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HRP20000508B1 - Supstituirani 2-benzilamino-2-fenil-acetamidni spojevi - Google Patents

Supstituirani 2-benzilamino-2-fenil-acetamidni spojevi

Info

Publication number
HRP20000508B1
HRP20000508B1 HR20000508A HRP20000508A HRP20000508B1 HR P20000508 B1 HRP20000508 B1 HR P20000508B1 HR 20000508 A HR20000508 A HR 20000508A HR P20000508 A HRP20000508 A HR P20000508A HR P20000508 B1 HRP20000508 B1 HR P20000508B1
Authority
HR
Croatia
Prior art keywords
benzylamino
phenyl
substituted
acetamide compounds
alkyl
Prior art date
Application number
HR20000508A
Other languages
English (en)
Inventor
Pevarello Paolo
Varasi Mario
Salvati Patricia
Post Claes
Original Assignee
Newron Pharmaceuticals S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newron Pharmaceuticals S.P.A. filed Critical Newron Pharmaceuticals S.P.A.
Publication of HRP20000508A2 publication Critical patent/HRP20000508A2/hr
Publication of HRP20000508B1 publication Critical patent/HRP20000508B1/hr
Publication of HRP20000508B9 publication Critical patent/HRP20000508B9/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Spoj koji je supstituirani 2-benzilamino-2-fenil-acetamid prikazan formulom (I), naznačen time, da:n iznosi nula, 1, 2 ili 3; X je -O-, -S-, -CH2- ili -NH-;svaki R, R1, R2 i R3 je nezavisno jedan oddrugoga: vodik, C1-C6 alkil, halogen, hidroksi, C1-C6 alkoksi ili trifluorometil; svaki R4 i R5 je nezavisno jedan od drugoga: vodik, C1-C6 alkil, C3-C7 cikloalkil; ili njegove farmaceutski prihvatljive soli, bilo u formi racemskih smjesa bilo kao individualni optički izomeri. Patent sadrži još 8 patentnih zahtjeva.
HR20000508A 1997-12-31 1998-12-12 Supstituirani 2-benzilamino-2-fenil-acetamidni spojevi HRP20000508B9 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9727521.8A GB9727521D0 (en) 1997-12-31 1997-12-31 Substituted 2-benzylamino-2-phenyl-acetamide compounds
PCT/EP1998/008158 WO1999035123A1 (en) 1997-12-31 1998-12-12 Substituted 2-benzylamino-2-phenyl-acetamide compounds

Publications (3)

Publication Number Publication Date
HRP20000508A2 HRP20000508A2 (en) 2001-02-28
HRP20000508B1 true HRP20000508B1 (hr) 2007-02-28
HRP20000508B9 HRP20000508B9 (hr) 2008-05-31

Family

ID=10824340

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000508A HRP20000508B9 (hr) 1997-12-31 1998-12-12 Supstituirani 2-benzilamino-2-fenil-acetamidni spojevi

Country Status (22)

Country Link
US (1) US6303819B1 (hr)
EP (1) EP1044186B9 (hr)
JP (1) JP3839665B2 (hr)
KR (1) KR100629628B1 (hr)
AT (1) ATE319680T1 (hr)
BG (1) BG64700B1 (hr)
CA (1) CA2316082C (hr)
CZ (1) CZ296722B6 (hr)
DE (1) DE69833797T2 (hr)
EA (1) EA003097B1 (hr)
ES (1) ES2256976T3 (hr)
GB (1) GB9727521D0 (hr)
HR (1) HRP20000508B9 (hr)
HU (1) HUP0100184A3 (hr)
ID (1) ID26622A (hr)
IL (1) IL136735A0 (hr)
NO (1) NO327259B1 (hr)
NZ (1) NZ505441A (hr)
PL (1) PL194745B1 (hr)
PT (1) PT1044186E (hr)
TR (1) TR200001950T2 (hr)
WO (1) WO1999035123A1 (hr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9727523D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
US20040019046A1 (en) * 2000-11-27 2004-01-29 Paolo Pevarello Phenylacetamido-pyrazole derivatives and their use as antitumor agents
CA2459470C (en) * 2001-09-03 2010-10-12 Patricia Salvati Pharmaceutical composition comprising gabapentin or an analogue thereof and an .alpha.-aminoamide and its analgesic use
US6667327B2 (en) 2002-02-04 2003-12-23 Hoffmann-La Roche Inc. Pyridine amido derivatives
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
WO2004087125A1 (en) * 2003-04-02 2004-10-14 Ionix Pharmaceuticals Limited Amino acid derivatives as inhibitors of mammalian sodium channels
EP1524267A1 (en) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Substituted benzylaminoalkylene heterocycles
JP2007509094A (ja) 2003-10-23 2007-04-12 エフ．ホフマン−ラ　ロシュ　アーゲー Ｍａｏ−ｂ阻害物質としてのベンズアゼピン誘導体
EP1533298A1 (en) 2003-11-21 2005-05-25 Newron Pharmaceuticals S.p.A. 3-aminopyrrolidone derivatives
EP1533302A1 (en) * 2003-11-21 2005-05-25 Newron Pharmaceuticals S.p.A. Histidine derivatives
EP1535908A1 (en) * 2003-11-24 2005-06-01 Newron Pharmaceuticals S.p.A. N-acyl-N'-benzyl-alkylendiamino drivatives
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
KR101277520B1 (ko) * 2004-09-10 2013-06-21 뉴론 파마슈티칼즈 에스. 피. 에이. （할로벤질옥시）벤질아미노－프로판아미드를 포함하는 선택적 나트륨 및／또는 칼슘 채널 조절제로서 유용한 약제학적 조성물
WO2007071311A1 (en) 2005-12-22 2007-06-28 Newron Pharmaceuticals S.P.A. 2 -phenylethylamino derivatives as calcium and/or sodium channel modulators
EP1870097A1 (en) 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
KR101132534B1 (ko) * 2007-03-05 2012-08-22 에프. 호프만-라 로슈 아게 오렉신 길항제로서의 아미노아마이드
US11111208B2 (en) * 2019-06-17 2021-09-07 RK Pharma Solutions LLC Process for the preparation of safinamide mesylate intermediate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
KR0147963B1 (ko) * 1995-01-10 1998-08-17 강박광 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
US5688830A (en) 1996-01-25 1997-11-18 Syntex (U.S.A.) Inc. Treatment of neuropathic pain

Also Published As

Publication number Publication date
NZ505441A (en) 2001-12-21
PL194745B1 (pl) 2007-06-29
BG104569A (en) 2001-02-28
HUP0100184A3 (en) 2002-11-28
PL341514A1 (en) 2001-04-23
HRP20000508A2 (en) 2001-02-28
CZ296722B6 (cs) 2006-05-17
KR20010033779A (ko) 2001-04-25
US6303819B1 (en) 2001-10-16
EA200000728A1 (ru) 2001-02-26
CZ20002496A3 (cs) 2000-12-13
ID26622A (id) 2001-01-25
HRP20000508B9 (hr) 2008-05-31
HK1028021A1 (en) 2001-02-02
NO20003398D0 (no) 2000-06-29
HUP0100184A2 (hu) 2001-07-30
BG64700B1 (bg) 2005-12-30
JP3839665B2 (ja) 2006-11-01
NO327259B1 (no) 2009-05-25
DE69833797D1 (de) 2006-05-04
WO1999035123A1 (en) 1999-07-15
CA2316082C (en) 2006-02-07
EA003097B1 (ru) 2002-12-26
PT1044186E (pt) 2006-07-31
GB9727521D0 (en) 1998-02-25
CA2316082A1 (en) 1999-07-15
EP1044186B9 (en) 2006-06-21
ATE319680T1 (de) 2006-03-15
IL136735A0 (en) 2001-06-14
DE69833797T2 (de) 2006-10-19
NO20003398L (no) 2000-08-02
ES2256976T3 (es) 2006-07-16
JP2002500214A (ja) 2002-01-08
KR100629628B1 (ko) 2006-09-29
TR200001950T2 (tr) 2000-11-21
EP1044186B1 (en) 2006-03-08
EP1044186A1 (en) 2000-10-18

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: NEWRON PHARMACEUTICALS S.P.A., IT

B1PR Patent granted
B9IS Complete republication of an hr-b document
B9IS Complete republication of an hr-b document
ODRP Renewal fee for the maintenance of a patent

Payment date: 20081114

Year of fee payment: 11

PBON Lapse due to non-payment of renewal fee

Effective date: 20091213