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HRP940701B1 - 2,4- and 2,5-substituted pyridine-n-oxydes, process for their preparation and utilization - Google Patents

2,4- and 2,5-substituted pyridine-n-oxydes, process for their preparation and utilization

Info

Publication number
HRP940701B1
HRP940701B1 HRP-1133/91A HRP940701A HRP940701B1 HR P940701 B1 HRP940701 B1 HR P940701B1 HR P940701 A HRP940701 A HR P940701A HR P940701 B1 HRP940701 B1 HR P940701B1
Authority
HR
Croatia
Prior art keywords
substituted pyridine
oxydes
utilization
preparation
collagen
Prior art date
Application number
HRP-1133/91A
Inventor
Volkmar Guenzler-Pukall
Original Assignee
Volkmar Guenzler-Pukall
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Volkmar Guenzler-Pukall filed Critical Volkmar Guenzler-Pukall
Publication of HRP940701A2 publication Critical patent/HRP940701A2/en
Publication of HRP940701B1 publication Critical patent/HRP940701B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

2,4- and 2,5-substituted pyridine N-oxides which have fibrosuppressive and immunosuppressive activity are presented. The said compounds are likewise suitable for the treatment of disturbances of the metabolism of collagen and collagen-like substances and of the biosynthesis of C1q.
HRP-1133/91A 1990-06-28 1994-10-19 2,4- and 2,5-substituted pyridine-n-oxydes, process for their preparation and utilization HRP940701B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4020570A DE4020570A1 (en) 1990-06-28 1990-06-28 2,4- AND 2,5-SUBSTITUTED PYRIDINE-N-OXIDES, METHOD FOR THE PRODUCTION AND USE THEREOF
YU113391A YU113391A (en) 1990-06-28 1991-06-27 2,4 AND 2,5 SUBSTITUTED PIRIDIN-N OXIDES AND PROCEDURE FOR THEIR PRODUCTION

Publications (2)

Publication Number Publication Date
HRP940701A2 HRP940701A2 (en) 1997-02-28
HRP940701B1 true HRP940701B1 (en) 1999-08-31

Family

ID=6409247

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP-1133/91A HRP940701B1 (en) 1990-06-28 1994-10-19 2,4- and 2,5-substituted pyridine-n-oxydes, process for their preparation and utilization

Country Status (27)

Country Link
EP (1) EP0463592B1 (en)
JP (1) JPH0832687B2 (en)
KR (1) KR920000724A (en)
CN (1) CN1038585C (en)
AT (1) ATE110059T1 (en)
AU (1) AU636990B2 (en)
BR (1) BR9102699A (en)
CA (1) CA2045868A1 (en)
CZ (1) CZ283782B6 (en)
DE (2) DE4020570A1 (en)
DK (1) DK0463592T3 (en)
EG (1) EG19851A (en)
ES (1) ES2061118T3 (en)
FI (1) FI101070B (en)
HR (1) HRP940701B1 (en)
HU (1) HU214627B (en)
IE (1) IE65300B1 (en)
IL (1) IL98629A (en)
LT (1) LT3918B (en)
MA (1) MA22191A1 (en)
MX (1) MX26415A (en)
MY (1) MY107573A (en)
NO (1) NO178026C (en)
NZ (1) NZ238701A (en)
PT (1) PT98108B (en)
YU (1) YU113391A (en)
ZA (1) ZA914958B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU9492A (en) * 1991-02-05 1995-03-27 Hoechst Ag. 2,4- and 2,5-BIS-TETRAZOLYL pyridines and the process for their preparation
CA2085954A1 (en) * 1991-12-24 1993-06-25 Klaus Weidmann Substituted pyridine n-oxides, processes for their preparation, and their use
TW352384B (en) * 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
TW222585B (en) * 1992-09-11 1994-04-21 Hoechst Ag
DE4233124A1 (en) * 1992-10-02 1994-04-07 Hoechst Ag Acylsulfonamido and sulfonamidopyridine-2-carboxylic acid esters and their pyridine N-oxides, processes for their preparation and their use as medicaments
US6451816B1 (en) 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
DE19624704A1 (en) * 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab New pyridylalkanoic acid amides
DE19624659A1 (en) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab New pyridylalkene and pyridylalkanoic acid amides
FR2766187B1 (en) 1997-07-17 2000-06-02 Rhone Poulenc Rorer Sa PYRAZINE DERIVATIVES, THEIR PREPARATION AND THE MEDICINES CONTAINING THEM
DE19756212A1 (en) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab New cyclic imide-substituted pyridylalkane, alkene and alkyarboxylic acid amides
US6903118B1 (en) 1997-12-17 2005-06-07 Klinge Pharma Gmbh Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
DE19756235A1 (en) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab New piperidinyl-substituted pyridylalkane alkene and alkane carboxylic acid amides
DE19756261A1 (en) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab New aryl-substituted pyridylalkane, alkene and alkyarboxylic acid amides
EP1031564A1 (en) 1999-02-26 2000-08-30 Klinge Pharma GmbH Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy
EP1368323B1 (en) 2001-02-14 2010-06-30 Warner-Lambert Company LLC Pyrimidine matrix metalloproteinase inhibitors
DOP2002000332A (en) 2001-02-14 2002-08-30 Warner Lambert Co MATRIX METALOPROTEINAS PYRIDINE INHIBITORS
DOP2002000333A (en) 2001-02-14 2002-09-30 Warner Lambert Co DERIVATIVES OF ISOFTALIC ACID AS INHIBITORS OF METALOPROTEINASES OF THE MATRIX
US6924276B2 (en) 2001-09-10 2005-08-02 Warner-Lambert Company Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
EP1434585A1 (en) 2001-10-12 2004-07-07 Warner-Lambert Company LLC Alkyne matrix metalloproteinase inhibitors
DE10160357A1 (en) * 2001-12-08 2003-06-18 Aventis Pharma Gmbh Use of pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides for the selective inhibition of collagenases
US6933298B2 (en) 2001-12-08 2005-08-23 Aventis Pharma Deutschland Gmbh Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides and the use thereof for selectively inhibiting collagenases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5623987B2 (en) * 1972-02-04 1981-06-03
JPS6052702B2 (en) 1976-08-27 1985-11-20 中外製薬株式会社 Pyridine derivatives and their manufacturing method
JPS57109792A (en) * 1980-12-26 1982-07-08 Banyu Pharmaceut Co Ltd Penicillin derivative and salt thereof
DE3432094A1 (en) 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt ESTER OF PYRIDINE-2,4- AND -2,5-DICARBONIC ACID AS A MEDICINAL PRODUCT FOR INHIBITING PROLIN AND LYSINE HYDROXYLASE
JP2512924B2 (en) * 1987-01-21 1996-07-03 萬有製薬株式会社 Hair restorer
DE3703962A1 (en) 1987-02-10 1988-08-18 Hoechst Ag PYRIDINE-2,4- AND 2,5-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
DE3703959A1 (en) * 1987-02-10 1988-08-18 Hoechst Ag PYRIDINE-2,4- AND 2,5-DICARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
DE3703963A1 (en) * 1987-02-10 1988-08-18 Hoechst Ag PYRIDINE-2,4- AND 2,, 5-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF, AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
JP2600786B2 (en) * 1988-04-12 1997-04-16 萬有製薬株式会社 Hair restorer
DE3826471A1 (en) 1988-08-04 1990-02-22 Hoechst Ag Improved process for the preparation of N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboximides
DE3924093A1 (en) 1989-07-20 1991-02-07 Hoechst Ag N, N'-BIS (ALKOXY-ALKYL) -PYRIDINE-2,4-DICARBONESAUREDIAMIDES, METHOD FOR THE PRODUCTION AND USE THEREOF
ZA91291B (en) 1990-01-16 1991-09-25 Hoechst Ag Di(nitroxyalkyl)amides of pyridine-2,4-and-2,5-dicarboxylic acids,a process for the preparation thereof,and the use thereof

Also Published As

Publication number Publication date
HUT59104A (en) 1992-04-28
DE59102547D1 (en) 1994-09-22
ATE110059T1 (en) 1994-09-15
NZ238701A (en) 1994-06-27
EP0463592A1 (en) 1992-01-02
ZA914958B (en) 1992-03-25
JPH04230264A (en) 1992-08-19
IL98629A0 (en) 1992-07-15
CS195991A3 (en) 1992-02-19
BR9102699A (en) 1992-02-04
HU912158D0 (en) 1991-12-30
NO178026C (en) 1996-01-10
CZ283782B6 (en) 1998-06-17
JPH0832687B2 (en) 1996-03-29
NO178026B (en) 1995-10-02
FI913118L (en) 1991-12-29
FI101070B (en) 1998-04-15
KR920000724A (en) 1992-01-29
NO912541L (en) 1991-12-30
DE4020570A1 (en) 1992-01-02
FI913118A0 (en) 1991-06-26
PT98108A (en) 1993-06-30
NO912541D0 (en) 1991-06-27
LT3918B (en) 1996-04-25
EG19851A (en) 1996-10-31
EP0463592B1 (en) 1994-08-17
CA2045868A1 (en) 1991-12-29
MY107573A (en) 1996-04-30
ES2061118T3 (en) 1994-12-01
CN1038585C (en) 1998-06-03
LTIP1464A (en) 1995-05-25
IE912253A1 (en) 1992-01-01
IL98629A (en) 1996-05-14
YU113391A (en) 1995-10-03
AU636990B2 (en) 1993-05-13
HRP940701A2 (en) 1997-02-28
HU214627B (en) 1998-04-28
DK0463592T3 (en) 1994-12-19
CN1057649A (en) 1992-01-08
MA22191A1 (en) 1991-12-31
IE65300B1 (en) 1995-10-18
PT98108B (en) 1998-12-31
AU7935691A (en) 1992-01-02
MX26415A (en) 1993-05-01

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Payment date: 20000627

Year of fee payment: 10

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