HRP20051019A2 - A method for the preparation of enantiomerically pure mirtazapine - Google Patents

A method for the preparation of enantiomerically pure mirtazapine

Info

Publication number: HRP20051019A2
Authority: HR; Croatia
Prior art keywords: preparation; enantiomerically pure; mirtazapine; acid; pure mirtazapine
Prior art date: 2003-07-10

Application number

HR20051019A

Other languages

English (en)

Croatian (hr)

Inventor

Hubertus Wieringa Johannes

Antonius Martinus Van De Ven Adrianus

Johannes Kemperman Gerardus

Original Assignee

Akzo Nobel N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-10

Filing date

2004-07-05

Publication date

2006-02-28

2004-07-05 Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.

2006-02-28 Publication of HRP20051019A2 publication Critical patent/HRP20051019A2/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

HR20051019A 2003-07-10 2004-07-05 A method for the preparation of enantiomerically pure mirtazapine HRP20051019A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03102095		2003-07-10
PCT/EP2004/051357 WO2005005410A1 (en)	2003-07-10	2004-07-05	A method for the preparation of enantiomerically pure mirtazapine

Publications (1)

Publication Number	Publication Date
HRP20051019A2 true HRP20051019A2 (en)	2006-02-28

Family

ID=34042934

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20051019A HRP20051019A2 (en)	2003-07-10	2004-07-05	A method for the preparation of enantiomerically pure mirtazapine

Country Status (35)

Country	Link
US (2)	US8058436B2 (is)
EP (1)	EP1656365B1 (is)
JP (1)	JP4668184B2 (is)
KR (1)	KR20060056315A (is)
CN (1)	CN100558722C (is)
AR (1)	AR046494A1 (is)
AT (1)	ATE433965T1 (is)
AU (1)	AU2004255874B2 (is)
BR (1)	BRPI0412447A (is)
CA (1)	CA2531165C (is)
CO (1)	CO5640123A2 (is)
CY (1)	CY1109327T1 (is)
DE (1)	DE602004021605D1 (is)
DK (1)	DK1656365T3 (is)
EC (1)	ECSP066271A (is)
ES (1)	ES2327123T3 (is)
HR (1)	HRP20051019A2 (is)
IL (1)	IL172549A0 (is)
IS (1)	IS2674B (is)
LT (1)	LT5382B (is)
LV (1)	LV13441B (is)
MX (1)	MXPA06000325A (is)
NO (1)	NO20056175L (is)
NZ (1)	NZ544360A (is)
PE (1)	PE20050323A1 (is)
PL (1)	PL1656365T3 (is)
PT (1)	PT1656365E (is)
RS (1)	RS20050972A (is)
RU (1)	RU2352566C2 (is)
SG (1)	SG144914A1 (is)
SI (1)	SI1656365T1 (is)
TW (1)	TWI335915B (is)
UA (1)	UA83666C2 (is)
WO (1)	WO2005005410A1 (is)
ZA (1)	ZA200600019B (is)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5080050B2 (ja) *	2005-09-26	2012-11-21	住友化学株式会社	光学活性なピペラジン化合物の製造方法
CN102153620A (zh) *	2005-09-26	2011-08-17	住友化学株式会社	光学活性的哌嗪化合物的制造方法
TW200808804A (en) *	2006-05-22	2008-02-16	Organon Nv	Mirtazapine for the treatment of neuropathic pain
TW200815370A (en) *	2006-06-16	2008-04-01	Organon Nv	Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine
WO2008099715A1 (ja) *	2007-02-09	2008-08-21	Kaneka Corporation	光学活性２－アリールピペラジン誘導体の製造法
JP5192707B2 (ja)	2007-03-22	2013-05-08	住友化学株式会社	ミルタザピンの製造方法
US7994314B2 (en)	2007-04-11	2011-08-09	N.V. Organon	Method for the preparation of an enantiomerically pure benzazepine
JP5635905B2 (ja) *	2007-04-11	2014-12-03	メルク・シャープ・エンド・ドーム・ベー・フェー	ミルタザピンの調製方法
KR101485418B1 (ko) *	2013-05-29	2015-01-26	주식회사 메디켐코리아	고순도 미르타자핀의 제조방법
WO2016138357A1 (en)	2015-02-27	2016-09-01	Kindred Biosciences, Inc.	Stimulation of appetite, management of weight loss, and treatment of anorexia in dogs and cats
KR102540021B1 (ko) *	2020-12-02	2023-06-07	(주)유케이케미팜	대량 생산에 적합한 미르타자핀의 제조방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3959470A (en) *	1972-11-28	1976-05-25	Mikhail Davidovich Mashkovsky	Psychotropic medicinal preparation
NL189199C (nl) *	1975-04-05	1993-02-01	Akzo Nv	Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
IE903557A1 (en) *	1989-10-05	1991-04-10	Sankyo Co	Novel tetracyclic compounds having anti-allergic and¹anti-asthmatic activities, their preparation and use
US6303595B1 (en)	1997-11-14	2001-10-16	Akzo Nobel N.V.	Use of mirtazapine for treating sleep apneas
JPH11222407A (ja) *	1997-11-14	1999-08-17	Sankyo Co Ltd	新規殺菌剤
KR20020019902A (ko)	1999-04-19	2002-03-13	추후보정	피페라진 고리 함유 화합물의 신규한 합성법 및 결정화법
US20030069417A1 (en) *	1999-04-19	2003-04-10	Claude Singer	Novel synthesis and crystallization of piperazine ring-containing compounds
US6068695A (en) *	1999-07-13	2000-05-30	Bayer Corporation	Process for the continuous preparation of quinacridones
AU6476300A (en)	1999-09-30	2001-05-10	Sumika Fine Chemicals Co., Ltd.	Process for the preparation of a piperazine derivative
AU6474200A (en) *	1999-12-13	2001-06-18	Sumika Fine Chemicals Co., Ltd.	Process for the preparation of a pyridinemethanol compound
EP1658850A1 (en)	2000-02-11	2006-05-24	Akzo Nobel N.V.	The use of mirtazapine for the treatment of sleep disorders
JP2001342188A (ja) *	2000-03-27	2001-12-11	Takeda Chem Ind Ltd	縮合ピラゾール誘導体、その製造法および用途
TW200538100A (en) *	2004-04-21	2005-12-01	Akzo Nobel Nv	Mirtazapine salts

2004
- 2004-05-07 UA UAA200600274A patent/UA83666C2/ru unknown
- 2004-06-28 TW TW093118845A patent/TWI335915B/zh not_active IP Right Cessation
- 2004-07-05 CN CNB2004800194891A patent/CN100558722C/zh not_active Expired - Lifetime
- 2004-07-05 CA CA2531165A patent/CA2531165C/en not_active Expired - Fee Related
- 2004-07-05 NZ NZ544360A patent/NZ544360A/en not_active IP Right Cessation
- 2004-07-05 US US10/564,193 patent/US8058436B2/en not_active Expired - Fee Related
- 2004-07-05 SI SI200431183T patent/SI1656365T1/sl unknown
- 2004-07-05 KR KR1020067000511A patent/KR20060056315A/ko not_active Abandoned
- 2004-07-05 DK DK04741958T patent/DK1656365T3/da active
- 2004-07-05 PL PL04741958T patent/PL1656365T3/pl unknown
- 2004-07-05 EP EP04741958A patent/EP1656365B1/en not_active Expired - Lifetime
- 2004-07-05 RS YUP-2005/0972A patent/RS20050972A/sr unknown
- 2004-07-05 WO PCT/EP2004/051357 patent/WO2005005410A1/en not_active Ceased
- 2004-07-05 HR HR20051019A patent/HRP20051019A2/xx not_active Application Discontinuation
- 2004-07-05 SG SG200805127-8A patent/SG144914A1/en unknown
- 2004-07-05 MX MXPA06000325A patent/MXPA06000325A/es active IP Right Grant
- 2004-07-05 AU AU2004255874A patent/AU2004255874B2/en not_active Expired
- 2004-07-05 ES ES04741958T patent/ES2327123T3/es not_active Expired - Lifetime
- 2004-07-05 JP JP2006518216A patent/JP4668184B2/ja not_active Expired - Lifetime
- 2004-07-05 BR BRPI0412447-2A patent/BRPI0412447A/pt not_active IP Right Cessation
- 2004-07-05 RU RU2006103992/04A patent/RU2352566C2/ru not_active IP Right Cessation
- 2004-07-05 PT PT04741958T patent/PT1656365E/pt unknown
- 2004-07-05 AT AT04741958T patent/ATE433965T1/de active
- 2004-07-05 DE DE602004021605T patent/DE602004021605D1/de not_active Expired - Lifetime
- 2004-07-07 PE PE2004000653A patent/PE20050323A1/es not_active Application Discontinuation
- 2004-07-08 AR ARP040102412A patent/AR046494A1/es not_active Application Discontinuation
2005
- 2005-12-12 LT LT2005107A patent/LT5382B/lt not_active IP Right Cessation
- 2005-12-13 IL IL172549A patent/IL172549A0/en not_active IP Right Cessation
- 2005-12-15 IS IS8184A patent/IS2674B/is unknown
- 2005-12-23 NO NO20056175A patent/NO20056175L/no not_active Application Discontinuation
2006
- 2006-01-03 ZA ZA200600019A patent/ZA200600019B/en unknown
- 2006-01-09 EC EC2006006271A patent/ECSP066271A/es unknown
- 2006-01-10 CO CO06001617A patent/CO5640123A2/es not_active Application Discontinuation
- 2006-02-10 LV LVP-06-21A patent/LV13441B/en unknown
2008
- 2008-07-02 US US12/667,969 patent/US20100179319A1/en not_active Abandoned
2009
- 2009-08-25 CY CY20091100894T patent/CY1109327T1/el unknown

Also Published As

Publication number	Publication date
SG144914A1 (en)	2008-08-28
TWI335915B (en)	2011-01-11
JP4668184B2 (ja)	2011-04-13
AR046494A1 (es)	2005-12-14
CY1109327T1 (el)	2014-07-02
CN100558722C (zh)	2009-11-11
LV13441B (en)	2006-08-20
KR20060056315A (ko)	2006-05-24
PE20050323A1 (es)	2005-05-16
RU2006103992A (ru)	2006-06-27
LT5382B (lt)	2006-11-27
ECSP066271A (es)	2006-07-28
DK1656365T3 (da)	2009-09-14
PL1656365T3 (pl)	2009-10-30
RS20050972A (sr)	2008-06-05
HK1086841A1 (en)	2006-09-29
IS8184A (is)	2005-12-15
TW200510426A (en)	2005-03-16
LT2005107A (en)	2006-06-27
AU2004255874B2 (en)	2010-10-28
DE602004021605D1 (de)	2009-07-30
AU2004255874A1 (en)	2005-01-20
MXPA06000325A (es)	2006-03-30
IL172549A0 (en)	2006-04-10
UA83666C2 (ru)	2008-08-11
PT1656365E (pt)	2009-09-01
IS2674B (is)	2010-09-15
NO20056175L (no)	2006-01-23
US20100179319A1 (en)	2010-07-15
EP1656365A1 (en)	2006-05-17
NZ544360A (en)	2008-05-30
BRPI0412447A (pt)	2006-09-19
ES2327123T3 (es)	2009-10-26
RU2352566C2 (ru)	2009-04-20
SI1656365T1 (sl)	2009-10-31
CA2531165C (en)	2011-08-30
CA2531165A1 (en)	2005-01-20
CO5640123A2 (es)	2006-05-31
CN1820000A (zh)	2006-08-16
US8058436B2 (en)	2011-11-15
JP2009513537A (ja)	2009-04-02
EP1656365B1 (en)	2009-06-17
US20060229300A1 (en)	2006-10-12
ATE433965T1 (de)	2009-07-15
ZA200600019B (en)	2007-01-31
WO2005005410A1 (en)	2005-01-20

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ATE417051T1 (de)	2008-12-15	Polymorphe von clopidogrel-hydrogensulfat
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MY144633A (en)	2011-10-14	New tricyclic derivatives, method of preparing same and pharmaceutical compositions containing them
CR9472A (es)	2007-12-04	Derivados de aminoacidos
ATE410485T1 (de)	2008-10-15	Härtbare farbige zusammensetzung, farbfilter und verfahren zu deren herstellung
ATE527258T1 (de)	2011-10-15	Pyrroloä2,3-cüpyridinverbindung, verfahren zu deren herstellung und anwendung
EA200600601A1 (ru)	2006-10-27	Производные аминопиридина в качестве ингибиторов индуцируемой no-синтазы
ATE415404T1 (de)	2008-12-15	Lösungsmittelfreies verfahren zur herstellung von diketopyrrolopyrrol-derivaten
DE502007006121D1 (de)	2011-02-10	Elektrochemische herstellung sterisch gehinderter amine
EA200700550A1 (ru)	2007-10-26	Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
ATE526312T1 (de)	2011-10-15	Verfahren zur herstellung von reinen 4- pyrrolidinophenylbenzyletherderivaten als maob- inhibitoren
NO20061344L (no)	2006-03-24	Imidazopyridinderivater som induserbare NO-syntaseoinhibitorer
PT1317455E (pt)	2004-11-30	Processo para a preparacao de um composto de imidazopiridina substituido
UY29012A1 (es)	2005-10-31	"oxazolididonas y composiciones y metodos relacionados"
ATE444323T1 (de)	2009-10-15	Neuartige epoxidverbindungen und verfahren zu ihrer herstellung
ATE423096T1 (de)	2009-03-15	Verfahren zur herstellung von 2- azabicycloä3.3.0üoctan-3-carbonsäurederivaten
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ATE466003T1 (de)	2010-05-15	Herstellung von 2-aminothiazol-5- carbonsäurederivaten
NO20061343L (no)	2006-03-24	Imidazo[4,5-b]pyridinderivater som induserbare NO-syntaseinhibitorer
DE50304869D1 (de)	2006-10-12	Verfahren zur herstellung einer spezifischen kristallmodifikation von 2-(2-chlor-4-mesyl-benzoyl)-cyclohexan-1,3-dion
HRP20060168A2 (en)	2006-09-30	Novel method of preparing 3-fluorinated quinolines

Legal Events

Date	Code	Title	Description
2006-02-28	A1OB	Publication of a patent application
2006-08-28	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2006-12-12	PPPP	Transfer of rights	Owner name: N.V. ORGANON, NL
2011-06-29	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20110629 Year of fee payment: 8
2013-01-08	OBST	Application withdrawn