HK1236340A - Use of sweetener composition for manufacture of food for preventing hyperglycemic and hypoglycemic symptoms - Google Patents

Description

Application of sweet composition in preparing food for preventing hyperglycemia and hypoglycemia symptoms

This application is a divisional application, the application number of the parent: 201280052150.6, filing date: day 9, 17, 2012, title: sweetener compositions for reducing diabetes comprising slowly digestible ingredients.

Technical Field

The present invention relates to a sweetener composition for alleviating diabetes, which contains D-psicose and slowly digestible polysaccharide or anti-digestible polysaccharide as active ingredients. The invention relates in particular to the use of a sweetening composition for the preparation of a food product intended to prevent the symptoms of hyperglycemia and hypoglycemia.

Background

Sugar contains sucrose as a main ingredient, and is one of representative sweeteners exhibiting sweetness after being added to foods. Sugar has excellent sweetness and thus has been considered as one of the most preferable sweeteners added to various foods and processed foods to improve the taste of the foods and stimulate appetite. However, recently, as the deleterious effects of sugars have been revealed, problems with their use are being reported. Specifically, excessive sugar intake is a major cause of dental decay and various lifestyle-related diseases such as obesity, diabetes, and the like. For these reasons, there is a worldwide need for alternative sugars as sugar substitutes.

Diabetes mellitus is a type of metabolic disease caused by insufficient secretion of insulin or by the inability of secreted insulin to function effectively. Diabetes is characterized by high blood glucose levels, thereby causing various symptoms and resulting in the excretion of glucose in the urine. There are two types of diabetes, type 1 and type 2. Type 1 diabetes is known as "juvenile diabetes (juveniles)" and is caused by the body's inability to produce insulin. In type 2 diabetes, insufficient insulin is produced. Type 2 diabetes is caused by insulin resistance, a condition in which cells cannot burn glucose efficiently due to impaired insulin response, resulting in elevated blood glucose levels. Type 2 diabetes is known to be affected to a large extent by environmental factors such as high calorie, high fat and high protein diet, lack of exercise, stress, etc. In addition, it is known that diabetes may be caused by a specific gene defect or pancreatic surgery, infection, drugs, and the like.

In diabetes, while generally the hyperglycemic symptoms are most pronounced and noticeable, the hypoglycemic symptoms may be as fatal as the hyperglycemic symptoms. In persons with normal blood glucose levels, such persons typically exhibit hypoglycemic symptoms when fasting blood glucose levels fall below 55 milligrams per deciliter (mg/dL). However, it is known that diabetic patients may exhibit hypoglycemic symptoms even if the patient's blood glucose level is above 70 mg/dl. Thus, unconditional provision of a sweetener with low calories or a sweetener capable of inhibiting sugar absorption may cause unexpected adverse reactions due to excessive lowering of blood glucose levels in diabetic patients.

In this situation, there is a strong need for improved sweeteners having sweetness and low calories suitable for replacing sugar, thereby preventing excessive sugar intake by inhibiting only sugar absorption.

D-psicose (D-psicose) is an epimer (epimer) of D-fructose (D-fructose) and is a subclass of functional sugars known as rare sugars. It is known that D-psicose has a high sweetness equivalent to about 60 to 70% of the sweetness of sugar and has a calorie close to zero, and thus may be effective in preventing or treating adult diseases such as obesity. In addition, it is also known that D-psicose has an effect of preventing and treating diabetes because it can inhibit the absorption of sugars such as glucose, D-fructose, and the like. In addition, D-psicose is known to have excellent solubility, and thus has received great attention in application to foods.

D-psicose has relatively good sweetness, but has relatively low sweetness compared to sugar. In this regard, the use of D-psicose alone as a sweetener for food additives does not satisfy consumers who have been accustomed to the taste of sugar, thereby hindering market acceptance. In order to overcome these problems derived from the use of D-psicose alone, that is, in order to use D-psicose alone while attaining sweetness satisfying general consumers, the amount of D-psicose will inevitably be increased, which may cause food using D-psicose to have an excessively sticky feeling, thereby causing deterioration in texture of food.

On the other hand, digestion-resistant maltodextrins (digestion-resistant maltodextrins) are a class of dietary fibers (polysaccharides). As can be seen from its name, digestion-resistant maltodextrin is a dietary fiber that is indigestible in the human body and is characterized by having a high molecular weight carbohydrate structure with a degree of polymerization higher than that of typical maltodextrin.

As prior art related to the present invention, there are korean patent laid-open publication No. 10-2011-.

Disclosure of Invention

[ problem ] to provide a method for producing a semiconductor device

The present invention aims to provide a sweetener composition for alleviating diabetes, which contains D-psicose and a slowly digestible polysaccharide or an anti-digestible polysaccharide as active ingredients. The invention aims in particular to provide the application of a sweet taste composition in preparing food for preventing hyperglycemia and hypoglycemia symptoms.

The inventors of the present invention have found that, when D-psicose, which is a low-calorie sweetener and is known to have effects of preventing and alleviating diabetes, is used alone, D-psicose cannot effectively exert an effect as a sweetener due to low sweetness. For this reason, various efforts have been made to produce sweeteners having improved sweetness by mixing D-psicose with other sugars or sugar alcohols having superior sweetness, such as tagatose, xylose, xylitol, etc. However, it was found that such mixing may excessively inhibit digestion and absorption of sugars introduced into the body, and thus may result in excessively low blood sugar levels, thereby again causing side effects fatal to diabetic patients.

The inventors have developed a sweetener composition for alleviating diabetes using D-psicose in combination with a slowly digestible polysaccharide or a digestion-resistant polysaccharide, which composition may provide advantages including slowly digesting glucose in the body, causing the blood glucose level to gradually rise after eating, thereby preventing hyperglycemia symptoms in which the blood glucose level of a diabetic patient is sharply increased, while preventing hypoglycemia symptoms fatal to the diabetic patient, by slowly but continuously and appropriately providing sugar.

[ technical solution ] A method for producing a semiconductor device

According to one embodiment of the present invention, a sweetener composition for alleviating diabetes contains D-psicose and a slowly digestible polysaccharide or an anti-digestible polysaccharide as active ingredients.

According to another embodiment, the slowly digestible polysaccharide or the digestion resistant polysaccharide may comprise at least one polysaccharide selected from the group consisting of palatinose (palatinose), trehalose (trehalase), digestion resistant maltodextrin, and oligosaccharides.

According to another embodiment of the present invention, the sweetener composition for reducing diabetes may further comprise a high intensity sweetener.

According to another embodiment of the present invention, the high intensity sweetener may comprise at least one selected from the group consisting of steviol glycosides, sucralose, aspartame, Siraitia grosvenorii (Siraitia grosvenor) extract, glycyrrhiza uralensis (glycyrrhiza uralensis Fischer) extract, thaumatin (thaumatin), and agave (agave) syrup.

According to another embodiment of the invention, the slowly digestible polysaccharide or the digestion resistant polysaccharide may be present in an amount of 0.01 to 200 times the weight of D-psicose and the high intensity sweetener may be present in an amount of 0.001 to 2 times the weight of D-psicose.

[ MEANS FOR CARRYING OUT THE PROBLEMS ]

By using D-psicose in combination with a slowly digestible polysaccharide or a digestion-resistant polysaccharide, the present invention provides a sweetener composition for alleviating diabetes, which can achieve very slow digestion of glucose in the body to gradually increase the blood glucose level, thereby preventing hyperglycemia symptoms in diabetic patients, in which the blood glucose level is sharply increased, while preventing hypoglycemia symptoms, which are fatal to diabetic patients, by slowly but continuously and appropriately providing sugar without excessively inhibiting the supply of sugar.

In addition, according to another embodiment, the present invention provides a sweetener composition comprising D-psicose and a slowly digestible polysaccharide or a digestion resistant polysaccharide in a specific ratio, and thus having outstanding properties in reducing diabetes compared to sweetener compositions prepared in other optional ingredient ratios.

According to another embodiment, the present invention provides a sweetener composition for alleviating diabetes, which can reduce calories while increasing sweetness by adding a specific high-intensity sweetener and has improved sweetness quality.

According to another embodiment, the present invention provides a sweetener composition for alleviating diabetes by using sucralose in a high intensity sweetener, which exhibits a sweetness similar to that of sugar while providing a low glycemic index and substantially zero calories, thereby achieving superior short or long term glycemic control in type 1 or type 2 diabetic patients.

Drawings

Fig. 1 is a graph showing blood glucose changes in experimental example 1.

Fig. 2 is a graph showing the change in area under the glucose curve in experimental example 2.

Detailed Description

Hereinafter, the present invention will be described in more detail. Descriptions of details that are apparent to those of ordinary skill in this or related arts will be omitted herein.

The present invention provides a sweetener composition for alleviating diabetes, which contains D-psicose and a slowly digestible polysaccharide or an anti-digestible polysaccharide as active ingredients.

The term "slowly digestible" means a property that digestion proceeds at a slow rate in the small intestine of the human body.

The term "digestion-resistant" means a property that does not readily undergo digestion in the small intestine of a human body.

Another embodiment of the present invention provides a sweetener composition for reducing diabetes comprising at least one polysaccharide selected from the group consisting of palatinose, trehalose, digestion-resistant maltodextrin and oligosaccharides as a slowly digestible polysaccharide or digestion-resistant polysaccharide.

Polysaccharides refer to sugars formed by the combination of two or more monosaccharide units, i.e., sugars higher than disaccharides.

Palatinose (palatinose) is a natural disaccharide found in nature. The palatinose can be obtained from honey, sugar cane, etc. In industry, palatinose can be produced by treating a sugar with an enzyme capable of altering the structure of the sugar. Palatinose has a disaccharide structure in which glucose molecules are bonded to fructose molecules.

Palatinose can provide a delayed sugar absorption effect when consumed with a sugar such as sugar or starch. Palatinose was digested at a slow rate corresponding to the rate of 1/5 sugar digestion. That is, because digestion and absorption of palatinose proceed at a slow rate and an increase in blood glucose level is avoided, palatinose provides an effect of inhibiting insulin secretion and fat accumulation.

Trehalose (trehalase) is a class of storage carbohydrates and is found primarily in various bacterial, fungal, yeast, insect, animal, plant, and similar species. Trehalose is a non-reducing disaccharide in which two glucose molecules are bound.

Digestion-resistant maltodextrins (digestion-resistant maltodextrins) are a class of dietary fibers and refer to polysaccharides that are indigestible in the body.

An oligosaccharide (oligosaccharide) refers to a polysaccharide in which two or more monomer units are bound via a glycosidic bond. Specifically, since fructooligosaccharides (fructooligosaccharides), galactooligosaccharides (galactooligosaccharides), soybean oligosaccharides (soybean oligosaccharides), branched oligosaccharides, galactooligosaccharides (lactooligosaccharides), chitooligosaccharides (chitooligosaccharides), gentiooligosaccharides (gentiooligosaccharides), and the like corresponding to digestion-resistant oligosaccharides are not digested by digestive enzymes in vivo, the blood glucose level does not rise after ingestion of oligosaccharides. Thus, oligosaccharides do not substantially affect blood glucose levels, and absorption of organic acids produced by intestinal fermentation does not substantially affect blood glucose levels.

The oligosaccharide used in the present invention is not limited in the number of bonded monosaccharides (e.g., disaccharides, trisaccharides, tetrasaccharides, pentasaccharides, etc.), and reducing or non-reducing oligosaccharides may be used.

Another embodiment of the present invention provides a sweetener composition for reducing diabetes further comprising a high intensity sweetener.

High intensity sweeteners are those that exhibit sweetness several times to several hundred times higher than that of sugar.

The high-intensity sweetener is not particularly limited, but the high-intensity sweetener may include at least one selected from the group consisting of steviol glycoside, sucralose, aspartame, luo han guo extract, licorice extract, thaumatin (thaumatin), and agave syrup.

Steviol glycoside refers to a material obtained by treating a water-soluble extract of Stevia (Stevia rebaudiana) leaves. Preferably, rebaudioside A (Reb A) is used as steviol glycoside. When rebaudioside a is used as a high intensity sweetener, the bitterness, metallic taste and the like of high intensity sweeteners such as stevioside can be avoided, thereby providing a sweetener composition for preventing and treating obesity which has a superior taste.

Sucralose (sucralose) refers to a synthetic sugar analog obtained by substituting the hydroxyl group of a sugar with chlorine.

Aspartame (aspartame) refers to an amino acid type synthetic sweetener prepared from phenylalanine and aspartic acid (aspartic acid).

Momordica grosvenori (Siraitia grosvenor) extract refers to an extract obtained from the fruit of momordica grosvenori, which is a perennial herb belonging to the Cucurbitaceae family (Cucurbitaceae). The extract used in the present invention is not particularly limited in terms of extraction method. Any extract prepared by a method known in the art of the present invention or the like can be used.

The extract of licorice (Glycyrrhiza uralensis Fischer) refers to an extract obtained from licorice, which is a perennial herb belonging to the genus Cinnamomum (genus Cassia). The extract used in the present invention is not particularly limited in its extraction method. Any extract prepared by a method known in the art of the present invention or the like can be used.

Thaumatin (thaumatin) refers to a protein-type sweetener obtained by extracting from the fruit of thaumatin (Thaumatococcus danielii), followed by purifying the extract. The extract is not limited in terms of extraction method, and any extract prepared by a method known in the technical field of the present invention or the like may be used.

Agave (Agave) syrup refers to syrup from tequila Blue tequila WebreAgave, which belongs to the desert Agave (Agave deseriti Engelm) family. The agave syrup used in the present invention is not particularly limited, but is a natural organic product in the form of syrup obtained by collecting blue tequila at six ages, extracting the collected blue tequila to obtain a juice, and heating the juice to an appropriate temperature to concentrate it.

Agave syrup is a natural sweetener having a sweetness of 1.5 times that of general sugar and a Glycemic Index (GI) of about 1/3 that of general sugar. The main component of agave syrup is inulin corresponding to a collection of polysaccharides, wherein polysaccharides refer to a class of sugars in which fructose polymers, which are dietary fibers, called fructans (fructans) are continuously linked. Unlike fructose, inulin does not substantially affect blood glucose and insulin and does not increase triglyceride levels. Therefore, agave syrup is suitable for diabetic patients and has an effect of helping to prevent and control diseases associated with blood glucose levels. Additionally, agave syrup may contain minerals such as iron, calcium, potassium, magnesium, etc.

According to another embodiment, the present invention provides a sweetener composition for alleviating diabetes by using sucralose in a high intensity sweetener, which exhibits the most similar sweetness to sugar while providing a low glycemic index and substantially zero calories, thereby achieving superior short or long term glycemic control in type 1 or type 2 diabetic patients.

According to another embodiment, the sweetener composition for alleviating diabetes comprises a slowly digestible polysaccharide or a digestion-resistant polysaccharide in an amount of 0.01 to 200 times, preferably 0.01 to 100 times, more preferably 0.1 to 50 times the weight of D-psicose.

Further, the sweetener composition for alleviating diabetes contains the high-intensity sweetener in an amount of 0.001 to 2 times, preferably 0.001 to 1.5 times, and more preferably 0.001 to 1 times the weight of D-psicose.

Within this content range, the sweetener may have the following advantages: can suppress the problem of sharp rise in blood sugar level or hypoglycemic symptom of too low fasting blood sugar level after ingestion of the sweetener, and the sweetener has sweetness similar to that of sugar.

Hereinafter, the present invention will be described in more detail with reference to examples, comparative examples, and experimental examples. These examples are provided for illustration only and should not be construed as limiting the invention in any way.

Example 1, example 2 and comparative examples 1 to 3

Preparation of sweetener compositions

Sweetener compositions as listed in table 1 were prepared.

In comparative example 1, 5 g of sugar was used. The sweetener compositions of comparative examples 2 and 3 and examples 1 and 2 were prepared by formulating the components as listed in table 1 such that the compositions exhibited a sweetness similar to 5 grams of sugar.

TABLE 1

Among sweetener compositions, erythritol used in comparative example 2 corresponds to a material that is substantially zero calorie and provides only sweetness without affecting blood glucose level. Rebaudioside a used in example 2 is a steviol glycoside and is a natural high-intensity sweetener prepared by extracting a component having a sweet taste from steviol glycoside.

Experimental example 1

Measuring blood glucose changes

(1) Preparation of samples for measuring blood glucose and method of ingestion

To measure changes in blood glucose levels after eating each of the sweetener compositions prepared in comparative examples 1 to 3 and examples 1 and 2, the following experiments were performed on a normal group having a fasting blood glucose index of 100 mg/dl or less and consisting of five males and five females aged twenty to forty.

Sweetener composition ingestion is by providing the same diet to individuals and then allowing them to drink coffee containing the sweetener composition.

The diets given to the subjects were as listed in table 2.

TABLE 2

Food material	Dosage (gram)
		Bread	75
Ham	20
		Lettuce	20
Strawberry jam	20
		Crab stick	30
Cheddar cheese (Cheddar cheese)	10

As shown in table 2, the diet given to the individual consisted of 75 grams of bread, 20 grams of ham, 20 grams of lettuce, 20 grams of strawberry jam, 30 grams of crab stick, and 10 grams of cheddar cheese. As a result of analysis using a korean food composition table (CanPro 3.0, korean nutrition association), the total calorie content of the diet was found to be 356.4 kcal, which was composed of 59.57% sugar, 18.14% protein, and 22.27% lipid.

After eating, the individual consumed coffee made by mixing 1.6 grams of sugar-free coffee with the sweetener compositions prepared in comparative examples 1-3 and examples 1 and 2 in 200 grams of hot water.

The coffee compositions administered to the subjects are listed in table 3.

TABLE 3

(2) Measuring changes in blood glucose levels

To measure the change in blood glucose after eating, the blood glucose level before eating was checked, and the individual was then provided with a meal, followed by coffee. Blood glucose was measured at 30 minute intervals for 2 hours.

Changes in blood glucose levels after eating and coffee intake are summarized in table 4 (see fig. 1).

TABLE 4

Corresponding to the time zones in examples 1 and 2, showing a significant difference in blood glucose below p < 0.01 compared to comparative example 1 (sugar)

Experimental example 2

Measuring the change in area under the blood glucose curve

The same experiment as in Experimental example 1 was conducted at 30-minute intervals for 2 hours in order to measure the G-AUC (Area under the curve of glucose) of an individual.

The results of the G-AUC are summarized in Table 5.

TABLE 5

As shown in table 5, both example 1 and example 2 showed a significant decrease in G-AUC over 120 minutes compared to the composition of comparative example 1 (see fig. 2).

As can be seen from the results of experimental example 1 and experimental example 2, blood glucose increased for about 60 minutes after eating, and after 60 minutes of eating, blood glucose levels showed a tendency to return to fasting blood glucose levels.

When a subject drinks coffee containing the sweetener composition after eating, the blood sugar increase levels by 60 minutes after drinking coffee are, in order from high to low, comparative example 1, comparative example 2, comparative example 3, example 2, and example 1. The blood glucose levels in examples 1 and 2 were higher than comparative examples 1 to 3 at 90 to 120 minutes after eating and drinking coffee.

One of the major causes of diabetes is poor insulin control, which causes problems. That is, blood glucose levels rise sharply after eating, resulting in excessive insulin secretion, and fasting blood glucose levels causing a hypoglycemic condition.

Comparative example 1 shows that the increase in blood glucose was greatest due to the combined increase in blood glucose caused by the diet and the sugar-containing coffee. Comparative example 2 shows an increase in blood glucose due to diet alone. Comparative example 3 shows that D-psicose has an effect of reducing the degree of increase in blood glucose after eating.

It can be seen that the compositions of examples 1 and 2 inhibited a sharp rise in blood glucose after eating and showed an increase in fasting blood glucose as compared to the composition of the comparative example. It is understood that the composition of example 1 provides the effect of preventing hypoglycemia by continuously supplying blood glucose at the time of fasting or after a certain period of time has passed after eating, and at the same time, inhibits abrupt change in blood glucose.

In other words, in examples 1 and 2, it was determined that the carbohydrate absorption inhibitory effect by D-psicose and the food digestion delaying effect by digestion-resistant maltodextrin in the small intestine could significantly reduce the sharp rise in blood glucose after eating, thereby allowing slow digestion of food, thereby continuously supplying sugar to the body even 2 hours after eating.

Experimental example 3

Sensory evaluation of sweetener compositions

To evaluate sensory perception of the sweetener compositions prepared in examples 1 and 2, 25 adult males and females aged twenty to fifty years were subjected to sensory evaluation using coffee each containing sucrose (corresponding to comparative example 1 of experimental example 1) and coffee each containing the sweetener compositions of examples 1 and 2 prepared in the same manner as experimental example 1.

Sensory analysis was evaluated in the range of 1 to 5. The results of the sensory analysis are summarized in table 6.

TABLE 6

	Overall acceptance	Color acceptance	Overall flavor acceptance	Degree of taste acceptance	Acceptability of aftertaste
						Sugar-containing coffee	3.30	3.62	3.52	3.34	3.22
Example 1	3.15	3.50	3.35	3.30	3.20
						Example 2	3.28	3.55	3.47	3.20	3.24

As can be seen from the results of experimental example 1 to experimental example 3, it has been determined that the sweetener composition of the present invention has sweetness and sensory quality similar to sugar as well as the effect of preventing a sharp rise in blood glucose and a fasting hypoglycemic condition. Thus, the sweetener composition is compatible with potent sweeteners for diabetic patients. In addition, sweetener compositions can be applied in a variety of ways to persons in need of blood glucose control/management.

Claims (11)

1. Use of a sweet composition for the preparation of a healthy functional food for preventing hyperglycemic and hypoglycemic symptoms, comprising administering the sweet composition to a subject, wherein the sweet composition contains D-psicose and a slowly digestible or indigestible polysaccharide as active ingredients.

2. The use of claim 1, wherein preventing hyperglycemic and hypoglycemic symptoms comprises preventing post-prandial hyperglycemic and fasting hypoglycemic symptoms.

3. The use of claim 1, wherein the slowly digestible polysaccharide or the digestion resistant polysaccharide comprises at least one polysaccharide selected from the group consisting of palatinose, trehalose, digestion resistant maltodextrin, and oligosaccharides.

4. The use of claim 1, wherein the sweet composition further comprises a high intensity sweetener.

5. The use of claim 4, wherein the high intensity sweetener comprises at least one high intensity sweetener selected from the group consisting of steviol glycosides, sucralose, aspartame, Lo Han Guo extract, licorice extract, thaumatin, and agave syrup.

6. Use according to claim 4, wherein the slowly digestible polysaccharide or the digestion resistant polysaccharide is present in an amount of 0.01 to 200 times the weight of D-psicose and the high intensity sweetener is present in an amount of 0.001 to 2 times the weight of D-psicose.

7. The use of claim 2, wherein the post-prandial blood glucose level of the individual for preventing hyperglycemic and hypoglycemic symptoms is between fasting blood glucose levels to less than 129% of fasting blood glucose levels.

8. The use of claim 1, wherein the sweet composition is administered after a meal.

9. Use according to claim 2, wherein said post-prandial representation is within 1 hour after a meal.

10. Use according to claim 2, wherein said post-prandial representation is within 2 hours after a meal.

11. The use of claim 1, wherein the sweet composition is provided as a beverage.