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Publication of HN2008001792ApublicationCriticalpatent/HN2008001792A/en
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents
(AREA)
Abstract
ESTA INVENCION SE REFIERE A UN ANTICUERPO O FRAGMENTO DE UNION A ANTIGENMO DEL MISMO, QUE SE UNE A RECEPTOR IL-6 HUMANO (SEQ ID NO:1) CON UNA Kd DE APROXIMADAMENTE 500 PM O INFERIOR, MEDIDA POR RESONANCIA DE PLASMON SUPERFICIAL. EN UNA REALIZACION MAS ESPECIFICA, EL ANTICUERPO O FRAGMENTO DE UNION A ANTIGENO TIENE UNA Kd INFERIOR A 300PM O INFERIOR A 200PM O INCLUSO INFERIOR. EL ANTICUERPO O FRAGMENTO DE UNION A ANTIGENO DE LA INVENCION SE UNE A hIL-6R CON UNA AFINIDAD SUPERIOR EN AL MENOS UN FACTOR DE 2 A AQUELLAS CON LA QUE SE UNE A IL-6R DE MONOTHIS INVENTION REFERS TO AN ANTIBODY OR FRAGMENT OF UNION TO ANTIGENMO OF THE SAME, THAT JOINS A HUMAN IL-6 RECEPTOR (SEQ ID NO: 1) WITH A KD OF APPROXIMATELY 500 PM OR LOWER, MEASURED BY RESONANCE OF SUPERFICIAL PLASMON. IN A MORE SPECIFIC EMBODIMENT, THE ANTIBODY OR FRAGMENT OF ANTIGEN UNION HAS A KD LESS THAN 300PM OR LOWER THAN 200PM OR EVEN LOWER. THE ANTIBODY OR FRAGMENT OF UNION TO ANTIGEN OF THE INVENTION JOINS hIL-6R WITH A SUPERIOR AFFINITY IN AT LEAST A FACTOR OF 2 TO THOSE WITH WHICH JOINS IL-6R DE MONO
HN2008001792A2006-06-022008-12-09
HIGH AFFINITY ANTIBODIES TOWARDS RECEPTOR OF HUMAN IL-6
HN2008001792A
(en)
Antibody or fragment thereof that binds to cd127; and method of treating autoimmune disease or an inflammatory disorder in humans, which comprises administering an antagonist of at least one of the expansion of th17 mediated by the il-7 receptor and the survival of th17 mediated by the il-7 receptor.
A HUMAN OR HUMANIZED ANTIBODY, OR A FRAGMENT OF THE SAME WITH AN ANTIGEN LINK REGION THAT IS SPECIFIC TO DIRECT THE PROTEIN TO THE HUMAN TIMIC STROMAL LIMPHOPROTEIN RECEPTOR (HTSLPR)
ANTI-RECEIVER MONOCLONAL ANTIBODY OF INTERLEUCINE 17 (IL-17RA) OR FRAGMENT OF ANTIGEN UNION OF THE SAME; POLINUCLEOTIDE THAT CODIFIES IT; PREPARATION METHOD; AND METHOD TO TREAT A DISORDER INFLUENCED BY THE ACTIVATION OF IL-17RA.
Humanized antibody that binds to the human il-7 receptor alpha chain (cd127); antigen binding protein comprising one or more complementarity determining regions of said antibody; nucleic acid molecule encoding an antibody or enhancement protein; expression vector, recombinant host cell; procedure for the production of an antigen binding protein; procedure to treat autoimmune or inflammatory disease.