HN2005000370A - Derivados de pirido-pirimidina, su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de pirido-pirimidina, su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- HN2005000370A HN2005000370A HN2005000370A HN2005000370A HN2005000370A HN 2005000370 A HN2005000370 A HN 2005000370A HN 2005000370 A HN2005000370 A HN 2005000370A HN 2005000370 A HN2005000370 A HN 2005000370A HN 2005000370 A HN2005000370 A HN 2005000370A
- Authority
- HN
- Honduras
- Prior art keywords
- alkyl
- group
- preparation
- cycloalkyl
- phenyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 239000000543 intermediate Substances 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- -1 CH2COR4 Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000002393 azetidinyl group Chemical group 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedimiento de preparacion, intermediarios, composicion farmacéutica y uso para enfermedades causadas por proliferacion celular, leucemias y tumores. Reivindicacion 1: Compuesto que responde a la formula (1), en la cual: R1 se selecciona en un grupo constituido por alquilo C1-6, cicloalquilo C3-7, CH2COR4, fenilo, o fenilo sustituido por hidroxi y/o halogeno y/o alquilo C1-6; R4 representa un grupo hidroxilo, alcoxi C1-4, amino, alquilamino C1-4, dialquilamino C1-4; Ar1 representa un radical elegido entre un grupo de formulas (2); R5 representa un grupo ciano, hidroxialquilo C1-4, alcoxiC1-6alquiloC1-6 o un grupo (CH2)nR7R8, CO2R7, CONHR7R8, CONR7R8, CONR8R9, (CH2)nNR7COR8, (CH2)nNR7COOR8; R6 representa un átomo de hidrogeno, un grupo alquilo C1-4 o uno de los valores de R5; o bien R5 y R6, tal como se los ha definido precedentemente, están enlazados para formar un ciclo de 4 a 7 eslabones que comprenden de 0 a 2 heteroátomos elegidos entre N y O, y dicho ciclo de 4 a 7 eslabones está sustituido, eventualmente, por un o varios sustituyentes elegidos, independientemente, entre halogeno, alquilo C1-4, alquilo C1-4, halogenado, hidroxialquilo C1-4, alcoxiC1-4alquiloC1-4, (CH2)nNR7R8, o un grupo terbutoxicarbonilo; R7 y R8 representan cada uno de ellos, independientemente entre sí, un sustituyente elegido entre H, alquilo C1-4, alquiloC1-4-OH, cicloalquilo C3-7, cicloalquilo-C3-7-NH2, alquil-C1-4cicloalquilo-C3-7, C(=NH)NH2, SO2-alquiloC1-6, SO2-fenilo, R8 también puede representar un grupo terbutoxicarbonilo o benciloxicarbonilo; o R7 y R8 junto con el átomo de nitrogeno al cual están enlazados, constituyen un radical azetidinilo, pirrolidinilo, piperidinilo, piperazinilo o morfolinilo, dicho radical está no sustituido o sustituido una o varias veces, por un grupo alquilo C1-6, alquiloC1-4-OH, COO-alquiloC1-6, F; R9 representa un átomo de hidrogeno o un grupo alquilo C1-4; Ar2 representa un grupo fenilo no sustituido o sustituido de 1 a 5 veces, por sustituyentes semejantes o diferentes, elegidos entre un átomo de halogeno, un grupo alquilo C1-4, trifluorometilo o alcoxi C1-4; n representa 1, 2 o 3; m representa 0, 1, 2 o 3. Reivindicacion 5: Intermediario de síntesis para la preparacion de productos de acuerdo con cualquiera de las reivindicaciones 1 a 4, caracterizado porque responde a la formula general (3), en la cual R1 y Ar2 son tal como se los ha definido en una de las reivindicaciones 1 a 4. Reivindicacion 6: Intermediario de síntesis para la preparacion de productos de acuerdo con cualquiera de las reivindicaciones 1 a 5, caracterizado porque responde a la formula general (4), en la cual R1 y Ar2 son tal como se los ha definido en alguna de las reivindicaciones 1 a 6. Reivindicacion 7: Intermediario de síntesis para la preparacion de productos de acuerdo con cualquiera de las reivindicaciones 1 a 6, caracterizado porque responde a la formula general (5), en la cual Ar2 es tal como se ha definido en una de las reivindicaciones 1 a 3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0407898A FR2873118B1 (fr) | 2004-07-15 | 2004-07-15 | Derives de pyrido-pyrimidine, leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HN2005000370A true HN2005000370A (es) | 2009-06-01 |
Family
ID=34947008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HN2005000370A HN2005000370A (es) | 2004-07-15 | 2005-07-14 | Derivados de pirido-pirimidina, su preparacion y su aplicacion en terapeutica |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US7544682B2 (es) |
| EP (1) | EP1773835B1 (es) |
| JP (1) | JP5161568B2 (es) |
| KR (1) | KR101236676B1 (es) |
| CN (1) | CN101124223A (es) |
| AR (1) | AR049845A1 (es) |
| AU (1) | AU2005271071B2 (es) |
| BR (1) | BRPI0513287A (es) |
| CA (1) | CA2572614A1 (es) |
| CR (1) | CR8842A (es) |
| EA (1) | EA011406B1 (es) |
| EC (1) | ECSP067111A (es) |
| FR (1) | FR2873118B1 (es) |
| GT (1) | GT200500191A (es) |
| HN (1) | HN2005000370A (es) |
| IL (1) | IL180256A (es) |
| MA (1) | MA28742B1 (es) |
| MX (1) | MX2007000508A (es) |
| NO (1) | NO20070837L (es) |
| PA (1) | PA8639301A1 (es) |
| PE (1) | PE20060380A1 (es) |
| SV (1) | SV2006002170A (es) |
| TN (1) | TNSN06440A1 (es) |
| TW (1) | TWI391390B (es) |
| UA (1) | UA95223C2 (es) |
| UY (1) | UY29015A1 (es) |
| WO (1) | WO2006016067A2 (es) |
| ZA (1) | ZA200700992B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2873118B1 (fr) * | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | Derives de pyrido-pyrimidine, leur application en therapeutique |
| US7737155B2 (en) * | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
| US7750015B2 (en) * | 2005-05-17 | 2010-07-06 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
| KR20080016567A (ko) * | 2005-05-17 | 2008-02-21 | 쉐링 코포레이션 | 지질혈증장애의 치료를 위한 니코틴산 수용체 효능제로서의헤테로사이클 |
| FR2887882B1 (fr) | 2005-07-01 | 2007-09-07 | Sanofi Aventis Sa | Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique |
| FR2896246B1 (fr) | 2006-01-13 | 2008-08-15 | Sanofi Aventis Sa | Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. |
| US7763623B2 (en) * | 2006-01-20 | 2010-07-27 | Schering Corporation | Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia |
| FR2910813B1 (fr) * | 2006-12-28 | 2009-02-06 | Sanofi Aventis Sa | Nouvelle utilisation therapeutique pour le traitement des leucemies |
| SA08280783B1 (ar) * | 2007-01-11 | 2011-04-24 | استرازينيكا ايه بي | مشتقات بيريدوبيريميدين كمثبطات pde4 |
| TW200835497A (en) * | 2007-01-11 | 2008-09-01 | Astrazeneca Ab | Chemical compounds 636 |
| PL2168966T3 (pl) * | 2007-06-15 | 2017-06-30 | Msd K.K. | Pochodna bicykloaniliny |
| FR2933701A1 (fr) * | 2008-07-08 | 2010-01-15 | Sanofi Aventis | Derives anticancereux, leur preparation et leur application en therapeutique |
| FR2955109B1 (fr) * | 2010-01-08 | 2012-09-07 | Sanofi Aventis | Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1171218A (en) | 1967-11-09 | 1969-11-19 | Parke Davis & Co | New Heterocyclic Amine Compounds and Methods for their Production |
| IL115256A0 (en) * | 1994-11-14 | 1995-12-31 | Warner Lambert Co | 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use |
| RU2191188C2 (ru) | 1994-11-14 | 2002-10-20 | Варнер-Ламберт Компани | Производные 6-арилпиридо[2,3-d]-пиримидины и -нафтиридины, фармацевтическая композиция, обладающая ингибирующим действием клеточной пролиферации, вызываемой протеиновой тирозинкиназой, и способ ингибирования клеточной пролиферации |
| US5620981A (en) | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| AU7315700A (en) | 1999-09-20 | 2001-04-24 | Takeda Chemical Industries Ltd. | Melanin concentrating hormone antagonist |
| BR0107751A (pt) | 2000-01-25 | 2002-11-12 | Warner Lambert Co | Inibidores de pirido[2,3-d]pirimidina-2,7-diaminas quinase |
| US7053070B2 (en) * | 2000-01-25 | 2006-05-30 | Warner-Lambert Company | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors |
| HUP0300136A2 (en) | 2000-03-06 | 2003-05-28 | Warner Lambert Co | 5-alkylpyrido [2,3-d]pyrimidines tyrosine kinase inhibitors, pharmaceutical compositions containing them and their use |
| AP1333A (en) | 2000-08-04 | 2004-11-28 | Warner Lambert Co | 2-(4-pyridyl) amino-6-dialkoxyphenyl-pyrido [2,3-d] pyrimidin-7-ones. |
| AU2002324450A1 (en) | 2001-06-21 | 2003-01-08 | Ariad Pharmaceuticals, Inc. | Novel pyridopyrimidines and uses thereof |
| WO2003026666A1 (en) * | 2001-09-26 | 2003-04-03 | Bayer Pharmaceuticals Corporation | 2-phenylamino-4- (5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, as src kinase inhibitors |
| AU2002361846A1 (en) * | 2001-12-21 | 2003-07-15 | Bayer Pharmaceuticals Corporation | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
| CN1293078C (zh) * | 2002-04-03 | 2007-01-03 | 霍夫曼-拉罗奇有限公司 | 咪唑并稠合化合物 |
| AU2002952453A0 (en) * | 2002-11-01 | 2002-11-21 | Novogen Research Pty Ltd | Aminated isoflavonoid derivatives and uses thereof |
| TW200413381A (en) * | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
| WO2004063195A1 (en) | 2003-01-03 | 2004-07-29 | Sloan-Kettering Institute For Cancer Research | Pyridopyrimidine kinase inhibitors |
| TW200502236A (en) * | 2003-03-28 | 2005-01-16 | Hoffmann La Roche | Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents |
| WO2005034869A2 (en) * | 2003-10-08 | 2005-04-21 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| WO2005105097A2 (en) | 2004-04-28 | 2005-11-10 | Gpc Biotech Ag | Pyridopyrimidines for treating inflammatory and other diseases |
| FR2873118B1 (fr) * | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | Derives de pyrido-pyrimidine, leur application en therapeutique |
| FR2887882B1 (fr) | 2005-07-01 | 2007-09-07 | Sanofi Aventis Sa | Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique |
| FR2896246B1 (fr) | 2006-01-13 | 2008-08-15 | Sanofi Aventis Sa | Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. |
-
2004
- 2004-07-15 FR FR0407898A patent/FR2873118B1/fr not_active Expired - Fee Related
-
2005
- 2005-07-13 AR ARP050102895A patent/AR049845A1/es unknown
- 2005-07-13 UA UAA200701578A patent/UA95223C2/ru unknown
- 2005-07-13 JP JP2007520863A patent/JP5161568B2/ja not_active Expired - Fee Related
- 2005-07-13 EA EA200700144A patent/EA011406B1/ru not_active IP Right Cessation
- 2005-07-13 ZA ZA200700992A patent/ZA200700992B/en unknown
- 2005-07-13 KR KR1020077000780A patent/KR101236676B1/ko not_active Expired - Fee Related
- 2005-07-13 CN CNA2005800278656A patent/CN101124223A/zh active Pending
- 2005-07-13 BR BRPI0513287-8A patent/BRPI0513287A/pt not_active IP Right Cessation
- 2005-07-13 EP EP05788772.1A patent/EP1773835B1/fr not_active Expired - Lifetime
- 2005-07-13 MX MX2007000508A patent/MX2007000508A/es active IP Right Grant
- 2005-07-13 SV SV2005002170A patent/SV2006002170A/es unknown
- 2005-07-13 WO PCT/FR2005/001809 patent/WO2006016067A2/fr not_active Ceased
- 2005-07-13 CA CA002572614A patent/CA2572614A1/fr not_active Abandoned
- 2005-07-13 AU AU2005271071A patent/AU2005271071B2/en not_active Ceased
- 2005-07-14 PE PE2005000811A patent/PE20060380A1/es not_active Application Discontinuation
- 2005-07-14 TW TW094123921A patent/TWI391390B/zh not_active IP Right Cessation
- 2005-07-14 HN HN2005000370A patent/HN2005000370A/es unknown
- 2005-07-14 UY UY29015A patent/UY29015A1/es not_active Application Discontinuation
- 2005-07-14 GT GT200500191A patent/GT200500191A/es unknown
- 2005-07-14 PA PA20058639301A patent/PA8639301A1/es unknown
-
2006
- 2006-12-21 IL IL180256A patent/IL180256A/en not_active IP Right Cessation
- 2006-12-26 EC EC2006007111A patent/ECSP067111A/es unknown
- 2006-12-26 TN TNP2006000440A patent/TNSN06440A1/fr unknown
-
2007
- 2007-01-08 US US11/651,376 patent/US7544682B2/en not_active Expired - Fee Related
- 2007-01-09 CR CR8842A patent/CR8842A/es unknown
- 2007-01-17 MA MA29620A patent/MA28742B1/fr unknown
- 2007-02-13 NO NO20070837A patent/NO20070837L/no not_active Application Discontinuation
-
2009
- 2009-03-31 US US12/415,256 patent/US7893259B2/en not_active Expired - Fee Related
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