previously, inhaled oils were the most commonly used essential oils. The warmer the water to which the essential oils are applied, the greater the volatility and the deeper the active ingredient.

However, hot vapor does not have a good effect on inflamed mucous membranes, but rather exacerbates inflammation, and the use of essential oils in this way is now less and less recommended. Frequent scalding accidents signal the dangers of application, especially in young children.

Due to its ease of application, quick and effective action, the use of natural ingredients and the absence of side effects, the patented pharmaceutical formulation is a truly ideal and advanced formulation. Recommended for patients with nearly 100 patients.

Advantages:

- there was no need for cough suppressant codein preparations.

- antihistamines for the treatment of mucosal edema and high secretion eg. Sandosten dg. unnecessary.

- administration of preparations containing ephedrine eg. Calciphedrine is also commonly used to relieve croup cough, which was not needed in the cases studied.

- provides a night's rest without soothing.

- the heart does not need support because of the irritating cough, unless otherwise there is no heart failure.

- it facilitates the circulation by inhibiting the exudate of the other fluid and facilitates its absorption.

The subject of the present invention is "Ung. contratussicum ”was compared with the effect of Ung. bronchial resorbent P.M., Balsamum contra pertussim DRF, Pinimenthol S ointment (Spitzner). The duration of action, the duration of effect, the improvement in well-being and the onset of respiratory relief, and the reduction in cough stimulus were observed. The duration of healing was also monitored. In addition to the measurable and recordable results, this follow-up also included many subjective elements, but changes in well-being can also provide important data for healing factors.

We found it to be the most beneficial in the relief of cough and respiratory effect due to its diverse essential oil Ung. contratussicum ointment, which has the lowest relative total oil content.

Therefore, it is believed that the active ingredients of the components are synergistic, may act at multiple attack points, and have a certain anti-inflammatory and sedative effect.

The effectiveness and durability of the absorption is ensured by the base material of the ointment and the method of application. For some drugs, the extent of absorption is affected by the hydration of the stratum corneum, which can be increased e.g. occlusive dressings, but also using ointment bases that seal the skin more or less hermetically. For example, Vaseline-containing ointments such as Ung. simplex too. (Pharmacy 33. 413-417.1989.)

When treated with a mixture of essential oil components, the chest was rubbed with 5 to 10 drops - the antitussive effect was transient and then disappeared.

Inhalation of essential oil from hot-water vapor also has a short duration of action, and hot vapor is not beneficial for inflamed mucous membranes (it is still not considered modern).

Therefore, our attention has been turned to the formulation of an ointment.

Unguentum simplex Ph. Hg. VII. (simple ointment) when using ointment stock.

Due to its rapid action, the preparation is suitable for the relief of dry-tortured and catarrhal coughs, but due to its long-lasting effect, it also has a beneficial effect on the inflammatory state of the bronchi.

In the pharmaceutical formulation, the synergistic effect of the components was confirmed in practice.

All ingredients are known in official medicine, are officially known in several European countries, or have been until recently.

Claims (1)

A process for the preparation of a cough suppressant and dehydrating breast ointment characterized in that 0.1 to 1.0 g of anise oil, 1 to 5.0 g of eucalyptus oil, 0.5 to 4.0 g of thyme oil, 0, 5, 5 g of rosemary oil, 0.8 g juniper oil, 0.1-1 g pine oil, 0.1-0.5 g peppermint oil, 0.5-2.0 g fennel oil, 1-3.0 g camphor, 0.1-0.5 g Methyl salicylate, 0.1 to 1.0 g of tinctura valerianae alcoholica, and 80.0 to 92.0 g of Unguentum simplex (ad 100.0 grams) are prepared as an ointment.