HN2000000225A - PHARMACEUTICALLY ACTIVE COMPOUNDS - Google Patents
PHARMACEUTICALLY ACTIVE COMPOUNDSInfo
- Publication number
- HN2000000225A HN2000000225A HN2000000225A HN2000000225A HN2000000225A HN 2000000225 A HN2000000225 A HN 2000000225A HN 2000000225 A HN2000000225 A HN 2000000225A HN 2000000225 A HN2000000225 A HN 2000000225A HN 2000000225 A HN2000000225 A HN 2000000225A
- Authority
- HN
- Honduras
- Prior art keywords
- active compounds
- pharmaceutically active
- pharmaceutically
- veterinarily acceptable
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 206010057671 Female sexual dysfunction Diseases 0.000 abstract 2
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 abstract 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 1
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 abstract 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 abstract 1
- 101100189582 Dictyostelium discoideum pdeD gene Proteins 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 101150098694 PDE5A gene Proteins 0.000 abstract 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 102100029175 cGMP-specific 3',5'-cyclic phosphodiesterase Human genes 0.000 abstract 1
- 229940029575 guanosine Drugs 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Los compuestos de fórmula (I): en la que R1, R2, R4 y R13 son como se definen o una sal farmacéutica o veterinariamente aceptable o polimorfo del mismo, o un solvato farmacéutica o veterinariamente aceptable o profármaco del mismo: son inhibidores potentes y selectivos de TIPO 5 CYCLIC GUANOSINE 3'', 5''-monofosfato fosfodiesterasa (cGMP PDE5) y tienen utilidad en el tratamiento de, entre otros, la disfunción eréctil masculina (MED) y la disfunción sexual femenina (DSF).The compounds of formula (I): wherein R1, R2, R4 and R13 are as defined or a pharmaceutically or veterinarily acceptable or polymorphic salt thereof, or a pharmaceutically or veterinarily acceptable solvate or prodrug thereof: they are potent inhibitors and selective TYPE 5 CYCLIC GUANOSINE 3 '', 5 '' - monophosphate phosphodiesterase (cGMP PDE5) and are useful in the treatment of, among others, male erectile dysfunction (MED) and female sexual dysfunction (FSD).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9924063.2A GB9924063D0 (en) | 1999-10-11 | 1999-10-11 | Pharmaceutically active compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HN2000000225A true HN2000000225A (en) | 2001-04-16 |
Family
ID=10862547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HN2000000225A HN2000000225A (en) | 1999-10-11 | 2000-10-05 | PHARMACEUTICALLY ACTIVE COMPOUNDS |
Country Status (4)
| Country | Link |
|---|---|
| GB (1) | GB9924063D0 (en) |
| HN (1) | HN2000000225A (en) |
| UA (1) | UA72773C2 (en) |
| ZA (1) | ZA200202763B (en) |
-
1999
- 1999-10-11 GB GBGB9924063.2A patent/GB9924063D0/en not_active Ceased
-
2000
- 2000-10-05 HN HN2000000225A patent/HN2000000225A/en unknown
- 2000-11-10 UA UA2002042898A patent/UA72773C2/en unknown
-
2002
- 2002-04-09 ZA ZA200202763A patent/ZA200202763B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9924063D0 (en) | 1999-12-15 |
| UA72773C2 (en) | 2005-04-15 |
| ZA200202763B (en) | 2003-06-25 |
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