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HRP20050409A2 - Ophthalmic compositions for treating ocular hypertension - Google Patents

Ophthalmic compositions for treating ocular hypertension Download PDF

Info

Publication number
HRP20050409A2
HRP20050409A2 HR20050409A HRP20050409A HRP20050409A2 HR P20050409 A2 HRP20050409 A2 HR P20050409A2 HR 20050409 A HR20050409 A HR 20050409A HR P20050409 A HRP20050409 A HR P20050409A HR P20050409 A2 HRP20050409 A2 HR P20050409A2
Authority
HR
Croatia
Prior art keywords
alkyl
heterocyclyl
aryl
alkenyl
compound
Prior art date
Application number
HR20050409A
Other languages
English (en)
Croatian (hr)
Inventor
B. Doherty James
Chen Meng-Hsin
Liu Luping
Swaminathan Natarajan R.
Robert Tynebor M.
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Publication of HRP20050409A2 publication Critical patent/HRP20050409A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HR20050409A 2002-11-08 2003-11-04 Ophthalmic compositions for treating ocular hypertension HRP20050409A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42480802P 2002-11-08 2002-11-08
US50009103P 2003-09-04 2003-09-04
PCT/US2003/035080 WO2004043933A1 (fr) 2002-11-08 2003-11-04 Compositions ophtalmiques pour le traitement d'hypertension oculaire

Publications (1)

Publication Number Publication Date
HRP20050409A2 true HRP20050409A2 (en) 2006-02-28

Family

ID=32314559

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20050409A HRP20050409A2 (en) 2002-11-08 2003-11-04 Ophthalmic compositions for treating ocular hypertension

Country Status (22)

Country Link
US (2) US7196082B2 (fr)
EP (1) EP1562909B1 (fr)
JP (2) JP4456072B2 (fr)
KR (1) KR20050072805A (fr)
AR (1) AR041991A1 (fr)
AU (2) AU2003286884A1 (fr)
BR (1) BR0316040A (fr)
CA (1) CA2505086C (fr)
CL (1) CL2003002293A1 (fr)
DO (1) DOP2003000747A (fr)
EC (1) ECSP055781A (fr)
HR (1) HRP20050409A2 (fr)
IS (1) IS7822A (fr)
MA (1) MA27497A1 (fr)
MX (1) MXPA05004889A (fr)
NO (1) NO20052751D0 (fr)
NZ (1) NZ539593A (fr)
PE (1) PE20040692A1 (fr)
PL (1) PL377172A1 (fr)
RU (1) RU2005117627A (fr)
TW (1) TWI250873B (fr)
WO (2) WO2004043932A1 (fr)

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Publication number Priority date Publication date Assignee Title
KR20040028469A (ko) 2002-09-30 2004-04-03 엘지전자 주식회사 1 회 기록 가능한 광디스크의 디펙트 영역 관리방법
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
DE602004020079D1 (de) * 2003-09-04 2009-04-30 Merck & Co Inc Ophthalmische zusammensetzungen zur behandlung der okularen hypertonie
US7563816B2 (en) * 2004-07-20 2009-07-21 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
EP1647549A1 (fr) 2004-10-14 2006-04-19 Laboratoire Theramex Indazoles, benzisoxazoles et benzisothiazoles en tant qu'agents oestrogéniques
AU2007210073B2 (en) * 2006-01-31 2011-10-06 Array Biopharma Inc. Kinase inhibitors and methods of use thereof
JP2009533326A (ja) * 2006-03-13 2009-09-17 メルク エンド カムパニー インコーポレーテッド 高眼圧症の治療用眼科用組成物
JP5255559B2 (ja) * 2006-03-31 2013-08-07 アボット・ラボラトリーズ インダゾール化合物
US20100113472A1 (en) * 2008-11-03 2010-05-06 Chemocentryx, Inc. Compounds for the treatment of osteoporosis and cancers
WO2012071369A2 (fr) 2010-11-24 2012-05-31 The Trustees Of Columbia University In The City Of New York Antagoniste rbp4 non rétinoïde pour le traitement de la dégénérescence maculaire liée à l'âge et de la maladie de stargardt
US9333202B2 (en) 2012-05-01 2016-05-10 The Trustees Of Columbia University In The City Of New York Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
WO2014152018A1 (fr) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York Octahydrocyclopentapyrroles, leur préparation et leur utilisation
ES2705247T3 (es) 2013-03-14 2019-03-22 Univ Columbia 4-fenilpiperidinas, su preparación y uso
WO2014151959A1 (fr) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York N-alkyl-2-phénoxyéthanamines, leurs préparation et utilisation
US9944644B2 (en) 2013-03-14 2018-04-17 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles their preparation and use
BR112016025356B1 (pt) 2014-04-30 2023-04-18 The Trustees Of Columbia University In The City Of New York Compostos de 4-fenilpiperidinas substituídas, composições e seus usos
CN104211638A (zh) * 2014-08-13 2014-12-17 李增 一种脂肪氨基取代的芸香碱类衍生物及其制备和作为抗阿尔兹海默症的药物中的应用
EP3402780A1 (fr) 2016-01-14 2018-11-21 Beth Israel Deaconess Medical Center, Inc. Modulateurs de mastocytes et leurs utilisations

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534580A1 (fr) * 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
US5151444B1 (en) * 1987-09-18 1999-07-06 R Tech Ueno Ltd Ocular hypotensive agents
WO1989010757A1 (fr) 1988-05-10 1989-11-16 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis Nouvelle preparation ophtalmique pour le traitement de glaucomes
US5296504A (en) * 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
EP1225168B8 (fr) * 1988-09-06 2015-03-18 Pfizer Health AB Dérivé de prostaglandine-F-2-alpha pour le traitement du glaucome et de l'hypertension oculaire
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5922773A (en) 1992-12-04 1999-07-13 The Children's Medical Center Corp. Glaucoma treatment
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
JP3208210B2 (ja) * 1993-03-17 2001-09-10 旭化成株式会社 結晶性芳香族ポリカーボネートプレポリマーの製造方法及び芳香族ポリカーボネートの製造方法
JPH08511024A (ja) 1993-06-08 1996-11-19 バイディ ファーマシューティカルズ 眼内圧を低下させる方法および組成物
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US5573758A (en) * 1995-04-28 1996-11-12 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
AP1147A (en) * 1996-05-03 2003-02-25 Pfizer Substituted indazole derivatives and related compounds.
US5925342A (en) * 1996-11-13 1999-07-20 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
GB2321455A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Lipophilic derivatives of biologically active compounds
EP1114816A4 (fr) 1998-09-14 2002-09-04 Ono Pharmaceutical Co DERIVES E DE PHENYL-PROSTAGLANDINE A SUBSTITUTION-$g(V) ET MEDICAMENTS LES CONTENANT COMME INGREDIENT ACTIF
TR200201643T2 (tr) 1999-12-22 2002-11-21 Pfizer Products Inc. Osteoporoz tedavisi için EP4 reseptörünü seçici agonistler.
EP1251862B1 (fr) 2000-01-18 2008-10-01 Merck & Co., Inc. Compositions ophthalmiques pour traiter l'hypertension oculaire
US6956036B1 (en) * 2000-03-17 2005-10-18 Alcon, Inc. 6-hydroxy-indazole derivatives for treating glaucoma
WO2001070702A1 (fr) 2000-03-17 2001-09-27 Alcon, Inc. Derives de 6-hydroxy-indazole destines au traitement du glaucome
KR20030095183A (ko) 2000-03-17 2003-12-18 알콘, 인코퍼레이티드 녹내장 치료용 5-하이드록시 인다졸 유도체
WO2001072268A1 (fr) 2000-03-31 2001-10-04 Toray Industries, Inc. Agents de régulation de la pousse du cheveu ou de sa formation
WO2002024647A1 (fr) 2000-09-21 2002-03-28 Ono Pharmaceutical Co., Ltd. Agonistes du recepteur de l'ep4 comprenant comme principe actif des derives de la 8-azaprostaglandine
JP3984164B2 (ja) 2000-11-27 2007-10-03 ファイザー・プロダクツ・インク 骨粗鬆症治療用ｅｐ４受容体選択的アゴニスト
FR2827861B1 (fr) 2001-07-27 2004-04-02 Aventis Pharma Sa Derives des indazoles ou des indoles, leur utilisation en medecine humaine et plus particulierement en cancerologie

Also Published As

Publication number Publication date
PE20040692A1 (es) 2004-10-08
EP1562909B1 (fr) 2012-06-27
EP1562909A1 (fr) 2005-08-17
TWI250873B (en) 2006-03-11
US7547720B2 (en) 2009-06-16
JP2006508190A (ja) 2006-03-09
US7196082B2 (en) 2007-03-27
NO20052751L (no) 2005-06-07
KR20050072805A (ko) 2005-07-12
WO2004043932A1 (fr) 2004-05-27
CA2505086A1 (fr) 2004-05-27
AU2003286884A1 (en) 2004-06-03
US20040097575A1 (en) 2004-05-20
MA27497A1 (fr) 2005-08-01
PL377172A1 (pl) 2006-01-23
AU2003287506B8 (en) 2009-05-28
AR041991A1 (es) 2005-06-08
MXPA05004889A (es) 2005-07-22
NZ539593A (en) 2006-12-22
AU2003287506A1 (en) 2004-06-03
JP4456072B2 (ja) 2010-04-28
ECSP055781A (es) 2005-09-20
TW200501949A (en) 2005-01-16
WO2004043933A1 (fr) 2004-05-27
CA2505086C (fr) 2009-08-25
CL2003002293A1 (es) 2005-01-14
JP5061293B2 (ja) 2012-10-31
BR0316040A (pt) 2005-09-13
IS7822A (is) 2005-04-25
JP2010006825A (ja) 2010-01-14
NO20052751D0 (no) 2005-06-07
DOP2003000747A (es) 2004-05-31
RU2005117627A (ru) 2006-01-20
AU2003287506B2 (en) 2009-04-23
US20070129418A1 (en) 2007-06-07

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