HN1999000041A - GMPC PDE5 INHIBITING PIRAZOLIPIRIMIDINONES FOR THE TREATMENT OF SEXUAL DYSFECTION - Google Patents
GMPC PDE5 INHIBITING PIRAZOLIPIRIMIDINONES FOR THE TREATMENT OF SEXUAL DYSFECTIONInfo
- Publication number
- HN1999000041A HN1999000041A HN1999000041A HN1999000041A HN1999000041A HN 1999000041 A HN1999000041 A HN 1999000041A HN 1999000041 A HN1999000041 A HN 1999000041A HN 1999000041 A HN1999000041 A HN 1999000041A HN 1999000041 A HN1999000041 A HN 1999000041A
- Authority
- HN
- Honduras
- Prior art keywords
- alkyl
- treatment
- optionally substituted
- pirazolipirimidinones
- dysfection
- Prior art date
Links
- 101100189582 Dictyostelium discoideum pdeD gene Proteins 0.000 title abstract 2
- 101150098694 PDE5A gene Proteins 0.000 title abstract 2
- 102100029175 cGMP-specific 3',5'-cyclic phosphodiesterase Human genes 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title 1
- 230000001568 sexual effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 206010057671 Female sexual dysfunction Diseases 0.000 abstract 2
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 1
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 abstract 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 229940029575 guanosine Drugs 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000004712 monophosphates Chemical class 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Los compuestos de fórmulas (IA) y (IB) en la que R1 es alquilo C1 a C3 opcionalmente sustituido con fenilo, Het o un grupo heterocíclico unido a N seleccionado entre piperidinilo y morfolinilo en el que dicho grupo fenilo está opcionalmente sustituido por uno o moresubstitutents seleccionados de alcoxi de C1 a C4 halo CN CF3 OCF3 o alquilo C1 a C4 en el que dicho grupo alquilo C1 a C4 está opcionalmente sustituido por alquilo de C1 a C4 haloalquilo o haloalcoxi cualquiera de los cuales está sustituido por uno o más átomos de halo R2 es alquilo C1 a C6 y R13 es OR3 o NR5R6, o sales farmacéutica o veterinariamente aceptables de los mismos, o solvatos farmacéuticamente o veterinariamente aceptable de cualquier entidad son inhibidores potentes y selectivos de tipo 5 de guanosina cíclica 3 ', 5'-monofosfato fosfodiesterasa (cGMP PDE5) y tienen utilidad en el tratamiento de, entre otras cosas, la disfunción eréctil masculina (MED) y disfunción sexual femenina (FSD).The compounds of formulas (IA) and (IB) in which R1 is C1 to C3 alkyl optionally substituted with phenyl, Het or an N-linked heterocyclic group selected from piperidinyl and morpholinyl in which said phenyl group is optionally substituted by one or moresubstitutents selected from C1 to C4 alkoxy halo CN CF3 OCF3 or C1 to C4 alkyl in which said C1 to C4 alkyl group is optionally substituted by C1 to C4 alkyl haloalkyl or haloalkoxy any of which is substituted by one or more atoms of halo R2 is C1 to C6 alkyl and R13 is OR3 or NR5R6, or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of any entity are potent and selective type 5 inhibitors of cyclic guanosine 3 ', 5'- phosphodiesterase monophosphate (cGMP PDE5) and have utility in the treatment of, among other things, male erectile dysfunction (MED) and female sexual dysfunction (FSD).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9808315.7A GB9808315D0 (en) | 1998-04-20 | 1998-04-20 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HN1999000041A true HN1999000041A (en) | 2001-06-18 |
Family
ID=10830602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HN1999000041A HN1999000041A (en) | 1998-04-20 | 1999-04-09 | GMPC PDE5 INHIBITING PIRAZOLIPIRIMIDINONES FOR THE TREATMENT OF SEXUAL DYSFECTION |
Country Status (3)
| Country | Link |
|---|---|
| GB (1) | GB9808315D0 (en) |
| HN (1) | HN1999000041A (en) |
| ZA (1) | ZA992793B (en) |
-
1998
- 1998-04-20 GB GBGB9808315.7A patent/GB9808315D0/en not_active Ceased
-
1999
- 1999-04-09 HN HN1999000041A patent/HN1999000041A/en unknown
- 1999-04-19 ZA ZA9902793A patent/ZA992793B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9808315D0 (en) | 1998-06-17 |
| ZA992793B (en) | 2000-10-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO5271649A1 (en) | GMP [SUB C] PDE5 INHIBITING PIRAZOLOPIRIMIDINONES FOR THE TREATMENT OF SEXUAL DYSFUNCTION | |
| BR9810233A (en) | Pyrozolpyrimidinones that inhibit guanosine phosphodiesterase 3`, 5`- cyclic monosphophate type 5 (cgmp pde5) for the treatment of sexual dysfunction. | |
| AR023659A1 (en) | AN INHIBITOR COMPOUND OF P38, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND THE USE OF SUCH COMPOSITION IN THE TREATMENT AND PREVENTION OF PATHOLOGICAL STATES | |
| CO6241157A2 (en) | "DERIVATIVES OF 6- (PIRROLIDIN-3-IL) -1H-PIRAZOLO {3,4-D} PIRIMIDIN-4 (5H) -ONA USEFUL AS PDE9 INHIBITORS" | |
| PE20010736A1 (en) | PIRAZOLE- [4,3-d] -PYRIMIDIN-7-ONA AS INHIBITORS OF 3`, 5'-GUANOSINMONOPHOSPHATE CYCLIC PHOSPHODIESTERASE | |
| CO5611062A2 (en) | PIRIMIDINE COMPOSITE AND COMPOSITION FOR PEST CONTROL CONTAINING THE SAME | |
| PE20020051A1 (en) | METHODS AND COMPOSITIONS INCLUDING NUCLEOSIDES TO TREAT FLAVIVIRUSES AND PESTIVIRUSES | |
| AR067945A1 (en) | FUSIONED BICYCLE PYRIMIDINS | |
| PE20040197A1 (en) | PYRAZOLOPYRIDINES SUBSTITUTED WITH CARBAMATE | |
| CO6270320A2 (en) | USEFUL PIPERIDINE DERIVATIVES AS AN OREXINE RECEIVER ANTAGONISTS | |
| ES2162466T3 (en) | DERIVATIVES OF 1,2,4-TRIAZOL (4,3-B) PIRIDO (3,2-D) PIRIDAZINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
| MEP12608A (en) | Derivatives of n-[phenyl (pyrrolidine-2-yl) methyl]benzamide and n-[(azepan-2-yl)phenylmethyl]benzamide, preparation method thereof and application of same in therapeutics | |
| PE20020756A1 (en) | IMIDAZOTRIAZINONES SUBSTITUTED AS INHIBITORS OF PHOSPHODIESTERASE PDE 2 | |
| CO5540387A2 (en) | NEW DERIVATIVES OF OXAZOLIDINONES AS ANTIBACTERIALS | |
| AR057855A1 (en) | DERIVATIVES OF PIRAZINA AND PHARMACEUTICAL COMPOSITION | |
| EA201070817A1 (en) | IMIDAZO [1,2-α] PYRIDIN-2-CARBOXAMID DERIVATIVES, THEIR RECEIVING AND THEIR USE IN THERAPY | |
| AR038276A1 (en) | METHODS TO INCREASE THE OSEA TRAINING. | |
| HRP20070584T3 (en) | AMINOQINOLINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGAND | |
| MXPA02012411A (en) | Pyridine-2-yl-aminoalkyl carbonyl glycyl-$g(b)-alanine and derivatives thereof. | |
| AR035650A1 (en) | PROCEDURE FOR THE PREPARATION OF PIRAZOLO COMPOUNDS [4,3-D] PIRIMIDIN-7-ONA | |
| AR066576A1 (en) | NEW DERIVATIVES OF PIRAZOLONA | |
| ATE445619T1 (en) | PYRIDINYLPYRAZOLOPYRIMIDINONE DERIVATIVES AS PDE 7 INHIBITORS | |
| HN1999000041A (en) | GMPC PDE5 INHIBITING PIRAZOLIPIRIMIDINONES FOR THE TREATMENT OF SEXUAL DYSFECTION | |
| AR058405A1 (en) | INHIBITING AMIDAS OF LEUCOTRENE A4 HIDROLASA | |
| ECSP992915A (en) | PYRAZOLOPIRIMIDINONAS INHIBITORS OF GMPc PDES FOR THE TREATMENT OF SEXUAL DYSFUNCTION |