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HN1997000079A - Analogos de indazol sustituido. - Google Patents

Analogos de indazol sustituido.

Info

Publication number
HN1997000079A
HN1997000079A HN1997000079A HN1997000079A HN1997000079A HN 1997000079 A HN1997000079 A HN 1997000079A HN 1997000079 A HN1997000079 A HN 1997000079A HN 1997000079 A HN1997000079 A HN 1997000079A HN 1997000079 A HN1997000079 A HN 1997000079A
Authority
HN
Honduras
Prior art keywords
analogs
indazole
replaced
present
invention refers
Prior art date
Application number
HN1997000079A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of HN1997000079A publication Critical patent/HN1997000079A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A ANALOGOS DE INDAZOL SUSTITUIDO.
HN1997000079A 1996-06-25 1997-06-05 Analogos de indazol sustituido. HN1997000079A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2038596P 1996-06-25 1996-06-25

Publications (1)

Publication Number Publication Date
HN1997000079A true HN1997000079A (es) 1997-12-26

Family

ID=21798354

Family Applications (1)

Application Number Title Priority Date Filing Date
HN1997000079A HN1997000079A (es) 1996-06-25 1997-06-05 Analogos de indazol sustituido.

Country Status (42)

Country Link
US (1) US6040329A (es)
EP (1) EP0912558B1 (es)
JP (1) JP3152940B2 (es)
KR (1) KR20000022516A (es)
CN (1) CN1080260C (es)
AP (1) AP1025A (es)
AR (1) AR007456A1 (es)
AT (1) ATE244713T1 (es)
AU (1) AU716376B2 (es)
BG (1) BG64052B1 (es)
BR (1) BR9712782A (es)
CA (1) CA2258285C (es)
CO (1) CO4900056A1 (es)
CZ (1) CZ423398A3 (es)
DE (1) DE69723447T2 (es)
DK (1) DK0912558T3 (es)
DZ (1) DZ2254A1 (es)
EA (1) EA002274B1 (es)
ES (1) ES2201299T3 (es)
GT (1) GT199700075A (es)
HN (1) HN1997000079A (es)
HR (1) HRP970350B1 (es)
HU (1) HUP9903009A3 (es)
ID (1) ID18579A (es)
IL (1) IL127036A (es)
IS (1) IS4910A (es)
MA (1) MA24225A1 (es)
MY (1) MY116915A (es)
NO (1) NO986103L (es)
NZ (1) NZ332752A (es)
OA (1) OA10934A (es)
PA (1) PA8432301A1 (es)
PL (1) PL330974A1 (es)
PT (1) PT912558E (es)
SI (1) SI0912558T1 (es)
SK (1) SK176598A3 (es)
TN (1) TNSN97108A1 (es)
TR (1) TR199802685T2 (es)
TW (1) TW434237B (es)
WO (1) WO1997049702A1 (es)
YU (1) YU60198A (es)
ZA (1) ZA975581B (es)

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JP4373497B2 (ja) 1996-06-19 2009-11-25 ローン−プーラン・ロレ・リミテツド 置換されたアザビシクロ化合物、ならびにｔｎｆおよびサイクリックａｍｐホスホジエステラーゼ産生の阻害剤としてのそれらの使用
JP3554337B2 (ja) * 1996-09-04 2004-08-18 ファイザー・インク インダゾール誘導体、およびホスホジエステラーゼ（ｐｄｅ）タイプ４と腫瘍壊死因子（ｔｎｆ）産生の阻害剤としてのインダゾール誘導体の使用
US6248746B1 (en) 1998-01-07 2001-06-19 Euro-Celtique S.A. 3-(arylalkyl) xanthines
AU754184B2 (en) * 1997-11-04 2002-11-07 Pfizer Products Inc. Therapeutically active compounds based on indazole bioisostere replacement of catechol in PDE4 inhibitors
CZ20001621A3 (cs) * 1997-11-04 2001-08-15 Pfizer Products Inc. Bioisoterické nahrazení katecholu indazolem v terapeuticky aktivních sloučeninách
US6362213B1 (en) 1999-12-23 2002-03-26 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
EP1244649B1 (en) * 1999-12-23 2005-03-02 Icos Corporation Cyclic amp-specific phosphodiesterase inhibitors
US6953774B2 (en) 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
US7153871B2 (en) 2001-01-22 2006-12-26 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
US7205320B2 (en) 2001-01-22 2007-04-17 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
US6982274B2 (en) * 2001-04-16 2006-01-03 Eisai Co., Ltd. 1H-indazole compound
AU2002217111B2 (en) 2001-12-14 2007-05-31 Merck Serono Sa Methods of inducing ovulation using a non-polypeptide cAMP level modulator
EP1539697A1 (en) 2002-07-19 2005-06-15 Memory Pharmaceutical Corporation Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs
JP2006502995A (ja) * 2002-07-19 2006-01-26 メモリー・ファーマシューティカルズ・コーポレイション ホスホジエステラーゼ４阻害剤としての６−アミノ−１ｈ−インダゾール及び４−アミノベンゾフラン化合物
MXPA05005345A (es) * 2002-11-19 2005-08-26 Memory Pharm Corp Inhibidores de fosfodiesterasa 4.
AU2004232973A1 (en) 2003-04-18 2004-11-04 Memory Pharmaceuticals Corporation Pyrazole derivatives as phosphodiesterase 4 inhibitors
US20090048255A1 (en) * 2003-07-21 2009-02-19 Schumacher Richard A Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs
MY141255A (en) * 2003-12-11 2010-03-31 Memory Pharm Corp Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
JP2008516964A (ja) 2004-10-15 2008-05-22 メモリー ファーマシューティカルス コーポレーション ホスホジエステラーゼ４阻害剤としてのピラゾール誘導体
US7601847B2 (en) 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols
WO2006129158A2 (en) * 2005-05-30 2006-12-07 Ranbaxy Laboratories Limited 3 - indazolyl - isoxazoline derivatives as inhibitors of phosphodiesterase type - i
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
US7781460B2 (en) 2005-09-05 2010-08-24 Ranbaxy Laboratories Limited Substituted indazoles as inhibitors of phosphodiesterase type-IV
US7915286B2 (en) 2005-09-16 2011-03-29 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
PL2124944T3 (pl) 2007-03-14 2012-08-31 Sun Pharmaceutical Ind Ltd Pochodne pirazolo[3,4-b]pirydyny jako inhibitory fosfodiesterazy
US20100029689A1 (en) * 2008-07-02 2010-02-04 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CA2778949C (en) * 2009-10-30 2018-02-27 Janssen Pharmaceutica Nv Imidazo[1,2-b]pyridazine derivatives and their use as pde10 inhibitors
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
US20150125438A1 (en) * 2012-07-20 2015-05-07 Sang Jae Kim Anti-Inflammatory Peptides and Composition Comprising the Same
US9856263B2 (en) 2014-04-28 2018-01-02 Pfizer Inc. Heteroaromatic compounds and their use as dopamine D1 ligands
KR20220167441A (ko) * 2021-06-11 2022-12-21 주식회사 메타센테라퓨틱스 신규한 인돌 유도체 및 이의 최종당화산물 관련 질환의 치료 용도
KR20220167804A (ko) * 2021-06-11 2022-12-22 주식회사 메타센테라퓨틱스 인돌 유도체를 포함하는 최종당화산물 관련 질환의 치료용 조성물

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Also Published As

Publication number Publication date
ATE244713T1 (de) 2003-07-15
CN1080260C (zh) 2002-03-06
AR007456A1 (es) 1999-10-27
ID18579A (id) 1998-04-23
PT912558E (pt) 2003-11-28
PA8432301A1 (es) 1999-12-27
YU60198A (sh) 1999-09-27
MY116915A (en) 2004-04-30
NO986103D0 (no) 1998-12-23
BR9712782A (pt) 1999-12-07
HRP970350A2 (en) 1998-06-30
DZ2254A1 (fr) 2002-12-18
MA24225A1 (fr) 1997-12-31
CA2258285C (en) 2002-11-26
HUP9903009A3 (en) 2002-01-28
EA002274B1 (ru) 2002-02-28
IL127036A0 (en) 1999-09-22
SK176598A3 (en) 2000-06-12
EP0912558B1 (en) 2003-07-09
NZ332752A (en) 2001-04-27
IL127036A (en) 2001-06-14
CA2258285A1 (en) 1997-12-31
OA10934A (en) 2002-02-18
CN1223651A (zh) 1999-07-21
ES2201299T3 (es) 2004-03-16
BG64052B1 (bg) 2003-11-28
US6040329A (en) 2000-03-21
DK0912558T3 (da) 2003-08-18
WO1997049702A1 (en) 1997-12-31
HUP9903009A2 (hu) 2000-05-28
KR20000022516A (ko) 2000-04-25
TW434237B (en) 2001-05-16
SI0912558T1 (en) 2003-10-31
AP9701020A0 (en) 1997-07-31
BG103056A (en) 1999-10-29
PL330974A1 (en) 1999-06-21
EP0912558A1 (en) 1999-05-06
AP1025A (en) 2001-11-19
NO986103L (no) 1998-12-23
HK1018700A1 (en) 1999-12-30
CZ423398A3 (cs) 1999-12-15
DE69723447D1 (de) 2003-08-14
TR199802685T2 (xx) 1999-03-22
JP3152940B2 (ja) 2001-04-03
HRP970350B1 (en) 2003-04-30
IS4910A (is) 1998-11-27
DE69723447T2 (de) 2003-12-24
AU2785797A (en) 1998-01-14
JPH11514668A (ja) 1999-12-14
TNSN97108A1 (fr) 2005-03-15
AU716376B2 (en) 2000-02-24
ZA975581B (en) 1998-12-24
CO4900056A1 (es) 2000-03-27
EA199801047A1 (ru) 1999-06-24
GT199700075A (es) 1998-12-04

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