HK1238129B - Temperature-controlled medicinal storage devices - Google Patents
Temperature-controlled medicinal storage devices Download PDFInfo
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- HK1238129B HK1238129B HK17112358.2A HK17112358A HK1238129B HK 1238129 B HK1238129 B HK 1238129B HK 17112358 A HK17112358 A HK 17112358A HK 1238129 B HK1238129 B HK 1238129B
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Description
优先权申请的所有主题在该主题不与本文不一致的程度上通过引用并入本文。All subject matter of the priority application is incorporated herein by reference to the extent such subject matter is not inconsistent herewith.
发明内容Summary of the Invention
在一方面,药物储存容器包括但不限于:包括一个或多个外壁的干燥剂单元,所述一个或多个外壁密封在一起以形成围绕内部干燥剂区域的不透气屏障,所述一个或多个外壁包括孔;位于所述内部干燥剂区域内的加热元件;能操作地附接到所述加热元件的控制器;包括一个或多个外壁的冷却单元,所述一个或多个外壁密封在一起以形成围绕内部蒸发区域的不透气且不透液的屏障,所述一个或多个外壁包括孔;压缩器系统,其包括定位在所述冷却单元的所述内部蒸发区域内的至少一个蒸发器盘管单元,所述压缩器系统能操作地连接到所述控制器;包括第一端和第二端的蒸汽管道,所述蒸汽管道在所述第一端附接到围绕所述干燥剂单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述第二端附接到围绕所述蒸发冷却单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述干燥剂单元的所述内部干燥剂区域和所述冷却单元的所述内部蒸发区域之间形成内部不透气通道;蒸汽控制单元,其附接到所述蒸汽管道,所述蒸汽控制单元能操作地附接到所述控制器;以及药物储存单元,其包括围绕药物储存区域的一个或多个外壁,所述药物储存区域包括能操作地连接到所述控制器的至少一个温度传感器。In one aspect, a medicinal storage container includes, but is not limited to: a desiccant unit comprising one or more outer walls, the one or more outer walls being sealed together to form an air-tight barrier around an interior desiccant region, the one or more outer walls including apertures; a heating element positioned within the interior desiccant region; a controller operably attached to the heating element; a cooling unit comprising one or more outer walls, the one or more outer walls being sealed together to form an air-tight and liquid-tight barrier around an interior evaporative region, the one or more outer walls including apertures; a compressor system comprising at least one evaporator coil unit positioned within the interior evaporative region of the cooling unit, the compressor system operably connected to the controller; and a compressor comprising a first end and a a steam conduit at a second end, the steam conduit being attached at the first end to the outer surface of the one or more outer walls surrounding the hole of the desiccant unit, the steam conduit being attached at the second end to the outer surface of the one or more outer walls surrounding the hole of the evaporative cooling unit, the steam conduit forming an internal airtight passage between the internal desiccant area of the desiccant unit and the internal evaporative area of the cooling unit; a steam control unit attached to the steam conduit, the steam control unit being operably attached to the controller; and a drug storage unit comprising one or more outer walls surrounding a drug storage area, the drug storage area comprising at least one temperature sensor operably connected to the controller.
在一方面,药物储存容器包括但不限于:包括一个或多个外壁的干燥剂单元,所述一个或多个外壁密封在一起以形成围绕内部干燥剂区域的不透气屏障,所述一个或多个外壁包括孔;位于所述内部干燥剂区域内的加热元件;能操作地附接到所述加热元件的控制器;冷却单元,其包括一个或多个外壁,所述一个或多个外壁密封在一起以形成围绕内部蒸发区域的不透气且不透液的屏障,所述一个或多个外壁包括孔;压缩器系统,其包括定位在所述冷却单元的所述内部蒸发区域内的至少一个蒸发器盘管单元,所述压缩器系统能操作地连接到所述控制器;包括一个或多个壁的冷冻器单元,所述冷冻器单元与位于所述冷却单元的所述内部蒸发区域内的所述至少一个蒸发器盘管单元热接触;蒸汽管道,其包括第一端和第二端,所述蒸汽管道在所述第一端附接到围绕所述干燥剂单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述第二端附接到围绕所述蒸发冷却单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述干燥剂单元的所述内部干燥剂区域和所述冷却单元的所述内部蒸发区域之间形成内部不透气通道;蒸汽控制单元,其附接到所述蒸汽管道,所述蒸汽控制单元能操作地附接到所述控制器;以及药物储存单元,其包括围绕药物储存区域的一个或多个外壁,所述药物储存区域包括能操作地连接到所述控制器的至少一个温度传感器。In one aspect, a medicinal storage container includes, but is not limited to: a desiccant unit comprising one or more outer walls, the one or more outer walls being sealed together to form an airtight barrier around an inner desiccant region, the one or more outer walls including apertures; a heating element positioned within the inner desiccant region; a controller operably attached to the heating element; a cooling unit comprising one or more outer walls, the one or more outer walls being sealed together to form an airtight and liquidtight barrier around an inner evaporative region, the one or more outer walls including apertures; a compressor system comprising at least one evaporator coil unit positioned within the inner evaporative region of the cooling unit, the compressor system operably connected to the controller; a freezer unit comprising one or more walls, the freezer unit being coupled to the inner evaporative region of the cooling unit; thermally contacting the at least one evaporator coil unit within the evaporation region; a steam conduit comprising a first end and a second end, the steam conduit being attached at the first end to the outer surface of the one or more outer walls surrounding the aperture of the desiccant unit, the steam conduit being attached at the second end to the outer surface of the one or more outer walls surrounding the aperture of the evaporative cooling unit, the steam conduit forming an internal airtight passage between the internal desiccant region of the desiccant unit and the internal evaporation region of the cooling unit; a steam control unit attached to the steam conduit, the steam control unit being operably attached to the controller; and a drug storage unit comprising one or more outer walls surrounding the drug storage region, the drug storage region comprising at least one temperature sensor operably connected to the controller.
在一方面,药物储存容器包括但不限于:包括一个或多个外壁的干燥剂单元,所述一个或多个外壁密封在一起以形成围绕内部干燥剂区域的不透气屏障,所述一个或多个外壁包括孔;位于所述内部干燥剂区域内的加热元件;能操作地附接到所述加热元件的控制器;冷却单元,其包括一个或多个外壁,所述一个或多个外壁密封在一起以形成围绕内部蒸发区域的不透气且不透液的屏障,所述一个或多个外壁包括孔;压缩器系统,其包括定位在所述冷却单元的所述内部蒸发区域内的至少一个蒸发器盘管单元,所述压缩器系统能操作地连接到所述控制器;蒸汽管道,其包括第一端和第二端,所述蒸汽管道在所述第二端附接到围绕所述干燥剂单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述第一端附接到围绕所述蒸发冷却单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述干燥剂单元的所述内部干燥剂区域和所述冷却单元的所述内部蒸发区域之间形成内部不透气通道;蒸汽控制单元,其附接到所述蒸汽管道,所述蒸汽控制单元能操作地附接到所述控制器;附接到所述蒸汽管道的热控制单元,所述热控制单元能操作地附接到所述控制器;以及药物储存单元,其包括围绕药物储存区域的一个或多个外壁,所述药物储存区域包括能操作地连接到所述控制器的至少一个温度传感器。In one aspect, a medicinal storage container includes, but is not limited to: a desiccant unit comprising one or more outer walls, the one or more outer walls being sealed together to form an airtight barrier around an inner desiccant region, the one or more outer walls including apertures; a heating element positioned within the inner desiccant region; a controller operably attached to the heating element; a cooling unit comprising one or more outer walls, the one or more outer walls being sealed together to form an airtight and liquidtight barrier around an inner evaporative region, the one or more outer walls including apertures; a compressor system comprising at least one evaporator coil unit positioned within the inner evaporative region of the cooling unit, the compressor system operably connected to the controller; a steam line comprising a first end and a second end, the steam line extending between the first and second ends. The second end is attached to the outer surface of the one or more outer walls surrounding the hole of the desiccant unit, the steam pipe is attached at the first end to the outer surface of the one or more outer walls surrounding the hole of the evaporative cooling unit, the steam pipe forms an internal airtight passage between the internal desiccant area of the desiccant unit and the internal evaporative area of the cooling unit; a steam control unit, which is attached to the steam pipe, and the steam control unit is operably attached to the controller; a thermal control unit attached to the steam pipe, and the thermal control unit is operably attached to the controller; and a drug storage unit, which includes one or more outer walls surrounding the drug storage area, and the drug storage area includes at least one temperature sensor operably connected to the controller.
除了前述之外,在形成本文所阐述的本公开的一部分的权利要求、附图和文本中描述了其他方面。前述发明内容仅是说明性的,并且不旨在以任何方式进行限制。除了上述说明性方面、实施方式和特征之外,通过参考附图和以下详细描述,其它方面、实施方式和特征将变得显而易见。In addition to the foregoing, further aspects are described in the claims, drawings, and text forming a part of the present disclosure set forth herein. The foregoing summary is illustrative only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments, and features described above, further aspects, embodiments, and features will become apparent by reference to the drawings and the following detailed description.
附图说明BRIEF DESCRIPTION OF THE DRAWINGS
图1是药物储存容器的示意图。FIG1 is a schematic diagram of a drug storage container.
图2是药物储存容器的示意图。FIG. 2 is a schematic diagram of a drug storage container.
图3是药物储存容器的示意图。FIG3 is a schematic diagram of a drug storage container.
图4是药物储存容器的示意图。FIG. 4 is a schematic diagram of a drug storage container.
图5是药物储存容器的示意图。FIG5 is a schematic diagram of a drug storage container.
图6是药物储存容器的示意图。FIG. 6 is a schematic diagram of a drug storage container.
图7是药物储存容器的示意图。FIG. 7 is a schematic diagram of a drug storage container.
图8是药物储存容器的示意图。FIG8 is a schematic diagram of a drug storage container.
具体实施方式DETAILED DESCRIPTION
在以下详细描述中,参考形成其一部分的附图。在附图中,类似的符号通常标识相似的组件,除非上下文另有规定。在详细说明、附图和权利要求中描述的说明性实施方式不意味着限制。在不脱离本文所呈现的主题的精神或范围的情况下,可以利用其他实施方式,并且可以进行其它改变。In the following detailed description, reference is made to the accompanying drawings, which form a part hereof. In the drawings, similar symbols generally identify similar components, unless the context dictates otherwise. The illustrative embodiments described in the detailed description, drawings, and claims are not meant to be limiting. Other embodiments may be utilized, and other changes may be made, without departing from the spirit or scope of the subject matter presented herein.
在不同附图中使用相同的符号通常表示类似或相同的项目,除非上下文另有规定。The use of the same symbols in different drawings generally indicates similar or identical items, unless context dictates otherwise.
本文所述的药物储存容器包括与基于压缩器的冷却系统集成的受控蒸发冷却系统。所述药物储存容器包括蒸发冷却系统,所述蒸发冷却系统被校准和控制以在以天或周计的一段时间内将容器的内部储存区域保持在预定温度范围内,即使在没有操作基于压缩器的系统的功率的情况下也如此。在使用药物储存容器期间,药物储存区域内的温度在延长的时间段(例如数周或数月)内保持在温度范围内。药物储存容器包括在蒸发冷却系统中用作附属系统的与蒸发冷却系统串联操作的液体的基于压缩器的冷却。在一些实施方式中,校准药物储存容器以将容器的内部药物储存区域维持在预定温度范围内。在一些实施方式中,校准药物储存容器以将容器的内部药物储存区域维持在0摄氏度和10摄氏度之间的预定温度范围内。在一些实施方式中,校准药物储存容器以将容器的内部药物储存区域维持在2摄氏度和8摄氏度之间的预定温度范围内。药物储存容器可以是适于例如用于储存药剂,例如疫苗,其中储存温度必须保持在高于0摄氏度的温度范围内以防止储存材料冻结,但也必须低于临界阈值(例如10摄氏度)以维持药剂的生物活性。如本文所述的药物储存容器需要最小的功率(例如小于标准制冷单元的功率需求的功率需求)来操作和控制蒸发冷却的速率。药物储存容器可以被再充入(recharge)、修复或更新,以允许在一段时间内重复使用该储存容器。The medicinal storage container described herein includes a controlled evaporative cooling system integrated with a compressor-based cooling system. The medicinal storage container includes an evaporative cooling system that is calibrated and controlled to maintain the internal storage area of the container within a predetermined temperature range over a period of time measured in days or weeks, even when there is no power to operate the compressor-based system. During use of the medicinal storage container, the temperature within the medicinal storage area is maintained within the temperature range over an extended period of time (e.g., weeks or months). The medicinal storage container includes a compressor-based cooling system for a liquid that operates in series with the evaporative cooling system as an auxiliary system in the evaporative cooling system. In some embodiments, the medicinal storage container is calibrated to maintain the internal medicinal storage area of the container within a predetermined temperature range. In some embodiments, the medicinal storage container is calibrated to maintain the internal medicinal storage area of the container within a predetermined temperature range between 0 degrees Celsius and 10 degrees Celsius. In some embodiments, the medicinal storage container is calibrated to maintain the internal medicinal storage area of the container within a predetermined temperature range between 2 degrees Celsius and 8 degrees Celsius. The pharmaceutical storage container can be suitable, for example, for storing pharmaceutical agents, such as vaccines, where the storage temperature must be maintained within a temperature range above 0 degrees Celsius to prevent the stored material from freezing, but must also be below a critical threshold (e.g., 10 degrees Celsius) to maintain the biological activity of the pharmaceutical agent. The pharmaceutical storage container as described herein requires minimal power (e.g., less than the power requirement of a standard refrigeration unit) to operate and control the rate of evaporative cooling. The pharmaceutical storage container can be recharged, repaired, or renewed to allow the storage container to be reused over a period of time.
多种实施方式被配置成用于包括预期的温度变化的不同的环境条件。在一些实施方式中,药物储存容器被设计用于其中电能供应在至少一些时间是间歇的或不确定的环境中。例如,一些药物储存容器被设计为用于以下环境:其中电力仅仅每天平均2小时可用,其中一些天具有较多的可用功率而一些天没有功率可用。例如,一些药物储存容器被设计为用于以下环境:其中电力仅仅每天平均4小时可用,其中一些天具有较多的可用功率,而一些天没有功率可用。例如,一些药物储存容器被设计为用于以下环境:其中电力仅仅每周平均6小时可用,其中一些天具有较多的可用功率而一些天没有功率可用。药物储存容器的一些实施方式不需要每天操作外部电源以将药物储存区域的内部温度保持在预设温度范围内。药物储存容器的一些实施方式不需要每周操作外部电源以将药物储存区域的内部温度保持在预设温度范围内。在一些实施方式中,药物储存容器是无源的,并且不需要外部功率。在一些实施方式中,药物储存容器是手动的,并且不需要外部功率(例如,由手动曲柄或类似的手动机构提供功率)。Various embodiments are configured for use in different environmental conditions, including those with expected temperature variations. In some embodiments, the medicinal storage container is designed for use in environments where the electrical energy supply is intermittent or uncertain at least some of the time. For example, some medicinal storage containers are designed for use in environments where electricity is only available for an average of 2 hours per day, with some days having more available power and some days having no power available. For example, some medicinal storage containers are designed for use in environments where electricity is only available for an average of 4 hours per day, with some days having more available power and some days having no power available. For example, some medicinal storage containers are designed for use in environments where electricity is only available for an average of 6 hours per week, with some days having more available power and some days having no power available. Some embodiments of the medicinal storage container do not require daily operation of an external power source to maintain the internal temperature of the medicinal storage area within a preset temperature range. Some embodiments of the medicinal storage container do not require weekly operation of an external power source to maintain the internal temperature of the medicinal storage area within a preset temperature range. In some embodiments, the medicinal storage container is passive and does not require external power. In some embodiments, the medicinal storage container is manually operated and does not require external power (e.g., powered by a hand crank or similar manual mechanism).
在一些实施方式中,药物储存容器被配置为在没有电力的情况下,当药物储存容器外部的环境温度连续为约43摄氏度时,将容器的药物储存区域维持在0摄氏度和10摄氏度之间的温度范围内至少7天。在一些实施方式中,药物储存容器被配置为在没有电力的情况下,当药物储存容器外部的环境温度(例如在白天/夜晚周期中)在大约30摄氏度和大约43摄氏度之间的范围内波动时,将容器的药物储存区域维持在0摄氏度和10摄氏度之间的温度范围内至少7天。在一些实施方式中,药物储存容器被配置为在没有电力的情况下,当药物储存容器外部的环境温度连续为约43摄氏度时,将容器的药物储存区域维持在0摄氏度和10摄氏度之间的温度范围内至少14天。在一些实施方式中,药物储存容器被配置为在没有电力的情况下,当药物储存容器外部的环境温度(例如在白天/夜晚周期中)在大约30摄氏度和大约43摄氏度之间的范围内波动时,将容器的药物储存区域维持在0摄氏度和10摄氏度之间的温度范围内至少14天。在一些实施方式中,药物储存容器被配置成在功率每天不超过2小时可用持续数月或数年的情况下,当药物储存容器外部的环境温度连续为约43摄氏度时,将容器的药物储存区域无限期地维持在0摄氏度和10摄氏度之间的温度范围内。在一些实施方式中,药物储存容器被配置成在功率每天不超过2小时可用持续数月或数年的情况下,当药物储存容器外部的环境温度(例如在白天/夜晚周期中)在大约30摄氏度和大约43摄氏度之间的范围内波动时,将容器的药物储存区域无限期地维持在0摄氏度和10摄氏度之间的温度范围内。In some embodiments, the medicinal storage container is configured to maintain the medicinal storage area of the container within a temperature range of between 0 degrees Celsius and 10 degrees Celsius for at least 7 days in the absence of power when the ambient temperature external to the medicinal storage container is continuously approximately 43 degrees Celsius. In some embodiments, the medicinal storage container is configured to maintain the medicinal storage area of the container within a temperature range of between 0 degrees Celsius and 10 degrees Celsius for at least 7 days in the absence of power when the ambient temperature external to the medicinal storage container fluctuates (e.g., during a day/night cycle) within a range of between approximately 30 degrees Celsius and approximately 43 degrees Celsius. In some embodiments, the medicinal storage container is configured to maintain the medicinal storage area of the container within a temperature range of between 0 degrees Celsius and 10 degrees Celsius for at least 14 days in the absence of power when the ambient temperature external to the medicinal storage container is continuously approximately 43 degrees Celsius. In some embodiments, the medicinal storage container is configured to maintain the medicinal storage region of the container within a temperature range of between 0 degrees Celsius and 10 degrees Celsius for at least 14 days in the absence of power, when the ambient temperature external to the medicinal storage container (e.g., during a day/night cycle) fluctuates within a range of between about 30 degrees Celsius and about 43 degrees Celsius. In some embodiments, the medicinal storage container is configured to maintain the medicinal storage region of the container within a temperature range of between 0 degrees Celsius and 10 degrees Celsius indefinitely, when power is available for no more than 2 hours per day for several months or years, when the ambient temperature external to the medicinal storage container is continuously at about 43 degrees Celsius. In some embodiments, the medicinal storage container is configured to maintain the medicinal storage region of the container within a temperature range of between 0 degrees Celsius and 10 degrees Celsius indefinitely, when power is available for no more than 2 hours per day for several months or years, when the ambient temperature external to the medicinal storage container (e.g., during a day/night cycle) fluctuates within a range of between about 30 degrees Celsius and about 43 degrees Celsius.
通常,药物储存容器具有用于在医疗诊所或卫生站内使用的尺寸、重量和形状,并且被配置用于在诊所或卫生站将药物(例如疫苗和热不稳定药物)稳定地储存。药物储存容器(诸如本文所述的那些)可以是可移动的。在一些实施方式中,药物储存容器是便携式的,并且可以由个人携带延长的时间段,例如在整个出行的一天。在一些实施方式中,药物储存容器是可移动的,但不一定构造成可由单个人容易地携带。药物储存容器的一些实施方式例如在大约8千克(Kg)和大约15千克之间的质量范围内。例如,在一些实施方式中,药物储存容器的质量为大约8Kg。例如,在一些实施方式中,药物储存容器的质量约为9Kg。例如,在一些实施方式中,药物储存容器的质量约为10Kg。例如,在一些实施方式中,药物储存容器的质量为大约11Kg。例如,在一些实施方式中,药物储存容器的质量约为12Kg。例如,在一些实施方式中,药物储存容器的质量为大约13Kg。例如,在一些实施方式中,药物储存容器的质量为约14Kg。例如,在一些实施方式中,药物储存容器的质量为约15Kg。药物储存容器的一些实施方式例如在大约16千克(Kg)和大约25千克之间的质量范围内。药物储存容器的一些实施方式例如在大约26千克(Kg)和大约50千克之间的质量范围内。Typically, a medication storage container has a size, weight, and shape for use in a medical clinic or health station, and is configured to stably store medications (e.g., vaccines and heat-labile medications) at the clinic or health station. Medicinal storage containers (such as those described herein) can be removable. In some embodiments, the medication storage container is portable and can be carried by an individual for an extended period of time, such as throughout a day of travel. In some embodiments, the medication storage container is removable, but is not necessarily configured to be easily carried by a single person. Some embodiments of the medication storage container, for example, have a mass range of between approximately 8 kilograms (kg) and approximately 15 kilograms. For example, in some embodiments, the mass of the medication storage container is approximately 8 kg. For example, in some embodiments, the mass of the medication storage container is approximately 9 kg. For example, in some embodiments, the mass of the medication storage container is approximately 10 kg. For example, in some embodiments, the mass of the medication storage container is approximately 11 kg. For example, in some embodiments, the mass of the medication storage container is approximately 12 kg. For example, in some embodiments, the mass of the medication storage container is approximately 13 kg. For example, in some embodiments, the mass of the medication storage container is approximately 14 kg. For example, in some embodiments, the mass of the medicinal storage container is about 15 kg. Some embodiments of the medicinal storage container are, for example, within a mass range of about 16 kilograms (kg) and about 25 kilograms. Some embodiments of the medicinal storage container are, for example, within a mass range of about 26 kilograms (kg) and about 50 kilograms.
在一些实施方式中,诸如本文所描述的药物储存容器之类的药物储存容器是在医疗环境中使用的标准顶部开口的冰箱或冷冻机的大致尺寸和形状。例如,在一些实施方式中,药物储存容器为大约1平方米。例如,在一些实施方式中,药物储存容器在每侧上的长度为大约1米或更小。在一些实施方式中,药物储存容器的总内部体积约为10升。在一些实施方式中,药物储存容器的总内部体积约为15升。在一些实施方式中,药物储存容器的总内部体积约为20升。在一些实施方式中,药物储存容器的总内部体积大约为25升。在一些实施方式中,药物储存容器的总内部体积大约为30升。在一些实施方式中,药物储存容器的总内部体积约为35升。在一些实施方式中,药物储存容器的总内部体积大约为40升。在一些实施方式中,药物储存容器的总内部体积为大约45升。在一些实施方式中,药物储存容器的总内部体积大约为50升。在一些实施方式中,药物储存容器的总内部体积大约为55升。在一些实施方式中,药物储存容器的总内部体积约为60升。在一些实施方式中,药物储存容器的总内部体积大约为65升。在一些实施方式中,药物储存容器的总内部体积约为70升。在一些实施方式中,药物储存容器的总内部体积为约75升。在一些实施方式中,药物储存容器的总内部体积大约为80升。在一些实施方式中,药物储存容器的总内部体积约为85升。在一些实施方式中,药物储存容器的总内部体积约为90升。在一些实施方式中,药物储存容器的总内部体积约为95升。在一些实施方式中,药物储存容器的总内部体积约为100升。In some embodiments, a medical storage container, such as the ones described herein, is approximately the size and shape of a standard open-top refrigerator or freezer used in a medical setting. For example, in some embodiments, the medical storage container is approximately 1 square meter. For example, in some embodiments, the length of the medical storage container on each side is approximately 1 meter or less. In some embodiments, the total internal volume of the medical storage container is approximately 10 liters. In some embodiments, the total internal volume of the medical storage container is approximately 15 liters. In some embodiments, the total internal volume of the medical storage container is approximately 20 liters. In some embodiments, the total internal volume of the medical storage container is approximately 25 liters. In some embodiments, the total internal volume of the medical storage container is approximately 30 liters. In some embodiments, the total internal volume of the medical storage container is approximately 35 liters. In some embodiments, the total internal volume of the medical storage container is approximately 40 liters. In some embodiments, the total internal volume of the medical storage container is approximately 45 liters. In some embodiments, the total internal volume of the medical storage container is approximately 50 liters. In some embodiments, the total internal volume of the medical storage container is approximately 55 liters. In some embodiments, the total internal volume of the medical storage container is approximately 60 liters. In some embodiments, the total internal volume of the medicinal storage container is approximately 65 liters. In some embodiments, the total internal volume of the medicinal storage container is approximately 70 liters. In some embodiments, the total internal volume of the medicinal storage container is approximately 75 liters. In some embodiments, the total internal volume of the medicinal storage container is approximately 80 liters. In some embodiments, the total internal volume of the medicinal storage container is approximately 85 liters. In some embodiments, the total internal volume of the medicinal storage container is approximately 90 liters. In some embodiments, the total internal volume of the medicinal storage container is approximately 95 liters. In some embodiments, the total internal volume of the medicinal storage container is approximately 100 liters.
在一些实施方式中,药物储存容器包括:干燥剂单元,其包括一个或多个外壁,所述一个或多个外壁被密封在一起以形成围绕内部干燥剂区域的不透气屏障,所述一个或多个外壁包括孔;位于所述内部干燥剂区域内的加热元件;能操作地附接到所述加热元件的控制器;冷却单元,其包括一个或多个外壁,所述一个或多个外壁密封在一起以形成围绕内部蒸发区域的不透气且不透液的屏障,所述一个或多个外壁包括孔;压缩器系统,其包括定位在所述冷却单元的内部蒸发区域内的至少一个蒸发器盘管单元,所述压缩器系统能操作地连接到所述控制器;蒸汽管道,其包括第一端和第二端,所述蒸汽管道在所述第一端附接到围绕所述干燥剂单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述第二端附接到围绕所述蒸发冷却单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述干燥剂单元的所述内部干燥剂区域和所述冷却单元的所述内部蒸发区域之间形成内部不透气通道;蒸汽控制单元,其附接到所述蒸汽管道,所述蒸汽控制单元能操作地附接到所述控制器;以及药物储存单元,其包括围绕药物储存区域的一个或多个外壁,所述药物储存区域包括能操作地连接到所述控制器的至少一个温度传感器。In some embodiments, a medicinal storage container includes: a desiccant unit including one or more outer walls that are sealed together to form an airtight barrier around an interior desiccant region, the one or more outer walls including an aperture; a heating element positioned within the interior desiccant region; a controller operably attached to the heating element; a cooling unit including one or more outer walls that are sealed together to form an airtight and liquidtight barrier around an interior evaporative region, the one or more outer walls including an aperture; a compressor system including at least one evaporator coil unit positioned within the interior evaporative region of the cooling unit, the compressor system operably connected to the controller; and a steam line. comprising a first end and a second end, the steam conduit being attached at the first end to the outer surface of the one or more outer walls surrounding the hole of the desiccant unit, the steam conduit being attached at the second end to the outer surface of the one or more outer walls surrounding the hole of the evaporative cooling unit, the steam conduit forming an internal airtight passage between the internal desiccant area of the desiccant unit and the internal evaporative area of the cooling unit; a steam control unit being attached to the steam conduit, the steam control unit being operably attached to the controller; and a drug storage unit comprising one or more outer walls surrounding a drug storage area, the drug storage area comprising at least one temperature sensor operably connected to the controller.
为了说明的目的,在本文的附图中表示的项目不一定按比例绘制。For illustrative purposes, items shown in the figures herein are not necessarily drawn to scale.
图1示出了药物储存容器100的各方面。为了示出药物储存容器100的内部特征,将图1的示意图描绘为基本横截面的侧视图。所示的药物储存容器100包括在图1的视图中的最左侧上的药物储存单元。药物储存单元包括环绕药物储存区域150的外壁151。在一些实施方式中,药物储存单元包括邻近药物储存区域的一个或多个壁,所述一个或多个壁被制造成在所述药物储存区域的预期温度下是导热的。在一些实施方式中,外壁由导热材料制成,例如铝或铜。在一些实施方式中,外壁由刚性塑料材料制成。外壁151可以包括出入孔(access aperture)。FIG1 shows various aspects of a medicinal storage container 100. To illustrate the internal features of the medicinal storage container 100, the schematic diagram of FIG1 is depicted as a side view of a basic cross-section. The medicinal storage container 100 shown includes a medicinal storage unit on the far left side of the view in FIG1. The medicinal storage unit includes an outer wall 151 surrounding a medicinal storage area 150. In some embodiments, the medicinal storage unit includes one or more walls adjacent to the medicinal storage area, the one or more walls being manufactured to be thermally conductive at the expected temperature of the medicinal storage area. In some embodiments, the outer wall is made of a thermally conductive material, such as aluminum or copper. In some embodiments, the outer wall is made of a rigid plastic material. The outer wall 151 may include an access aperture.
药物储存单元包括可操作地连接到药物储存容器的控制器的至少一个温度传感器。温度传感器可以例如被定位和配置为检测药物储存单元内的旨在与一种或多种医药产品(例如疫苗或生物制剂)一起使用的空间的温度。例如,如图1所示,在一些实施方式中,药物储存单元包括至少一个温度传感器159,其通过线连接器157连接到控制器170。温度传感器可以包括例如电子温度传感器。温度传感器可以包括例如化学温度传感器。温度传感器可以包括例如机械温度传感器。温度传感器可以包括例如基于双金属的温度传感器。温度传感器可以包括例如热电偶。温度传感器可以包括例如低能温度传感器,例如Thermodo装置(丹麦哥本哈根的Robocat)。一些实施方式包括其中药物储存单元的至少一个温度传感器被定位和配置为检测具有药物储存区域的空间内的温度。一些实施方式包括其中药物储存单元的至少一个温度传感器被定位和配置为检测药物储存区域的外壁的温度。在一些实施方式中,至少一个温度传感器固定在药物储存区域内。在一些实施方式中,至少一个温度传感器固定到药物储存区域的外壁,例如在一定的位置处固定,在该位置处热量预期通过外壁传导。在一些实施方式中,至少一个温度传感器固定到药物储存区域的外壁中的凹陷或凹部,凹陷或凹部定位在药物储存区域的内部空间中。The drug storage unit includes at least one temperature sensor operably connected to a controller of the drug storage container. The temperature sensor can, for example, be positioned and configured to detect the temperature of a space within the drug storage unit that is intended for use with one or more pharmaceutical products (e.g., vaccines or biologics). For example, as shown in FIG1 , in some embodiments, the drug storage unit includes at least one temperature sensor 159, which is connected to the controller 170 via a wire connector 157. The temperature sensor can include, for example, an electronic temperature sensor. The temperature sensor can include, for example, a chemical temperature sensor. The temperature sensor can include, for example, a mechanical temperature sensor. The temperature sensor can include, for example, a bimetallic-based temperature sensor. The temperature sensor can include, for example, a thermocouple. The temperature sensor can include, for example, a low-energy temperature sensor, such as a Thermodo device (Robocat, Copenhagen, Denmark). Some embodiments include wherein the at least one temperature sensor of the drug storage unit is positioned and configured to detect the temperature within a space having a drug storage area. Some embodiments include wherein the at least one temperature sensor of the drug storage unit is positioned and configured to detect the temperature of an outer wall of the drug storage area. In some embodiments, at least one temperature sensor is fixed within the drug storage area. In some embodiments, at least one temperature sensor is affixed to an outer wall of the drug storage area, for example, at a location where heat is expected to be conducted through the outer wall. In some embodiments, at least one temperature sensor is affixed to a recess or depression in the outer wall of the drug storage area, the recess or depression being positioned within the interior space of the drug storage area.
在一些实施方式中,药物储存容器的药物储存单元包括可逆地配合到外壁中的出入孔的盖。在一些实施方式中,药物储存容器的药物储存单元包括定位在与所述药物储存区域的顶部区域相邻的所述外壁中的铰接盖,所述铰接盖被配置成使得用户能够接近所述药物储存区域。例如,在图1所示的视图中,药物储存单元包括利用铰链153附接到药物储存容器100的可逆固定的盖155。如图1示出的实施方式中所示,铰接盖可以被配置为由使用者向上打开。图1用双向箭头描绘了盖155的打开和关闭的方向。在一些实施方式中,药物储存容器的药物储存单元包括构造成在储存期间容纳一种或多种药剂的内部搁板或搁架。例如,药物储存容器的药物储存单元可以包括一个或多个具有一定尺寸和形状的架子,以在医疗专业人员(例如疫苗接种员)使用之前将一种或多种可注射疫苗的辅助包装保持在储存中。搁板或搁架可以固定到药物储存单元的外壁。搁板或搁架可以相对于通过可逆固定的盖的出入口定位。一些实施方式包括附加的存货清单或跟踪组件,例如条形码扫描器或RFID标签读取器。一些实施方式包括定位成照射药物储存单元的内部的灯,例如LED。In some embodiments, the drug storage unit of a drug storage container includes a lid that reversibly fits into an access hole in the outer wall. In some embodiments, the drug storage unit of a drug storage container includes a hinged lid positioned in the outer wall adjacent to the top area of the drug storage area, the hinged lid being configured to allow a user to access the drug storage area. For example, in the view shown in FIG1 , the drug storage unit includes a reversibly fixed lid 155 attached to the drug storage container 100 using hinge 153. As shown in the embodiment shown in FIG1 , the hinged lid can be configured to be opened upward by the user. FIG1 depicts the opening and closing directions of the lid 155 using bidirectional arrows. In some embodiments, the drug storage unit of a drug storage container includes an internal shelf or rack configured to accommodate one or more medications during storage. For example, the drug storage unit of a drug storage container may include one or more shelves of a certain size and shape to store auxiliary packaging for one or more injectable vaccines prior to use by a medical professional (e.g., a vaccinator). The shelf or rack can be fixed to the outer wall of the drug storage unit. The shelf or racks can be positioned relative to the access door by a reversibly fixed cover. Some embodiments include additional inventory or tracking components, such as a barcode scanner or RFID tag reader. Some embodiments include a light, such as an LED, positioned to illuminate the interior of the drug storage unit.
在一些实施方式中,药物储存容器的药物储存单元的总内部体积可以为在约1升(L)至约5.0L的范围内。在一些实施方式中,药物储存容器的药物储存单元的总内部体积可以为在约5L至约10.0L的范围内。在一些实施方式中,药物储存容器的药物储存单元的总内部体积可以为在约1.5L至约4.0L的范围内。例如,在一些实施方式中,药物储存单元的总体积为约1.5L。例如,在一些实施方式中,药物储存单元的总内部体积为约2.0L。例如,在一些实施方式中,药物储存单元的总内部体积为约2.5L。例如,在一些实施方式中,药物储存单元的总内部体积为约3.0L。例如,在一些实施方式中,药物储存单元的总内部体积为约3.5L。例如,在一些实施方式中,药物储存单元的总内部体积为约4.0L。例如,在一些实施方式中,药物储存单元的总内部体积为约5.0L。例如,在一些实施方式中,药物储存单元的总内部体积为约7.5L。例如,在一些实施方式中,药物储存单元的总内部体积为约10.0L。In some embodiments, the total internal volume of the medicinal storage unit of the medicinal storage container may be in the range of about 1 liter (L) to about 5.0 L. In some embodiments, the total internal volume of the medicinal storage unit of the medicinal storage container may be in the range of about 5 L to about 10.0 L. In some embodiments, the total internal volume of the medicinal storage unit of the medicinal storage container may be in the range of about 1.5 L to about 4.0 L. For example, in some embodiments, the total volume of the medicinal storage unit is about 1.5 L. For example, in some embodiments, the total internal volume of the medicinal storage unit is about 2.0 L. For example, in some embodiments, the total internal volume of the medicinal storage unit is about 2.5 L. For example, in some embodiments, the total internal volume of the medicinal storage unit is about 3.0 L. For example, in some embodiments, the total internal volume of the medicinal storage unit is about 3.5 L. For example, in some embodiments, the total internal volume of the medicinal storage unit is about 4.0 L. For example, in some embodiments, the total internal volume of the medicinal storage unit is about 5.0 L. For example, in some embodiments, the total internal volume of the medicinal storage unit is about 7.5 L. For example, in some embodiments, the total internal volume of the drug storage unit is approximately 10.0 L.
在图1所示的实施方式中,药物储存容器100包括位于药物储存单元和干燥剂单元之间的冷却单元。在所示实施方式中,冷却单元包括位于药物储存单元附近的第一侧壁和位于干燥剂单元附近的第二侧壁。在图1所示的实施方式中,冷却单元位于药物储存容器100的大致中心。一些实施方式包括多个冷却单元。例如,一些实施方式包括邻近药物储存容器的单个药物储存单元的相对侧壁定位的两个冷却单元。例如,一些实施方式包括四个冷却单元,每个冷却单元定位成与药物储存容器的基本矩形的药物储存单元的四个侧壁中的一个相邻。例如,一些实施方式包括两个冷却单元,每个冷却单元定位成与药物储存容器的不同药物储存单元相邻。In the embodiment shown in FIG1 , the medicinal storage container 100 includes a cooling unit positioned between the medicinal storage unit and the desiccant unit. In the illustrated embodiment, the cooling unit includes a first sidewall positioned adjacent to the medicinal storage unit and a second sidewall positioned adjacent to the desiccant unit. In the embodiment shown in FIG1 , the cooling unit is positioned approximately in the center of the medicinal storage container 100. Some embodiments include multiple cooling units. For example, some embodiments include two cooling units positioned adjacent to opposing sidewalls of a single medicinal storage unit of the medicinal storage container. For example, some embodiments include four cooling units, each positioned adjacent to one of the four sidewalls of the substantially rectangular medicinal storage unit of the medicinal storage container. For example, some embodiments include two cooling units, each positioned adjacent to a different medicinal storage unit of the medicinal storage container.
在一些实施方式中,药物储存容器的冷却单元包括:上部区域,所述上部区域邻近外壁中的孔定位;下部区域,所述下部区域位于所述上部区域的下方;以及基本上位于所述下部区域内的蒸发液体。在一些实施方式中,药物储存容器的冷却单元包括在蒸发冷却单元的内部蒸发区域内的至少一种蒸发液体。如本文所使用的,“蒸发液体”是在药物储存容器的使用期间在蒸发单元的内部区域的预期温度和气体压力下具有蒸发性质的液体。例如,在一些实施方式中,蒸发单元的内部蒸发区域包括在药物储存容器外部的大气压力的约5%的局部气体压力,并且内部蒸发区域内的蒸发液体包括水。例如,在一些实施方式中,蒸发单元的内部蒸发区域包括在药物储存容器外部的大约10%的大气压力的局部气体压力,并且内部蒸发区域内的蒸发液体包括甲醇。例如,在一些实施方式中,蒸发单元的内部蒸发区域包括在药物储存容器外部的大气压力的大约15%的局部气体压力,并且内部蒸发区域内的蒸发液体包括氨。例如,在一些实施方式中,蒸发液体可以包括另外的试剂以促进或降低蒸发液体的蒸发势。在一个实施方式中使用的蒸发液体的体积可以取决于多种因素,该多种因素包括:蒸发液体的类型,在使用容器期间药物储存区域的温度范围,蒸发器盘管单元的预期温度,用于容器中的绝缘体的类型、位置和数量,所使用的干燥剂的类型,在使用容器期间可用的期望外部功率,以及在容器使用期间的期望环境温度。在一些实施方式中,所使用的蒸发液体的总体积可以是蒸发单元的内部蒸发区域的总体积的大约90%。在一些实施方式中,所使用的蒸发液体的总体积可以是蒸发单元的内部蒸发区域的总体积的大约85%。在一些实施方式中,所使用的蒸发液体的总体积可以是蒸发单元的内部蒸发区域的总体积的大约80%。In some embodiments, a cooling unit for a medicinal storage container includes: an upper region positioned adjacent to an aperture in an outer wall; a lower region positioned below the upper region; and a evaporative liquid substantially within the lower region. In some embodiments, the cooling unit for a medicinal storage container includes at least one evaporative liquid within an internal evaporative region of the evaporative cooling unit. As used herein, an "evaporative liquid" is a liquid that has evaporative properties at the expected temperature and gas pressure of the internal region of the evaporative unit during use of the medicinal storage container. For example, in some embodiments, the internal evaporative region of the evaporative unit comprises a local gas pressure of approximately 5% of the atmospheric pressure outside the medicinal storage container, and the evaporative liquid within the internal evaporative region comprises water. For example, in some embodiments, the internal evaporative region of the evaporative unit comprises a local gas pressure of approximately 10% of the atmospheric pressure outside the medicinal storage container, and the evaporative liquid within the internal evaporative region comprises methanol. For example, in some embodiments, the internal evaporative region of the evaporative unit comprises a local gas pressure of approximately 15% of the atmospheric pressure outside the medicinal storage container, and the evaporative liquid within the internal evaporative region comprises ammonia. For example, in some embodiments, the evaporative liquid may include an additional agent to promote or reduce the evaporation potential of the evaporative liquid. The volume of vaporized liquid used in one embodiment can depend on a variety of factors, including: the type of vaporized liquid, the temperature range of the medication storage area during use of the container, the expected temperature of the evaporator coil unit, the type, location, and amount of insulation used in the container, the type of desiccant used, the expected external power available during use of the container, and the expected ambient temperature during use of the container. In some embodiments, the total volume of vaporized liquid used can be approximately 90% of the total volume of the internal evaporation area of the evaporation unit. In some embodiments, the total volume of vaporized liquid used can be approximately 85% of the total volume of the internal evaporation area of the evaporation unit. In some embodiments, the total volume of vaporized liquid used can be approximately 80% of the total volume of the internal evaporation area of the evaporation unit.
在一些实施方式中,药物储存容器的冷却单元邻近药物储存区域的两个或更多个侧面定位。例如,在一些实施方式中,药物储存容器的冷却单元被配置为邻近药物储存区域的两个侧面定位。例如,在一些实施方式中,药物储存容器的冷却单元被配置为邻近药物储存区域的三个侧面定位。例如,在一些实施方式中,药物储存容器的冷却单元被配置为邻近药物储存区域的四个侧面定位。在一些实施方式中,药物储存区域包括被构造成具有基本上圆形的外部的一个或多个壁,药物储存容器的冷却单元包括被定位和构造成与所述基本上圆形的外部可逆地匹配的外表面。In some embodiments, the cooling unit of the medicinal storage container is positioned adjacent to two or more sides of the medicinal storage area. For example, in some embodiments, the cooling unit of the medicinal storage container is configured to be positioned adjacent to two sides of the medicinal storage area. For example, in some embodiments, the cooling unit of the medicinal storage container is configured to be positioned adjacent to three sides of the medicinal storage area. For example, in some embodiments, the cooling unit of the medicinal storage container is configured to be positioned adjacent to four sides of the medicinal storage area. In some embodiments, the medicinal storage area includes one or more walls configured to have a substantially circular exterior, and the cooling unit of the medicinal storage container includes an outer surface positioned and configured to reversibly mate with the substantially circular exterior.
在一些实施方式中,药物储存容器的冷却单元包括连接到邻近内部蒸发区域的至少一个表面的液体保持单元。在一些实施方式中,液体保持单元连接到冷却单元的内部蒸发区域的内表面。在一些实施方式中,液体保持单元连接到与冷却单元的内部蒸发区域相邻的至少一个表面。液体保持单元可以被配置成使得在药物储存容器的运输或移动期间蒸发液体的小量(例如液滴)在内部蒸发区域内的运动以及进入蒸汽管道的运动最小化。例如,液体保持单元可以包括具有适当尺寸的孔的网或筛网,以基本上抑制液滴通过。液体保持单元应当允许气体和液体蒸汽自由流过液体保持单元,同时抑制较大量的液体,例如液滴或小液滴。In some embodiments, the cooling unit of the medicinal storage container includes a liquid retention unit connected to at least one surface adjacent to the internal evaporation region. In some embodiments, the liquid retention unit is connected to the inner surface of the internal evaporation region of the cooling unit. In some embodiments, the liquid retention unit is connected to at least one surface adjacent to the internal evaporation region of the cooling unit. The liquid retention unit can be configured to minimize the movement of a small amount of evaporated liquid (e.g., droplets) within the internal evaporation region and into the steam conduit during transportation or movement of the medicinal storage container. For example, the liquid retention unit can include a mesh or screen with holes of appropriate size to substantially inhibit the passage of droplets. The liquid retention unit should allow gas and liquid vapor to flow freely through the liquid retention unit while inhibiting larger amounts of liquid, such as droplets or small droplets.
在图1所示的实施方式中,药物储存容器100包括冷却单元,该冷却单元包括一个或多个外壁115,该一个或多个外壁密封在一起以形成围绕内部蒸发区域110的不透气且不透液的屏障,该一个或多个外壁115包括孔133。在图1所示的实施方式中,孔133位于冷却单元外壁115的顶侧内。孔133固定到具有液密和气密密封的蒸汽管道130的第一端180。In the embodiment shown in Figure 1, the medicinal storage container 100 includes a cooling unit comprising one or more outer walls 115 that are sealed together to form an air-tight and liquid-tight barrier around the interior evaporation region 110, the one or more outer walls 115 including an aperture 133. In the embodiment shown in Figure 1, the aperture 133 is located within the top side of the cooling unit outer wall 115. The aperture 133 is secured to the first end 180 of the vapor conduit 130 with a liquid-tight and airtight seal.
如图1所示,药物储存容器100的蒸汽管道130具有第一端180和第二端185,蒸汽管道130的每个端部分别在与蒸发单元110和干燥剂单元120中的每一个的顶部边缘相邻的位置处连接到蒸发单元110和干燥剂单元120。如本文所使用的,“管道”是指具有中空的内部和在远端处的至少两个孔的结构,例如管道、管或沟槽。在一些实施方式中,管道的内部中空部具有基本圆形的横截面。在一些实施方式中,管道的内部中空部具有基本上为矩形、椭圆形或不规则形状的横截面。在一些实施方式中,管道的外部呈箱状或矩形,而其内的连续空间形成部分中空的内部。本文所用的“蒸汽管道”是指构造成用于气体(包括蒸汽形式的蒸发液体)移动通过管道的管道。在一些实施方式中,蒸汽管道130、蒸发单元110和干燥剂单元120由单独的部件制成,然后用不透气的密封件连接在一起。在一些实施方式中,蒸汽管道130、蒸发单元110和干燥剂单元120基本上制造为单个单元,例如用吹塑塑料或金属制造。例如,一个或多个部件可以由聚碳酸酯塑料制成。例如,一个或多个部件可以由铝或不锈钢制成。尽管在图1所示的实施方式中蒸汽控制单元140是可见的,但是在一些实施方式中,蒸汽控制单元140完全在蒸汽管道130内部,并且在药物储存容器100外部不可见。As shown in FIG1 , the steam conduit 130 of the medicinal storage container 100 has a first end 180 and a second end 185 , with each end of the steam conduit 130 connected to the evaporation unit 110 and the desiccant unit 120 at a position adjacent to the top edge of each of the evaporation unit 110 and the desiccant unit 120, respectively. As used herein, a "conduit" refers to a structure having a hollow interior and at least two holes at a distal end, such as a pipe, tube, or groove. In some embodiments, the interior hollow portion of the conduit has a substantially circular cross-section. In some embodiments, the interior hollow portion of the conduit has a substantially rectangular, oval, or irregularly shaped cross-section. In some embodiments, the exterior of the conduit is box-shaped or rectangular, while the continuous space within it forms a partially hollow interior. As used herein, a "steam conduit" refers to a conduit configured for the movement of gas (including evaporated liquid in the form of vapor) through the conduit. In some embodiments, the steam conduit 130, the evaporation unit 110, and the desiccant unit 120 are made from separate components and then connected together with an airtight seal. In some embodiments, the steam conduit 130, evaporation unit 110, and desiccant unit 120 are substantially fabricated as a single unit, for example, from blow-molded plastic or metal. For example, one or more components may be made of polycarbonate plastic. For example, one or more components may be made of aluminum or stainless steel. Although the steam control unit 140 is visible in the embodiment shown in FIG1 , in some embodiments, the steam control unit 140 is completely internal to the steam conduit 130 and is not visible from outside the medicinal storage container 100.
蒸汽控制单元位于蒸汽管道的第一端和蒸汽管道的第二端之间的接合处。一些实施方式包括在蒸汽管道的内部尺寸内的蒸汽控制单元。在一些实施方式中,蒸汽控制单元完全在蒸汽管道内部。在一些实施方式中,蒸汽控制单元包括在蒸汽管道外部的一个或多个部件。蒸汽控制单元包括阀区域和控制区域。控制区域例如利用线连接器连接到控制器。蒸汽控制单元被定位和配置成可逆地抑制蒸汽通过蒸汽管道。蒸汽控制单元可以被配置为响应于从控制器接收到的信号可逆地阻止蒸汽通过蒸汽管道。The steam control unit is located at the junction between the first end of the steam conduit and the second end of the steam conduit. Some embodiments include the steam control unit within the internal dimensions of the steam conduit. In some embodiments, the steam control unit is completely inside the steam conduit. In some embodiments, the steam control unit includes one or more components outside the steam conduit. The steam control unit includes a valve area and a control area. The control area is connected to the controller, for example, using a wire connector. The steam control unit is positioned and configured to reversibly inhibit steam from passing through the steam conduit. The steam control unit can be configured to reversibly prevent steam from passing through the steam conduit in response to a signal received from the controller.
在一些实施方式中,蒸汽控制单元包括至少一个阀,所述至少一个阀被配置为控制气体通过蒸汽管道的在干燥剂单元的内部干燥剂区域和冷却单元的内部蒸发区域之间的内部通道的运动,所述至少一个阀被配置为响应于从所述控制器接收到的信号而操作。蒸汽控制单元可以包括是机械阀的阀,例如蝶阀。蒸汽控制单元可以机械操作。蒸汽控制单元可包括配置成操作阀的马达。在一些实施方式中,阀是直接物理连接到蒸汽控制单元的控制区域的蝶阀。蒸汽控制单元响应于由控制器例如通过连接在蒸汽控制单元和控制器之间的线连接器发送的信号操作。阀的定位和尺寸设置成包括至少两个位置,即在阀区域内的基本打开位置和基本关闭位置。当阀处于基本打开位置时,在蒸汽控制单元的阀区域内的阀的尺寸允许气体(包括蒸汽)在蒸汽管道的第一端和蒸汽管道的第二端之间自由流动,以平衡蒸汽管道的第一端和蒸汽管道的第二端之间的气体压力。当阀处于基本关闭位置时,阀的尺寸和形状基本上阻挡气体在蒸汽管道的第一端和蒸汽管道的第二端之间的流动。在一些实施方式中,蒸汽控制单元的阀直接连接到马达。例如,在一些实施方式中,马达是伺服马达。例如,在一些实施方式中,马达是步进马达。马达直接连接到阀,并且在接收到来自控制器的信号时引起阀的打开和关闭。马达可以通过线连接器直接连接到控制器。在一些实施方式中,阀包括一个或多个中间位置,该一个或多个中间位置部分地阻止气体流过蒸汽管道的第一端和蒸汽管道的第二端之间的阀,但不完全阻挡气流。例如,阀可以具有“半流”位置或减少通过阀的气体流动并且因此在蒸汽管道的第一端和蒸汽管道的第二端之间相对于完全打开位置减小大约一半的位置。例如,阀可以具有“四分之一流”位置或者减少通过阀的气体流动并且因此在蒸汽管道的第一端和蒸汽管道的第二端之间相对于完全打开位置减小到大约一个四分之一的气体流量的位置。In some embodiments, the steam control unit includes at least one valve configured to control the movement of gas through an internal passage of the steam conduit between an internal desiccant region of the desiccant unit and an internal evaporation region of the cooling unit, the at least one valve being configured to operate in response to a signal received from the controller. The steam control unit may include a valve that is a mechanical valve, such as a butterfly valve. The steam control unit may be mechanically operated. The steam control unit may include a motor configured to operate the valve. In some embodiments, the valve is a butterfly valve that is directly physically connected to a control region of the steam control unit. The steam control unit operates in response to a signal sent by the controller, such as via a wired connector connected between the steam control unit and the controller. The valve is positioned and dimensioned to include at least two positions: a substantially open position within the valve region and a substantially closed position. When the valve is in the substantially open position, the size of the valve within the valve region of the steam control unit allows gas (including steam) to flow freely between a first end and a second end of the steam conduit to balance the gas pressure between the first end and the second end of the steam conduit. When the valve is in the substantially closed position, the size and shape of the valve substantially block the flow of gas between the first end and the second end of the steam conduit. In some embodiments, the valve of the steam control unit is directly connected to the motor. For example, in some embodiments, the motor is a servo motor. For example, in some embodiments, the motor is a stepper motor. The motor is directly connected to the valve and causes the valve to open and close when it receives a signal from the controller. The motor can be directly connected to the controller via a wire connector. In some embodiments, the valve includes one or more intermediate positions that partially block the flow of gas through the valve between the first end of the steam conduit and the second end of the steam conduit, but do not completely block the flow of gas. For example, the valve can have a "half flow" position or a position that reduces the flow of gas through the valve and thereby reduces the flow of gas between the first end of the steam conduit and the second end of the steam conduit relative to the fully open position by approximately half. For example, the valve can have a "quarter flow" position or a position that reduces the flow of gas through the valve and thereby reduces the flow of gas to approximately one-quarter of the flow of gas between the first end of the steam conduit and the second end of the steam conduit relative to the fully open position.
在一些实施方式中,药物储存容器包括任选的发射器单元。例如,蒸汽控制单元的控制区域可以包括发射器单元,该发射器单元包括天线和被配置为从天线发送信号的电路。被配置为从天线发送信号的电路可以响应于控制器,例如被配置为从天线发送信号的电路可以基于从控制器接收的数据(例如,基于来自传感器的数据的一个或多个数据点、关于马达的活动的信息或由控制器进行计算的结果)发送信号。在一些实施方式中,控制器可以包括发射器单元。发射器单元可以是例如BluetoothTM单元。发射器单元可以是例如IR发射器。In some embodiments, the drug storage container includes an optional transmitter unit. For example, the control area of the steam control unit may include a transmitter unit, which includes an antenna and a circuit configured to send a signal from the antenna. The circuit configured to send a signal from the antenna can be responsive to the controller, for example, the circuit configured to send a signal from the antenna can send a signal based on data received from the controller (for example, based on one or more data points of data from a sensor, information about the activity of the motor, or the result of a calculation performed by the controller). In some embodiments, the controller may include a transmitter unit. The transmitter unit may be, for example, a Bluetooth™ unit. The transmitter unit may be, for example, an IR transmitter.
在一些实施方式中,蒸汽控制单元包括阀区域,该阀区域包括阀和可移动单元。可移动单元物理地附接到阀并且构造成响应于刺激而提供抵靠阀的物理力。例如,在一些实施方式中,可移动单元是附接到阀的曲柄机构。例如,在一些实施方式中,可移动单元包括阀盖和连接到阀内部的阀杆,阀内部包括盘和盘的物理座。例如,在一些实施方式中,阀包括管道的物理可变形区域,并且可移动单元包括至少两个物理元件,该至少两个物理元件被定位成响应于来自控制器的信号而压靠管道的物理可变形区域的相对的外表面。例如,在一些实施方式中,阀区域包括具有管道的物理可变形区域的阀和包括在阀外部上的可逆夹具的可移动单元,其中可移动单元可操作地附接到控制器。在一些实施方式中,可移动单元包括马达。在一些实施方式中,可移动单元完全在蒸汽控制单元内部。在一些实施方式中,可移动单元包括在蒸汽控制单元外部的一个或多个元件。在一些实施方式中,可移动单元包括被动操作的一个或多个元件,例如响应于温度而改变配置的双金属元件。In some embodiments, a steam control unit includes a valve region comprising a valve and a movable unit. The movable unit is physically attached to the valve and configured to apply a physical force against the valve in response to a stimulus. For example, in some embodiments, the movable unit is a crank mechanism attached to the valve. For example, in some embodiments, the movable unit comprises a valve cap and a valve stem connected to the interior of the valve, the interior of the valve comprising a disc and a physical seat for the disc. For example, in some embodiments, the valve comprises a physically deformable region of a pipe, and the movable unit comprises at least two physical elements positioned to press against opposing outer surfaces of the physically deformable region of the pipe in response to a signal from a controller. For example, in some embodiments, the valve region comprises a valve comprising a physically deformable region of the pipe and a movable unit comprising a reversible clamp on the exterior of the valve, wherein the movable unit is operably attached to the controller. In some embodiments, the movable unit comprises a motor. In some embodiments, the movable unit is entirely within the steam control unit. In some embodiments, the movable unit comprises one or more elements external to the steam control unit. In some embodiments, the movable unit comprises one or more passively operated elements, such as a bimetallic element that changes configuration in response to temperature.
在一些实施方式中,药物储存容器包括围绕冷却单元和药物储存单元的一个或多个绝缘段。例如,图1描绘了具有围绕冷却单元和药物储存单元的绝缘体113的药物储存容器100。绝缘体可以包括例如泡沫绝缘体。绝缘体可以包括例如一个或多个真空绝热板(VIP板)。绝缘体可以包括例如一个或多个面板,其包括由真空空间包围的多层绝缘体(MLI)的内层。绝缘体可以包括例如基于玻璃纤维的绝缘材料。绝缘体可以包括例如陶瓷绝缘材料。绝缘体的类型和量可以基于包括药物储存区域的预期温度范围、容器的预期环境温度范围和容器所使用的外部功率量的因素来选择。In some embodiments, the drug storage container includes one or more insulating sections surrounding the cooling unit and the drug storage unit. For example, FIG1 depicts a drug storage container 100 having an insulator 113 surrounding the cooling unit and the drug storage unit. The insulator may include, for example, foam insulation. The insulator may include, for example, one or more vacuum insulation panels (VIP panels). The insulator may include, for example, one or more panels comprising an inner layer of multi-layer insulation (MLI) surrounded by a vacuum space. The insulator may include, for example, a fiberglass-based insulating material. The insulator may include, for example, a ceramic insulating material. The type and amount of the insulator may be selected based on factors including the expected temperature range of the drug storage area, the expected ambient temperature range of the container, and the amount of external power used by the container.
药物储存容器包括至少一个蒸发器盘管单元。在一些实施方式中,至少一个蒸发器盘管单元邻近容器的外壁定位。在一些实施方式中,至少一个蒸发器盘管单元位于容器内,在邻近冷却单元内的内部蒸发区域的真空空间的区域中。在一些实施方式中,至少一个蒸发器盘管单元位于冷却单元的内部蒸发区域内。例如,在图1所示的实施方式中,蒸发器盘管单元基本上居中地定位在冷却单元的内部蒸发区域110内。在一些实施方式中,至少一个蒸发器盘管单元邻近于冷却单元的靠近干燥剂单元的外壁定位。在一些实施方式中,位于冷却单元的内部蒸发区域内的至少一个蒸发器盘管单元基本上位于冷却单元的中心。在一些实施方式中,定位在冷却单元的内部蒸发区域内的至少一个蒸发器盘管单元定位成邻近冷却单元的靠近药物储存单元的外壁。The medicinal storage container includes at least one evaporator coil unit. In some embodiments, the at least one evaporator coil unit is positioned adjacent to an outer wall of the container. In some embodiments, the at least one evaporator coil unit is located within the container in an area of the vacuum space adjacent to an internal evaporation region within the cooling unit. In some embodiments, the at least one evaporator coil unit is located within the internal evaporation region of the cooling unit. For example, in the embodiment shown in FIG1 , the evaporator coil unit is positioned substantially centrally within the internal evaporation region 110 of the cooling unit. In some embodiments, the at least one evaporator coil unit is positioned adjacent to an outer wall of the cooling unit adjacent to the desiccant unit. In some embodiments, the at least one evaporator coil unit located within the internal evaporation region of the cooling unit is substantially located at the center of the cooling unit. In some embodiments, the at least one evaporator coil unit located within the internal evaporation region of the cooling unit is positioned adjacent to an outer wall of the cooling unit adjacent to the medicinal storage unit.
在一些实施方式中,冷却单元包括固定到所述至少一个蒸发器盘管单元的一个或多个热传导元件。例如,一个或多个热传导元件可以定位在内部蒸发区域内。例如,冷却单元可以包括固定到位于内部蒸发区域内的蒸发器盘管单元上的一个或多个热翅片(thermal fin)和/或热凸缘,该一个或多个热翅片和/或热凸缘定位和构造成在冷却单元的内部和蒸发器盘管单元之间传递热能。例如,冷却单元可以包括固定到位于内部蒸发区域内的蒸发器盘管单元上的一个或多个热翅片和/或热凸缘,该一个或多个热翅片和/或热凸缘定位和构造成在保持在冷却单元内部的液体和蒸发器盘管单元之间传递热能。热传导元件可以由导热金属(例如铝或铜)制成。In some embodiments, the cooling unit includes one or more thermally conductive elements secured to the at least one evaporator coil unit. For example, the one or more thermally conductive elements may be positioned within the interior evaporation region. For example, the cooling unit may include one or more thermal fins and/or thermal flanges secured to the evaporator coil unit located within the interior evaporation region, the one or more thermal fins and/or thermal flanges being positioned and configured to transfer thermal energy between the interior of the cooling unit and the evaporator coil unit. For example, the cooling unit may include one or more thermal fins and/or thermal flanges secured to the evaporator coil unit located within the interior evaporation region, the one or more thermal fins and/or thermal flanges being positioned and configured to transfer thermal energy between the liquid held within the interior of the cooling unit and the evaporator coil unit. The thermally conductive elements may be made of a thermally conductive metal, such as aluminum or copper.
图1还描绘了所示的药物储存容器100的实施方式包括压缩器系统160,压缩器系统160包括定位在冷却单元的内部蒸发区域110内的至少一个蒸发器盘管单元190,压缩器系统160可操作地连接到控制器170。在图1所示的实施方式中,蒸发器盘管单元190基本上位于内部蒸发区域110的中心。在一些实施方式中,蒸发器盘管单元基本上位于内部蒸发区域的外部。虽然内部蒸发区域110被密封为不透气且不透液的,但是位于冷却单元的内部蒸发区域110内的蒸发器盘管单元190利用横穿冷却单元的下壁115的线连接到压缩器系统160的其余部分。压缩器系统可操作地连接到控制器。例如,在图1所示的实施方式中,压缩器系统160利用线连接器165可操作地连接到控制器170。虽然图1所示的实施方式示出了压缩器系统160利用横穿内部蒸发区域110的下壁115的线连接器165可操作地连接到控制器170,但是一些实施方式包括横穿侧壁或顶壁的一根或多根线。横穿线可以包括与壁相邻的密封件,以围绕内部蒸发区域形成气密和液密密封。FIG1 also depicts an embodiment of the illustrated medicinal storage container 100 including a compressor system 160 comprising at least one evaporator coil unit 190 positioned within the interior evaporative region 110 of the cooling unit, the compressor system 160 being operably connected to a controller 170. In the embodiment shown in FIG1 , the evaporator coil unit 190 is substantially located in the center of the interior evaporative region 110. In some embodiments, the evaporator coil unit is substantially located outside the interior evaporative region. Although the interior evaporative region 110 is sealed to be airtight and liquidtight, the evaporator coil unit 190 within the interior evaporative region 110 of the cooling unit is connected to the remainder of the compressor system 160 using a wire that traverses the lower wall 115 of the cooling unit. The compressor system is operably connected to the controller. For example, in the embodiment shown in FIG1 , the compressor system 160 is operably connected to the controller 170 using a wire connector 165. 1 shows compressor system 160 operably connected to controller 170 using a wire connector 165 that traverses the lower wall 115 of interior evaporative region 110, some embodiments include one or more wires that traverse the side walls or top wall. The traversing wires may include seals adjacent to the wall to form an air-tight and liquid-tight seal around the interior evaporative region.
在一些实施方式中,压缩器系统包括单级蒸汽压缩系统。在一些实施方式中,压缩器系统包括定位在内部蒸发区域内的蒸发器盘管单元,蒸发器盘管单元连接到闭环系统中的压缩器、冷凝器和膨胀阀,其中压缩器、冷凝器和膨胀阀定位在所述药物储存容器的所述内部蒸发区域外部的相邻区域中。在一些实施方式中,位于药物储存容器的在内部蒸发区域外部的相邻区域中的压缩器系统的部分在药物储存容器的基部内。在一些实施方式中,压缩器系统包括:至少一个蒸发器盘管单元,其定位在冷却单元的内部蒸发区域内;压缩器单元;冷凝器单元;和计量装置,其中所述压缩器单元、所述冷凝器单元和所述计量装置定位在所述冷却单元的所述内部蒸发区域的外部。计量装置可以包括例如膨胀阀。计量装置可以包括例如毛细管计量装置。In some embodiments, the compressor system comprises a single-stage vapor compression system. In some embodiments, the compressor system comprises an evaporator coil unit positioned within an internal evaporation region, the evaporator coil unit being connected to a compressor, a condenser, and an expansion valve in a closed-loop system, wherein the compressor, condenser, and expansion valve are positioned in an adjacent area outside the internal evaporation region of the medicinal storage container. In some embodiments, the portion of the compressor system located in the adjacent area outside the internal evaporation region of the medicinal storage container is within the base of the medicinal storage container. In some embodiments, the compressor system comprises: at least one evaporator coil unit positioned within the internal evaporation region of a cooling unit; a compressor unit; a condenser unit; and a metering device, wherein the compressor unit, the condenser unit, and the metering device are positioned outside the internal evaporation region of the cooling unit. The metering device may comprise, for example, an expansion valve. The metering device may comprise, for example, a capillary metering device.
图1示出了一个实施方式,其中蒸发器盘管单元190定位在冷却单元的内部蒸发区域110内,制冷剂管横穿冷却单元的内部蒸发区域110的下壁,以将蒸发器盘管单元190连接到邻近冷却单元定位的压缩器系统160的其余部分。制冷剂管横穿冷却单元的内部蒸发区域的壁的位置用不透气且不透液的密封件密封,以便将蒸发液体保持在冷却单元的内部蒸发区域内。在一些实施方式中,压缩器系统包括开关,开关被配置为响应于从控制器接收到的信号而打开和关闭压缩器系统。FIG1 illustrates an embodiment in which an evaporator coil unit 190 is positioned within the interior evaporation region 110 of a cooling unit, with a refrigerant tube traversing the lower wall of the interior evaporation region 110 of the cooling unit to connect the evaporator coil unit 190 to the remainder of a compressor system 160 positioned adjacent to the cooling unit. The location where the refrigerant tube traverses the wall of the interior evaporation region of the cooling unit is sealed with an airtight and liquidtight seal to retain the evaporating liquid within the interior evaporation region of the cooling unit. In some embodiments, the compressor system includes a switch configured to turn the compressor system on and off in response to a signal received from a controller.
在一些实施方式中,冷却单元包括在内部蒸发区域内的一个或多个温度传感器,所述一个或多个温度传感器可操作地附接到控制器。一个或多个温度传感器可以例如利用线连接器附接到控制器。图1示出了位于冷却单元的内部蒸发区域110内的温度传感器119,温度传感器119利用线连接器附接到控制器170。一个或多个温度传感器可以包括例如电子温度传感器。一个或多个温度传感器可以包括例如化学温度传感器。一个或多个温度传感器可以包括例如机械温度传感器。一个或多个温度传感器可以包括例如基于双金属的温度传感器。一个或多个温度传感器可以包括例如热电偶。一个或多个温度传感器可以包括例如低能温度传感器,例如Thermodo装置(丹麦哥本哈根的Robocat)。在内部蒸发区域内的一个或多个温度传感器可以被定位和配置为检测在内部蒸发区域内的位置处的蒸发液体的温度。内部蒸发区域内的一个或多个温度传感器可以被定位和配置为检测内部蒸发区域内的位置(例如在蒸发液体的液位之上)处的空间的温度。内部蒸发区域内的一个或多个温度传感器可以被配置为定期地(例如每秒、每5秒或每10秒)发送关于检测到的温度的信号。内部蒸发区域内的一个或多个温度传感器可以被配置为响应于从控制器接收到查询信号而发送关于检测到的温度的信号。In some embodiments, the cooling unit includes one or more temperature sensors within the internal evaporative region, operably attached to the controller. The one or more temperature sensors can be attached to the controller, for example, using a wired connector. FIG1 shows a temperature sensor 119 located within the internal evaporative region 110 of the cooling unit, which is attached to the controller 170 using a wired connector. The one or more temperature sensors can include, for example, an electronic temperature sensor. The one or more temperature sensors can include, for example, a chemical temperature sensor. The one or more temperature sensors can include, for example, a mechanical temperature sensor. The one or more temperature sensors can include, for example, a bimetallic-based temperature sensor. The one or more temperature sensors can include, for example, a thermocouple. The one or more temperature sensors can include, for example, a low-energy temperature sensor, such as a Thermodo device (Robocat, Copenhagen, Denmark). The one or more temperature sensors within the internal evaporative region can be positioned and configured to detect the temperature of the evaporating liquid at a location within the internal evaporative region. The one or more temperature sensors within the internal evaporative region can be positioned and configured to detect the temperature of the space at a location within the internal evaporative region (e.g., above the level of the evaporating liquid). The one or more temperature sensors within the internal evaporative region can be configured to periodically (e.g., every second, every 5 seconds, or every 10 seconds) transmit a signal regarding the detected temperature. One or more temperature sensors within the interior evaporative region may be configured to transmit a signal regarding a detected temperature in response to receiving a query signal from the controller.
药物储存容器包括控制器,该控制器被定位和配置成调节药物储存容器的其他部件的功能。控制器可以包括电子控制器。例如,在一些实施方式中,电子控制器是“bang-bang”控制器。例如,在一些实施方式中,电子控制器是有界系统控制器。例如,在一些实施方式中,电子控制器是阈值系统控制器。例如,在一些实施方式中,电子控制器是反馈系统控制器。例如,在一些实施方式中,电子控制器是PID控制器。控制器可以包括存储器,例如电子存储器。在一些实施方式中,控制器可以包括查找表,例如包括容器内的单元的可接受参数(例如温度和压力)的范围的查找表。在一些实施方式中,控制器可以包括计算参数,例如特定实施方式的药物储存区域相对于容器的外部温度的预期热泄漏。控制器可操作地附接到压缩器系统。在图1所示的实施方式中,药物储存容器100包括控制器170。在所示实施方式中,控制器170利用线连接器165连接到压缩器系统160。在一些实施方式中,控制器利用无线连接器连接到压缩器系统。控制器连接到能源。在一些实施方式中,控制器连接到电源。例如,在一些实施方式中,控制器连接到市政电源、发电机、太阳能电池板或其它电源。在图1所示的实施方式中,控制器170附接到线连接器175,线连接器175可以例如通过墙壁插座连接到市政电源。The medicinal storage container includes a controller positioned and configured to regulate the functions of other components of the medicinal storage container. The controller may include an electronic controller. For example, in some embodiments, the electronic controller is a "bang-bang" controller. For example, in some embodiments, the electronic controller is a bounded system controller. For example, in some embodiments, the electronic controller is a threshold system controller. For example, in some embodiments, the electronic controller is a feedback system controller. For example, in some embodiments, the electronic controller is a PID controller. The controller may include memory, such as electronic memory. In some embodiments, the controller may include a lookup table, such as a lookup table including ranges of acceptable parameters (e.g., temperature and pressure) for cells within the container. In some embodiments, the controller may include calculated parameters, such as expected heat leakage from the medicinal storage area relative to the external temperature of the container for a particular embodiment. The controller is operably attached to the compressor system. In the embodiment shown in FIG. 1 , the medicinal storage container 100 includes a controller 170. In the illustrated embodiment, the controller 170 is connected to the compressor system 160 using a wired connector 165. In some embodiments, the controller is connected to the compressor system using a wireless connector. The controller is connected to an energy source. In some embodiments, the controller is connected to a power source. For example, in some embodiments, the controller is connected to a mains power source, a generator, a solar panel, or other power source. In the embodiment shown in Figure 1, the controller 170 is attached to a wire connector 175, which can be connected to a mains power source, such as through a wall socket.
控制器可以包括被配置为执行特定操作和处理的电路。例如,控制器可以包括被配置为从附接的传感器接受数据并且确定数据是否在预设范围内的电路,其中控制器向马达发送信号,导致相对于数据是高于还是低于预设范围而打开或关闭蒸汽控制单元的阀。例如,在一些实施方式中,控制器包括接收源自温度传感器的数据、将该数据与预设温度范围进行比较的电路,并且如果来自温度传感器的数据指示高于预设范围的检测温度,则控制器向马达发送信号以启动阀打开。例如,在一些实施方式中,控制器包括接收源自温度传感器的数据、将该数据与预设温度范围进行比较的电路,并且如果来自温度传感器的数据指示在预设范围内的检测温度,则控制器不向马达发送信号。例如,在一些实施方式中,控制器包括接收源自温度传感器的数据、将该数据与预设温度范围进行比较的电路,并且如果来自温度传感器的数据指示低于预设范围的检测温度,则控制器向马达发送信号以启动阀关闭。在一些实施方式中,对于来自药物储存区域内的温度传感器的数据,预设温度范围在2摄氏度和8摄氏度之间。在一些实施方式中,预设温度范围在3摄氏度和7摄氏度之间。在一些实施方式中,预设温度范围在-2摄氏度和+2摄氏度之间。在一些实施方式中,预设温度范围在-3摄氏度和-7摄氏度之间。The controller may include circuitry configured to perform specific operations and processes. For example, the controller may include circuitry configured to receive data from an attached sensor and determine whether the data is within a preset range, wherein the controller sends a signal to a motor to cause the valve of the vapor control unit to open or close depending on whether the data is above or below the preset range. For example, in some embodiments, the controller includes circuitry that receives data from a temperature sensor, compares the data to a preset temperature range, and if the data from the temperature sensor indicates a detected temperature above the preset range, the controller sends a signal to the motor to initiate valve opening. For example, in some embodiments, the controller includes circuitry that receives data from a temperature sensor, compares the data to a preset temperature range, and if the data from the temperature sensor indicates a detected temperature within the preset range, the controller does not send a signal to the motor. For example, in some embodiments, the controller includes circuitry that receives data from a temperature sensor, compares the data to a preset temperature range, and if the data from the temperature sensor indicates a detected temperature below the preset range, the controller sends a signal to the motor to initiate valve closing. In some embodiments, the preset temperature range for data from a temperature sensor within the medication storage area is between 2 degrees Celsius and 8 degrees Celsius. In some embodiments, the preset temperature range is between 3 degrees Celsius and 7 degrees Celsius. In some embodiments, the preset temperature range is between -2 degrees Celsius and +2 degrees Celsius. In some embodiments, the preset temperature range is between -3 degrees Celsius and -7 degrees Celsius.
在一些实施方式中,控制器包括计算从传感器接收的数据与预定目标值之间的误差值的电路。该计算可以包括随时间推移接受的数据,即来自单个传感器的多个数据点。该计算可以包括从多个传感器接受的数据。响应于计算出的误差值,控制器可以计算预测的未来误差值。然后该电路计算组合误差值。如果所计算的过去、现在和未来误差值的计算组合超过预设设定点,则电路然后向马达发起信号以改变阀的打开。例如,蒸汽控制单元的一些实施方式的预设设定点为5摄氏度。在这样的实施方式中,如果所计算的过去、现在和未来误差值的组合(例如8摄氏度)高于预设设定点,则控制器将向马达发送信号,该信号属于用以启动马达以打开附接的阀的类型。类似地,在这样的实施方式中,如果所计算的过去、现在和未来误差值的组合(例如2摄氏度)低于预设设定点,则控制器将向马达发送信号,该信号属于用以启动马达以关闭附接的阀的类型。In some embodiments, the controller includes circuitry that calculates the error value between data received from a sensor and a predetermined target value. This calculation can include data received over time, i.e., multiple data points from a single sensor. This calculation can include data received from multiple sensors. In response to the calculated error value, the controller can calculate a predicted future error value. The circuitry then calculates a combined error value. If the calculated combination of past, present, and future error values exceeds a preset set point, the circuitry then initiates a signal to the motor to change the opening of the valve. For example, some embodiments of the steam control unit have a preset set point of 5 degrees Celsius. In such an embodiment, if the calculated combination of past, present, and future error values (e.g., 8 degrees Celsius) is above the preset set point, the controller will send a signal to the motor that is used to activate the motor to open the attached valve. Similarly, in such an embodiment, if the calculated combination of past, present, and future error values (e.g., 2 degrees Celsius) is below the preset set point, the controller will send a signal to the motor that is used to activate the motor to close the attached valve.
在一些实施方式中,控制器可操作地连接到内部干燥剂区域内的一个或多个温度传感器、蒸汽控制单元和加热元件。控制器被配置为从部件(例如温度传感器)接收信号,并向部件发送信号。例如,响应于指示药物储存区域中的升高的温度的信号,控制器可以向蒸汽控制单元发送信号,该信号的类型将导致蒸汽控制单元打开管道中的阀以增加在蒸发冷却区域中的蒸发冷却,并且相应地降低药物储存区域中的温度。在图1所示的实施方式中,控制器170利用线连接器157可操作地连接到定位在药物储存区域150内的温度传感器159。控制器170还利用线连接器145可操作地连接到蒸汽控制单元140。类似地,控制器170利用线连接器可操作地连接到干燥剂区域120内的加热元件127。在一些实施方式中,控制器包括:被配置为响应于从药物储存区域内的至少一个温度传感器接收到的信号来控制加热元件的操作的电路。在一些实施方式中,控制器利用线连接器可操作地附接到加热元件和至少一个温度传感器。In some embodiments, a controller is operably connected to one or more temperature sensors, a steam control unit, and a heating element within the internal desiccant region. The controller is configured to receive signals from components (e.g., temperature sensors) and send signals to the components. For example, in response to a signal indicating an elevated temperature within the medication storage region, the controller can send a signal to the steam control unit, the type of signal that will cause the steam control unit to open a valve in a conduit to increase evaporative cooling within the evaporative cooling region and, accordingly, reduce the temperature within the medication storage region. In the embodiment shown in FIG1 , controller 170 is operably connected to temperature sensor 159 positioned within medication storage region 150 using wire connector 157. Controller 170 is also operably connected to steam control unit 140 using wire connector 145. Similarly, controller 170 is operably connected to heating element 127 within desiccant region 120 using wire connectors. In some embodiments, the controller includes circuitry configured to control the operation of the heating element in response to signals received from at least one temperature sensor within the medication storage region. In some embodiments, the controller is operably attached to the heating element and at least one temperature sensor using wire connectors.
在一些实施方式中,药物储存容器包括围绕药物储存单元和冷却单元的热绝缘体。例如,在图1所示的实施方式中,药物储存容器100包括围绕药物储存单元的面向外的外壁151和冷却单元的面向外的外壁115的热绝缘体113。该热绝缘体也可以定位成抵靠冷却单元的靠近干燥剂单元的面向外的外壁。一些实施方式还包括在面对外壁的外表面之间的位于药物储存容器的药物储存单元、冷却单元和干燥剂单元之间的热绝缘体。例如,在图1所示的实施方式中,热绝缘体117位于药物储存单元的外壁151和冷却单元的外壁115的相对表面之间。在一些实施方式中,热绝缘体包括基于塑料的泡沫材料。在一些实施方式中,热绝缘体包括一个或多个真空绝热板(VIP板)。在一些实施方式中,干燥剂单元的外部不包括额外的绝缘体,以便例如在吸收期间允许热量从容器的该区域扩散。In some embodiments, the medicinal storage container includes a thermal insulator surrounding the medicinal storage unit and the cooling unit. For example, in the embodiment shown in Figure 1, the medicinal storage container 100 includes a thermal insulator 113 surrounding the outward-facing outer wall 151 of the medicinal storage unit and the outward-facing outer wall 115 of the cooling unit. This thermal insulator can also be positioned against the outward-facing outer wall of the cooling unit near the desiccant unit. Some embodiments also include a thermal insulator between the medicinal storage unit, the cooling unit, and the desiccant unit of the medicinal storage container between the outer surfaces of the facing outer walls. For example, in the embodiment shown in Figure 1, a thermal insulator 117 is located between the opposing surfaces of the outer wall 151 of the medicinal storage unit and the outer wall 115 of the cooling unit. In some embodiments, the thermal insulator includes a plastic-based foam material. In some embodiments, the thermal insulator includes one or more vacuum insulation panels (VIP panels). In some embodiments, the exterior of the desiccant unit does not include additional insulation to allow heat to diffuse from this area of the container, for example, during absorption.
在一些实施方式中,存在一个或多个热传递单元,其定位在热绝缘体内,定位在药物储存单元的邻近冷却单元的外壁的外壁的相对表面之间。例如,热传递单元可以包括定位和构造成促进热量从药物储存容器内部传递到冷却单元内部的一个或多个热虹吸管、一个或多个热管或一个或多个蒸汽室。在一些实施方式中,例如,热管可以定位在热绝缘体内,该热绝缘体定位在药物储存单元的邻近冷却单元的外壁的外壁的相对表面之间,并且被配置成将热量从药物储存容器内部传递到冷却单元内部。热传递单元可以例如被定位和构造成将热能或热量从药物储存容器内部传递到冷却单元内部。In some embodiments, one or more heat transfer units are positioned within a thermal insulator positioned between opposing surfaces of an outer wall of the drug storage unit adjacent to an outer wall of the cooling unit. For example, the heat transfer unit can include one or more thermosiphons, one or more heat pipes, or one or more vapor chambers positioned and configured to facilitate heat transfer from the interior of the drug storage container to the interior of the cooling unit. In some embodiments, for example, a heat pipe can be positioned within a thermal insulator positioned between opposing surfaces of an outer wall of the drug storage unit adjacent to an outer wall of the cooling unit and configured to transfer heat from the interior of the drug storage container to the interior of the cooling unit. The heat transfer unit can, for example, be positioned and configured to transfer thermal energy or heat from the interior of the drug storage container to the interior of the cooling unit.
在一些实施方式中,药物储存容器包括定位在药物储存容器下方的基部单元,该基部单元包括基本上围绕压缩器系统和控制器的至少一个区域的一个或多个壁。例如,图1示出了包括基部单元105的药物储存容器100。基部可以是例如由金属或塑料制成的框架或封闭的盒状结构。基部可以例如具有足够的高度以定位药物储存容器的顶部,以供例如医疗专业人员的使用者接近。In some embodiments, the medicinal storage container includes a base unit positioned below the medicinal storage container, the base unit including one or more walls that substantially surround at least one area of the compressor system and the controller. For example, FIG1 illustrates a medicinal storage container 100 including a base unit 105. The base can be, for example, a frame or a closed box-like structure made of metal or plastic. The base can, for example, be of sufficient height to position the top of the medicinal storage container for access by a user, such as a medical professional.
药物储存容器包括干燥剂单元,所述干燥剂单元包括一个或多个外壁,所述一个或多个外壁密封在一起以形成围绕内部干燥剂区域的不透气屏障。在一些实施方式中,外壁包括导体材料,例如导热金属。外壁包括孔,该孔用不透蒸汽且不透液的密封件密封到蒸汽管道的端部。在图1所示的实施方式中,药物储存容器100包括干燥剂单元120。干燥剂单元包括蒸汽密封室,蒸汽密封室包括与蒸汽管道的内部区域蒸汽接触的内部干燥剂区域。图1所示的干燥剂单元120附接到蒸汽管道130的第二端185。干燥剂单元包括定位在内部干燥剂区域内的加热元件。在图1所示的实施方式中,干燥剂单元120包括沿着冷却单元的内部蒸发区域110远端的壁的基本上平面构造的加热元件127。在一些实施方式中,加热元件是电加热元件。在一些实施方式中,加热元件处于盘绕结构。一些实施方式包括固定到加热元件的一个或多个热传导元件,例如一个或多个导热翅片或凸缘,其被定位成分配来自干燥剂单元内的加热元件的热量。在一些实施方式中,加热元件被定位和配置成以均匀分布加热干燥剂单元内的干燥剂材料。在一些实施方式中,加热元件邻近干燥剂单元的壁的内表面定位。在一些实施方式中,加热元件邻近干燥剂单元的壁的外表面定位。在一些实施方式中,加热元件位于干燥剂单元的壁的外部,加热元件被定位和构造成通过传导和/或对流加热干燥剂单元内的干燥剂材料。The medicinal storage container includes a desiccant unit comprising one or more outer walls that are sealed together to form an airtight barrier surrounding an internal desiccant region. In some embodiments, the outer walls comprise a conductive material, such as a thermally conductive metal. The outer walls include a hole that is sealed to the end of a steam conduit with a vapor-tight and liquid-tight seal. In the embodiment shown in FIG1 , the medicinal storage container 100 includes a desiccant unit 120. The desiccant unit includes a steam-tight chamber that includes an internal desiccant region that is in vapor contact with the internal region of the steam conduit. The desiccant unit 120 shown in FIG1 is attached to the second end 185 of the steam conduit 130. The desiccant unit includes a heating element positioned within the internal desiccant region. In the embodiment shown in FIG1 , the desiccant unit 120 includes a substantially planar heating element 127 along a wall distal to the internal evaporation region 110 of the cooling unit. In some embodiments, the heating element is an electric heating element. In some embodiments, the heating element is in a coiled configuration. Some embodiments include one or more heat transfer elements, such as one or more heat conductive fins or flanges, secured to the heating element, which are positioned to distribute heat from the heating element within the desiccant unit. In some embodiments, the heating element is positioned and configured to evenly distribute the heat to the desiccant material within the desiccant unit. In some embodiments, the heating element is positioned adjacent to the inner surface of the wall of the desiccant unit. In some embodiments, the heating element is positioned adjacent to the outer surface of the wall of the desiccant unit. In some embodiments, the heating element is located outside the wall of the desiccant unit, and the heating element is positioned and configured to heat the desiccant material within the desiccant unit by conduction and/or convection.
在一些实施方式中,干燥剂单元包括内部干燥剂区域内的一个或多个干燥剂材料单元。在一些实施方式中,干燥剂单元包括在内部干燥剂区域内的小于大气压力的气体压力。在一些实施方式中,干燥剂单元包括在内部干燥剂区域内小于1托的气体压力。在一些实施方式中,干燥剂单元包括在内部干燥剂区域内的小于0.1托的气体压力。在一些实施方式中,干燥剂单元包括位于内部干燥剂区域内的开孔金属泡沫(open-cell metal foam),开孔金属泡沫被定位成在内部干燥剂区域内分配气体。在一些实施方式中,干燥剂单元包括定位在内部干燥剂区域内的一个或多个管,所述一个或多个管定位成在内部干燥剂区域内分配气体。In some embodiments, the desiccant unit comprises one or more units of desiccant material within the internal desiccant region. In some embodiments, the desiccant unit comprises a gas pressure within the internal desiccant region that is less than atmospheric pressure. In some embodiments, the desiccant unit comprises a gas pressure within the internal desiccant region that is less than 1 Torr. In some embodiments, the desiccant unit comprises a gas pressure within the internal desiccant region that is less than 0.1 Torr. In some embodiments, the desiccant unit comprises an open-cell metal foam within the internal desiccant region, the open-cell metal foam being positioned to distribute gas within the internal desiccant region. In some embodiments, the desiccant unit comprises one or more tubes positioned within the internal desiccant region, the one or more tubes being positioned to distribute gas within the internal desiccant region.
一些实施方式包括邻近干燥剂单元的一个或多个外表面定位的绝缘体。在一个实施方式中,绝缘体可以包括例如比围绕储存区域的绝缘体更小的绝缘容量。一些实施方式包括邻近干燥剂单元的一个或多个外表面定位的绝缘单元。一些实施方式包括邻近干燥剂单元的一个或多个外表面定位的可移动绝缘单元。例如,可移动绝缘单元可以包括机械系统,以改变位于干燥剂单元的一个或多个外表面附近的绝缘体的配置。例如,可移动绝缘单元可以包括滑动面板,该滑动面板被配置为随时间推移移动以覆盖干燥剂单元的相对较多或相对较少的外表面。一些实施方式包括可移动绝缘单元,其被配置为由用户缠绕在干燥剂单元的外部周围,然后被移除。Some embodiments include an insulator positioned adjacent to one or more exterior surfaces of the desiccant unit. In one embodiment, the insulator may include, for example, a smaller insulating capacity than the insulation surrounding the storage area. Some embodiments include an insulating unit positioned adjacent to one or more exterior surfaces of the desiccant unit. Some embodiments include a removable insulating unit positioned adjacent to one or more exterior surfaces of the desiccant unit. For example, the removable insulating unit may include a mechanical system to change the configuration of the insulator positioned adjacent to one or more exterior surfaces of the desiccant unit. For example, the removable insulating unit may include a sliding panel that is configured to move over time to cover relatively more or relatively less of the exterior surface of the desiccant unit. Some embodiments include a removable insulating unit that is configured to be wrapped around the exterior of the desiccant unit by a user and then removed.
在一些实施方式中,所述干燥剂单元包括单向阀单元,所述单向阀单元被构造成使得具有超过预设极限的压力的气体能够从所述干燥剂单元的所述内部干燥剂区域向外排出。例如,干燥剂单元可以包括吹出阀,该吹出阀构造成在干燥剂单元内的气体压力超过预定最大水平的情况下打开。单向阀单元例如可以是容器的安全特征。In some embodiments, the desiccant unit includes a one-way valve unit configured to allow gas having a pressure exceeding a preset limit to be vented outwardly from the internal desiccant region of the desiccant unit. For example, the desiccant unit may include a blow-out valve configured to open if the gas pressure within the desiccant unit exceeds a predetermined maximum level. The one-way valve unit may, for example, be a safety feature of the container.
药物储存容器包括具有第一端和第二端的蒸汽管道,所述蒸汽管道在第一端附接到围绕干燥剂单元的孔的一个或多个外壁的外表面,蒸汽管道在所述第二端附接到围绕所述蒸发冷却单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述干燥剂单元的内部干燥剂区域和所述冷却单元的内部蒸发区域之间形成内部不透气通道。药物储存容器还包括附接到蒸汽管道的蒸汽控制单元,蒸汽控制单元可操作地附接到控制器。例如,图1示出了非线性管状结构的蒸汽管道130。蒸汽管道130包括密封到冷却单元的内部蒸发区域110中的孔133的第一端180。蒸汽管道130包括密封到干燥剂单元120的井(well)中的孔135的第二端185。图1所示的蒸汽管道130构造成包括基本上竖直的第二端185,第二端185固定到第一端180的定位成与竖直第二端185成大约45度的区域。蒸汽管道130包括蒸汽控制单元140,蒸汽控制单元140在接近基本上竖直的第二端185与定位成与竖直第二端185成大约45度的第一端180的接合处的位置处固定到蒸汽管道130。蒸汽控制单元140利用线连接器145连接到控制器170。The medicinal storage container includes a steam conduit having a first end and a second end, wherein the steam conduit is attached to the outer surface of one or more outer walls surrounding the aperture of the desiccant unit at the first end and to the outer surface of the one or more outer walls surrounding the aperture of the evaporative cooling unit at the second end, the steam conduit forming an internal airtight passage between the internal desiccant region of the desiccant unit and the internal evaporative region of the cooling unit. The medicinal storage container also includes a steam control unit attached to the steam conduit, the steam control unit being operably attached to a controller. For example, FIG1 shows a steam conduit 130 having a nonlinear tubular structure. The steam conduit 130 includes a first end 180 that is sealed to the aperture 133 in the internal evaporative region 110 of the cooling unit. The steam conduit 130 includes a second end 185 that is sealed to the aperture 135 in the well of the desiccant unit 120. The steam conduit 130 shown in FIG1 is configured to include a substantially vertical second end 185 that is fixed to a region of the first end 180 that is positioned approximately 45 degrees from the vertical second end 185. The steam pipe 130 includes a steam control unit 140 secured to the steam pipe 130 near the junction of a substantially vertical second end 185 and a first end 180 positioned approximately 45 degrees from the vertical second end 185. The steam control unit 140 is connected to the controller 170 using a wire connector 145.
在一些实施方式中,药物储存容器包括蒸汽管道,所述蒸汽管道包括具有足以抑制干燥剂单元的至少一个外壁与冷却单元的至少一个外壁之间的热传导的长度和直径的基本管状结构。在一些实施方式中,药物储存容器包括构造成使干燥剂单元和冷却单元之间的热能传导最小化的蒸汽管道。例如,蒸汽管道可以是细长的和/或成角度的,以最小化干燥剂单元和冷却单元之间的热能传导。在一些实施方式中,药物储存容器包括蒸汽管道,蒸汽管道包括固定到蒸汽管道的外表面的一个或多个热传导元件。例如,蒸汽管道可以包括固定到蒸汽管道的外表面的由导热材料制成的一个或多个热翅片。在一些实施方式中,药物储存容器包括蒸汽管道,蒸汽管道包括:蒸汽管道的不透气壁;在所述蒸汽管道的第一端和所述干燥剂单元之间的不透气密封件;以及在所述蒸汽管道的第二端和所述冷却单元之间的不透气密封件。在一些实施方式中,药物储存容器包括蒸汽管道,所述蒸汽管道包括穿过蒸汽管道的内部通道的外部可破坏的密封件,所述密封件构造成防止气体流过蒸汽管道的内部通道。例如,蒸汽管道可以包括不透气薄膜,该不透气薄膜被制造为堵塞蒸汽管道的内径的脆性密封件,该密封件可被外力破坏,例如在蒸汽管道的邻近所述内部密封件的位置的外部上的尖锐的片(tap)。在一些实施方式中,药物储存容器包括:第一温度传感器,其位于蒸汽管道内的第一端附近,第一温度传感器可操作地附接到控制器;以及第二温度传感器,其位于所述蒸汽管道内的所述第二端附近,所述第二温度传感器可操作地附接到所述控制器。In some embodiments, a medicinal storage container includes a steam conduit comprising a substantially tubular structure having a length and diameter sufficient to inhibit heat transfer between at least one outer wall of the desiccant unit and at least one outer wall of the cooling unit. In some embodiments, the medicinal storage container includes a steam conduit configured to minimize heat transfer between the desiccant unit and the cooling unit. For example, the steam conduit can be elongated and/or angled to minimize heat transfer between the desiccant unit and the cooling unit. In some embodiments, the medicinal storage container includes a steam conduit comprising one or more heat-conducting elements secured to an outer surface of the steam conduit. For example, the steam conduit can include one or more heat-conducting fins made of a thermally conductive material secured to an outer surface of the steam conduit. In some embodiments, the medicinal storage container includes a steam conduit comprising: an air-impermeable wall of the steam conduit; an air-impermeable seal between a first end of the steam conduit and the desiccant unit; and an air-impermeable seal between a second end of the steam conduit and the cooling unit. In some embodiments, the medicinal storage container includes a steam conduit comprising an externally breakable seal extending through an interior passage of the steam conduit, the seal configured to prevent gas from flowing through the interior passage of the steam conduit. For example, the steam conduit can include an airtight membrane fabricated as a brittle seal that blocks the inner diameter of the steam conduit, the seal being breakable by an external force, such as a sharp tap on the exterior of the steam conduit adjacent the inner seal. In some embodiments, the medicinal storage container includes: a first temperature sensor positioned within the steam conduit near a first end, the first temperature sensor being operably attached to a controller; and a second temperature sensor positioned within the steam conduit near the second end, the second temperature sensor being operably attached to the controller.
蒸汽管道包括固定到蒸汽管道和控制器的蒸汽控制单元。在一些实施方式中,蒸汽控制单元完全在蒸汽管道内部并且从外部不可见。在一些实施方式中,蒸汽控制单元与蒸汽管道成一体。蒸汽控制单元可控地增加和减小蒸汽控制单元内部的管道的内部尺寸,其用于改变通过蒸汽控制单元的蒸汽流量,因此改变蒸汽管道的第一端和蒸汽管道的第二端之间的蒸汽流量。参见:“Calculating Pipe Sizes&Pressure Drops in VacuumSystems”,第9节-Technical Reference,Rietschle Thomas Company,通过引用将其并入。在一些实施方式中,蒸汽控制单元包括至少一个阀,所述至少一个阀被配置为控制气体通过蒸汽管道的在干燥剂单元的内部干燥剂区域和冷却单元的内部蒸发区域之间的内部通道的流动,所述至少一个阀被配置为响应于从所述控制器接收到的信号而操作。在一些实施方式中,药物储存容器包括连接到控制器的加速度计,所述加速度计被配置为当所述容器在其侧面翻转或倾斜时发送信号以关闭蒸汽控制单元内的阀。The steam conduit includes a steam control unit secured to the steam conduit and a controller. In some embodiments, the steam control unit is entirely within the steam conduit and is not visible from the outside. In some embodiments, the steam control unit is integral to the steam conduit. The steam control unit controllably increases and decreases the internal dimensions of a conduit within the steam control unit, thereby varying the flow of steam through the steam control unit and, therefore, between a first end of the steam conduit and a second end of the steam conduit. See: "Calculating Pipe Sizes & Pressure Drops in Vacuum Systems," Section 9 - Technical Reference, Rietschle Thomas Company, incorporated herein by reference. In some embodiments, the steam control unit includes at least one valve configured to control the flow of gas through an internal passageway of the steam conduit between an internal desiccant region of the desiccant unit and an internal evaporation region of the cooling unit, the at least one valve being configured to operate in response to a signal received from the controller. In some embodiments, the medicinal storage container includes an accelerometer connected to the controller, the accelerometer being configured to send a signal to close the valve within the steam control unit when the container is flipped or tilted on its side.
在一些实施方式中,蒸汽控制单元包括定位成感测蒸汽管道内部内的一个或多个条件的传感器。在一些实施方式中,蒸汽控制单元包括温度传感器。在一些实施方式中,蒸汽控制单元包括压力传感器。在一些实施方式中,蒸汽控制单元包括真空传感器。根据实施方式,传感器可以包括例如电子温度传感器、化学温度传感器或机械温度传感器。传感器可以包括例如低能温度传感器,例如Thermodo装置(丹麦哥本哈根的Robocat)。根据实施方式,传感器可以包括例如电子气体压力传感器或机械气体压力传感器。用于测量气体压力的传感器可以包括布尔登管(Bourdon tube)。用于测量气体压力的传感器可以包括基于隔膜的气体压力传感器。用于测量温度的传感器可以包括例如热电偶。传感器可以包括气体压力、气体组成和温度的组合传感器。例如,传感器可以包括NODE装置(VariableTechnologies,Chattanooga TN)。在一些实施方式中,传感器可以包括电源,例如电池。在一些实施方式中,传感器连接到控制器并且例如通过线连接器从控制器接收功率。In some embodiments, the steam control unit includes a sensor positioned to sense one or more conditions within the interior of the steam pipe. In some embodiments, the steam control unit includes a temperature sensor. In some embodiments, the steam control unit includes a pressure sensor. In some embodiments, the steam control unit includes a vacuum sensor. Depending on the embodiment, the sensor may include, for example, an electronic temperature sensor, a chemical temperature sensor, or a mechanical temperature sensor. The sensor may include, for example, a low-energy temperature sensor, such as a Thermodo device (Robocat, Copenhagen, Denmark). Depending on the embodiment, the sensor may include, for example, an electronic gas pressure sensor or a mechanical gas pressure sensor. The sensor for measuring gas pressure may include a Bourdon tube. The sensor for measuring gas pressure may include a diaphragm-based gas pressure sensor. The sensor for measuring temperature may include, for example, a thermocouple. The sensor may include a combination sensor of gas pressure, gas composition, and temperature. For example, the sensor may include a NODE device (Variable Technologies, Chattanooga, TN). In some embodiments, the sensor may include a power source, such as a battery. In some embodiments, the sensor is connected to the controller and receives power from the controller, for example, via a wire connector.
一些实施方式包括属于温度传感器的传感器。温度传感器可以包括例如机械温度传感器。温度传感器可以包括例如电子温度传感器。例如,一些实施方式包括属于温度传感器的传感器,温度传感器包括热电偶、双金属温度传感器、红外温度计、电阻温度计或硅带隙温度传感器中的一种或多种。Some embodiments include a sensor that is a temperature sensor. The temperature sensor may include, for example, a mechanical temperature sensor. The temperature sensor may include, for example, an electronic temperature sensor. For example, some embodiments include a sensor that is a temperature sensor, the temperature sensor including one or more of a thermocouple, a bimetallic temperature sensor, an infrared thermometer, a resistance thermometer, or a silicon bandgap temperature sensor.
一些实施方式包括属于气体压力传感器的传感器。气体压力传感器可以包括例如机械气体压力传感器,例如布尔登管。气体压力传感器可以包括具有毛细管的膨胀阀。气体压力传感器可以包括例如电子气体压力传感器。例如,一些实施方式包括属于真空传感器的传感器。例如,在使用容器之前,蒸汽管道的内部可以基本上被排空,或者在相对于大气压力的低气体压力下,然后在蒸发液体的蒸发期间减小真空。因此,来自真空传感器的数据可以指示蒸发速率或容器内蒸发液体的总蒸发水平。在一些实施方式中,气体压力传感器可以包括压阻应变仪,电容性气体压力传感器或电磁气体压力传感器。在一些实施方式中,压力传感器包括电容压力传感器。Some embodiments include sensors that are gas pressure sensors. The gas pressure sensor may include, for example, a mechanical gas pressure sensor, such as a Bourdon tube. The gas pressure sensor may include an expansion valve having a capillary tube. The gas pressure sensor may include, for example, an electronic gas pressure sensor. For example, some embodiments include sensors that are vacuum sensors. For example, before using the container, the interior of the steam pipe may be substantially evacuated, or at a low gas pressure relative to atmospheric pressure, and then the vacuum is reduced during evaporation of the evaporating liquid. Thus, data from the vacuum sensor may indicate the evaporation rate or the total evaporation level of the evaporating liquid within the container. In some embodiments, the gas pressure sensor may include a piezoresistive strain gauge, a capacitive gas pressure sensor, or an electromagnetic gas pressure sensor. In some embodiments, the pressure sensor includes a capacitive pressure sensor.
包括蒸汽控制单元的蒸汽管道被配置为控制蒸汽在干燥剂单元的内部干燥剂区域和蒸发冷却单元的内部蒸发区域之间的流动。如图1所示,在一些实施方式中,蒸汽管道被配置为在相邻单元之间横穿的管状结构。蒸汽管道被构造成在需要容器的最大蒸发冷却的情况下允许足够的气体(包括蒸发的蒸汽)移动到干燥剂单元的内部干燥剂区域。因此,蒸汽管道的尺寸、形状和布置将取决于包括容器的尺寸、容器所需的温度范围、蒸汽管道内蒸汽移动的可逆控制水平、以及干燥剂材料和在特定实施方式中使用的液体的物理性质的因素。例如,在一些实施方式中,储存区域的目标温度范围在0和10摄氏度之间,并且药物储存容器包括大约1升的液体水和相应体积的包括氯化钙的干燥剂材料,以吸收大于1升的水。参见“The Calcium Chloride Handbook,A Guide to Properties,Forms,Storage andHandling,”DOW Chemical Company,日期为2003年8月,其通过引用并入本文。例如,对于具有水作为蒸发液体和氯化钙作为干燥剂材料的药物储存容器的一些实施方式,其中便携式冷却单元以基本上真空的内部(即小于或等于300mTorr的压强)开始,估计当阀处于完全打开位置时,每小时大约1克的水将蒸发。因此,在外部环境温度为大约25摄氏度的情况下,1升水和1.5kg氯化钙可以将蒸发冷却单元保持在大约6摄氏度和9摄氏度之间大约一个月。例如,对于具有水作为蒸发液体和氯化钙作为干燥剂材料的药物储存容器的一些实施方式,其中便携式冷却单元以基本上真空的内部(即小于或等于300mTorr的压强)开始,估计当阀处于完全打开位置时,每小时大约2-5克的水将蒸发。蒸发速率将取决于实施方式的构造和使用情况。一些实施方式包括在蒸汽控制单元内的传感器,传感器通过有线连接器可操作地连接到控制器。传感器可以包括例如温度或压力传感器。一些实施方式包括多个温度传感器。The steam conduit comprising a steam control unit is configured to control the flow of steam between the internal desiccant region of the desiccant unit and the internal evaporation region of the evaporative cooling unit. As shown in Figure 1, in some embodiments, the steam conduit is configured as a tubular structure that crosses between adjacent units. The steam conduit is constructed to allow sufficient gas (including evaporated steam) to move to the internal desiccant region of the desiccant unit when the maximum evaporative cooling of the container is required. Therefore, the size, shape and arrangement of the steam conduit will depend on factors including the size of the container, the temperature range required for the container, the reversible control level of steam movement in the steam conduit, and the physical properties of the desiccant material and the liquid used in the specific embodiment. For example, in some embodiments, the target temperature range of the storage area is between 0 and 10 degrees Celsius, and the drug storage container includes approximately 1 liter of liquid water and a corresponding volume of desiccant material including calcium chloride to absorb more than 1 liter of water. See "The Calcium Chloride Handbook, A Guide to Properties, Forms, Storage and Handling," DOW Chemical Company, dated August 2003, which is incorporated herein by reference. For example, for some embodiments of a medicinal storage container having water as the evaporating liquid and calcium chloride as the desiccant material, wherein the portable cooling unit starts with a substantially vacuum interior (i.e., a pressure of less than or equal to 300 mTorr), it is estimated that when the valve is in the fully open position, approximately 1 gram of water will evaporate per hour. Therefore, when the external ambient temperature is approximately 25 degrees Celsius, 1 liter of water and 1.5 kg of calcium chloride can keep the evaporative cooling unit between approximately 6 degrees Celsius and 9 degrees Celsius for approximately one month. For example, for some embodiments of a medicinal storage container having water as the evaporating liquid and calcium chloride as the desiccant material, wherein the portable cooling unit starts with a substantially vacuum interior (i.e., a pressure of less than or equal to 300 mTorr), it is estimated that when the valve is in the fully open position, approximately 2-5 grams of water will evaporate per hour. The evaporation rate will depend on the configuration and use of the embodiment. Some embodiments include a sensor within the vapor control unit, which is operably connected to the controller via a wired connector. The sensor can include, for example, a temperature or pressure sensor. Some embodiments include multiple temperature sensors.
在容器的使用期间,定位在药物储存区域内的温度传感器可以经由线将数据传输到控制器。控制器被配置为响应于接收到的数据可操作地控制蒸汽控制单元。在包括电子控制器的实施方式中,电子控制器从固定到药物储存区域的一个或多个温度传感器接收数据,并且确定检测到的值是在预定范围外还是在预定范围内。根据该确定,电子控制器可以启动阀打开或关闭以将温度或压力返回到预定值范围。例如,在一些实施方式中,如果电子温度传感器发送包括9摄氏度的温度数据的信号,则控制器将确定接收到的温度数据在3摄氏度至7摄氏度的预定范围之外。响应于该确定,控制器将向连接到蒸汽控制单元内的阀的马达发送信号,该类型的信号启动马达以打开阀。举另一示例而言,在一些实施方式中,如果电子温度传感器发送包括1摄氏度的温度数据的信号,则控制器将确定接收的温度数据在3摄氏度至7摄氏度的预定范围之外。响应于该确定,控制器将向连接到蒸汽控制单元内的阀的马达发送信号,该类型的信号启动马达以关闭阀。During use of the container, a temperature sensor positioned within the medication storage area can transmit data to a controller via a wire. The controller is configured to operatively control the vapor control unit in response to the received data. In embodiments including an electronic controller, the electronic controller receives data from one or more temperature sensors affixed to the medication storage area and determines whether the detected value is within or outside a predetermined range. Based on this determination, the electronic controller can activate the valve to open or close to return the temperature or pressure to the predetermined range. For example, in some embodiments, if the electronic temperature sensor transmits a signal containing temperature data of 9 degrees Celsius, the controller will determine that the received temperature data is outside the predetermined range of 3 to 7 degrees Celsius. In response to this determination, the controller will send a signal to a motor connected to a valve within the vapor control unit that activates the motor to open the valve. As another example, in some embodiments, if the electronic temperature sensor transmits a signal containing temperature data of 1 degree Celsius, the controller will determine that the received temperature data is outside the predetermined range of 3 to 7 degrees Celsius. In response to this determination, the controller will send a signal to a motor connected to a valve within the vapor control unit that activates the motor to close the valve.
然而,根据实施方式,在控制器、温度传感器和蒸汽控制单元内的阀之间的不同类型的连接是可能的。例如,在一些实施方式中,蒸汽控制单元包括热电偶,该热电偶被配置成将物理压力施加在机械控制器上,该机械控制器将该物理压力传递到阀的控制元件以导致阀的打开或关闭。例如,在一些实施方式中,温度传感器包括电子温度传感器,其经由有线或无线连接(例如通过IR传输或短波长无线电传输(例如蓝牙))将关于随时间推移而检测到的温度的数据发送到电子控制器。However, depending on the embodiment, different types of connections between the controller, the temperature sensor, and the valve within the steam control unit are possible. For example, in some embodiments, the steam control unit includes a thermocouple configured to exert physical pressure on a mechanical controller that transmits the physical pressure to a control element of the valve to cause the valve to open or close. For example, in some embodiments, the temperature sensor includes an electronic temperature sensor that transmits data about the temperature detected over time to the electronic controller via a wired or wireless connection (e.g., by IR transmission or short wavelength radio transmission (e.g., Bluetooth)).
图2示出了药物储存容器的实施方式,示出了在使用中的容器的各方面。图2所示的实施方式与图1所示的实施方式具有类似性。在图2所示的视图中,蒸发区域110包括存在于蒸发区域110的下部中的蒸发液体200。蒸发液体200具有在药物储存容器100的蒸发区域110内的顶表面203。空间240存在于蒸发液体200的顶表面203上方。空间240定位成允许气体和蒸汽从蒸发液体200上方的空间240自由流动通过管道130的第一端180。FIG2 illustrates an embodiment of a medicinal storage container, showing various aspects of the container in use. The embodiment shown in FIG2 is similar to the embodiment shown in FIG1 . In the view shown in FIG2 , the evaporation region 110 includes an evaporating liquid 200 located in a lower portion of the evaporation region 110. The evaporating liquid 200 has a top surface 203 within the evaporation region 110 of the medicinal storage container 100. A space 240 exists above the top surface 203 of the evaporating liquid 200. The space 240 is positioned to allow gas and vapor to flow freely from the space 240 above the evaporating liquid 200 through the first end 180 of the conduit 130.
图2还描绘了位于干燥剂单元120内的干燥剂材料250。干燥剂材料250的单元由具有干燥剂性质或从周围空间中的液体蒸汽中移除液体的能力的至少一种材料制成。干燥剂材料的单元可以例如通过从周围空间中的水蒸汽吸收或吸附水来操作。所选择的一个或多个干燥剂材料单元将取决于具体实施方式,特别是在操作与特定容器成一体的特定蒸发冷却单元所需的估计时间段内吸收液体所需的足够量的干燥剂材料的体积。在一些实施方式中,所选择的干燥剂材料单元在常规操作条件下将是固体材料。一个或多个干燥剂材料单元可以包括非干燥剂材料,例如粘合材料、支架材料或支撑材料。一个或多个干燥剂材料单元可以包括两种或更多种类型的干燥剂材料。本文所述的药物储存容器旨在与蒸发冷却一起使用几天或几周,并且在任何给定的实施方式中对于那些时间段包括足够的干燥剂材料和相应的蒸发液体。关于液体-干燥剂材料对的更多信息,参见:Saha等人的“A NewGeneration Cooling Device Employing CaCl2-in-silica Gel-water System,”International Journal of Heat and Mass Transfer,52:516-524(2009),其通过引用并入本文。在具体实施方式中使用的一种或多种干燥剂材料的选择还将取决于具体实施方式中的目标冷却温度范围。例如,在一些实施方式中,干燥剂材料可以包括碳酸钙。例如,在一些实施方式中,干燥剂材料可以包括氯化锂。例如,在一些实施方式中,干燥剂材料可以包括液氨。例如,在一些实施方式中,干燥剂材料可以包括沸石。例如,在一些实施方式中,干燥剂材料可以包括二氧化硅。关于干燥剂材料的更多信息可以在以下文献中获得:Dawoud和Aristov的“Experimental Study on the Kinetics of Water Vapor Sorption onSelective Water Sorbents,Silica Gel and Alumina Under Typical OperatingConditions of Sorption Heat Pumps,”International Journal of Heat and MassTransfer,46:273-281(2004);Conde-Petit的“Aqueous Solutions of Lithium andCalcium Chlorides:-Property Formulations for Use in Air ConditioningEquipment Design,”M.Conde Engineering,(2009);“Zeolite/Water Refrigerators,”BINE Informationsdienst,projektinfo 16/10;“Calcium Chloride Handbook:A Guideto Properties,Forms,Storage and Handling,”Dow Chemical Company,(August,2003);“Calcium Chloride,A Guide to Physical Properties,”Occidental ChemicalCorporation,Form No.173-01791-0809P&M;和Restuccia等人的“Selective WaterSorbent for Solid Sorption Chiller:Experimental Results and Modelling,”International Journal of Refrigeration 27:284-293(2004),这些文献各自通过引用并入本文。在一些实施方式中,干燥剂材料在常规处理预防措施下被认为是无毒的。干燥剂材料的选择还取决于材料的任何放热性质,以便在特定实施方式中保持期望的整个药物储存容器的热性质。FIG2 also depicts a desiccant material 250 located within the desiccant unit 120. The unit of desiccant material 250 is made of at least one material having desiccant properties or the ability to remove liquid from liquid vapor in the surrounding space. The unit of desiccant material can, for example, operate by absorbing or adsorbing water from water vapor in the surrounding space. The one or more desiccant material units selected will depend on the specific embodiment, in particular the volume of the desiccant material required to absorb the sufficient amount of liquid within the estimated time period required to operate the specific evaporative cooling unit integrated with the specific container. In some embodiments, the selected desiccant material unit will be a solid material under normal operating conditions. One or more desiccant material units may include non-desiccant materials, such as adhesive materials, bracket materials, or support materials. One or more desiccant material units may include two or more types of desiccant materials. The medicinal storage container described herein is intended to be used with evaporative cooling for several days or weeks, and in any given embodiment includes enough desiccant material and corresponding evaporative liquid for those time periods. For more information on liquid-desiccant material pairs, see: Saha et al., “A New Generation Cooling Device Employing CaCl2-in-silica Gel-water System,” International Journal of Heat and Mass Transfer, 52:516-524 (2009), which is incorporated herein by reference. The selection of one or more desiccant materials used in a particular embodiment will also depend on the target cooling temperature range in the particular embodiment. For example, in some embodiments, the desiccant material may include calcium carbonate. For example, in some embodiments, the desiccant material may include lithium chloride. For example, in some embodiments, the desiccant material may include liquid ammonia. For example, in some embodiments, the desiccant material may include zeolite. For example, in some embodiments, the desiccant material may include silicon dioxide. More information about desiccant materials can be found in the following: Dawoud and Aristov, “Experimental Study on the Kinetics of Water Vapor Sorption on Selective Water Sorbents, Silica Gel and Alumina Under Typical Operating Conditions of Sorption Heat Pumps,” International Journal of Heat and Mass Transfer, 46:273-281 (2004); Conde-Petit, “Aqueous Solutions of Lithium and Calcium Chlorides:—Property Formulations for Use in Air Conditioning Equipment Design,” M. Conde Engineering, (2009); “Zeolite/Water Refrigerators,” BINE Informationsdienst, projektinfo 16/10; “Calcium Chloride Handbook: A Guide to Properties, Forms, Storage and Handling,” Dow Chemical Company, (August, 2003); “Calcium Chloride, A Guide to Physical Properties,” Occidental Chemical Corporation, Form No. 173-01791-0809 P&M; and Restuccia et al., "Selective WaterSorbent for Solid Sorption Chiller: Experimental Results and Modelling," International Journal of Refrigeration 27: 284-293 (2004), each of which is incorporated herein by reference. In some embodiments, the desiccant material is considered non-toxic under conventional handling precautions. The choice of desiccant material also depends on any exothermic properties of the material in order to maintain the desired thermal properties of the entire pharmaceutical storage container in a particular embodiment.
在使用期间,药物储存容器具有不同的操作模式,具体取决于包括外部功率可用性在内的条件。在可靠的电源(例如稳定的市政电源或可操作的太阳能电源)可用的情况下,控制器可以充分地操作蒸发器盘管,以在容器的药物储存区域内维持稳定的温度范围。例如,从药物储存区域内的至少一个温度传感器发送到控制器的信息可以是控制器发送信号以根据需要打开或关闭压缩器系统的信号从而维持蒸发液体的适当温度的基础。蒸发液体可以用作热镇流器(thermal ballast),以将药物储存区域内的温度保持在具有最小温度通量的预设范围内。在一些实施方式中,蒸发器盘管单元被构造成冻结蒸发液体以在药物储存区域内保持适当的温度。在一些实施方式中,蒸发器盘管单元被构造成冷却蒸发液体以在药物储存区域内保持适当的温度。在一些实施方式中,药物储存容器包括配置成储存一些功率储备的电池,例如足以在没有足够功率操作压缩器系统的情况下操作控制器。During use, the medicinal storage container has different operating modes, depending on conditions including the availability of external power. When a reliable power source (e.g., stable utility power or an operational solar power source) is available, the controller can fully operate the evaporator coil to maintain a stable temperature range within the medicinal storage area of the container. For example, information sent to the controller from at least one temperature sensor within the medicinal storage area can be the basis for the controller to send a signal to turn the compressor system on or off as needed to maintain the appropriate temperature of the evaporating liquid. The evaporating liquid can act as a thermal ballast to maintain the temperature within the medicinal storage area within a preset range with a minimum temperature flux. In some embodiments, the evaporator coil unit is configured to freeze the evaporating liquid to maintain the appropriate temperature within the medicinal storage area. In some embodiments, the evaporator coil unit is configured to cool the evaporating liquid to maintain the appropriate temperature within the medicinal storage area. In some embodiments, the medicinal storage container includes a battery configured to store some power reserve, for example, sufficient to operate the controller in the event that there is insufficient power to operate the compressor system.
在某一时刻,预期用于药物储存容器的电源将不再可用。例如,由于紧急情况或能力不足,市政电力系统可能不可操作,或者太阳能电力可能在晚上不可用。蒸发液体的热质量将保持药物储存区域内的温度一段时间,具体取决于包括蒸发液体的质量、其热性质、药物储存容器的绝缘参数、储存区域的温度范围和容器的环境温度的因素。当操作压缩器系统的功率不可用时,控制器将基于例如由电池提供的储备功率继续操作。在温度传感器向控制器发送指示药物储存区域需要冷却以将药物储存区域保持在适当温度范围内的信号时,控制器然后可以打开蒸汽控制单元内的阀,以增加蒸发液体的蒸发和蒸汽从蒸发液体到干燥剂的通路。这将导致蒸发液体的冷却,然后蒸发液体将在适当的温度范围内继续作为药物储存区域的热镇流器。At some point, it is expected that the power source for the medication storage container will no longer be available. For example, due to an emergency or capacity shortage, the municipal power system may be inoperable, or solar power may be unavailable at night. The thermal mass of the evaporating liquid will maintain the temperature within the medication storage area for a period of time, depending on factors including the mass of the evaporating liquid, its thermal properties, the insulation parameters of the medication storage container, the temperature range of the storage area, and the ambient temperature of the container. When power to operate the compressor system is unavailable, the controller will continue operation based on reserve power, such as provided by a battery. When the temperature sensor sends a signal to the controller indicating that the medication storage area needs to be cooled to maintain the medication storage area within the appropriate temperature range, the controller can then open a valve within the vapor control unit to increase evaporation of the evaporating liquid and the passage of vapor from the evaporating liquid to the desiccant. This will result in cooling of the evaporating liquid, which will then continue to serve as thermal ballast for the medication storage area within the appropriate temperature range.
随着时间的推移,当蒸汽移动通过蒸汽管道时,最初存在于冷却单元中的蒸发液体的一部分质量将被转移到干燥剂单元的内部。因此,容器将周期性地需要通过蒸汽管道从干燥剂单元再充入(recharge)蒸发液体,以便保持容器的功能。由于冷却单元、蒸汽管道和干燥剂单元的内部是气体密封和液体密封的连续区域,所以蒸发液体可以作为蒸汽返回到冷却单元以对系统进行再充入。在一些实施方式中,控制器包括用于操作容器的再充入循环的电路。在一些实施方式中,控制器被配置为例如通过可操作地连接到控制器的按钮或类似用户输入设备接受来自用户的输入以开始再充入循环。Over time, when steam moves through the steam line, a portion of the mass of the evaporated liquid initially present in the cooling unit will be transferred to the inside of the desiccant unit. Therefore, the container will periodically need to be recharged with evaporated liquid from the desiccant unit through the steam line to maintain the functionality of the container. Since the inside of the cooling unit, the steam line, and the desiccant unit are continuous areas that are gas-tight and liquid-tight, the evaporated liquid can return to the cooling unit as steam to recharge the system. In some embodiments, the controller includes a circuit for operating the recharge cycle of the container. In some embodiments, the controller is configured to accept input from the user to start the recharge cycle, for example, by a button or similar user input device that is operably connected to the controller.
控制器基于为特定实施方式预定的因素激活系统的再充入循环,所述因素包括可用外部电源的提供、环境温度、当前存在于冷却单元中的蒸发液的温度、药物储存区域内的温度、以及在一些实施方式中来自用户的输入。在再充入期间,控制器启动位于干燥剂单元的内部干燥剂区域内的加热元件的加热。加热器被激活到预定温度持续预定时间段。加热元件的时间和温度设置取决于实施方式,例如,存在于容器中的干燥剂和蒸发液体的类型、以及干燥剂单元及其内部干燥剂区域的尺寸和形状。例如,在一些实施方式中,加热元件在再充入循环期间在300摄氏度下保持至少30分钟。例如,在一些实施方式中,加热元件在再充入循环期间在250摄氏度下保持至少60分钟。在加热元件是热的时间期间,与干燥剂单元中的干燥剂相关的蒸发液体转变成蒸汽。蒸汽移动通过蒸汽管道并在冷却单元的相对冷的内部蒸发区域内冷凝。在加热元件关闭之后,干燥剂单元可以例如通过辐射冷却而冷却,并且再充入循环完成。在一些实施方式中,控制器被配置为当压缩器系统运行时仅启动再充气循环,以确保蒸发液体将在冷却单元的内部蒸发区域内冷凝。在一些实施方式中,控制器被配置成仅当到容器的环境温度低于预定阈值水平时才启动再充入循环,以便确保冷却过程的足够的辐射加热。在一些实施方式中,干燥剂单元包括单向通风阀(blow valve),该单向通风阀被配置成在干燥剂单元内的气体压力超过阈值水平的情况下打开。The controller activates the system's recharge cycle based on factors predetermined for a particular embodiment, including the availability of external power, ambient temperature, the temperature of the evaporative liquid currently present in the cooling unit, the temperature within the medication storage area, and, in some embodiments, user input. During the recharge period, the controller activates heating of a heating element located within the desiccant unit's internal desiccant area. The heater is activated to a predetermined temperature for a predetermined period of time. The timing and temperature settings of the heating element depend on the embodiment, such as the type of desiccant and evaporative liquid present in the container, and the size and shape of the desiccant unit and its internal desiccant area. For example, in some embodiments, the heating element is maintained at 300 degrees Celsius for at least 30 minutes during the recharge cycle. For example, in some embodiments, the heating element is maintained at 250 degrees Celsius for at least 60 minutes during the recharge cycle. During the time the heating element is hot, the evaporative liquid associated with the desiccant in the desiccant unit is converted into vapor. The vapor travels through a vapor conduit and condenses within the relatively cool internal evaporative area of the cooling unit. After the heating element is turned off, the desiccant unit can be cooled, for example, by radiative cooling, and the recharge cycle is complete. In some embodiments, the controller is configured to only initiate a refill cycle when the compressor system is operating to ensure that the evaporated liquid will condense within the internal evaporation region of the cooling unit. In some embodiments, the controller is configured to initiate a refill cycle only when the ambient temperature to the container is below a predetermined threshold level to ensure sufficient radiant heating for the cooling process. In some embodiments, the desiccant unit includes a one-way vent valve that is configured to open if the gas pressure within the desiccant unit exceeds a threshold level.
在不更换干燥剂或蒸发液体的情况下,预期再充入系统可以在容器的整个使用寿命期间操作多次。例如,假设药物储存容器将具有每月一次的再充入并且在操作中使用10年,则容器将包括在容器的构造中的预期可再充入以再使用至少120次(每年12次持续10年)的干燥剂和蒸发液体。例如,假设药物储存容器将具有每两周一次的再充入并且在操作中使用达5年,则容器将包括在容器的构造中的预期可再充入以再使用至少130次(每年26次持续5年)的干燥剂和蒸发液体。在一些实施方式中,药物储存容器被配置为在不更换干燥剂或蒸发液体的情况下在容器的多年使用期间再充入至少200次。In the case of not replacing desiccant or evaporative liquid, it is expected that the refill system can operate multiple times during the entire service life of the container. For example, assuming that the medicinal storage container will have a monthly refill and is used in operation for 10 years, the container will include in the construction of the container an expected refill to reuse at least 120 times (12 times per year for 10 years) of desiccant and evaporative liquid. For example, assuming that the medicinal storage container will have a biweekly refill and is used in operation for 5 years, the container will include in the construction of the container an expected refill to reuse at least 130 times (26 times per year for 5 years) of desiccant and evaporative liquid. In some embodiments, the medicinal storage container is configured to be refilled at least 200 times during the multi-year use of the container without replacing desiccant or evaporative liquid.
药物储存容器被配置为在低和/或间歇的功率可用性情况下有效地操作。药物储存容器被构造成在有功率可用时使用基于压缩器的冷却系统而有效地操作。当功率不可用时,蒸发液体可以用作热镇流器以保持对药物储存区域的冷却。当蒸发液加热超过预定温度时,其在没有外部功率的情况下可以通过蒸发冷却被再冷却。此外,当外部功率可用且条件保证时,容器可根据需要对蒸发冷却系统进行再充入。The medicinal storage container is configured to operate efficiently in conditions of low and/or intermittent power availability. The medicinal storage container is configured to operate efficiently using a compressor-based cooling system when power is available. When power is unavailable, the evaporative liquid can be used as a thermal ballast to maintain cooling of the medicinal storage area. When the evaporative liquid heats above a predetermined temperature, it can be recooled through evaporative cooling in the absence of external power. Furthermore, when external power is available and conditions warrant, the container can recharge the evaporative cooling system as needed.
图3示出了药物储存容器100的方面。图3所示的实施方式包括药物储存单元,药物储存单元包括围绕药物储存区域150的外壁151,药物储存区域150包括利用线连接器157可操作地连接到控制器170的温度传感器159。图3所示的药物储存容器100还包括冷却单元,冷却单元包括外壁115,外壁115密封在一起以形成围绕内部蒸发区域110的不透气且不透液的屏障,外壁包括孔133。药物储存容器100包括干燥剂单元,干燥剂单元包括外壁320,外壁320密封在一起以形成围绕内部干燥剂区域120的不透气屏障,外壁320包括孔135。药物储存容器100包括蒸汽管道130,蒸汽管道130包括第一端180和第二端185,蒸汽管道130在第二端185附接到围绕干燥剂单元的孔135的外壁320的外表面,蒸汽管道130在第一端180附接到围绕蒸发冷却单元的孔133的外壁115的外表面,蒸汽管道130在干燥剂单元的内部干燥剂区域120和冷却单元的内部蒸发区域110之间形成内部不透气通道。药物储存容器100还包括定位在内部干燥剂区域120内的加热元件127和可操作地附接到加热元件127的控制器170。所示实施方式包括压缩器系统160,压缩器系统160包括定位在冷却单元的内部蒸发器区域110内的蒸发器盘管单元190,压缩器系统160可操作地连接到控制器170。FIG3 illustrates aspects of a medicinal storage container 100. The embodiment shown in FIG3 includes a medicinal storage unit comprising an outer wall 151 surrounding a medicinal storage region 150, the medicinal storage region 150 including a temperature sensor 159 operably connected to a controller 170 using a wired connector 157. The medicinal storage container 100 shown in FIG3 also includes a cooling unit comprising outer walls 115 sealed together to form an air- and liquid-tight barrier around an interior evaporation region 110, the outer walls including apertures 133. The medicinal storage container 100 includes a desiccant unit comprising outer walls 320 sealed together to form an air- and liquid-tight barrier around an interior desiccant region 120, the outer walls including apertures 135. Medicinal storage container 100 includes a steam conduit 130 having a first end 180 and a second end 185. Steam conduit 130 is attached at second end 185 to the outer surface of outer wall 320 surrounding aperture 135 of the desiccant unit. Steam conduit 130 is attached at first end 180 to the outer surface of outer wall 115 surrounding aperture 133 of the evaporative cooling unit. Steam conduit 130 forms an internal, airtight passage between the interior desiccant region 120 of the desiccant unit and the interior evaporative region 110 of the cooling unit. Medicinal storage container 100 also includes a heating element 127 positioned within the interior desiccant region 120 and a controller 170 operably attached to heating element 127. The illustrated embodiment includes a compressor system 160 including an evaporator coil unit 190 positioned within the interior evaporator region 110 of the cooling unit. Compressor system 160 is operably connected to controller 170.
一些实施方式包括定位在蒸发冷却单元的内部蒸发区域内的至少一个液位传感器,液位传感器被定位和配置为检测内部蒸发区域内的蒸发液位。例如,在一些实施方式中,液位传感器被定位和配置成检测蒸发液体的表面(例如,图2中所示的表面203)。例如,在一些实施方式中,液位传感器被定位和配置为检测蒸发液位至少与特定位置一样高,该特定位置例如为预定的最小位置以确保存在足够的蒸发液体以保持蒸发冷却单元的热性质。在图3所示的实施方式中,内部蒸发区域110包围液位传感器310。在一些实施方式中,液位传感器是霍尔效应传感器。Some embodiments include at least one liquid level sensor positioned within the internal evaporative region of the evaporative cooling unit, the liquid level sensor being positioned and configured to detect the evaporative liquid level within the internal evaporative region. For example, in some embodiments, the liquid level sensor is positioned and configured to detect the surface of the evaporative liquid (e.g., surface 203 shown in FIG. 2 ). For example, in some embodiments, the liquid level sensor is positioned and configured to detect that the evaporative liquid level is at least as high as a specific position, such as a predetermined minimum position to ensure that sufficient evaporative liquid is present to maintain the thermal properties of the evaporative cooling unit. In the embodiment shown in FIG. 3 , the internal evaporative region 110 surrounds the liquid level sensor 310. In some embodiments, the liquid level sensor is a Hall effect sensor.
在一些实施方式中,药物储存容器包括位于干燥剂单元的一个或多个外壁的外表面与冷却单元的一个或多个外壁的外表面之间的间隙。图3所示的实施方式包括位于干燥剂单元的外壁320和蒸发冷却单元的相邻外壁115之间的间隙300。间隙可以被配置为例如在蒸发冷却单元和干燥剂单元的相邻侧之间的空的空间,该间隙具有足够的尺寸和形状,以促进干燥剂单元的辐射冷却,同时到蒸发冷却单元的热量传递最小。在图3所示的实施方式中,蒸发冷却单元和干燥剂单元均在单元的下表面处固定到药物储存容器100的基部105。In some embodiments, the medicinal storage container includes a gap between the outer surface of one or more outer walls of the desiccant unit and the outer surface of one or more outer walls of the cooling unit. The embodiment shown in FIG3 includes a gap 300 between an outer wall 320 of the desiccant unit and an adjacent outer wall 115 of the evaporative cooling unit. The gap can be configured, for example, as an empty space between the evaporative cooling unit and adjacent sides of the desiccant unit, the gap having a sufficient size and shape to promote radiative cooling of the desiccant unit while minimizing heat transfer to the evaporative cooling unit. In the embodiment shown in FIG3, both the evaporative cooling unit and the desiccant unit are secured to the base 105 of the medicinal storage container 100 at the lower surfaces of the units.
在一些实施方式中,药物储存容器包括:位于所述干燥剂单元的所述一个或多个外壁的外表面与所述冷却单元的所述一个或多个外壁的外表面之间的间隙;以及固定到所述干燥剂单元的所述一个或多个外壁的所述外表面上的风扇,所述风扇的尺寸、形状和位置使所述间隙内的空气循环。在一些实施方式中,风扇是被动控制的风扇,被配置为当间隙中的温度达到预设温度时操作。在一些实施方式中,风扇被配置为每当干燥剂单元内的加热元件操作时操作。一些实施方式包括定位在间隙内和/或周围的多个风扇,风扇被定向并构造成增加间隙内的空气流。In some embodiments, the medicinal storage container comprises: a gap between the outer surface of the one or more outer walls of the desiccant unit and the outer surface of the one or more outer walls of the cooling unit; and a fan fixed to the outer surface of the one or more outer walls of the desiccant unit, the size, shape and position of the fan causing air to circulate within the gap. In some embodiments, the fan is a passively controlled fan configured to operate when the temperature in the gap reaches a preset temperature. In some embodiments, the fan is configured to operate whenever a heating element within the desiccant unit is operated. Some embodiments include multiple fans positioned within and/or around the gap, the fans being oriented and configured to increase the air flow within the gap.
例如,图3示出了包括位于干燥剂单元的侧壁和蒸发冷却单元的相邻侧壁之间的间隙300的实施方式。图3所示的药物储存容器100还包括定位在间隙300的顶部边缘处的风扇305,该风扇被配置为循环间隙300内的空气。在一些实施方式中,邻近间隙定位的风扇的操作是由控制器控制。在一些实施方式中,邻近间隙定位的风扇的操作由控制器响应于来自位于干燥剂单元内部的温度传感器的信息来控制。在所示的实施方式中,风扇305利用线连接器连接到控制器170。在所示的实施方式中,温度传感器129也通过线连接器连接到控制器170。For example, FIG3 shows an embodiment including a gap 300 between a side wall of the desiccant unit and an adjacent side wall of the evaporative cooling unit. The medicinal storage container 100 shown in FIG3 also includes a fan 305 positioned at the top edge of the gap 300, which is configured to circulate air within the gap 300. In some embodiments, the operation of the fan positioned adjacent to the gap is controlled by a controller. In some embodiments, the operation of the fan positioned adjacent to the gap is controlled by a controller in response to information from a temperature sensor located inside the desiccant unit. In the embodiment shown, the fan 305 is connected to the controller 170 using a wired connector. In the embodiment shown, the temperature sensor 129 is also connected to the controller 170 via a wired connector.
一些实施方式包括其中存在定位在蒸汽管道的第一端内的至少一个温度传感器和定位在蒸汽管道的第二端内的至少一个温度传感器。位于蒸汽管道的第一端和蒸汽管道的第二端内的温度传感器可以可操作地附接到控制器。位于蒸汽管道的第一端和蒸汽管道的第二端内的温度传感器可以被配置为利用有线或无线连接将传感器数据发送到控制器。控制器可以被配置为响应于来自位于蒸汽管道的第一端内和蒸汽管道的第二端内的温度传感器的传感器数据以及来自位于容器的药物储存区域内的温度传感器的传感器数据而操作蒸汽控制单元,例如调节蒸汽控制单元内的阀的打开和关闭状态。Some embodiments include a device wherein there is at least one temperature sensor positioned within the first end of the steam conduit and at least one temperature sensor positioned within the second end of the steam conduit. The temperature sensors located within the first end of the steam conduit and the second end of the steam conduit can be operably attached to a controller. The temperature sensors located within the first end of the steam conduit and the second end of the steam conduit can be configured to transmit sensor data to the controller using a wired or wireless connection. The controller can be configured to operate the steam control unit, for example, to adjust the open and closed state of a valve within the steam control unit, in response to sensor data from the temperature sensors located within the first end of the steam conduit and the second end of the steam conduit, as well as sensor data from the temperature sensor located within the drug storage area of the container.
图4示出了药物储存容器100的实施方式的方面。所示实施方式包括定位在蒸汽管道130的第一端180内的第一温度传感器410和定位在蒸汽管道130的第二端185内的第二温度传感器400。第一温度传感器410和第二温度传感器400都利用线连接器145附接到控制器170。容器100还包括位于干燥剂单元的外壁和蒸发冷却单元的相邻外壁之间的间隙300。风扇305位于间隙内。FIG4 illustrates aspects of an embodiment of a medicinal storage container 100. The illustrated embodiment includes a first temperature sensor 410 positioned within the first end 180 of the steam conduit 130 and a second temperature sensor 400 positioned within the second end 185 of the steam conduit 130. Both the first temperature sensor 410 and the second temperature sensor 400 are attached to the controller 170 using a wire connector 145. The container 100 also includes a gap 300 located between the outer wall of the desiccant unit and the adjacent outer wall of the evaporative cooling unit. A fan 305 is located within the gap.
一些实施方式包括具有固定到外表面的多个热传导元件的蒸汽管道。在图4所示的实施方式中,例如,蒸汽管道130的第一端180包括多个热传导元件420,热传导元件420是附接到管道的外表面的热翅片。一些实施方式包括属于附接到管道的内表面的热翅片的热传导元件,翅片定位在管道的内部空间内。热传导元件被配置和定位成增加来自蒸汽管道的热辐射,例如以促进蒸发管道的内表面上的蒸发液体的冷凝。Some embodiments include a steam pipe having multiple heat-conducting elements affixed to an outer surface. In the embodiment shown in FIG. 4 , for example, first end 180 of steam pipe 130 includes multiple heat-conducting elements 420, which are heat fins attached to the outer surface of the pipe. Some embodiments include heat-conducting elements that are heat fins attached to the inner surface of the pipe, with the fins positioned within the interior volume of the pipe. The heat-conducting elements are configured and positioned to increase heat radiation from the steam pipe, for example, to promote condensation of evaporative liquid on the inner surface of the evaporation pipe.
一些实施方式被配置为与处于冷冻状态的一种或多种蒸发液体一起使用。例如,当外部功率可用时,压缩器系统可以被配置为将蒸发冷却单元内的冰箱盘管操作到低于与容器一起使用的特定蒸发液体的冰点的温度。当外部功率不可用或不充足时,或者为了将药物储存区域的内部维持在低于蒸发液体的冰点的温度时,冷冻的蒸发液体可以用作热镇流器。Some embodiments are configured for use with one or more evaporative liquids in a frozen state. For example, when external power is available, the compressor system can be configured to operate the refrigerator coil within the evaporative cooling unit to a temperature below the freezing point of the particular evaporative liquid used with the container. When external power is unavailable or insufficient, or to maintain the interior of the medication storage area at a temperature below the freezing point of the evaporative liquid, the frozen evaporative liquid can be used as thermal ballast.
图5示出了药物储存容器100的实施方式的方面。在所示的实施方式中,容器100包括具有位于储存区域内的温度传感器159的药物储存区域150。温度传感器159利用线连接器157连接到控制器170。容器100包括位于冷却单元的内部蒸发区域110内的液位传感器310。液位传感器310靠近冷却单元的与药物储存区域150相邻的壁定位。液位传感器配置成利用线连接器315将关于检测到的液位的信息发送到控制器170。冷却单元的内部蒸发区域110还包括靠近冷却单元的与干燥剂单元相邻的壁定位的蒸发盘管单元190,该壁与冷却单元的邻近药物储存区域150的壁相对。两个温度传感器510、520位于冷却单元的内部蒸发区域110内,温度传感器中的一个510定位成邻近液位传感器310的上部区域,温度传感器中的一个520定位成邻近液位传感器310的下部区域。邻近液位传感器310定位的温度传感器510、520被配置为利用线连接器530将温度传感器数据发送到控制器170。容器100可以可选地包括与冷却单元的固定到蒸汽管道130的第一端180的外壁中的孔133相邻定位的第三温度传感器500。FIG5 illustrates aspects of an embodiment of a medication storage container 100. In the illustrated embodiment, the container 100 includes a medication storage area 150 having a temperature sensor 159 located within the storage area. The temperature sensor 159 is connected to a controller 170 using a wired connector 157. The container 100 includes a liquid level sensor 310 located within the interior evaporative region 110 of the cooling unit. The liquid level sensor 310 is positioned proximate to a wall of the cooling unit adjacent to the medication storage area 150. The liquid level sensor is configured to transmit information regarding a detected liquid level to the controller 170 using a wired connector 315. The interior evaporative region 110 of the cooling unit also includes an evaporative coil unit 190 positioned proximate to a wall of the cooling unit adjacent to the desiccant unit, which is opposite the wall of the cooling unit adjacent to the medication storage area 150. Two temperature sensors 510 and 520 are located within the interior evaporative region 110 of the cooling unit, with one temperature sensor 510 positioned proximate to an upper region of the liquid level sensor 310 and one temperature sensor 520 positioned proximate to a lower region of the liquid level sensor 310. Temperature sensors 510, 520 located adjacent level sensor 310 are configured to send temperature sensor data to controller 170 using wire connector 530. Vessel 100 may optionally include a third temperature sensor 500 located adjacent hole 133 in the outer wall of the cooling unit secured to first end 180 of steam conduit 130.
图6示出了类似图5所示的药物储存容器的药物储存容器100在其使用周期的阶段期间的方面。在所示的阶段,外部功率已经可用,并且压缩器系统160已经操作以将冷却单元的内部蒸发区域110内的蒸发盘管单元190冷却到低于蒸发液体的冰点的温度。例如,在一些实施方式中,蒸发液体是水,并且蒸发盘管单元可以将水冷却到0摄氏度以下。在图6所示的实施方式和阶段中,蒸发液体200包括与蒸发盘管单元190相邻的冻结部分和与液位传感器310相邻的液体部分。蒸发液体200的液体部分具有在冷却单元的内部蒸发区域110内的液体表面203。蒸发液体200的冻结部分具有在位于蒸发盘管单元190和在邻近液位传感器190定位的温度传感器510、520之间的位置处定位在冷却单元的内部蒸发区域110内的面600。FIG6 illustrates aspects of a medicinal storage container 100, similar to the medicinal storage container shown in FIG5 , during a stage of its lifecycle. At the stage shown, external power is available, and the compressor system 160 is operating to cool the evaporation coil unit 190 within the cooling unit's internal evaporation region 110 to a temperature below the freezing point of the evaporation liquid. For example, in some embodiments, the evaporation liquid is water, and the evaporation coil unit may cool the water to below 0 degrees Celsius. In the embodiment and stage shown in FIG6 , the evaporation liquid 200 includes a frozen portion adjacent to the evaporation coil unit 190 and a liquid portion adjacent to the liquid level sensor 310. The liquid portion of the evaporation liquid 200 has a liquid surface 203 within the cooling unit's internal evaporation region 110. The frozen portion of the evaporation liquid 200 has a surface 600 located within the cooling unit's internal evaporation region 110 at a location between the evaporation coil unit 190 and the temperature sensors 510, 520 located adjacent to the liquid level sensor 190.
在类似于图6所示的实施方式和使用情况下,当足够的外部功率可用时,压缩器系统可以操作。压缩器系统可以通过蒸发盘管单元将冷却单元的内部蒸发区域内的蒸发液体冷却到低于蒸发液体的冰点的温度。随着时间的推移,蒸发液体中的一些将冻结(例如,如图6所示)。如果外部电源结束或中断,则冷却和冷冻的蒸发液体可以用作热镇流器,以用于药物储存区域的连续冷却。如果外部电源持续足够的时间段,则冷却单元的内部蒸发区域内的温度传感器将向控制器提供信息,该信息即内部蒸发区域接近被冷冻的蒸发液体填充。类似地,在一些实施方式中,液位传感器可以被配置成当液体开始冻结时将信息发送到控制器并且液位传感器不再如自由流动液体中所期望的那样操作。响应于接收到的信息,控制器可以向压缩器系统发送信号以停止或减少蒸发盘管单元的操作。随后,响应于从一个或多个温度传感器或液位传感器接收到的新信息,控制器可以向压缩器系统发送信号,以在稍后时间开始或增加蒸发盘管单元的操作。In embodiments and use cases similar to those shown in FIG6 , the compressor system can operate when sufficient external power is available. The compressor system can cool the evaporative liquid within the internal evaporative region of the cooling unit to a temperature below the freezing point of the evaporative liquid via the evaporator coil unit. Over time, some of the evaporative liquid will freeze (e.g., as shown in FIG6 ). If the external power source ends or is interrupted, the cooled and frozen evaporative liquid can serve as a thermal ballast for continued cooling of the medication storage area. If the external power source continues for a sufficient period of time, a temperature sensor within the internal evaporative region of the cooling unit will provide information to the controller indicating that the internal evaporative region is nearly filled with frozen evaporative liquid. Similarly, in some embodiments, the liquid level sensor can be configured to send information to the controller when the liquid begins to freeze and the liquid level sensor no longer operates as expected for free-flowing liquid. In response to this information, the controller can send a signal to the compressor system to stop or reduce operation of the evaporator coil unit. Subsequently, in response to new information received from one or more temperature sensors or liquid level sensors, the controller can send a signal to the compressor system to resume or increase operation of the evaporator coil unit at a later time.
在一些实施方式中,药物储存容器包括:干燥剂单元,其包括一个或多个外壁,所述一个或多个外壁被密封在一起以形成围绕内部干燥剂区域的不透气屏障,所述一个或多个外壁包括孔;位于所述内部干燥剂区域内的加热元件;可操作地附接到所述加热元件的控制器;冷却单元,其包括一个或多个外壁,所述一个或多个外壁密封在一起以形成围绕内部蒸发区域的不透气且不透液的屏障,所述一个或多个外壁包括孔;压缩器系统,其包括定位在所述冷却单元的所述内部蒸发区域内的至少一个蒸发器盘管单元,所述压缩器系统可操作地连接到所述控制器;包括一个或多个壁的冷冻器单元,所述冷冻器单元与位于所述冷却单元的所述内部蒸发区域内的所述至少一个蒸发器盘管单元热接触;蒸汽管道,其包括第一端和第二端,所述蒸汽管道在所述第一端附接到围绕所述干燥剂单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述第二端附接到围绕所述蒸发冷却单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述干燥剂单元的所述内部干燥剂区域和所述冷却单元的所述内部蒸发区域之间形成内部不透气通道;蒸汽控制单元,其附接到所述蒸汽管道,所述蒸汽控制单元可操作地附接到所述控制器;以及药物储存单元,其包括围绕药物储存区域的一个或多个外壁,所述药物储存区域包括可操作地连接到所述控制器的至少一个温度传感器。In some embodiments, a medicinal storage container includes: a desiccant unit including one or more outer walls that are sealed together to form an airtight barrier around an inner desiccant region, the one or more outer walls including apertures; a heating element positioned within the inner desiccant region; a controller operably attached to the heating element; a cooling unit including one or more outer walls that are sealed together to form an airtight and liquidtight barrier around an inner evaporative region, the one or more outer walls including apertures; a compressor system including at least one evaporator coil unit positioned within the inner evaporative region of the cooling unit, the compressor system operably connected to the controller; a freezer unit including one or more walls that are attached to the inner evaporative region of the cooling unit. the steam conduit being attached to the outer surface of the one or more outer walls surrounding the aperture of the desiccant unit and being attached to the outer surface of the one or more outer walls surrounding the aperture of the evaporative cooling unit at the second end, the steam conduit forming an internal airtight passage between the internal desiccant region of the desiccant unit and the internal evaporative region of the cooling unit; a steam control unit attached to the steam conduit, the steam control unit being operably attached to the controller; and a drug storage unit comprising one or more outer walls surrounding a drug storage area, the drug storage area comprising at least one temperature sensor operably connected to the controller.
图7示出了药物储存容器100的实施方式。在一些实施方式中,药物储存容器100包括干燥剂单元,所述干燥剂单元包括外壁320,所述外壁320密封在一起以形成围绕内部干燥剂区域120的不透气屏障,所述外壁320包括孔135。图7中所示的实施方式包括位于内部干燥剂区域120内的加热元件127。加热元件127利用线连接器附接到药物储存容器100的控制器170。图7还描绘了药物储存容器100的实施方式,其包括冷却单元,冷却单元包括外壁115,外壁115密封在一起以形成围绕内部蒸发区域240的不透气且不透液的屏障,外壁115包括孔133。所示实施方式包括压缩器系统160,压缩器系统160包括定位在冷却单元的内部蒸发区域240内的蒸发器盘管单元190,压缩器系统160可操作地连接到控制器170。在所示的实施方式中,蒸发器盘管单元190定位在冷却单元的邻近容器100的药物储存区域150的外壁115的远侧。所示实施方式还包括冷冻器单元700,冷冻器单元700包括外壁740,冷冻器单元700与位于冷却单元的内部蒸发区域240内的蒸发器盘管单元190热接触。图7示出了药物储存容器100的实施方式,其包括蒸汽管道130,蒸汽管道130包括第一端180和第二端185,蒸汽管道130在第二端185附接到围绕干燥剂单元的孔135的外壁的外表面,蒸汽管道130在第一端180附接到围绕蒸发冷却单元的孔133的外壁115的外表面,蒸汽管道130在干燥剂单元的内部干燥剂区域120和冷却单元的内部蒸发区域240之间形成内部不透气通道。在所示的实施方式中,蒸汽控制单元140附接到蒸汽管道130并且还利用线连接器145附接到控制器170。所示实施方式包括药物储存单元,药物储存单元包括围绕药物储存区域150的外壁151,药物储存区域150包括可操作地连接到控制器170的温度传感器159。FIG7 illustrates an embodiment of a medicinal storage container 100. In some embodiments, the medicinal storage container 100 includes a desiccant unit comprising outer walls 320 that are sealed together to form an airtight barrier around the interior desiccant region 120, the outer walls 320 including apertures 135. The embodiment shown in FIG7 includes a heating element 127 positioned within the interior desiccant region 120. The heating element 127 is attached to a controller 170 of the medicinal storage container 100 using a wired connector. FIG7 also depicts an embodiment of the medicinal storage container 100 that includes a cooling unit comprising outer walls 115 that are sealed together to form an airtight and liquidtight barrier around the interior evaporative region 240, the outer walls 115 including apertures 133. The illustrated embodiment includes a compressor system 160 comprising an evaporator coil unit 190 positioned within the interior evaporative region 240 of the cooling unit, the compressor system 160 being operably connected to a controller 170. In the illustrated embodiment, the evaporator coil unit 190 is positioned distally of the cooling unit's outer wall 115 adjacent to the medication storage region 150 of the container 100. The illustrated embodiment also includes a freezer unit 700, which includes an outer wall 740 and is in thermal contact with the evaporator coil unit 190 located within the cooling unit's interior evaporative region 240. FIG. 7 illustrates an embodiment of the medicinal storage container 100, which includes a steam conduit 130, comprising a first end 180 and a second end 185. The steam conduit 130 is attached at the second end 185 to the outer surface of the outer wall surrounding the aperture 135 of the desiccant unit. The steam conduit 130 is attached at the first end 180 to the outer surface of the outer wall 115 surrounding the aperture 133 of the evaporative cooling unit. The steam conduit 130 forms an internal, airtight passage between the desiccant unit's interior desiccant region 120 and the cooling unit's interior evaporative region 240. In the illustrated embodiment, a vapor control unit 140 is attached to the steam conduit 130 and is also attached to the controller 170 using a wire connector 145. The illustrated embodiment includes a drug storage unit comprising an outer wall 151 surrounding a drug storage area 150 including a temperature sensor 159 operably connected to a controller 170 .
图7示出了药物储存容器100的实施方式,其包括与位于冷却单元的内部蒸发区域240内的蒸发器盘管单元190相邻定位的冷冻器单元700。如图7所示,在一些实施方式中,冷冻器单元700包括具有一定尺寸、形状和位置的一个或多个壁740,以将一个或多个冰袋730保持在适当位置。根据实施方式,冷冻器单元的壁的尺寸、形状和位置可以将一个或多个WHO批准的标准冰袋固定在冷冻器单元中。在一些实施方式中,冷冻器单元的壁由导热材料(例如导热金属)制成。在一些实施方式中,冷冻器单元的壁由铝或铜制成。在一些实施方式中,冷冻器单元包括:孔,其尺寸、形状和位置用于使用者接近冷冻器单元内的材料;以及可逆地固定到孔的盖。例如,盖可以包括绝缘盖,该绝缘盖被定位和构造成当盖在适当位置时减少来自冷冻器单元的热泄漏,但是允许用户根据需要可逆地移除盖,以从冷冻器单元移除或更换一个或多个冷冻袋。一些实施方式包括可操作地附接到控制器的温度传感器。图7示出了药物储存容器100的实施方式,其包括具有温度传感器710的冷冻器单元700,温度传感器710定位成检测冷冻器单元700内的温度。在所示的实施方式中,温度传感器710利用线连接器720连接到控制器170。控制器被配置为从温度传感器接受信息,例如温度数据。FIG7 illustrates an embodiment of a medicinal storage container 100, which includes a freezer unit 700 positioned adjacent to an evaporator coil unit 190 within the interior evaporation region 240 of the cooling unit. As shown in FIG7 , in some embodiments, the freezer unit 700 includes one or more walls 740 sized, shaped, and positioned to hold one or more ice packs 730 in place. Depending on the embodiment, the freezer unit walls are sized, shaped, and positioned to secure one or more WHO-approved standard ice packs within the freezer unit. In some embodiments, the freezer unit walls are made of a thermally conductive material (e.g., a thermally conductive metal). In some embodiments, the freezer unit walls are made of aluminum or copper. In some embodiments, the freezer unit includes: an aperture sized, shaped, and positioned to provide user access to materials within the freezer unit; and a cover reversibly secured to the aperture. For example, the cover may include an insulating cover positioned and configured to reduce heat leakage from the freezer unit when in place, but allowing the user to reversibly remove the cover to remove or replace one or more freezer packs from the freezer unit as needed. Some embodiments include a temperature sensor operably attached to the controller. 7 illustrates an embodiment of a medicinal storage container 100 including a freezer unit 700 having a temperature sensor 710 positioned to detect the temperature within the freezer unit 700. In the illustrated embodiment, the temperature sensor 710 is connected to the controller 170 using a wire connector 720. The controller is configured to receive information, such as temperature data, from the temperature sensor.
在一些实施方式中,药物储存容器的冷冻器单元包括导热壁,该导热壁具有邻近内部冷冻器区域定位的第一侧以及定位成与所述至少一个蒸发器盘管单元的外表面热接触的第二侧。例如,图7示出了包括由导热材料(例如铝)制成的壁740的冷冻器单元700。在图7所示的视图中位于冷冻器单元700的左侧的冷冻器单元壁740具有邻近内部冷冻器区域定位的第一侧(例如,相对于图7的视图为右侧)和定位成与蒸发器盘管单元190的外表面热接触的第二侧(例如相对于图7的视图为左侧)。在一些实施方式中,第一侧和第二侧是壁的相对侧,如图7所示。In some embodiments, the freezer unit of the medicinal storage container includes a thermally conductive wall having a first side positioned adjacent to the interior freezer region and a second side positioned in thermal contact with the outer surface of the at least one evaporator coil unit. For example, FIG7 shows a freezer unit 700 including a wall 740 made of a thermally conductive material (e.g., aluminum). The freezer unit wall 740, which is located on the left side of the freezer unit 700 in the view shown in FIG7 , has a first side positioned adjacent to the interior freezer region (e.g., the right side relative to the view of FIG7 ) and a second side positioned in thermal contact with the outer surface of the evaporator coil unit 190 (e.g., the left side relative to the view of FIG7 ). In some embodiments, the first side and the second side are opposite sides of the wall, as shown in FIG7 .
药物储存容器的一些实施方式包括:干燥剂单元,其包括一个或多个外壁,所述一个或多个外壁密封在一起以形成围绕内部干燥剂区域的不透气屏障,所述一个或多个外壁包括孔;位于所述内部干燥剂区域内的加热元件;可操作地附接到所述加热元件的控制器;冷却单元,其包括一个或多个外壁,所述一个或多个外壁密封在一起以形成围绕内部蒸发区域的不透气且不透液的屏障,所述一个或多个外壁包括孔;压缩器系统,其包括定位在所述冷却单元的所述内部蒸发区域内的至少一个蒸发器盘管单元,所述压缩器系统可操作地连接到所述控制器;蒸汽管道,其包括第一端和第二端,所述蒸汽管道在所述第二端附接到围绕所述干燥剂单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述第一端附接到围绕所述蒸发冷却单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述干燥剂单元的所述内部干燥剂区域和所述冷却单元的所述内部蒸发区域之间形成内部不透气通道;蒸汽控制单元,其附接到所述蒸汽管道,所述蒸汽控制单元可操作地附接到所述控制器;附接到所述蒸汽管道的热控制单元,所述热控制单元可操作地附接到所述控制器;以及药物储存单元,其包括围绕药物储存区域的一个或多个外壁,所述药物储存区域包括可操作地连接到所述控制器的至少一个温度传感器。Some embodiments of a medicinal storage container include: a desiccant unit comprising one or more outer walls sealed together to form an airtight barrier around an interior desiccant region, the one or more outer walls including an aperture; a heating element positioned within the interior desiccant region; a controller operably attached to the heating element; a cooling unit comprising one or more outer walls sealed together to form an airtight and liquidtight barrier around an interior evaporative region, the one or more outer walls including an aperture; a compressor system comprising at least one evaporator coil unit positioned within the interior evaporative region of the cooling unit, the compressor system operably connected to the controller; a steam conduit comprising a first end and a second end, the steam conduit being positioned between the first and second ends. The second end is attached to the outer surface of the one or more outer walls surrounding the hole of the desiccant unit, the steam pipe is attached at the first end to the outer surface of the one or more outer walls surrounding the hole of the evaporative cooling unit, the steam pipe forms an internal airtight passage between the internal desiccant area of the desiccant unit and the internal evaporative area of the cooling unit; a steam control unit, which is attached to the steam pipe, and the steam control unit is operably attached to the controller; a thermal control unit attached to the steam pipe, and the thermal control unit is operably attached to the controller; and a drug storage unit, which includes one or more outer walls surrounding the drug storage area, and the drug storage area includes at least one temperature sensor operably connected to the controller.
例如,图8示出了包括干燥剂单元的药物储存容器100,干燥剂单元包括外壁320,外壁320密封在一起以形成围绕内部干燥剂区域120的不透气屏障,外壁320包括孔135。图8中所示的实施方式还包括定位在内部干燥剂区域120内的加热元件127和利用线连接器可操作地附接到加热元件12的控制器170。该实施方式包括冷却单元,冷却单元包括外壁115,外壁115密封在一起以形成围绕内部蒸发区域240的不透气且不透液的屏障,外壁115包括孔133。所示实施方式还包括压缩器系统160,压缩器系统160包括位于冷却单元的内部蒸发区域240内的蒸发器盘管单元190,压缩器系统160利用线连接器165可操作地连接到控制器170。所示的实施方式包括:蒸汽管道130,其包括第一端180和第二端185,蒸汽管道130在第二端185附接到围绕干燥剂单元的孔135的一个或多个外壁320的外表面,蒸汽管道130在第一端180附接到围绕蒸发冷却单元的孔133的外壁115的外表面,蒸汽管道130在干燥剂单元的内部干燥剂区域120和冷却单元的内部蒸发区域240之间形成内部不透气通道;以及附接到蒸汽管道130的蒸汽控制单元140,所述蒸汽控制单元140利用线连接器145可操作地附接到控制器170。图8所示的实施方式包括药物储存单元,所述药物储存单元包括围绕药物储存区域150的外壁151,所述药物储存区域150包括利用线连接器157可操作地连接到控制器170的温度传感器159。For example, FIG8 shows a medicinal storage container 100 including a desiccant unit comprising outer walls 320 that are sealed together to form an airtight barrier around the interior desiccant region 120, the outer walls 320 including apertures 135. The embodiment shown in FIG8 also includes a heating element 127 positioned within the interior desiccant region 120 and a controller 170 operably attached to the heating element 127 using a wire connector. The embodiment includes a cooling unit comprising outer walls 115 that are sealed together to form an airtight and liquidtight barrier around the interior evaporative region 240, the outer walls 115 including apertures 133. The illustrated embodiment also includes a compressor system 160 that includes an evaporator coil unit 190 positioned within the interior evaporative region 240 of the cooling unit, the compressor system 160 operably connected to the controller 170 using a wire connector 165. The illustrated embodiment includes a steam conduit 130 including a first end 180 and a second end 185, the steam conduit 130 being attached at the second end 185 to the outer surface of one or more outer walls 320 surrounding the aperture 135 of the desiccant unit, the steam conduit 130 being attached at the first end 180 to the outer surface of the outer wall 115 surrounding the aperture 133 of the evaporative cooling unit, the steam conduit 130 forming an internal airtight passage between the internal desiccant region 120 of the desiccant unit and the internal evaporative region 240 of the cooling unit, and a steam control unit 140 attached to the steam conduit 130, the steam control unit 140 being operably attached to the controller 170 using a wire connector 145. The embodiment illustrated in FIG8 includes a medication storage unit including an outer wall 151 surrounding a medication storage area 150, the medication storage area 150 including a temperature sensor 159 operably connected to the controller 170 using a wire connector 157.
所示实施方式还包括附接到蒸汽管道130的热控制单元800。所示的热控制单元800附接到蒸汽管道130的邻近第一端180的外部。热控制单元800利用线连接器145可操作地附接到控制器170。在一些实施方式中,热控制装置包括设置有与蒸汽管道的外表面相邻的冷却表面的珀尔帖装置(peltier device)。例如,珀尔帖装置可以被配置和定位在蒸汽管道上的位置处,该位置计算为充分冷却蒸汽管道的内表面以促进来自蒸发液体的冷凝物在蒸汽管道中形成并通过重力流返回到冷却单元的内部蒸发区域的内部。在一些实施方式中,热控制装置包括与蒸汽管道热接触的蒸发器盘管单元,蒸发器盘管单元附接到压缩器系统。例如,蒸发器盘管单元可以是与冷却单元内的蒸发器盘管不同的蒸发器盘管,并且可以由控制器独立控制。例如,蒸发器盘管单元可以是与冷却单元内的蒸发器盘管单元平行的(parallel)蒸发器盘管。例如,蒸发器盘管单元可以被配置和定位在蒸汽管道上的位置处,该位置计算为充分冷却蒸汽管道的内表面,以促进来自蒸发液体的冷凝物在蒸汽管道中形成并通过重力流返回到冷却单元的内部蒸发区域的内部。例如响应于来自位于蒸汽管道内或邻近蒸汽管道的温度传感器的信息,热控制单元可以由控制器打开和关闭。热控制单元可以由控制器打开和关闭,例如与打开加热元件协作以进行再充入循环。The illustrated embodiment also includes a thermal control unit 800 attached to the steam line 130. The illustrated thermal control unit 800 is attached to the exterior of the steam line 130 adjacent to the first end 180. The thermal control unit 800 is operably attached to the controller 170 using a wire connector 145. In some embodiments, the thermal control device includes a Peltier device having a cooling surface adjacent to the exterior surface of the steam line. For example, the Peltier device can be configured and positioned on the steam line at a location calculated to sufficiently cool the interior surface of the steam line to encourage condensate from the evaporating liquid to form in the steam line and return to the interior of the internal evaporation region of the cooling unit via gravity flow. In some embodiments, the thermal control device includes an evaporator coil unit in thermal contact with the steam line, the evaporator coil unit being attached to the compressor system. For example, the evaporator coil unit can be a different evaporator coil than the evaporator coil within the cooling unit and can be independently controlled by the controller. For example, the evaporator coil unit can be a parallel evaporator coil to the evaporator coil unit within the cooling unit. For example, the evaporator coil unit can be configured and positioned at a location on the steam line calculated to sufficiently cool the interior surface of the steam line to encourage condensate from the evaporated liquid to form in the steam line and return to the interior of the internal evaporation area of the cooling unit via gravity flow. The thermal control unit can be turned on and off by the controller, for example, in response to information from a temperature sensor located within or adjacent to the steam line. The thermal control unit can be turned on and off by the controller, for example, in conjunction with turning on the heating element for a recharge cycle.
现有技术已经进展到这一点,即在硬件、软件(例如,用作硬件规范的高级计算机程序)和/或系统的各方面的固件实现之间几乎没有区别,并且硬件、软件和/或固件的使用通常(但不总是,因为在某些情况下,硬件和软件之间的选择可能变得重要)是表示成本与效率之间的折衷的设计选择。存在可以实现本文描述的处理和/或系统和/或其他技术的各种工具(例如,硬件、软件(例如,用作硬件规范的高级计算机程序)和/或固件),并且优选的工具将随着部署处理和/或系统和/或其他技术的情况而变化。例如,如果实施者确定速度和精度是首要的,则实施者可以选择主要是硬件和/或固件的工具;替代地,如果灵活性是重要的,则实施者可以选择主要是软件(例如,用作硬件规范的高级计算机程序)实现;或者,再次替代地,实施者可以选择硬件、软件(例如,用作硬件规范的高级计算机程序)和/或固件的某种组合。因此,存在几种可能的工具,通过这些工具可以实现本文描述的处理和/或设备和/或其他技术,其中没有一个固有地优于另一个,因为要使用的任何工具是取决于其中将被部署的工具以及实施者对例如速度、灵活性或可预测性的具体关注(其中任何一个可以变化)的环境。实现的光学方面将典型地采用光学定向的硬件、软件(例如,用作硬件规范的高级计算机程序)和/或固件。The art has advanced to the point where there is little distinction between hardware, software (e.g., a high-level computer program used as a hardware specification), and/or firmware implementations of various aspects of a system, and the use of hardware, software, and/or firmware is often (but not always, as the choice between hardware and software may become important in certain circumstances) a design choice that represents a trade-off between cost and efficiency. There are various tools (e.g., hardware, software (e.g., a high-level computer program used as a hardware specification), and/or firmware) that can implement the processes and/or systems and/or other techniques described herein, and the preferred tool will vary depending on the circumstances in which the processes and/or systems and/or other techniques are deployed. For example, if an implementer determines that speed and accuracy are paramount, the implementer may choose a tool that is primarily hardware and/or firmware; alternatively, if flexibility is important, the implementer may choose a primarily software (e.g., a high-level computer program used as a hardware specification) implementation; or, again alternatively, the implementer may choose some combination of hardware, software (e.g., a high-level computer program used as a hardware specification), and/or firmware. Thus, there are several possible tools by which the processes and/or devices and/or other techniques described herein may be implemented, none of which is inherently superior to another, as any tool to be used is dependent upon the environment in which the tool will be deployed and the implementer's specific concerns, such as speed, flexibility, or predictability (any of which may vary). The optical aspects of the implementation will typically employ optically oriented hardware, software (e.g., a high-level computer program used as hardware specifications), and/or firmware.
在本文所描述的一些实施方式中,逻辑和类似实现可以包括计算机程序或其他控制结构。例如,电子电路可以具有被构造和布置成实现如本文所述的各种功能的一个或多个电流路径。在一些实施方式中,一种或多种介质可以被配置为当这样的介质保持或发送可操作以如本文所描述的执行的设备可检测指令时承载设备可检测的实现。在一些变型中,例如,例如通过执行接收或传输关于本文描述的一个或多个操作的一个或多个指令,实现可以包括对现有软件(例如,用作硬件规范的高级计算机程序)或固件或门阵列或可编程硬件的更新或修改。在一些变型中,实现可以包括专用硬件、软件(例如,用作硬件规范的高级计算机程序)、固件组件和/或执行或以其他方式调用专用组件的通用组件。规范或其他实现可以通过这里描述的有形传输介质的一个或多个实例来传输,可选地通过包传输或者以其他方式通过在不同时间通过分布式介质来传输。In some embodiments described herein, logic and similar implementations may include computer programs or other control structures. For example, an electronic circuit may have one or more current paths constructed and arranged to implement various functions as described herein. In some embodiments, one or more media may be configured to carry device-detectable implementations when such media holds or sends device-detectable instructions operable to perform as described herein. In some variations, for example, an implementation may include updating or modifying existing software (e.g., a high-level computer program used as a hardware specification) or firmware or gate arrays or programmable hardware, such as by executing one or more instructions to receive or transmit one or more operations described herein. In some variations, an implementation may include dedicated hardware, software (e.g., a high-level computer program used as a hardware specification), firmware components, and/or general components that execute or otherwise call dedicated components. Specifications or other implementations may be transmitted by one or more instances of the tangible transmission media described herein, optionally by packet transmission or otherwise by transmitting at different times through distributed media.
实现可以包括执行专用指令序列或调用电路,以启用、触发、协调、请求或以其它方式引起虚拟的本文所述的任何功能操作的一次或多次出现。在一些变型中,本文中的操作或其他逻辑描述可以表示为源代码,并且被编译或以其他方式调用为可执行指令序列。在一些背景中,例如,可以通过源代码(诸如C++)或其他代码序列来全部或部分地提供实现。在其它实现中,使用市场上可买到的技术和/或本领域技术,源代码或其他代码实现可以被编译/实现/翻译/转换为高级描述符语言(例如,最初以C或C++编程语言实现所描述的技术,并且此后将编程语言实现转换为逻辑可合成语言实现、硬件描述语言实现、硬件设计模拟实现和/或其他类似的一种或多种表达模式)。例如,逻辑表达式(例如,计算机编程语言实现)的一些或全部可以(例如,通过硬件描述语言(HDL)和/或超高速集成电路硬件描述符语言VHDL))表现为Verilog型硬件描述或其它电路模型,其然后可用于创建具有硬件(例如,专用集成电路)的物理实现。Implementation may include executing a dedicated instruction sequence or calling a circuit to enable, trigger, coordinate, request or otherwise cause one or more occurrences of any functional operation described herein of the virtual. In some variations, the operations or other logical descriptions herein may be represented as source code and compiled or otherwise called as an executable instruction sequence. In some contexts, for example, implementation may be provided in whole or in part by source code (such as C++) or other code sequences. In other implementations, using commercially available technology and/or the technology of the art, source code or other code implementations may be compiled/implemented/translated/converted into a high-level descriptor language (e.g., initially implementing the described technology in C or C++ programming languages, and thereafter converting the programming language implementation into a logic synthesizable language implementation, a hardware description language implementation, a hardware design simulation implementation and/or other similar one or more expression modes). For example, some or all of a logical expression (e.g., a computer programming language implementation) may be represented as a Verilog-type hardware description or other circuit model (e.g., by a hardware description language (HDL) and/or a very high-speed integrated circuit hardware descriptor language VHDL), which may then be used to create a physical implementation with hardware (e.g., an application-specific integrated circuit).
本文描述的主题的若干部分可以经由专用集成电路(ASIC)、现场可编程门阵列(FPGA)、数字信号处理器(DSP)或其它集成格式来实现。然而,本文公开的实施方式的一些方面可以全部或部分地等效地在集成电路中实现为在一个或多个计算机上运行的一个或多个计算机程序(例如,在一个或多个计算机系统上运行的一个或多个程序)、在一个或多个处理器上运行的一个或多个程序(例如,在一个或多个微处理器上运行的一个或多个程序)、固件或实际上其任何组合。另外,由本文描述的主题生成的信息能够以各种形式分布,并且本文描述的主题的说明性实施方式适用,而不管用于实际执行分布的信号承载介质的特定类型如何。信号承载介质的示例包括但不限于以下:可记录型介质(诸如软盘)、硬盘驱动器、压缩盘(CD)、数字视频盘(DVD)、数字磁带、计算机存储器等;以及传输型介质,例如数字和/或模拟通信介质(例如,光纤电缆、波导、有线通信链路、无线通信链路(例如,发射机,接收机,传输逻辑,接收逻辑等)等)。Some parts of the subject matter described herein can be implemented via application specific integrated circuits (ASICs), field programmable gate arrays (FPGAs), digital signal processors (DSPs), or other integrated formats. However, some aspects of the embodiments disclosed herein can be equivalently implemented in whole or in part in an integrated circuit as one or more computer programs running on one or more computers (e.g., one or more programs running on one or more computer systems), one or more programs running on one or more processors (e.g., one or more programs running on one or more microprocessors), firmware, or any combination thereof. In addition, the information generated by the subject matter described herein can be distributed in various forms, and the illustrative embodiments of the subject matter described herein apply regardless of the specific type of signal-bearing medium used to actually perform the distribution. Examples of signal-bearing media include, but are not limited to, the following: recordable media (such as floppy disks), hard drives, compact disks (CDs), digital video disks (DVDs), digital tapes, computer memories, etc.; and transmission media, such as digital and/or analog communication media (e.g., fiber optic cables, waveguides, wired communication links, wireless communication links (e.g., transmitters, receivers, transmission logic, reception logic, etc.), etc.).
本文所述的各种实施方式可以通过各种类型的机电系统单独地和/或共同地实现,所述机电系统具有宽范围的电气部件(例如硬件、软件(例如,用作硬件规范的高阶计算机程序)、固件和/或实质上它们的任何组合)以及宽范围的可以赋予机械力或运动的各种部件(例如刚性体、弹簧或扭转体、液压装置、电磁致动装置和/或实质上它们的任何组合)。因此,如本文所使用的,“机电系统”包括但不限于:与换能器(例如,致动器、马达、压电晶体、微机电系统(MEMS)等)可操作地耦合的电路、具有至少一个分立电路的电路、具有至少一个集成电路的电路、具有至少一个专用集成电路的电路、形成由计算机程序配置的通用计算设备(例如,由至少部分地执行本文所述的处理和/或设备的计算机程序配置的通用计算机或由至少部分地执行本文描述的处理和/或设备的计算机程序配置的微处理器)的电路、形成存储器设备(例如,存储器的形式(例如,随机存取、闪存、只读等))的电路,形成通信设备(例如,调制解调器、通信交换机、光电设备等)的电路、和/或其任何非电模拟物,例如光学或其他模拟物(例如,基于石墨烯的电路)。机电系统的示例包括但不限于:各种消费电子系统、医疗设备和/或通信系统/计算系统。The various embodiments described herein may be implemented individually and/or collectively by various types of electromechanical systems having a wide range of electrical components (e.g., hardware, software (e.g., a high-level computer program serving as hardware specifications), firmware, and/or substantially any combination thereof) and a wide range of various components that can impart mechanical force or motion (e.g., rigid bodies, springs or torsions, hydraulic devices, electromagnetic actuation devices, and/or substantially any combination thereof). Thus, as used herein, an "electromechanical system" includes, but is not limited to, circuits operatively coupled to transducers (e.g., actuators, motors, piezoelectric crystals, microelectromechanical systems (MEMS), etc.), circuits having at least one discrete circuit, circuits having at least one integrated circuit, circuits having at least one application-specific integrated circuit, circuits forming a general-purpose computing device configured by a computer program (e.g., a general-purpose computer configured by a computer program that at least partially performs the processes and/or devices described herein or a microprocessor configured by a computer program that at least partially performs the processes and/or devices described herein), circuits forming a memory device (e.g., in the form of memory (e.g., random access, flash memory, read-only, etc.)), circuits forming a communication device (e.g., a modem, a communication switch, an optoelectronic device, etc.), and/or any non-electrical analog thereof, such as an optical or other analog (e.g., a graphene-based circuit). Examples of electromechanical systems include, but are not limited to, various consumer electronics systems, medical devices, and/or communication systems/computing systems.
可以通过广泛范围的硬件、软件(例如,用作硬件规范的高级计算机程序)、固件和/或其任何组合来单独地和/或共同地实现的本文描述的各个方面可以被视为由各种类型的“电路”组成。因此,如本文所使用的“电路”包括但不限于:具有至少一个离散电路的电路、具有至少一个集成电路的电路、具有至少一个专用集成电路的电路、形成由计算机程序配置的通用计算设备(例如,由至少部分地执行本文所述的处理和/或设备的计算机程序配置的通用计算机,或由至少部分地执行本文中所描述的处理和/或设备的计算机程序配置的微处理器)的电路、形成存储器装置(例如,存储器形式(例如,随机存取、闪存、只读等))的电路,和/或形成通信设备(例如,调制解调器、通信交换机、光电设备等)的电路。本文所描述的主题可以以模拟或数字方式或其某种组合来实现。The various aspects described herein, which may be implemented individually and/or collectively by a wide range of hardware, software (e.g., a high-level computer program serving as hardware specifications), firmware, and/or any combination thereof, may be considered to be comprised of various types of "circuits." Thus, as used herein, "circuitry" includes, but is not limited to, circuitry having at least one discrete circuit, circuitry having at least one integrated circuit, circuitry having at least one application-specific integrated circuit, circuitry forming a general-purpose computing device configured by a computer program (e.g., a general-purpose computer configured by a computer program that at least partially performs the processes and/or devices described herein, or a microprocessor configured by a computer program that at least partially performs the processes and/or devices described herein), circuitry forming a memory device (e.g., a form of memory (e.g., random access, flash memory, read-only, etc.)), and/or circuitry forming a communication device (e.g., a modem, a communication switch, an optoelectronic device, etc.). The subject matter described herein may be implemented in an analog or digital manner, or some combination thereof.
本文描述的主题有时示出包含在不同的其它部件内或与不同的其它部件连接的不同部件。应当理解,这样描述的体系结构仅仅是示例性的,并且实际上可以实施实现相同功能的许多其他体系结构。在构思意义上,实现相同功能的部件的任何布置被有效地“关联”,使得实现期望的功能。因此,本文中组合以实现特定功能的任何两个组件可被视为彼此“相关联”,使得实现所需功能,而与架构或中间组件无关。同样地,这样相关联的任何两个部件也可以被视为彼此“可操作地连接”或“可操作地耦合”以实现期望的功能,并且能够这样相关联的任何两个部件也可以被视为彼此“可操作地可耦合”以实现期望的功能。可操作地可耦合的具体示例包括但不限于:物理上可配对和/或物理交互的组件、和/或无线可交互的和/或无线交互的组件、和/或逻辑上交互的和/或逻辑上可交互的组件。The subject matter described herein sometimes illustrates the different parts that are contained in different other parts or are connected with different other parts.Should be understood that the architecture described in this way is merely exemplary, and in fact many other architectures that realize the same function can be implemented.In the sense of conception, any arrangement of the parts that realize the same function is effectively "associated" so that the desired function is realized.Therefore, any two components that are combined to realize a specific function herein can be considered to be "associated" with each other so that the desired function is realized, and have nothing to do with architecture or intermediate components.Similarly, any two parts that are associated in this way can also be considered to be "operably connected" or "operably coupled" to realize the desired function, and any two parts that can be associated in this way can also be considered to be "operably coupled" to realize the desired function.The specific example of operable coupling includes but is not limited to: physically pairable and/or physically interactive components, and/or wirelessly interactive and/or wirelessly interactive components, and/or logically interactive and/or logically interactive components.
在本说明书中引用和/或在任何申请数据表中列出的所有上述美国专利、美国专利申请公开、美国专利申请、外国专利、外国专利申请和非专利公开在与本文不矛盾的程度上通过引用并入本文。All of the above-mentioned U.S. patents, U.S. patent application publications, U.S. patent applications, foreign patents, foreign patent applications, and non-patent publications cited in this specification and/or listed in any Application Data Sheet are incorporated herein by reference to the extent not inconsistent herewith.
本文所描述的主题的各方面在以下有编号的条款中阐述:Aspects of the subject matter described in this document are set forth in the following numbered clauses:
1.在一些实施方式中,药物储存容器包括:干燥剂单元,其包括一个或多个外壁,所述一个或多个外壁密封在一起以形成围绕内部干燥剂区域的不透气屏障,所述一个或多个外壁包括孔;位于所述内部干燥剂区域内的加热元件;可操作地附接到所述加热元件的控制器;冷却单元,其包括一个或多个外壁,所述一个或多个外壁密封在一起以形成围绕内部蒸发区域的不透气且不透液的屏障,所述一个或多个外壁包括孔;压缩器系统,其包括定位在所述冷却单元的所述内部蒸发区域内的至少一个蒸发器盘管单元,所述压缩器系统可操作地连接到所述控制器;蒸汽管道,其包括第一端和第二端,所述蒸汽管道在所述第一端附接到围绕所述干燥剂单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述第二端附接到围绕所述蒸发冷却单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述干燥剂单元的所述内部干燥剂区域和所述冷却单元的所述内部蒸发区域之间形成内部不透气通道;蒸汽控制单元,其附接到所述蒸汽管道,所述蒸汽控制单元可操作地附接到所述控制器;以及药物储存单元,其包括围绕药物储存区域的一个或多个外壁,所述药物储存区域包括可操作地连接到所述控制器的至少一个温度传感器。1. In some embodiments, a medicinal storage container comprises: a desiccant unit comprising one or more outer walls sealed together to form an airtight barrier around an inner desiccant region, the one or more outer walls comprising an aperture; a heating element positioned within the inner desiccant region; a controller operably attached to the heating element; a cooling unit comprising one or more outer walls sealed together to form an airtight and liquidtight barrier around an inner evaporative region, the one or more outer walls comprising an aperture; a compressor system comprising at least one evaporator coil unit positioned within the inner evaporative region of the cooling unit, the compressor system operably connected to the controller; a steam line, It includes a first end and a second end, wherein the steam conduit is attached at the first end to the outer surface of the one or more outer walls surrounding the hole of the desiccant unit, and the steam conduit is attached at the second end to the outer surface of the one or more outer walls surrounding the hole of the evaporative cooling unit, the steam conduit forming an internal airtight passage between the internal desiccant area of the desiccant unit and the internal evaporative area of the cooling unit; a steam control unit attached to the steam conduit, the steam control unit being operably attached to the controller; and a drug storage unit including one or more outer walls surrounding the drug storage area, the drug storage area including at least one temperature sensor operably connected to the controller.
2.一些实施方式包括如段落1所述的药物储存容器,其中所述干燥剂单元包括在所述内部干燥剂区域内的一个或多个干燥剂材料单元。2. Some embodiments include the medicinal storage container of paragraph 1, wherein the desiccant unit comprises one or more units of desiccant material within the interior desiccant region.
3.一些实施方式包括如段落1所述的药物储存容器,其中所述干燥剂单元包括蒸汽密封室,所述蒸汽密封室包括与所述蒸汽管道的内部区域蒸汽接触的内部干燥剂区域。3. Some embodiments include the medicinal storage container of paragraph 1, wherein the desiccant unit comprises a vapor-tight chamber including an interior desiccant region in vapor contact with an interior region of the steam conduit.
4.一些实施方式包括如段落1所述的药物储存容器,其中所述干燥剂单元包括单向阀单元,所述单向阀单元被构造成使得具有超过预设极限的压力的气体能够从所述干燥剂单元的所述内部干燥剂区域向外排出。4. Some embodiments include the medicinal storage container of paragraph 1, wherein the desiccant unit includes a one-way valve unit configured to allow gas having a pressure exceeding a preset limit to be discharged outwardly from the internal desiccant region of the desiccant unit.
5.一些实施方式包括如段落1所述的药物储存容器,其中所述干燥剂单元包括在所述内部干燥剂区域内的小于大气压力的气体压力。5. Some embodiments include the medicinal storage container of paragraph 1, wherein the desiccant unit comprises a gas pressure within the interior desiccant region that is less than atmospheric pressure.
6.一些实施方式包括如段落1所述的药物储存容器,其中所述干燥剂单元包括在所述内部干燥剂区域内的小于1托的气体压力。6. Some embodiments include the medicinal storage container of paragraph 1, wherein the desiccant unit comprises a gas pressure within the interior desiccant region of less than 1 Torr.
7.一些实施方式包括如段落1所述的药物储存容器,其中所述干燥剂单元包括在所述内部干燥剂区域内的小于0.1托的气体压力。7. Some embodiments include the medicinal storage container of paragraph 1, wherein the desiccant unit comprises a gas pressure within the interior desiccant region of less than 0.1 Torr.
8.一些实施方式包括如段落1所述的药物储存容器,其中所述干燥剂单元包括位于所述内部干燥剂区域内的开孔金属泡沫,所述开孔金属泡沫定位成在所述内部干燥剂区域内分配气体。8. Some embodiments include the medicinal storage container of paragraph 1, wherein the desiccant unit comprises an open-cell metal foam within the interior desiccant region, the open-cell metal foam positioned to distribute gas within the interior desiccant region.
9.一些实施方式包括如段落1所述的药物储存容器,其中所述干燥剂单元包括定位在所述内部干燥剂区域内的一个或多个管道,所述一个或多个管道定位成在所述内部干燥剂区域内分配气体。9. Some embodiments include the medicinal storage container of paragraph 1, wherein the desiccant unit comprises one or more conduits positioned within the interior desiccant region, the one or more conduits positioned to distribute gas within the interior desiccant region.
10.一些实施方式包括如段落1所述的药物储存容器,其中干燥剂单元的所述一个或多个外壁包括导电材料。10. Some embodiments include the medicinal storage container of paragraph 1, wherein the one or more outer walls of the desiccant unit comprise a conductive material.
11.一些实施方式包括如段落1所述的药物储存容器,其中位于所述内部干燥剂区域内的所述加热元件包括电加热元件。11. Some embodiments include the medicinal storage container of paragraph 1, wherein the heating element located within the internal desiccant region comprises an electric heating element.
12.一些实施方式包括如段落1所述的药物储存容器,其中位于所述内部干燥剂区域内的所述加热元件包括卷绕构型的加热元件。12. Some embodiments include the medicinal storage container of paragraph 1, wherein the heating element within the internal desiccant region comprises a heating element in a coiled configuration.
13.一些实施方式包括如段落1所述的药物储存容器,其中位于所述内部干燥剂区域内的所述加热元件包括固定到所述加热元件的一个或多个热传导元件。13. Some embodiments include the medicinal storage container of paragraph 1, wherein the heating element within the internal desiccant region comprises one or more heat-conductive elements secured to the heating element.
14.一些实施方式包括如段落1所述的药物储存容器,其中所述控制器包括电子控制器。14. Some embodiments include the medicinal storage container of paragraph 1, wherein the controller comprises an electronic controller.
15.一些实施方式包括如段落1所述的药物储存容器,其中所述控制器包括存储器。15. Some embodiments include the medicinal storage container of paragraph 1, wherein the controller comprises a memory.
16.一些实施方式包括如段落1中的药物储存容器,其中所述控制器包括被配置成响应于从所述药物储存区域内的所述至少一个温度传感器接收到的信号控制所述加热元件的操作的电路。16. Some embodiments include the medicinal storage container of paragraph 1, wherein the controller includes circuitry configured to control operation of the heating element in response to a signal received from the at least one temperature sensor within the medicinal storage area.
17.一些实施方式包括如段落1所述的药物储存容器,其中所述控制器包括查找表。17. Some embodiments include the medicinal storage container of paragraph 1, wherein the controller comprises a lookup table.
18.一些实施方式包括根据段落1所述的药物储存容器,其中所述控制器利用线连接器可操作地附接到所述加热元件和所述至少一个温度传感器。18. Some embodiments include the medicinal storage container of paragraph 1, wherein the controller is operably attached to the heating element and the at least one temperature sensor using wire connectors.
19.一些实施方式包括如段落1所述的药物储存容器,其中所述控制器可操作地附接到所述压缩器系统。19. Some embodiments include the medicinal storage container of paragraph 1, wherein the controller is operably attached to the compressor system.
20.一些实施方式包括如段落1所述的药物储存容器,其中所述控制器可操作地附接到电源。20. Some embodiments include the medicinal storage container of paragraph 1, wherein the controller is operably attached to a power source.
21.一些实施方式包括如段落1所述的药物储存容器,其中所述冷却单元包括:上部区域,所述上部区域邻近所述外壁中的所述孔定位;下部区域,所述下部区域位于所述上部区域的下方;以及基本上位于所述下部区域内的蒸发液体。21. Some embodiments include the medicinal storage container of paragraph 1, wherein the cooling unit comprises: an upper region positioned adjacent to the hole in the outer wall; a lower region located below the upper region; and a vaporized liquid substantially within the lower region.
22.一些实施方式包括如段落1所述的药物储存容器,其中所述冷却单元包括在所述蒸发冷却单元的所述内部蒸发区域内的至少一种蒸发液体。22. Some embodiments include the medicinal storage container of paragraph 1, wherein the cooling unit comprises at least one evaporative liquid within the interior evaporative region of the evaporative cooling unit.
23.一些实施方式包括如段落1所述的药物储存容器,其中所述冷却单元包括连接到邻近所述内部蒸发区域的至少一个表面的液体保持单元。23. Some embodiments include the medicinal storage container of paragraph 1, wherein the cooling unit comprises a liquid retention unit coupled to at least one surface adjacent the interior evaporative region.
24.一些实施方式包括如段落1所述的药物储存容器,其中所述冷却单元包括固定到位于所述内部蒸发区域内的所述至少一个蒸发器盘管单元的一个或多个热传导元件。24. Some embodiments include the medicinal storage container of paragraph 1, wherein the cooling unit comprises one or more heat-conducting elements secured to the at least one evaporator coil unit located within the interior evaporative region.
25.一些实施方式包括如段落1所述的药物储存容器,其中所述冷却单元包括在所述内部蒸发区域内的一个或多个温度传感器,所述一个或多个温度传感器可操作地附接到所述控制器。25. Some embodiments include the medicinal storage container of paragraph 1, wherein the cooling unit comprises one or more temperature sensors within the interior evaporative region, the one or more temperature sensors operably attached to the controller.
26.一些实施方式包括如段落1所述的药物储存容器,其中所述冷却单元包括位于所述内部蒸发区域内的液位传感器。26. Some embodiments include the medicinal storage container of paragraph 1, wherein the cooling unit comprises a liquid level sensor located within the interior evaporative region.
27.一些实施方式包括如段落1所述的药物储存容器,其中位于所述冷却单元的所述内部蒸发区域内的所述至少一个蒸发器盘管单元定位成邻近所述冷却单元的邻近所述干燥剂单元的所述外壁。27. Some embodiments include the medicinal storage container of paragraph 1, wherein the at least one evaporator coil unit within the interior evaporative region of the cooling unit is positioned adjacent the exterior wall of the cooling unit adjacent the desiccant unit.
28.一些实施方式包括如段落1所述的药物储存容器,其中位于所述冷却单元的所述内部蒸发区域内的所述至少一个蒸发器盘管单元基本上位于所述冷却单元的中心。28. Some embodiments include the medicinal storage container of paragraph 1, wherein the at least one evaporator coil unit located within the interior evaporative region of the cooling unit is located substantially in the center of the cooling unit.
29.一些实施方式包括如段落1所述的药物储存容器,其中位于所述冷却单元的所述内部蒸发区域内的所述至少一个蒸发器盘管单元邻近所述冷却单元的邻近所述药物储存单元的所述外壁定位。29. Some embodiments include the medicinal storage container of paragraph 1, wherein the at least one evaporator coil unit within the interior evaporative region of the cooling unit is positioned adjacent the exterior wall of the cooling unit adjacent the medicinal storage unit.
30.一些实施方式包括如段落1所述的药物储存容器,其中所述压缩器系统包括:至少一个蒸发器盘管单元,其定位在所述冷却单元的所述内部蒸发区域内;压缩器单元;冷凝器单元;和膨胀阀;其中所述压缩器单元、所述冷凝器单元和所述膨胀阀定位在所述冷却单元的所述内部蒸发区域的外部。30. Some embodiments include the medicinal storage container of paragraph 1, wherein the compressor system comprises: at least one evaporator coil unit positioned within the interior evaporative region of the cooling unit; a compressor unit; a condenser unit; and an expansion valve; wherein the compressor unit, the condenser unit, and the expansion valve are positioned outside the interior evaporative region of the cooling unit.
31.一些实施方式包括如段落1所述的药物储存容器,其中,所述压缩器系统包括开关,所述开关被配置为响应于从所述控制器接收到的信号而打开和关闭所述压缩器系统。31. Some embodiments include the medicinal storage container of paragraph 1, wherein the compressor system comprises a switch configured to open and close the compressor system in response to a signal received from the controller.
32.一些实施方式包括如段落1所述的药物储存容器,其中所述蒸汽管道包括基本管状结构,所述基本管状结构具有足够的长度和直径以抑制所述干燥剂单元的所述至少一个外壁与所述冷却单元的所述至少一个外壁之间的热传导。32. Some embodiments include the medicinal storage container of paragraph 1, wherein the steam conduit comprises a substantially tubular structure having a length and diameter sufficient to inhibit heat conduction between the at least one outer wall of the desiccant unit and the at least one outer wall of the cooling unit.
33.一些实施方式包括如段落1所述的药物储存容器,其中所述蒸汽管道被配置为使所述干燥剂单元和所述冷却单元之间的热能的传导最小化。33. Some embodiments include the medicinal storage container of paragraph 1, wherein the steam conduit is configured to minimize conduction of thermal energy between the desiccant unit and the cooling unit.
34.一些实施方式包括如段落1所述的药物储存容器,其中所述蒸汽管道包括:固定到所述蒸汽管道的外表面的一个或多个热传导元件。34. Some embodiments include the medicinal storage container of paragraph 1, wherein the steam conduit comprises: one or more heat-conductive elements secured to an exterior surface of the steam conduit.
35.一些实施方式包括如段落1所述的药物储存容器,其中所述蒸汽管道包括:所述蒸汽管道的不透气壁;在所述蒸汽管道的所述第一端和所述干燥剂单元之间的不透气密封件;以及在所述蒸汽管道的所述第二端和所述冷却单元之间的不透气密封件。35. Some embodiments include the medicinal storage container of paragraph 1, wherein the steam conduit comprises: an airtight wall of the steam conduit; an airtight seal between the first end of the steam conduit and the desiccant unit; and an airtight seal between the second end of the steam conduit and the cooling unit.
36.一些实施方式包括根据段落1所述的药物储存容器,其中所述蒸汽管道包括穿过所述蒸汽管道的所述内部通道的外部可破坏的密封件,所述密封件被构造成防止气体流过所述蒸汽管道的所述内部通道。36. Some embodiments include the medicinal storage container of paragraph 1, wherein the steam conduit includes an externally breakable seal across the interior passage of the steam conduit, the seal configured to prevent gas from flowing through the interior passage of the steam conduit.
37.一些实施方式包括如段落1所述的药物储存容器,其中所述蒸汽管道包括:第一温度传感器,其邻近所述蒸汽管道内的所述第一端定位,所述第一温度传感器可操作地连接到所述控制器;以及第二温度传感器,其邻近所述蒸汽管道内的所述第二端定位,所述第二温度传感器可操作地附接到所述控制器。37. Some embodiments include the medicinal storage container of paragraph 1, wherein the steam conduit comprises: a first temperature sensor positioned adjacent the first end within the steam conduit, the first temperature sensor operably connected to the controller; and a second temperature sensor positioned adjacent the second end within the steam conduit, the second temperature sensor operably attached to the controller.
38.一些实施方式包括如段落1所述的药物储存容器,其中所述蒸汽控制单元包括至少一个阀,所述至少一个阀被配置成控制气体通过所述蒸汽管道的在所述干燥剂单元的所述内部干燥剂区域和所述冷却单元的所述内部蒸发区域之间的所述内部通道的运动,所述至少一个阀构造成响应于从所述控制器接收到的信号而操作。38. Some embodiments include the medicinal storage container of paragraph 1, wherein the vapor control unit comprises at least one valve configured to control the movement of gas through the internal passage of the vapor conduit between the internal desiccant region of the desiccant unit and the internal evaporation region of the cooling unit, the at least one valve being configured to operate in response to a signal received from the controller.
39.一些实施方式包括如段落1所述的药物储存容器,其中所述蒸汽控制单元包括温度传感器。39. Some embodiments include the medicinal storage container of paragraph 1, wherein the vapor control unit comprises a temperature sensor.
40.一些实施方式包括如段落1所述的药物储存容器,其中所述蒸汽控制单元包括压力传感器。40. Some embodiments include the medicinal storage container of paragraph 1, wherein the vapor control unit comprises a pressure sensor.
41.一些实施方式包括如段落1所述的药物储存容器,其中所述药物储存单元包括邻近所述药物储存区域的一个或多个壁,所述一个或多个壁被制造成在所述药物储存区域的预期温度下是导热的。41. Some embodiments include the medicinal storage container of paragraph 1, wherein the medicinal storage unit includes one or more walls adjacent to the medicinal storage region, the one or more walls being made thermally conductive at an expected temperature of the medicinal storage region.
42.一些实施方式包括如段落1所述的药物储存容器,其中所述药物储存单元包括定位在与所述药物储存区域的顶部区域相邻的所述外壁中的铰接盖,所述铰接盖被配置成使得用户能够接近所述药物储存区域。42. Some embodiments include the medicinal storage container of paragraph 1, wherein the medicinal storage unit includes a hinged lid positioned in the outer wall adjacent a top region of the medicinal storage area, the hinged lid configured to enable a user to access the medicinal storage area.
43.一些实施方式包括如段落1所述的药物储存容器,其中所述药物储存单元的所述至少一个温度传感器被定位成检测所述药物储存区域内的温度。43. Some embodiments include the medicinal storage container of paragraph 1, wherein the at least one temperature sensor of the medicinal storage unit is positioned to detect a temperature within the medicinal storage region.
44.一些实施方式包括如段落1所述的药物储存容器,其中所述药物储存单元的所述至少一个温度传感器是电子温度传感器。44. Some embodiments include the medicinal storage container of paragraph 1, wherein the at least one temperature sensor of the medicinal storage unit is an electronic temperature sensor.
45.一些实施方式包括如段落1所述的药物储存容器,其还包括围绕所述冷却单元和所述药物储存单元的一个或多个绝缘段。45. Some embodiments include the medicinal storage container of paragraph 1, further comprising one or more insulating segments surrounding the cooling unit and the medicinal storage unit.
46.一些实施方式包括如段落1所述的药物储存容器,其还包括位于所述药物储存容器下方的基部单元,所述基部单元包括基本上围绕所述压缩器系统和所述控制器的至少一个区域的一个或多个壁。46. Some embodiments include the medicinal storage container of paragraph 1, further comprising a base unit positioned below the medicinal storage container, the base unit comprising one or more walls substantially surrounding at least one region of the compressor system and the controller.
47.一些实施方式包括如段落1所述的药物储存容器,其还包括位于所述干燥剂单元的所述一个或多个外壁的外表面与所述冷却单元的所述一个或多个外壁的外表面之间的间隙。47. Some embodiments include the medicinal storage container of paragraph 1, further comprising a gap between an outer surface of the one or more outer walls of the desiccant unit and an outer surface of the one or more outer walls of the cooling unit.
48.一些实施方式包括如段落1所述的药物储存容器,其还包括位于所述干燥剂单元的所述一个或多个外壁的外表面与所述冷却单元的所述一个或多个外壁的外表面之间的间隙;以及固定到所述干燥剂单元的所述一个或多个外壁的所述外表面上的风扇,所述风扇的尺寸、形状和位置使所述间隙内的空气循环。48. Some embodiments include the medicinal storage container of paragraph 1, further comprising a gap between the outer surface of the one or more outer walls of the desiccant unit and the outer surface of the one or more outer walls of the cooling unit; and a fan fixed to the outer surface of the one or more outer walls of the desiccant unit, the fan being sized, shaped, and positioned to circulate air within the gap.
49.在一些实施方式中,药物储存容器包括:干燥剂单元,其包括一个或多个外壁,所述一个或多个外壁密封在一起以形成围绕内部干燥剂区域的不透气屏障,所述一个或多个外壁包括孔;位于所述内部干燥剂区域内的加热元件;可操作地附接到所述加热元件的控制器;冷却单元,其包括一个或多个外壁,所述一个或多个外壁密封在一起以形成围绕内部蒸发区域的不透气且不透液的屏障,所述一个或多个外壁包括孔;压缩器系统,其包括定位在所述冷却单元的所述内部蒸发区域内的至少一个蒸发器盘管单元,所述压缩器系统可操作地连接到所述控制器;包括一个或多个壁的冷冻器单元,所述冷冻器单元与位于所述冷却单元的所述内部蒸发区域内的所述至少一个蒸发器盘管单元热接触;蒸汽管道,其包括第一端和第二端,所述蒸汽管道在所述第二端附接到围绕所述干燥剂单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述第一端附接到围绕所述蒸发冷却单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述干燥剂单元的所述内部干燥剂区域和所述冷却单元的所述内部蒸发区域之间形成内部不透气通道;蒸汽控制单元,其附接到所述蒸汽管道,所述蒸汽控制单元可操作地附接到所述控制器;以及药物储存单元,其包括围绕药物储存区域的一个或多个外壁,所述药物储存区域包括可操作地连接到所述控制器的至少一个温度传感器。49. In some embodiments, a medicinal storage container comprises: a desiccant unit comprising one or more outer walls, the one or more outer walls being sealed together to form an airtight barrier around an inner desiccant region, the one or more outer walls comprising apertures; a heating element positioned within the inner desiccant region; a controller operably attached to the heating element; a cooling unit comprising one or more outer walls, the one or more outer walls being sealed together to form an airtight and liquidtight barrier around an inner evaporative region, the one or more outer walls comprising apertures; a compressor system comprising at least one evaporator coil unit positioned within the inner evaporative region of the cooling unit, the compressor system being operably connected to the controller; a freezer unit comprising one or more walls, the freezer unit being coupled to the freezer located within the cooling unit. thermally contacting the at least one evaporator coil unit within the internal evaporative region; a steam conduit comprising a first end and a second end, the steam conduit being attached at the second end to the outer surface of the one or more outer walls surrounding the aperture of the desiccant unit, the steam conduit being attached at the first end to the outer surface of the one or more outer walls surrounding the aperture of the evaporative cooling unit, the steam conduit forming an internal airtight passage between the internal desiccant region of the desiccant unit and the internal evaporative region of the cooling unit; a steam control unit attached to the steam conduit, the steam control unit being operably attached to the controller; and a drug storage unit comprising one or more outer walls surrounding the drug storage region, the drug storage region comprising at least one temperature sensor operably connected to the controller.
50.一些实施方式包括如段落49所述的药物储存容器,其中所述干燥剂单元包括在所述内部干燥剂区域内的一个或多个干燥剂材料单元。50. Some embodiments include the medicinal storage container of paragraph 49, wherein the desiccant unit comprises one or more units of desiccant material within the interior desiccant region.
51.一些实施方式包括如段落49所述的药物储存容器,其中所述干燥剂单元包括蒸汽密封室,所述蒸汽密封室包括与所述蒸汽管道的内部区域蒸汽接触的内部干燥剂区域。51. Some embodiments include the medicinal storage container of paragraph 49, wherein the desiccant unit comprises a vapor-tight chamber including an interior desiccant region in vapor contact with an interior region of the steam conduit.
52.一些实施方式包括如段落49所述的药物储存容器,其中所述干燥剂单元包括单向阀单元,所述单向阀单元被构造成使得具有超过预设极限的压力的气体能够从所述干燥剂单元的所述内部干燥剂区域向外排出。52. Some embodiments include the medicinal storage container of paragraph 49, wherein the desiccant unit includes a one-way valve unit configured to allow gas having a pressure exceeding a preset limit to be discharged outwardly from the internal desiccant region of the desiccant unit.
53.一些实施方式包括如段落49所述的药物储存容器,其中所述干燥剂单元包括在所述内部干燥剂区域内的小于大气压力的气体压力。53. Some embodiments include the medicinal storage container of paragraph 49, wherein the desiccant unit comprises a gas pressure within the interior desiccant region that is less than atmospheric pressure.
54.一些实施方式包括如段落49所述的药物储存容器,其中所述干燥剂单元包括在所述内部干燥剂区域内的小于1托的气体压强。54. Some embodiments include the medicinal storage container of paragraph 49, wherein the desiccant unit comprises a gas pressure within the interior desiccant region of less than 1 Torr.
55.一些实施方式包括如段落49所述的药物储存容器,其中所述干燥剂单元包括在所述内部干燥剂区域内的小于0.1托的气体压强。55. Some embodiments include the medicinal storage container of paragraph 49, wherein the desiccant unit comprises a gas pressure within the interior desiccant region of less than 0.1 Torr.
56.一些实施方式包括如段落49所述的药物储存容器,其中所述干燥剂单元包括位于所述内部干燥剂区域内的开孔金属泡沫,所述开孔金属泡沫定位成在所述内部干燥剂区域内分配气体。56. Some embodiments include the medicinal storage container of paragraph 49, wherein the desiccant unit comprises an open-cell metal foam within the interior desiccant region, the open-cell metal foam positioned to distribute gas within the interior desiccant region.
57.一些实施方式包括如段落49所述的药物储存容器,其中所述干燥剂单元包括定位在所述内部干燥剂区域内的一个或多个管道,所述一个或多个管道定位成在所述内部干燥剂区域内分配气体。57. Some embodiments include the medicinal storage container of paragraph 49, wherein the desiccant unit comprises one or more conduits positioned within the interior desiccant region, the one or more conduits positioned to distribute gas within the interior desiccant region.
58.一些实施方式包括如段落49所述的药物储存容器,其中所述干燥剂单元的所述一个或多个外壁包括导电材料。58. Some embodiments include the medicinal storage container of paragraph 49, wherein the one or more outer walls of the desiccant unit comprise a conductive material.
59.一些实施方式包括如段落49所述的药物储存容器,其中位于所述内部干燥剂区域内的所述加热元件包括电加热元件。59. Some embodiments include the medicinal storage container of paragraph 49, wherein the heating element within the internal desiccant region comprises an electric heating element.
60.一些实施方式包括如段落49所述的药物储存容器,其中位于所述内部干燥剂区域内的所述加热元件包括卷绕构型的加热元件。60. Some embodiments include the medicinal storage container of paragraph 49, wherein the heating element within the interior desiccant region comprises a heating element in a coiled configuration.
61.一些实施方式包括如段落49所述的药物储存容器,其中位于所述内部干燥剂区域内的所述加热元件包括固定到所述加热元件的一个或多个热传导元件。61. Some embodiments include the medicinal storage container of paragraph 49, wherein the heating element within the internal desiccant region comprises one or more thermally conductive elements secured to the heating element.
62.一些实施方式包括如段落49所述的药物储存容器,其中所述控制器包括电子控制器。62. Some embodiments include the medicinal storage container of paragraph 49, wherein the controller comprises an electronic controller.
63.一些实施方式包括如段落49所述的药物储存容器,其中所述控制器包括存储器。63. Some embodiments include the medicinal storage container of paragraph 49, wherein the controller comprises a memory.
64.一些实施方式包括如段落49所述的药物储存容器,其中所述控制器包括被配置成响应于从所述药物储存区域内的所述至少一个温度传感器接收到的信号来控制所述加热元件的操作的电路。64. Some embodiments include the medicinal storage container of paragraph 49, wherein the controller comprises circuitry configured to control operation of the heating element in response to a signal received from the at least one temperature sensor within the medicinal storage area.
65.一些实施方式包括如段落49所述的药物储存容器,其中所述控制器包括查找表。65. Some embodiments include the medicinal storage container of paragraph 49, wherein the controller comprises a lookup table.
66.一些实施方式包括如段落49所述的药物储存容器,其中所述控制器利用线连接器可操作地附接到所述加热元件和所述至少一个温度传感器。66. Some embodiments include the medicinal storage container of paragraph 49, wherein the controller is operably attached to the heating element and the at least one temperature sensor using wire connectors.
67.一些实施方式包括如段落49所述的药物储存容器,其中所述控制器可操作地附接到所述压缩器系统。67. Some embodiments include the medicinal storage container of paragraph 49, wherein the controller is operably attached to the compressor system.
68.一些实施方式包括如段落49所述的药物储存容器,其中所述控制器可操作地附接到电源。68. Some embodiments include the medicinal storage container of paragraph 49, wherein the controller is operably attached to a power source.
69.一些实施方式包括如段落49所述的药物储存容器,其中所述冷却单元包括:上部区域,所述上部区域邻近所述外壁中的所述孔定位;下部区域,所述下部区域位于所述上部区域的下方;以及基本上位于所述下部区域内的蒸发液体。69. Some embodiments include the medicinal storage container of paragraph 49, wherein the cooling unit comprises: an upper region positioned adjacent to the hole in the outer wall; a lower region located below the upper region; and an evaporative liquid substantially within the lower region.
70.一些实施方式包括如段落49所述的药物储存容器,其中所述冷却单元包括在所述蒸发冷却单元的所述内部蒸发区域内的至少一种蒸发液体。70. Some embodiments include the medicinal storage container of paragraph 49, wherein the cooling unit comprises at least one evaporative liquid within the interior evaporative region of the evaporative cooling unit.
71.一些实施方式包括如段落49所述的药物储存容器,其中所述冷却单元包括连接到邻近所述内部蒸发区域的至少一个表面的液体保持单元。71. Some embodiments include the medicinal storage container of paragraph 49, wherein the cooling unit comprises a liquid retention unit coupled to at least one surface adjacent the interior evaporative region.
72.一些实施方式包括如段落49所述的药物储存容器,其中所述冷却单元包括固定到位于所述内部蒸发区域内的所述至少一个蒸发器盘管单元的一个或多个热传导元件。72. Some embodiments include the medicinal storage container of paragraph 49, wherein the cooling unit comprises one or more heat-conducting elements secured to the at least one evaporator coil unit located within the interior evaporative region.
73.一些实施方式包括如段落49所述的药物储存容器,其中所述冷却单元包括在所述内部蒸发区域内的一个或多个温度传感器,所述一个或多个温度传感器可操作地附接到所述控制器。73. Some embodiments include the medicinal storage container of paragraph 49, wherein the cooling unit comprises one or more temperature sensors within the interior evaporative region, the one or more temperature sensors operably attached to the controller.
74.一些实施方式包括如段落49所述的药物储存容器,其中所述冷却单元包括位于所述内部蒸发区域内的液位传感器。74. Some embodiments include the medicinal storage container of paragraph 49, wherein the cooling unit comprises a liquid level sensor located within the interior evaporative region.
75.一些实施方式包括如段落49所述的药物储存容器,其中定位在所述冷却单元的所述内部蒸发区域内的所述至少一个蒸发器盘管单元定位成与所述冷冻器单元的一个或多个壁相邻。75. Some embodiments include the medicinal storage container of paragraph 49, wherein the at least one evaporator coil unit positioned within the interior evaporative region of the cooling unit is positioned adjacent to one or more walls of the freezer unit.
76.一些实施方式包括如段落49所述的药物储存容器,其中所述压缩器系统包括:至少一个蒸发器盘管单元,其定位在所述冷却单元的所述内部蒸发区域内;压缩器单元;冷凝器单元;和膨胀阀;其中所述压缩器单元、所述冷凝器单元和所述膨胀阀位于所述冷却单元的所述内部蒸发区域的外部。76. Some embodiments include the medicinal storage container of paragraph 49, wherein the compressor system comprises: at least one evaporator coil unit positioned within the interior evaporative region of the cooling unit; a compressor unit; a condenser unit; and an expansion valve; wherein the compressor unit, the condenser unit, and the expansion valve are located outside the interior evaporative region of the cooling unit.
77.一些实施方式包括如段落49所述的药物储存容器,其中,所述压缩器系统包括开关,所述开关被配置为响应于从所述控制器接收到的信号而打开和关闭所述压缩器系统。77. Some embodiments include the medicinal storage container of paragraph 49, wherein the compressor system comprises a switch configured to open and close the compressor system in response to a signal received from the controller.
78.一些实施方式包括如段落49所述的药物储存容器,其中所述冷冻器单元包括一个或多个壁,所述一个或多个壁具有将一个或多个冰袋保持在适当位置的尺寸、形状和位置。78. Some embodiments include the medicinal storage container of paragraph 49, wherein the freezer unit comprises one or more walls sized, shaped, and positioned to hold one or more ice packs in place.
79.一些实施方式包括如段落49所述的药物储存容器,其中所述冷冻器单元包括:具有用于使用者接近所述冷冻器单元内的材料的尺寸、形状和位置的孔;和可逆地固定到所述孔的盖。79. Some embodiments include the medicinal storage container of paragraph 49, wherein the freezer unit comprises: an aperture sized, shaped, and positioned for user access to materials within the freezer unit; and a cover reversibly securable to the aperture.
80.一些实施方式包括如段落49所述的药物储存容器,其中所述冷冻器单元包括可操作地附接到所述控制器的温度传感器。80. Some embodiments include the medicinal storage container of paragraph 49, wherein the freezer unit includes a temperature sensor operably attached to the controller.
81.一些实施方式包括如段落49所述的药物储存容器,其中所述冷冻器单元包括导热壁,所述导热壁具有邻近内部冷冻器区域定位的第一侧,以及定位成与所述至少一个蒸发器盘管单元的外表面热接触的第二侧。81. Some embodiments include the medicinal storage container of paragraph 49, wherein the freezer unit comprises a thermally conductive wall having a first side positioned adjacent the interior freezer region and a second side positioned in thermal contact with an exterior surface of the at least one evaporator coil unit.
82.一些实施方式包括如段落49所述的药物储存容器,其中所述蒸汽管道包括基本管状结构,所述基本管状结构具有足够长度和直径以抑制所述干燥剂单元的所述至少一个外壁与所述冷却单元的所述至少一个外壁之间的热接触。82. Some embodiments include the medicinal storage container of paragraph 49, wherein the steam conduit comprises a substantially tubular structure having a length and diameter sufficient to inhibit thermal contact between the at least one outer wall of the desiccant unit and the at least one outer wall of the cooling unit.
83.一些实施方式包括如段落49所述的药物储存容器,其中所述蒸汽管道被配置成使所述干燥剂单元和所述冷却单元之间的热能的传导最小化。83. Some embodiments include the medicinal storage container of paragraph 49, wherein the steam conduit is configured to minimize conduction of thermal energy between the desiccant unit and the cooling unit.
84.一些实施方式包括如段落49所述的药物储存容器,其中所述蒸汽管道c包括固定到所述蒸汽管道的外表面的一个或多个热传导元件。84. Some embodiments include the medicinal storage container of paragraph 49, wherein the steam conduit c comprises one or more heat-conducting elements secured to an outer surface of the steam conduit.
85.一些实施方式包括如段落49所述的药物储存容器,其中所述蒸汽管道包括:所述蒸汽管道的不透气壁;在所述蒸汽管道的所述第一端和所述干燥剂单元之间的不透气密封件;以及在所述蒸汽管道的所述第二端和所述冷却单元之间的不透气密封件。85. Some embodiments include the medicinal storage container of paragraph 49, wherein the steam conduit comprises: an airtight wall of the steam conduit; an airtight seal between the first end of the steam conduit and the desiccant unit; and an airtight seal between the second end of the steam conduit and the cooling unit.
86.一些实施方式包括如段落49所述的药物储存容器,其中所述蒸汽管道包括穿过所述蒸汽管道的所述内部通道的外部可破坏的密封件,所述密封件被构造成防止气体流过所述蒸汽管道的所述内部通道。86. Some embodiments include the medicinal storage container of paragraph 49, wherein the steam conduit comprises an externally breakable seal across the interior passage of the steam conduit, the seal configured to prevent gas from flowing through the interior passage of the steam conduit.
87.一些实施方式包括如段落49所述的药物储存容器,其中所述蒸汽管道包括:第一温度传感器,其邻近所述蒸汽管道内的所述第一端定位,所述第一温度传感器可操作地附接到所述控制器;以及第二温度传感器,其邻近所述蒸汽管道内的所述第二端定位,所述第二温度传感器可操作地附接到所述控制器。87. Some embodiments include the medicinal storage container of paragraph 49, wherein the steam conduit comprises: a first temperature sensor positioned adjacent the first end within the steam conduit, the first temperature sensor being operably attached to the controller; and a second temperature sensor positioned adjacent the second end within the steam conduit, the second temperature sensor being operably attached to the controller.
88.一些实施方式包括如段落49所述的药物储存容器,其中所述蒸汽控制单元包括至少一个阀,所述至少一个阀被配置成控制气体通过所述蒸汽管道的在所述干燥剂单元的所述内部干燥剂区域和所述冷却单元的所述内部蒸发区域之间的所述内部通道的运动,所述至少一个阀被构造成响应于从所述控制器接收到的信号而操作。88. Some embodiments include the medicinal storage container of paragraph 49, wherein the vapor control unit comprises at least one valve configured to control the movement of gas through the internal passage of the vapor conduit between the internal desiccant region of the desiccant unit and the internal evaporation region of the cooling unit, the at least one valve being configured to operate in response to a signal received from the controller.
89.一些实施方式包括如段落49所述的药物储存容器,其中所述蒸汽控制单元包括温度传感器。89. Some embodiments include the medicinal storage container of paragraph 49, wherein the vapor control unit comprises a temperature sensor.
90.一些实施方式包括如段落49所述的药物储存容器,其中所述蒸汽控制单元包括压力传感器。90. Some embodiments include the medicinal storage container of paragraph 49, wherein the vapor control unit comprises a pressure sensor.
91.一些实施方式包括如段落49所述的药物储存容器,其中所述药物储存单元包括邻近所述药物储存区域的一个或多个壁,所述一个或多个壁被制造成在所述药物储存区域的预期温度下是导热的。91. Some embodiments include the medicinal storage container of paragraph 49, wherein the medicinal storage unit includes one or more walls adjacent to the medicinal storage region, the one or more walls being made thermally conductive at an expected temperature of the medicinal storage region.
92.一些实施方式包括如段落49所述的药物储存容器,其中所述药物储存单元包括定位在与所述药物储存区域的顶部区域相邻的所述外壁中的铰接盖,所述铰接盖被配置成使得用户能够接近所述药物储存区域。92. Some embodiments include the medicinal storage container of paragraph 49, wherein the medicinal storage unit includes a hinged lid positioned in the outer wall adjacent a top region of the medicinal storage area, the hinged lid configured to enable a user to access the medicinal storage area.
93.一些实施方式包括如段落49所述的药物储存容器,其中所述药物储存单元的所述至少一个温度传感器被定位成检测所述药物储存区域内的温度。93. Some embodiments include the medicinal storage container of paragraph 49, wherein the at least one temperature sensor of the medicinal storage unit is positioned to detect a temperature within the medicinal storage region.
94.一些实施方式包括如段落49所述的药物储存容器,其中所述药物储存单元的所述至少一个温度传感器是电子温度传感器。94. Some embodiments include the medicinal storage container of paragraph 49, wherein the at least one temperature sensor of the medicinal storage unit is an electronic temperature sensor.
95.一些实施方式包括如段落49所述的药物储存容器,其还包括围绕所述冷却单元、所述药物储存单元和所述冷冻器单元的一个或多个绝缘段。95. Some embodiments include the medicinal storage container of paragraph 49, further comprising one or more insulation segments surrounding the cooling unit, the medicinal storage unit, and the freezer unit.
96.一些实施方式包括如段落49所述的药物储存容器,其还包括位于所述药物储存容器下方的基部单元,所述基部单元包括基本上围绕所述压缩器系统和所述控制器的至少一个区域的一个或多个壁。96. Some embodiments include the medicinal storage container of paragraph 49, further comprising a base unit positioned below the medicinal storage container, the base unit comprising one or more walls substantially surrounding at least one region of the compressor system and the controller.
97.一些实施方式包括如段落49所述的药物储存容器,其还包括位于所述干燥剂单元的所述一个或多个外壁的外表面与所述冷却单元的所述一个或多个外壁的外表面之间的间隙。97. Some embodiments include the medicinal storage container of paragraph 49, further comprising a gap between an outer surface of the one or more outer walls of the desiccant unit and an outer surface of the one or more outer walls of the cooling unit.
98.一些实施方式包括如段落49所述的药物储存容器,其还包括:位于所述干燥剂单元的所述一个或多个外壁的外表面与所述冷却单元的所述一个或多个外壁的外表面之间的间隙;以及固定到所述干燥剂单元的所述一个或多个外壁的所述外表面上的风扇,所述风扇的尺寸、形状和位置使所述间隙内的空气循环。98. Some embodiments include the medicinal storage container of paragraph 49, further comprising: a gap between the outer surface of the one or more outer walls of the desiccant unit and the outer surface of the one or more outer walls of the cooling unit; and a fan fixed to the outer surface of the one or more outer walls of the desiccant unit, the fan being sized, shaped, and positioned to circulate air within the gap.
99.在一些实施方式中,药物储存容器包括:干燥剂单元,其包括一个或多个外壁,所述一个或多个外壁密封在一起以形成围绕内部干燥剂区域的不透气屏障,所述一个或多个外壁包括孔;位于所述内部干燥剂区域内的加热元件;可操作地附接到所述加热元件的控制器;冷却单元,其包括一个或多个外壁,所述一个或多个外壁密封在一起以形成围绕内部蒸发区域的不透气且不透液的屏障,所述一个或多个外壁包括孔;压缩器系统,其包括定位在所述冷却单元的所述内部蒸发区域内的至少一个蒸发器盘管单元,所述压缩器系统可操作地连接到所述控制器;蒸汽管道,其包括第一端和第二端,所述蒸汽管道在所述第二端附接到围绕所述干燥剂单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述第一端附接到围绕所述蒸发冷却单元的所述孔的所述一个或多个外壁的外表面,所述蒸汽管道在所述干燥剂单元的所述内部干燥剂区域和所述冷却单元的所述内部蒸发区域之间形成内部不透气通道;蒸汽控制单元,其附接到所述蒸汽管道,所述蒸汽控制单元可操作地附接到所述控制器;附接到所述蒸汽管道的热控制单元,所述热控制单元可操作地附接到所述控制器;以及药物储存单元,其包括围绕药物储存区域的一个或多个外壁,所述药物储存区域包括可操作地连接到所述控制器的至少一个温度传感器。99. In some embodiments, a medicinal storage container comprises: a desiccant unit comprising one or more outer walls, the one or more outer walls being sealed together to form an airtight barrier around an inner desiccant region, the one or more outer walls comprising an aperture; a heating element positioned within the inner desiccant region; a controller operably attached to the heating element; a cooling unit comprising one or more outer walls, the one or more outer walls being sealed together to form an airtight and liquidtight barrier around an inner evaporative region, the one or more outer walls comprising an aperture; a compressor system comprising at least one evaporator coil unit positioned within the inner evaporative region of the cooling unit, the compressor system being operably connected to the controller; a steam line comprising a first end and a second end, the steam line Attached at the second end to the outer surface of the one or more outer walls surrounding the hole of the desiccant unit, the steam conduit is attached at the first end to the outer surface of the one or more outer walls surrounding the hole of the evaporative cooling unit, the steam conduit forming an internal airtight passage between the internal desiccant area of the desiccant unit and the internal evaporative area of the cooling unit; a steam control unit attached to the steam conduit, the steam control unit being operably attached to the controller; a thermal control unit attached to the steam conduit, the thermal control unit being operably attached to the controller; and a drug storage unit comprising one or more outer walls surrounding a drug storage area, the drug storage area comprising at least one temperature sensor operably connected to the controller.
100.一些实施方式包括如段落99所述的药物储存容器,其中所述干燥剂单元包括在所述内部干燥剂区域内的一个或多个干燥剂材料单元。100. Some embodiments include the medicinal storage container of paragraph 99, wherein the desiccant unit comprises one or more units of desiccant material within the interior desiccant region.
101.一些实施方式包括如段落99所述的药物储存容器,其中所述干燥剂单元包括蒸汽密封室,所述蒸汽密封室包括与所述蒸汽管道的内部区域蒸汽接触的内部干燥剂区域。101. Some embodiments include the medicinal storage container of paragraph 99, wherein the desiccant unit comprises a vapor-tight chamber including an interior desiccant region in vapor contact with an interior region of the steam conduit.
102.一些实施方式包括如段落99所述的药物储存容器,其中所述干燥剂单元包括单向阀单元,所述单向阀单元被构造成使得具有超过预设极限的压力的气体能够从所述干燥剂单元的所述内部干燥剂区域向外排出。102. Some embodiments include the medicinal storage container of paragraph 99, wherein the desiccant unit includes a one-way valve unit configured to allow gas having a pressure exceeding a preset limit to be discharged outwardly from the internal desiccant region of the desiccant unit.
103.一些实施方式包括如段落99所述的药物储存容器,其中所述干燥剂单元包括在所述内部干燥剂区域内的小于大气压力的气体压力。103. Some embodiments include the medicinal storage container of paragraph 99, wherein the desiccant unit comprises a gas pressure within the interior desiccant region that is less than atmospheric pressure.
104.一些实施方式包括如段落99所述的药物储存容器,其中所述干燥剂单元包括在所述内部干燥剂区域内的小于1托的气体压强。104. Some embodiments include the medicinal storage container of paragraph 99, wherein the desiccant unit comprises a gas pressure within the interior desiccant region of less than 1 Torr.
105.一些实施方式包括如段落99所述的药物储存容器,其中所述干燥剂单元包括在所述内部干燥剂区域内的小于0.1托的气体压强。105. Some embodiments include the medicinal storage container of paragraph 99, wherein the desiccant unit comprises a gas pressure within the interior desiccant region of less than 0.1 Torr.
106.一些实施方式包括如段落99所述的药物储存容器,其中所述干燥剂单元包括位于所述内部干燥剂区域内的开孔金属泡沫,所述开孔金属泡沫定位成在所述内部干燥剂区域内分配气体。106. Some embodiments include the medicinal storage container of paragraph 99, wherein the desiccant unit comprises an open-cell metal foam within the interior desiccant region, the open-cell metal foam positioned to distribute gas within the interior desiccant region.
107.一些实施方式包括如段落99所述的药物储存容器,其中所述干燥剂单元包括定位在所述内部干燥剂区域内的一个或多个管道,所述一个或多个管道定位成在所述内部干燥剂区域内分配气体。107. Some embodiments include the medicinal storage container of paragraph 99, wherein the desiccant unit comprises one or more conduits positioned within the interior desiccant region, the one or more conduits positioned to distribute gas within the interior desiccant region.
108.一些实施方式包括如段落99所述的药物储存容器,其中干燥剂单元的所述一个或多个外壁包括导电材料。108. Some embodiments include the medicinal storage container of paragraph 99, wherein the one or more outer walls of the desiccant unit comprise a conductive material.
109.一些实施方式包括如段落99所述的药物储存容器,其中位于所述内部干燥剂区域内的所述加热元件包括电加热元件。109. Some embodiments include the medicinal storage container of paragraph 99, wherein the heating element located within the internal desiccant region comprises an electric heating element.
110.一些实施方式包括如段落99所述的药物储存容器,其中位于所述内部干燥剂区域内的所述加热元件包括处于卷绕构型的加热元件。110. Some embodiments include the medicinal storage container of paragraph 99, wherein the heating element within the interior desiccant region comprises a heating element in a coiled configuration.
111.一些实施方式包括如段落99所述的药物储存容器,其中位于所述内部干燥剂区域内的所述加热元件包括固定到所述加热元件的一个或多个热传导元件。111. Some embodiments include the medicinal storage container of paragraph 99, wherein the heating element within the internal desiccant region comprises one or more thermally conductive elements secured to the heating element.
112.一些实施方式包括如段落99所述的药物储存容器,其中所述控制器包括电子控制器。112. Some embodiments include the medicinal storage container of paragraph 99, wherein the controller comprises an electronic controller.
113.一些实施方式包括如段落99所述的药物储存容器,其中所述控制器包括存储器。113. Some embodiments include the medicinal storage container of paragraph 99, wherein the controller comprises a memory.
114.一些实施方式包括如段落99中的药物储存容器,其中所述控制器包括被配置成响应于从所述药物储存区域内的所述至少一个温度传感器接收到的信号来控制所述加热元件的操作的电路。114. Some embodiments include the medicinal storage container of paragraph 99, wherein the controller comprises circuitry configured to control operation of the heating element in response to a signal received from the at least one temperature sensor within the medicinal storage area.
115.一些实施方式包括如段落99所述的药物储存容器,其中所述控制器包括查找表。115. Some embodiments include the medicinal storage container of paragraph 99, wherein the controller comprises a lookup table.
116.一些实施方式包括如段落99所述的药物储存容器,其中所述控制器利用线连接器可操作地附接到所述加热元件和所述至少一个温度传感器。116. Some embodiments include the medicinal storage container of paragraph 99, wherein the controller is operably attached to the heating element and the at least one temperature sensor using wire connectors.
117.一些实施方式包括如段落99所述的药物储存容器,其中所述控制器可操作地附接到所述压缩器系统。117. Some embodiments include the medicinal storage container of paragraph 99, wherein the controller is operably attached to the compressor system.
118.一些实施方式包括如段落99所述的药物储存容器,其中所述控制器可操作地附接到电源。118. Some embodiments include the medicinal storage container of paragraph 99, wherein the controller is operably attached to a power source.
119.一些实施方式包括如段落99所述的药物储存容器,其中所述冷却单元包括:上部区域,所述上部区域邻近所述外壁中的所述孔定位;下部区域,所述下部区域位于所述上部区域的下方;以及基本上位于所述下部区域内的蒸发液体。119. Some embodiments include the medicinal storage container of paragraph 99, wherein the cooling unit comprises: an upper region positioned adjacent to the hole in the outer wall; a lower region located below the upper region; and an evaporative liquid substantially located within the lower region.
120.一些实施方式包括如段落99所述的药物储存容器,其中所述冷却单元包括在所述蒸发冷却单元的所述内部蒸发区域内的至少一种蒸发液体。120. Some embodiments include the medicinal storage container of paragraph 99, wherein the cooling unit comprises at least one evaporative liquid within the interior evaporative region of the evaporative cooling unit.
121.一些实施方式包括如段落99所述的药物储存容器,其中所述冷却单元包括连接到邻近所述内部蒸发区域的至少一个表面的液体保持单元。121. Some embodiments include the medicinal storage container of paragraph 99, wherein the cooling unit comprises a liquid retention unit coupled to at least one surface adjacent the interior evaporative region.
122.一些实施方式包括如段落99所述的药物储存容器,其中所述冷却单元包括固定到位于所述内部蒸发区域内的所述至少一个蒸发器盘管单元的一个或多个热传导元件。122. Some embodiments include the medicinal storage container of paragraph 99, wherein the cooling unit comprises one or more heat-conducting elements secured to the at least one evaporator coil unit located within the interior evaporative region.
123.一些实施方式包括如段落99所述的药物储存容器,其中所述冷却单元包括在所述内部蒸发区域内的一个或多个温度传感器,所述一个或多个温度传感器可操作地附接到所述控制器。123. Some embodiments include the medicinal storage container of paragraph 99, wherein the cooling unit comprises one or more temperature sensors within the interior evaporative region, the one or more temperature sensors operably attached to the controller.
124.一些实施方式包括如段落99所述的药物储存容器,其中所述冷却单元包括位于所述内部蒸发区域内的液位传感器。124. Some embodiments include the medicinal storage container of paragraph 99, wherein the cooling unit comprises a liquid level sensor located within the interior evaporative region.
125.一些实施方式包括如段落99所述的药物储存容器,其中位于所述冷却单元的所述内部蒸发区域内的所述至少一个蒸发器盘管单元定位成邻近所述冷却单元的靠近所述干燥剂单元的所述外壁。125. Some embodiments include the medicinal storage container of paragraph 99, wherein the at least one evaporator coil unit within the interior evaporative region of the cooling unit is positioned adjacent the exterior wall of the cooling unit proximate the desiccant unit.
126.一些实施方式包括如段落99所述的药物储存容器,其中位于所述冷却单元的所述内部蒸发区域内的所述至少一个蒸发器盘管单元基本上位于所述冷却单元的中心。126. Some embodiments include the medicinal storage container of paragraph 99, wherein the at least one evaporator coil unit located within the interior evaporative region of the cooling unit is located substantially in the center of the cooling unit.
127.一些实施方式包括如段落99所述的药物储存容器,其中定位在所述冷却单元的所述内部蒸发区域内的所述至少一个蒸发器盘管单元定位成邻近所述冷却单元的靠近所述药物储存单元的所述外壁。127. Some embodiments include the medicinal storage container of paragraph 99, wherein the at least one evaporator coil unit positioned within the interior evaporative region of the cooling unit is positioned adjacent the exterior wall of the cooling unit proximate the medicinal storage unit.
128.一些实施方式包括如段落99所述的药物储存容器,其中所述压缩器系统包括:至少一个蒸发器盘管单元,其位于所述冷却单元的所述内部蒸发区域内;压缩器单元;冷凝器单元;和膨胀阀;其中所述压缩器单元、所述冷凝器单元和所述膨胀阀位于所述冷却单元的所述内部蒸发区域的外部。128. Some embodiments include the medicinal storage container of paragraph 99, wherein the compressor system comprises: at least one evaporator coil unit located within the internal evaporative region of the cooling unit; a compressor unit; a condenser unit; and an expansion valve; wherein the compressor unit, the condenser unit, and the expansion valve are located outside the internal evaporative region of the cooling unit.
129.一些实施方式包括如段落99所述的药物储存容器,其中所述压缩器系统包括开关,所述开关被配置为响应于从所述控制器接收到的信号而打开和关闭所述压缩器系统。129. Some embodiments include the medicinal storage container of paragraph 99, wherein the compressor system comprises a switch configured to open and close the compressor system in response to a signal received from the controller.
130.一些实施方式包括如段落99所述的药物储存容器,其中所述蒸汽管道包括基本管状结构,所述基本管状结构具有足够长度和直径以抑制所述干燥剂单元的所述至少一个外壁和所述冷却单元的所述至少一个外壁之间的热传导。130. Some embodiments include the medicinal storage container of paragraph 99, wherein the steam conduit comprises a substantially tubular structure having a length and diameter sufficient to inhibit heat conduction between the at least one outer wall of the desiccant unit and the at least one outer wall of the cooling unit.
131.一些实施方式包括如段落99所述的药物储存容器,其中所述蒸汽管道被配置成使所述干燥剂单元和所述冷却单元之间的热能的传导最小化。131. Some embodiments include the medicinal storage container of paragraph 99, wherein the steam conduit is configured to minimize conduction of thermal energy between the desiccant unit and the cooling unit.
132.一些实施方式包括如段落99所述的药物储存容器,其中所述蒸汽管道包括固定到所述蒸汽管道的外表面的一个或多个热传导元件。132. Some embodiments include the medicinal storage container of paragraph 99, wherein the steam conduit comprises one or more heat-conductive elements secured to an exterior surface of the steam conduit.
133.一些实施方式包括如段落99所述的药物储存容器,其中所述蒸汽管道包括:所述蒸汽管道的不透气壁;在所述蒸汽管道的所述第一端和所述干燥剂单元之间的不透气密封件;以及在所述蒸汽管道的所述第二端和所述冷却单元之间的不透气密封件。133. Some embodiments include the medicinal storage container of paragraph 99, wherein the steam conduit comprises: an airtight wall of the steam conduit; an airtight seal between the first end of the steam conduit and the desiccant unit; and an airtight seal between the second end of the steam conduit and the cooling unit.
134.一些实施方式包括如段落99所述的药物储存容器,其中所述蒸汽管道包括穿过所述蒸汽管道的所述内部通道的外部可破坏的密封件,所述密封件构造成防止气体流过所述蒸汽管道的所述内部通道。134. Some embodiments include the medicinal storage container of paragraph 99, wherein the steam conduit includes an externally breakable seal across the interior passage of the steam conduit, the seal configured to prevent gas from flowing through the interior passage of the steam conduit.
135.一些实施方式包括如段落99所述的药物储存容器,其中所述蒸汽管道包括:第一温度传感器,其邻近所述蒸汽管道内的所述第一端定位,所述第一温度传感器可操作地附接到所述控制器;以及第二温度传感器,其邻近所述蒸汽管道内的所述第二端定位,所述第二温度传感器可操作地附接到所述控制器。135. Some embodiments include the medicinal storage container of paragraph 99, wherein the steam conduit comprises: a first temperature sensor positioned adjacent the first end within the steam conduit, the first temperature sensor being operably attached to the controller; and a second temperature sensor positioned adjacent the second end within the steam conduit, the second temperature sensor being operably attached to the controller.
136.一些实施方式包括如段落99所述的药物储存容器,其中所述蒸汽控制单元包括至少一个阀,所述至少一个阀被配置成控制气体通过所述蒸汽管道的在所述干燥剂单元的所述内部干燥剂区域和所述冷却单元的所述内部蒸发区域之间的所述内部通道的运动,所述至少一个阀构造成响应于从所述控制器接收到的信号而操作。136. Some embodiments include the medicinal storage container of paragraph 99, wherein the vapor control unit includes at least one valve configured to control the movement of gas through the internal passage of the vapor conduit between the internal desiccant region of the desiccant unit and the internal evaporation region of the cooling unit, the at least one valve being configured to operate in response to a signal received from the controller.
137.一些实施方式包括如段落99所述的药物储存容器,其中所述蒸汽控制单元包括温度传感器。137. Some embodiments include the medicinal storage container of paragraph 99, wherein the vapor control unit comprises a temperature sensor.
138.一些实施方式包括如段落99所述的药物储存容器,其中所述蒸汽控制单元包括压力传感器。138. Some embodiments include the medicinal storage container of paragraph 99, wherein the vapor control unit comprises a pressure sensor.
139.一些实施方式包括如段落99所述的药物储存容器,其中所述热控制单元包括珀尔帖装置,所述珀尔帖装置定位成具有与所述蒸汽管道的外表面相邻的冷却表面。139. Some embodiments include the medicinal storage container of paragraph 99, wherein the thermal control unit comprises a Peltier device positioned with a cooling surface adjacent to an exterior surface of the steam conduit.
140.一些实施方式包括如段落99所述的药物储存容器,其中所述热控制单元包括与所述蒸汽管道热接触的蒸发器盘管单元,所述蒸发器盘管单元附接到所述压缩器系统。140. Some embodiments include the medicinal storage container of paragraph 99, wherein the thermal control unit comprises an evaporator coil unit in thermal contact with the steam line, the evaporator coil unit being attached to the compressor system.
141.一些实施方式包括如段落99所述的药物储存容器,其中所述药物储存单元包括邻近所述药物储存区域的一个或多个壁,所述一个或多个壁被制造成在所述药物储存区域的预期温度下是导热的。141. Some embodiments include the medicinal storage container of paragraph 99, wherein the medicinal storage unit includes one or more walls adjacent to the medicinal storage region, the one or more walls being made thermally conductive at an expected temperature of the medicinal storage region.
142.一些实施方式包括如段落99所述的药物储存容器,其中所述药物储存单元包括定位在与所述药物储存区域的顶部区域相邻的所述外壁中的铰接盖,所述铰接盖被配置成使得用户能够接近所述药物储存区域。142. Some embodiments include the medicinal storage container of paragraph 99, wherein the medicinal storage unit includes a hinged lid positioned in the outer wall adjacent to a top region of the medicinal storage area, the hinged lid configured to enable a user to access the medicinal storage area.
143.一些实施方式包括如段落99所述的药物储存容器,其中所述药物储存单元的所述至少一个温度传感器被定位成检测所述药物储存区域内的温度。143. Some embodiments include the medicinal storage container of paragraph 99, wherein the at least one temperature sensor of the medicinal storage unit is positioned to detect a temperature within the medicinal storage region.
144.一些实施方式包括如段落99所述的药物储存容器,其中所述药物储存单元的所述至少一个温度传感器是电子温度传感器。144. Some embodiments include the medicinal storage container of paragraph 99, wherein the at least one temperature sensor of the medicinal storage unit is an electronic temperature sensor.
145.一些实施方式包括如段落99所述的药物储存容器,其还包括围绕所述冷却单元和所述药物储存单元的一个或多个绝缘段。145. Some embodiments include the medicinal storage container of paragraph 99, further comprising one or more insulating segments surrounding the cooling unit and the medicinal storage unit.
146.一些实施方式包括如段落99所述的药物储存容器,其还包括位于所述药物储存容器下方的基部单元,所述基部单元包括基本上围绕所述压缩器系统和所述控制器的至少一个区域的一个或多个壁。146. Some embodiments include the medicinal storage container of paragraph 99, further comprising a base unit positioned below the medicinal storage container, the base unit comprising one or more walls substantially surrounding at least one region of the compressor system and the controller.
147.一些实施方式包括如段落99所述的药物储存容器,其还包括位于所述干燥剂单元的所述一个或多个外壁的外表面与所述冷却单元的所述一个或多个外壁的外表面之间的间隙。147. Some embodiments include the medicinal storage container of paragraph 99, further comprising a gap between an outer surface of the one or more outer walls of the desiccant unit and an outer surface of the one or more outer walls of the cooling unit.
148.一些实施方式包括如段落99所述的药物储存容器,其还包括:位于所述干燥剂单元的所述一个或多个外壁的外表面与所述冷却单元的所述一个或多个外壁的外表面之间的间隙;以及固定到所述干燥剂单元的所述一个或多个外壁的所述外表面上的风扇,所述风扇的尺寸、形状和位置使所述间隙内的空气循环。148. Some embodiments include the medicinal storage container of paragraph 99, further comprising: a gap between the outer surface of the one or more outer walls of the desiccant unit and the outer surface of the one or more outer walls of the cooling unit; and a fan fixed to the outer surface of the one or more outer walls of the desiccant unit, the fan being sized, shaped, and positioned to circulate air within the gap.
虽然本文公开了多个方面和实施方式,但是其他方面和实施方式对于本领域技术人员将是显而易见的。本文公开的多个方面和实施方式是为了说明的目的,而不意图是限制性的,真正的范围和精神由所附权利要求指示。While various aspects and embodiments are disclosed herein, other aspects and embodiments will be apparent to those skilled in the art. The various aspects and embodiments disclosed herein are for purposes of illustration and are not intended to be limiting, with the true scope and spirit being indicated by the following claims.
Claims (42)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/454899 | 2014-08-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HK1238129A1 HK1238129A1 (en) | 2018-04-27 |
| HK1238129B true HK1238129B (en) | 2021-01-29 |
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