HK1231781B - Multi ceramide lamellar structure comprising fatty acid and neutralizing agent - Google Patents

Description

Multilayer ceramide sheet structure containing fatty acids and neutralizers

Technical Field

The present specification relates to a multi-layer ceramide sheet structure comprising a fatty acid and a neutralizing agent.

Background Art

The surface of human skin is formed by keratinocytes that degenerate from mature keratinocytes differentiated from the basal layer. These keratinocytes are bound by the double-chain sheet structure of ceramides that are present in large quantities in the stratum corneum, thus maintaining smooth and elastic skin. As for ceramides, two side-by-side alkyl chains form a rod morphology, with hydroxyl (-OH) and carbonyl (C=O) functional groups, so they can form α-crystals (α-crystals) that can be structurally sheet-like, but the α-crystalline phase is a metastable state, and thus it is easy to transform into γ-crystals (γ-crystals). In addition, it is poorly soluble in most oils, so it is difficult to stably store in the internal phase of O/W emulsions, and there are limitations in its large-scale use in cosmetic dosage forms.

Prior art literature

Patent Literature

Patent Document 1: KR10-0439932 B

Patent Document 2: KR10-2013-0037899 A

Summary of the Invention

To address the above-mentioned problems, one embodiment of the present invention provides a method for producing a sheet-like dosage form containing ceramide, which utilizes fatty acid salts, etc. to facilitate the arrangement of lipids forming the sheet structure, and has the effect of preventing fusion through charge repulsion, thereby achieving greater stability and convenience.

Another embodiment of the present invention provides a ceramide-containing sheet-like structure having a structure similar to the stratum corneum of the skin capable of retaining a large amount of water and effective active substances and having excellent phase stability.

Another embodiment of the present invention provides a multilayer ceramide sheet structure that exhibits excellent skin moisturizing effect and skin barrier function recovery effect when applied to the skin, and a skin external application composition containing the same.

One embodiment of the present invention provides a multilayered ceramide sheet structure comprising a solid-phase fatty acid salt obtained by mixing a fatty acid and a neutralizing agent at a molar ratio of 9:1 to 1.2:1.

One embodiment of the present invention provides a multilayered ceramide sheet structure, wherein the multilayered ceramide sheet structure further contains a fatty alcohol.

One embodiment of the present invention provides a multilayered ceramide sheet structure, wherein the fatty acid has 12 to 22 carbon atoms, and the neutralizing agent is a base.

One embodiment of the present invention provides a multilayered ceramide sheet structure, wherein the fatty acid comprises one or more of lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, and behenic acid, and the fatty alcohol comprises one or more of lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, arachidyl alcohol, and behenyl alcohol.

One embodiment of the present invention provides a multilayered ceramide sheet structure, wherein the base is a base comprising at least one of tromethamine, triethanolamine, sodium hydroxide, potassium hydroxide, aminomethyl propanol, aminomethyl propylene glycol, and arginine.

One embodiment of the present invention provides a multilayered ceramide sheet structure, wherein the fatty acid is stearic acid and the neutralizing agent is tromethamine.

Another embodiment of the present invention provides a multilayered ceramide sheet structure, wherein the molar ratio of the fatty acid to the neutralizer is 7:1 to 1.5:1.

Another embodiment of the present invention provides a multilayer ceramide sheet structure, wherein the ceramide is one or more of a natural ceramide and a ceramide pseudo-ceramide.

Another embodiment of the present invention provides a multilayer ceramide sheet structure, wherein the natural ceramide is any one or more of ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7, and ceramide 8.

Another embodiment of the present invention provides a multilayer ceramide sheet structure, wherein the ceramide-like compound is any one or more compounds represented by the following Chemical Formulas 1 to 6.

[Chemical Formula 1]

(In the above formula, R is a C9-C21 saturated or unsaturated aliphatic chain.)

[Chemical Formula 2]

(In the above formula, n is 1 or 2, and R and R' are C9-C21 saturated or unsaturated aliphatic chains.)

[Chemical Formula 3]

(In the above formula,

m and n are the same or different and are integers from 1 to 3;

k and l are the same or different and are 1 or 2;

j is 0 or 1;

R and R' are the same or different and are C1-C31 linear or branched saturated or unsaturated alkyl groups containing or not containing a hydroxyl group;

A ¹ , A ² and A ³ are the same or different and are hydrogen or any of the substituents of the following structures, excluding the case where A ¹ , A ² and A ³ are hydrogen at the same time:

and

[In the above formula, M, ^M1 and ^M2 are selected from alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-16, lauryl dimethyl benzyl ammonium chloride and stearyl dimethyl benzyl ammonium chloride, and L is an alkaline earth metal.]),

[Chemical Formula 4]

(In the above formula, R and R' are the same or different and are C10-C32 linear or branched saturated or unsaturated alkyl groups containing or not containing hydroxyl groups;

^R3 and ^R4 are the same or different and are hydrogen or C1-C4 alkyl or hydroxyalkyl;

R ⁵ is -A or -CH ₂ CH ₂ OA, wherein A is any one of the substituents of the following structures.

and

[In the above formula, M, ^M1 and ^M2 are selected from alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-16, lauryl dimethyl benzyl ammonium chloride and stearyl dimethyl benzyl ammonium chloride, and L is an alkaline earth metal.]),

[Chemical Formula 5]

(In the above formula, m and n are the same or different and are integers of 1 to 4; R and R' are the same or different and are C1-C31 linear or branched saturated or unsaturated alkyl groups containing or not containing a hydroxyl group; _A1 and _A2 are the same or different and are hydrogen or any of the substituents of the following structures;

and

[In the above formula, M, ^M1 and ^M2 are selected from alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-16, lauryl dimethyl benzyl ammonium chloride and stearyl dimethyl benzyl ammonium chloride, and L is an alkaline earth metal.]),

[Chemical Formula 6]

(In the above formula, m and n are the same or different and are integers of 1 to 3;

k and l are the same or different and are 1 or 2;

j is 0 or 1;

A ¹ , A ² and A ³ are the same or different and are hydrogen or any of the substituents of the following structures;

and

[In the above formula, ^M1 and ^M2 are alkali metals or organic bases containing nitrogen, and L is an alkaline earth metal.];

R is a substituent having the following structure:

[In the above formula, B is a methyl group at the 5-, 7-, or 8-position of tocopherol, m is an integer from 1 to 3, and D is -CH ₂ (CH ₃ )-CH- or -CH(CH ₃ )=C-.])

Yet another embodiment of the present invention provides an oil-in-water cosmetic composition comprising the multilayered ceramide sheet structure.

Yet another embodiment of the present invention provides a method for producing a multilayered ceramide sheet structure, comprising mixing an oil phase solution containing ceramide, an aqueous phase solution, and a solid fatty acid salt prepared by mixing a fatty acid and a neutralizing agent at a molar ratio of 9:1 to 1.2:1.

An oil-in-water cosmetic composition including the sheet-like structure according to one embodiment of the present invention has very excellent phase stability due to stabilization of ceramide by multilamellar liquid crystals.

An oil-in-water cosmetic composition including the sheet-like structure according to one embodiment of the present invention can stably contain a larger amount of ceramide.

An oil-in-water cosmetic composition including the sheet-like structure according to one embodiment of the present invention has excellent skin moisturizing effect and barrier function recovery effect when applied to the skin.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG1 is a photograph of the appearance of a gel dosage form comprising a ceramide sheet structure of the present invention having a molar ratio of fatty acid to neutralizer of 4:1.

FIG. 2 is a graph showing the results of a SAXS experiment conducted in Example 1 of the present invention to confirm whether a sheet-like structure is formed.

FIG. 3 is a photograph showing whether precipitation occurs when the molar ratio of the fatty acid to the neutralizer is changed to obtain a gel state.

DETAILED DESCRIPTION

Hereinafter, the present invention will be described in detail so that those skilled in the art can easily implement the present invention.

One embodiment of the present invention provides a multilayered ceramide sheet structure comprising a solid-phase fatty acid salt obtained by mixing a fatty acid and a neutralizing agent at a molar ratio of 9:1 to 1.2:1.

One embodiment of the present invention provides a multilayered ceramide sheet structure, wherein the multilayered ceramide sheet structure further contains a fatty alcohol.

One embodiment of the present invention provides a multilayered ceramide sheet structure, wherein the fatty acid has 12 to 22 carbon atoms, and the neutralizing agent is a base.

One embodiment of the present invention provides a multilayered ceramide sheet structure, wherein the fatty acid comprises one or more of lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, and behenic acid, and the fatty alcohol comprises one or more of lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, arachidyl alcohol, and behenyl alcohol.

One embodiment of the present invention provides a multilayered ceramide sheet structure, wherein the base is a base comprising at least one of tromethamine, triethanolamine, sodium hydroxide, potassium hydroxide, aminomethyl propanol, aminomethyl propylene glycol, and arginine.

One embodiment of the present invention provides a multilayered ceramide sheet structure, wherein the fatty acid is stearic acid and the neutralizing agent is tromethamine.

Another embodiment of the present invention provides a multilayer ceramide sheet structure, wherein the ceramide is one or more of a natural ceramide and a ceramide pseudo-ceramide.

Another embodiment of the present invention provides a multilayer ceramide sheet structure, wherein the natural ceramide is any one or more of ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7, and ceramide 8.

Another embodiment of the present invention provides a multilayer ceramide sheet structure, wherein the ceramide-like compound is any one or more compounds represented by the following Chemical Formulas 1 to 6.

[Chemical Formula 1]

(In the above formula, R is a C9-C21 saturated or unsaturated aliphatic chain.)

[Chemical Formula 2]

(In the above formula, n is 1 or 2; R and R' are C9-C21 saturated or unsaturated aliphatic chains.)

[Chemical Formula 3]

(In the above formula,

m and n are the same or different and are integers from 1 to 3;

k and l are the same or different and are 1 or 2;

j is 0 or 1;

R and R' are the same or different and are C1-C31 linear or branched saturated or unsaturated alkyl groups containing or not containing a hydroxyl group;

A ¹ , A ² and A ³ are the same or different and are hydrogen or any of the substituents of the following structures, excluding the case where A ¹ , A ² and A ³ are hydrogen at the same time:

and

[In the above formula, M, ^M1 and ^M2 are selected from alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-16, lauryl dimethyl benzyl ammonium chloride and stearyl dimethyl benzyl ammonium chloride, and L is an alkaline earth metal.]),

[Chemical Formula 4]

(In the above formula, R and R' are the same or different and are C10-C32 linear or branched saturated or unsaturated alkyl groups containing or not containing hydroxyl groups;

^R3 and ^R4 are the same or different and are hydrogen or C1-C4 alkyl or hydroxyalkyl;

R ⁵ is -A or -CH ₂ CH ₂ OA, wherein A is any one of the substituents of the following structures.

and

[In the above formula, M, ^M1 and ^M2 are selected from alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-16, lauryl dimethyl benzyl ammonium chloride and stearyl dimethyl benzyl ammonium chloride, and L is an alkaline earth metal.]),

[Chemical Formula 5]

(In the above formula, m and n are the same or different and are integers of 1 to 4; R and R' are the same or different and are C1-C31 linear or branched saturated or unsaturated alkyl groups containing or not containing a hydroxyl group; _A1 and _A2 are the same or different and are hydrogen or any of the substituents of the following structures;

and

[In the above formula, M, ^M1 and ^M2 are selected from alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-16, lauryl dimethyl benzyl ammonium chloride and stearyl dimethyl benzyl ammonium chloride, and L is an alkaline earth metal.]),

[Chemical Formula 6]

(In the above formula, m and n are the same or different and are integers of 1 to 3;

k and l are the same or different and are 1 or 2;

j is 0 or 1;

A ¹ , A ² and A ³ are the same or different and are hydrogen or any of the substituents of the following structures;

and

[In the above formula, ^M1 and ^M2 are alkali metals or organic bases containing nitrogen, and L is an alkaline earth metal.];

R is a substituent having the following structure:

[In the above formula, B is a methyl group at the 5-, 7-, or 8-position of tocopherol, m is an integer from 1 to 3, and D is -CH ₂ (CH ₃ )-CH- or -CH(CH ₃ )=C-.])

Yet another embodiment of the present invention provides an oil-in-water cosmetic composition comprising the multilayered ceramide sheet structure.

Specifically, the oil-in-water cosmetic composition may be in the form of a gel. Alternatively, the oil-in-water cosmetic composition may be in the form of a cream or lotion in which oil droplets are formed within the gel by appropriately adding oil.

In another embodiment of the present invention, the molar ratio of fatty acid to neutralizing agent may be 9:1 or less, 8.5:1 or less, 8:1 or less, 7.5:1 or less, 7.4:1 or less, 7.3:1 or less, 7.2:1 or less, 7.1:1 or less, 7:1 or less, 6.9:1 or less, 6.8:1 or less, 6.7:1 or less, 6.6:1 or less, 6.5:1 or less, 6.4:1 or less, 6.3:1 or less, 6.2:1 or less, 6.1:1 or less, 6:1 or less, 5.9:1 or less , 5.8:1 or less, 5.7:1 or less, 5.6:1 or less, 5.5:1 or less, 5:1 or less, 4.5:1 or less, 4:1 or less, 3.5:1 or less, 3:1 or less, 2.5:1 or less, 2.4:1 or less, 2.3:1 or less, 2.2:1 or less, 2.1:1 or less, 2:1 or less, 1.9:1 or less, 1.8:1 or less, 1.7:1 or less, 1.6:1 or less, 1.5:1 or less, 1.4:1 or less, 1.3:1 or less, or 1.2:1 or less.

In addition, the molar ratio of fatty acid to neutralizer can be 1.2:1 or more, 1.3:1 or more, 1.5:1 or more, 1.6:1 or more, 1.7:1 or more, 1.8:1 or more, 1.9:1 or more, 2.0:1 or more, 2.1:1 or more, 2.2:1 or more, 2.3:1 or more, 2.4:1 or more, 2.5:1 or more, 3:1 or more, 4:1 or more, 5:1 or more, 6:1 or more, 7:1 or more, 8:1 or more, 8.5:1 or more, or 9:1 or more.

When the molar ratio of fatty acid to neutralizing agent is within the above range, a stable lamellar structure containing ceramide can be obtained. In the case of a dosage form using only a nonionic emulsifier, the hydrophilic group portion of the emulsifier weakens the hydrogen bonding with the aqueous phase at high temperatures, and the fluidity of the lipid decreases at low temperatures, thereby having a technical problem of inducing the formation of a lamellar structure by maintaining a certain time within an appropriate temperature range. When a neutralized fatty acid is used as a surfactant, the interaction with the aqueous phase becomes stronger due to the charge generated by the fatty acid, and even if the dosage form is rapidly cooled after manufacturing, a lamellar structure is stably formed. The charge of the neutralized fatty acid also plays a role in stably maintaining the arrangement of the lamellar layer-aqueous phase-lamellar layer by generating a repulsive force between the lamellar layers. In addition, the charged fatty acid induces ion-dipole interaction with other fatty acids in the lamellar layer and the hydrophilic portion of the amphiphilic lipid, thereby improving the stability of the lamellar body itself.

Another embodiment of the present invention provides a multilayered ceramide sheet structure in which the ceramide is at least one of natural ceramide and pseudo-ceramide.

Yet another embodiment of the present invention provides a composition for external use on skin comprising the multilayered ceramide sheet structure. Specifically, the composition for external use on skin may be a cosmetic composition.

In one embodiment of the present invention, the multilayer ceramide sheet structure may further include one or more selected from alcohol, vegetable wax, synthetic wax, ozokerite, cetyl palmitate, beeswax, lipids, and lipopeptides. In addition, in one embodiment of the present invention, the multilayer ceramide sheet structure may further include an oil, and the oil may be a general oil, preferably an ester oil or a hydrocarbon oil, but is not limited thereto. Specifically, the ester oil may be isopropyl myristate, isopropyl palmitate, octyldodecanol myristate, cetyl caprylate, cetyl 2-ethylhexanoate, C14-18 alkyl ethylhexanoate, coconut oil-caprylate/caprate, and coconut oil decyl ester, and the diester oil may be butylene glycol dicaprylate, dicaprate, diisostearyl malate, di-C12-13 alkyl malate, neopentyl glycol diheptanoate, tridecyl stearate, neopentyl glycol dicaprylate/dicaprate, tridecyl trimellitate, and dicaprylyl carbonate. As the hydrocarbon oil, there may be mentioned hydrogenated polyisobutene, hydrogenated polydecene and squalane.

In this specification, the term "ceramide" may be one or more selected from natural ceramides and pseudoceramides. Natural ceramides are naturally occurring ceramides, including Ceramide 1, Ceramide 2, Ceramide 3, Ceramide 4, Ceramide 5, Ceramide 6, Ceramide 7, and Ceramide 8. Pseudoceramides include Ceramide 104 and Ceramide 102. In the present invention, pseudoceramides are a general term for compounds having a double-stranded lamellar structure similar to that of natural ceramides.

Another embodiment of the present invention provides a skin topical composition comprising the multilayered ceramide sheet structure. In this skin topical composition, the ceramide content is preferably 0.01 to 20% by weight, based on the total weight of the composition. More preferably, it is 0.05 to 10% by weight. When this range is met, phase stability is excellent and a large amount of water can be retained, making it very effective in moisturizing the skin and restoring its barrier function. A content of less than 0.01% makes it difficult to achieve the desired moisturizing feel and moisturizing power, while a content exceeding 20% makes it difficult to maintain stability. Therefore, it is preferable to maintain this range.

The composition according to one embodiment of the present invention has a double-layer structure, ie, a sheet-like structure, and therefore can contain a certain amount of poorly soluble substances, which can typically be ceramide 3B or the like.

The skin topical composition according to one embodiment of the present invention can be a skin topical composition for moisturizing or enhancing skin elasticity. As described above, the multilamellar liquid crystals formed by ceramide increase the water content, improving the skin barrier effect, and thus can be preferably used for moisturizing or enhancing skin elasticity.

One embodiment of the present invention provides a method for producing a multilayer ceramide sheet structure, comprising mixing an oil phase solution containing ceramide, an aqueous phase solution, and a solid fatty acid salt prepared by mixing a fatty acid and a neutralizing agent at a molar ratio of 9:1 to 1.2:1.

Furthermore, the skin external application composition according to one embodiment of the present invention can be produced by the method for producing the multilayered ceramide sheet structure of the present invention, the method comprising the step of mixing an oil phase solution containing ceramide, an aqueous phase solution, and a solid phase fatty acid and a neutralizing agent.

The multilayered ceramide sheet structure may be formed from a solid-phase fatty acid and a neutralizing agent.

The composition for external use on skin according to the present invention may be, for example, a pharmaceutical composition or a cosmetic composition.

The pharmaceutical composition may further contain preservatives, stabilizers, wettable powders or emulsifying agents, pharmaceutical adjuvants such as salts and/or buffers for adjusting osmotic pressure, and other therapeutically useful substances, and may be prepared into various non-oral dosage forms according to conventional methods. As a non-oral dosage form, it may be a transdermal dosage form, for example, a lotion, ointment, gel, cream, patch or spray dosage form, but is not limited thereto. The determination of the dosage of the above-mentioned active ingredient is within the level of those skilled in the art. Although the daily dosage of the drug varies depending on various factors such as the degree of disease progression, onset period, age, health status, complications, etc. of the subject to be administered, when based on adults, in general, the above-mentioned composition is administered in an amount of 1 μg/kg to 200 mg/kg, preferably 50 μg/kg to 50 mg/kg, divided into 1 to 3 doses a day. Any form of the above-mentioned dosage does not limit the scope of the present invention.

The dosage form of the cosmetic composition is not particularly limited and can be appropriately selected depending on the intended purpose. For example, it can be formulated into any one or more of the following: softening lotions (lotions and emulsions), nourishing lotions, essences, nourishing creams, massage creams, facial masks, gels, eye creams, eye essences, cleansing creams, cleansing foams, cleansing waters, powders, body lotions, body creams, body oils, and body essences, but is not limited thereto. The content of the active ingredient is not particularly limited, but can be 0.01 to 10% by weight based on the total weight of the composition. When the active ingredient meets the above content, it can exhibit excellent efficacy without side effects. The cosmetic composition may also contain a cosmetically acceptable excipient that acts as a diluent, dispersant, or carrier to facilitate distribution of the composition when applied to the skin. Preferably, the composition is an oil-in-water (O/W) emulsion. For emulsions, the weight of the aqueous phase, including water, is preferably 70% by weight or more. However, this is not limiting; any known cosmetically acceptable excipient may be used. In addition, the above-mentioned cosmetic composition may contain cosmetic adjuvants commonly used in the field of the present invention, such as fatty substances, organic solvents, silicon, thickeners, softeners, supplementary sunscreens, foam inhibitors, moisturizers, fragrances, preservatives, surfactants, fillers, chelating agents, cationic polymers, anionic polymers, nonionic polymers or amphiphilic polymers or mixtures thereof, propellants, alkalizing agents or acidifying agents, dyes, pigments or nanopigments (especially substances that can provide a supplementary light protection effect by physically blocking ultraviolet radiation), or other various ingredients commonly used in cosmetics, especially in the manufacture of sunscreen compositions. Among the organic solvents, lower alcohols and polyols such as ethanol, isopropyl alcohol, propylene glycol, glycerol and sorbitol can be mentioned. The fatty substance can be composed of oils or waxes or mixtures thereof, fatty acids, fatty acid esters, fatty alcohols, petrolatum, paraffin, lanolin, hydrogenated lanolin or acetylated lanolin. The oils are of animal, vegetable, mineral or synthetic origin and may be chosen in particular from hydrogenated palm oil, hydrogenated castor oil, liquid petrolatum, liquid paraffin, purcellin oil, volatile or non-volatile silicone oils and isoparaffins.

When the cosmetic composition is a sunscreen composition for protecting the human epidermis from the effects of ultraviolet rays, it may be in the form of a suspension or dispersion of a solvent or fatty substance, or in the form of an emulsion such as a cream or lotion (particularly an oil-in-water (O/W) or water-in-oil type, preferably an O/W type), or a vesicle dispersion, or in the form of an ointment, gel, solid stick, or aerosol foam. The emulsion may further contain an anionic surfactant, a nonionic surfactant, a cationic surfactant, or an amphoteric surfactant.

Furthermore, when the above-mentioned cosmetic composition is used for hair protection, it can be used in the form of a shampoo, lotion, gel or conditioner composition before or after shampooing, before or after dyeing or bleaching, during or before and after waving or straightening. It can be in the form of a lotion or gel for styling or hair care, a lotion or gel for drying or styling hair, a hair lacquer, a composition for waving or straightening hair, or a composition for dyeing or bleaching hair.

Furthermore, when the cosmetic composition is used as a makeup preparation for eyelashes, eyebrows, skin or hair, such as a skin treatment cream, foundation cream, lipstick, eye shadow, rouge, eyeliner, mascara or coloring gel, it can be a solid or paste type, and an anhydrous type or an aqueous type, such as an oil-in-water or water-in-oil emulsion, suspension or gel.

The present invention also relates to a skin disease therapeutic agent comprising the above-mentioned skin topical composition. The skin disease is not particularly limited and may, for example, be acne, psoriasis, hair loss, or abnormal keratinization. Furthermore, the present invention relates to a skin topical preparation comprising the above-mentioned skin topical composition. The above-mentioned skin topical preparation is a general term for any substance applied to the outside of the skin and may include cosmetics and pharmaceuticals in various dosage forms. Furthermore, the above-mentioned skin topical preparation is not particularly limited and may, for example, be a skin topical preparation for preventing skin aging or improving skin wrinkles.

The present invention will be described in more detail with reference to the following examples, which are provided to illustrate the present invention and are not intended to limit the scope of the present invention to them.

Example 1

【Table 1】

The raw materials were mixed according to the composition in Table 1 above and produced in a gel dosage form. Stearic acid and tromethamine were prepared at a molar ratio of 4:1. According to the composition in Table 1 above, the oil phase was heated to 80°C. In a separate container, the aqueous phase was heated to 70°C and dissolved. The aqueous phase was then mixed with the oil phase and stirred using a homomixer. After stirring, the contents were deaerated and cooled to 30°C.

As a result of the implementation, the resulting composition formed a stable gel as shown in FIG1 below.

Test Example 1-Whether a sheet structure is formed

In order to determine whether the composition of Example 1 formed a stable flaky structure, a SAXS (Small-angle X-ray scattering) experiment was conducted. Regarding the flaky structure, the formation of a flaky structure was determined when the reciprocal of the distance between the peaks showing significant scattering intensity after the SAXS experiment was approximately 1:2:3. The results of the SAXS experiment using the composition of Example 1 revealed a main peak with a ratio of approximately 1:2:3 relative to the reciprocal of the distance (Figure 2). Thus, the formation of a flaky structure was confirmed in the composition of Example 1 of the present invention.

Test Example 2-Precipitation Experiment

A gel dosage form was produced in the same manner as in Example 1 except that the molar ratio of stearic acid to tromethamine was set as shown in Table 2 below.

【Table 2】

The results of photographing the appearance of the gel dosage forms of Comparative Examples 1-2 and Examples 1-4 are shown in Figure 3. The results confirmed that when the molar ratio of fatty acid to neutralizer was 12:0 to 12:1, no gel was formed and wax precipitated, while when the molar ratio was 6:1 or higher, a gel property was formed.

Claims (9)

1. A multilayer ceramide sheet structure comprising a solid-phase fatty acid salt formed by mixing fatty acids and a neutralizing agent in a molar ratio of 9.0:1 to 1.2:1. The fatty acid is any one or more of lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, and benzolic acid. The neutralizing agent is any one or more bases selected from tromethamine, triethanolamine, sodium hydroxide, potassium hydroxide, aminomethylpropanol, aminomethylpropanediol, and arginine. 2. The multilayer ceramide sheet structure according to claim 1, wherein the multilayer ceramide sheet structure further comprises fatty alcohols. The fatty alcohol is any one or more of lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, arachidyl alcohol, and betaine alcohol. 3. The multilayer ceramide sheet structure according to claim 1, wherein the fatty acid is stearic acid and the neutralizing agent is tromethamine. 4. The multilayer ceramide sheet structure according to claim 1, wherein the molar ratio of the fatty acid to the neutralizing agent is 7.0:1 to 1.5:1. 5. The multilayer ceramide sheet structure according to claim 1, wherein the ceramide is a ceramide-like compound, and the ceramide-like compound is a compound represented by the following chemical formula 2. Chemical formula 2 In the above formula, n is 1 or 2, and R and R' are saturated or unsaturated aliphatic chains of C9-C21. 6. An oil-in-water cosmetic composition comprising the ceramide sheet structure according to any one of claims 1 to 5. 7. The water-in-oil cosmetic composition according to claim 6, wherein the composition is in gel form. 8. The water-in-oil cosmetic composition according to claim 6, wherein the composition is a cream or a lotion. 9. A method for manufacturing a multilayer ceramide sheet structure according to any one of claims 1 to 5, comprising the step of mixing an oil phase solution containing ceramide, an aqueous phase solution, and a solid fatty acid salt formed by mixing fatty acids and a neutralizing agent in a molar ratio of 9:1 to 1.2:1.