HK1227284B - Composition containing carbodiimide-based compound - Google Patents

Description

Composition containing carbodiimide compounds

Technical Field

The present invention relates to a dye composition, a moisturizing cosmetic composition, a hair care cosmetic composition, an ultraviolet light blocking composition, and a bioadhesive composition containing a carbodiimide compound.

Background Art

Generally, hair dyes, i.e., hair dyes, can be divided into permanent hair dyes (oxidative hair dyes), semi-permanent hair dyes (non-oxidative hair dyes), and short-term colorants based on the durability of the coloring color and the characteristics of the composition. In the case of oxidative hair dyes, low-molecular-weight oxidative dyes or pigments undergo an oxidative neutralization reaction in the hair to form pigments, thereby obtaining a variety of colors. Due to their excellent hair dyeing properties, they are a widely used type of hair dye. Such oxidative hair dye compositions are oxidized by an oxidant and contain one or more dyes or pigment precursors and one or more coupling agents to form dyes or pigments. However, such oxidative dye compositions need to be mixed with an oxidant such as a diluted hydrogen peroxide solution before being applied to the hair. The purpose of using such hair dyes is to dye the hair as completely as possible and to maintain the dyeing effect for a long time. In addition, non-oxidative hair dyes are useful hair dyes that can provide hair with a natural color close to the original color, are less damaging to the hair, and can be used together with perms, and their application is gradually expanding. However, currently commercially available hair dyes are all brightly colored and are prone to discoloration such as fading due to repeated shampooing during dyeing. In particular, oxidative hair dyes, under the influence of oxidants such as hydrogen peroxide, break the disulfide bonds (S-S) of the hair during the bleaching process, severely damaging the hair. Compared to healthy hair, dyed hair has the disadvantages of being less tactile and less moisturized.

Generally, moisturizing cosmetics are used to maintain normal moisture levels in skin and hair, making them soft and vibrant, while also preventing damage such as split ends and roughness. These moisturizing cosmetics are applied by topical application, powder application, or other similar methods to maintain healthy skin by maintaining normal moisture levels, beautifying the skin and hair, enhancing their appearance, or maintaining healthy skin. Furthermore, quasi-drugs are defined as those that, even if they have an effect on the human body, are minor, are not intended for the treatment or prevention of disease, and do not affect the structure or function of the body.

Moisturizing cosmetics generally include basic moisturizing cosmetics for conditioning and protecting the skin, foundation, moisturizing cosmetics for topical use (POINT), nail art use, makeup use, as well as body moisturizing cosmetics such as cleansing, sun protection isolation, and sunbathing products.

Typically, when the moisture content of skin, hair, and fibers decreases, the skin becomes dry, cracked, and roughened. Furthermore, the skin surface may flake, accompanied by itching. Furthermore, dry skin is susceptible to bacterial and fungal infections, and severe cases of dryness are referred to as xerosis. However, moisturizing the skin prevents damage caused by dryness, and the thin lipid membrane on the skin's surface protects the skin from direct exposure to external pollutants. Furthermore, moisturized skin becomes softer and more vibrant, concealing fine wrinkles and minimizing pores.

This type of moisturizer can be divided into the following categories: moisturizers that contain ingredients that are easily mixed with water and maintain the moisture content of the stratum corneum through hydrogen bonding when applied to the skin, moisturizers with functions similar to sebum, moisturizers that utilize the functions of natural moisturizing factors, general organic compound moisturizers, ceramides, and moisturizers that maintain a lamellar structure to achieve a moisturizing effect.

Moisturizers are categorized by function. First, skin moisturizers, which have similar functions to natural moisturizing factors, are substances with a strong affinity for water. They can absorb moisture from their surroundings, thereby maintaining moisture. Among these, the most representative skin moisturizer is glycerin, which penetrates the stratum corneum and forms a strong bond with proteins or lipids within the stratum corneum, thereby inhibiting water loss from the epidermis. However, in dry environments, moisturizers absorb moisture from the skin, causing it to become even drier, making them less effective than skin occlusives. Examples of such skin moisturizers include glycerin, propylene glycol, pyrrolidone carboxylic acid, sodium lactate, and urea.

Skin occlusive agents with functions similar to sebum are formed by a greasy substance on the skin surface to form a water-impermeable film, which plays a role similar to the sebum film of normal skin. When used under a state where moisture has been supplied to the skin in advance, such as by washing the face, moisture can be maintained for a long time, and the effect is better. The substances used as skin occlusive agents include various oily ingredients such as paraffin oil, vaseline, lanolin, jojoba oil, olive oil, and lipid mixtures. However, some skin occlusive agents are sticky and greasy, which brings inconvenience during use or after use.

In recent years, the importance of lipids between corneocytes in the stratum corneum has been highlighted, leading to extensive research and commercialization of moisturizing ingredients containing ceramides. As a result, it has been confirmed that a blend of ceramides, cholesterol, and fatty acids in appropriate proportions, when applied to the skin, can restore damaged skin and exhibit moisturizing properties.

In addition, extensive research has been conducted on enhancing moisturizing effects through emulsions or thin layer structures. In fact, compared with O/W moisturizers, W/O moisturizers are more effective. However, due to the ease of product manufacturing and the feeling of use, O/W moisturizing products have more sales.

In order to formulate such moisturizing cosmetics, conventional raw materials used include oily raw materials such as fats, waxes, hydrocarbons, higher fatty acids, higher alcohols, ester oils, silicone oils, anionic, cationic, zwitterionic, and nonionic surfactants, humectants, thickeners, and polymer compounds used as film-forming agents, ultraviolet absorbers and blockers, antioxidants, metal ion blocking agents, colorants containing dyes and pigments, fragrances, and preservatives.

However, when these moisturizing ingredients are applied to the skin, they only provide a temporary moisturizing effect during the period from treatment to washing, and require re-treatment after washing, which is cumbersome.

Generally, cosmetics for skin care are applied to the body by applying, spreading, or similar methods to improve the appearance of the skin and hair by imparting excellent properties such as smoothness, softness, elasticity, and calmness. These cosmetics are also intended to maintain healthy hair and skin and are applied to the body by application. Furthermore, quasi-drugs are defined as those that, even if they have an effect on the human body, are minor, are not intended for the treatment or prevention of disease, and have no intended effect on the body's structure or function.

Care cosmetics generally include basic care cosmetics for conditioning and protecting the skin and hair, foundation, topical care cosmetics, nail care cosmetics, makeup care cosmetics, as well as body care cosmetics such as cleansing, sun protection, isolation, and sun protection.

Care refers to when a product involves the correction or prevention of specific aspects related to the surface damage to be improved, especially when the surface quality is improved by applying certain substances.

Taking hair as an example, hair care requires ongoing maintenance. As we all know, hair is composed of a small number of cells that survive deep within the skin's surface, and are mostly dead. Therefore, hair care ingredients have no substantial effect on cell growth and do not affect the fundamental repair of cells. Therefore, while they may temporarily improve the properties of damaged hair, they will need to be reapplied after the damage is relieved.

Damage to the hair caused by physical or chemical treatments induces changes in the hair's physical structure. Although conditioning ingredients cannot cure the root cause of the hair problem, they can temporarily improve the hair's cosmetic value and function before washing it away with a cleanser.

Most hair damage is caused by cosmetic habits like shampooing, drying, combing, styling, conditioning, and perming, as well as environmental factors like exposure to chemicals, sunlight, air pollution, wind, seawater, and chlorinated swimming pools. Conditioning enhances the cosmetic value of plumped-up hair by reducing static electricity, strengthening hair, protecting against UV radiation, and increasing shine.

Hair care aims to reduce breakage and porosity, improve strength and shine, and alleviate hair damage. Cationic polymer conditioners are highly effective conditioning ingredients due to their affinity for directly participating in the electrical interaction between the opposite charges of the polymer and the hair surface. Conditioners typically remain on the surface of the hair strand, reducing friction and static electricity caused by combing. Alternatively, they can impart elasticity, maintain curls, enhance volume, and improve manageability.

Recent hair conditioners provide one or more of the following functions: improving combability of wet and dry hair, filling damaged areas of the hair, rearranging the hair to provide softness, minimizing porosity, imparting shine to the hair and giving it a silky feel, providing protection against thermal and mechanical damage, imparting moisturizing, elasticity, and a voluminous feel to the hair, and eliminating static electricity.

Typically, the cuticle of human hair is composed of flat, overlapping cells (dandruff). Cuticle cells adhere to the hair fiber from the root to the tip like roof tiles. Each cuticle layer is approximately 0.3 to 0.5 μm thick, with the visible portion measuring approximately 5 to 10 μm. The cuticle of human hair typically consists of 5 to 10 layers. Each cuticle cell is composed of multiple sublayers (sublamellae), including the epicuticle, A-layer, outer cuticle, inner cuticle, and inner layer, and a cell membrane complex. The outermost epicuticle is covered with covalently bonded lipids (fatty acids), the most abundant component of which is 18-methyleicosanoic acid (18-MEA). This layer forms the outer layer of the cuticle cell membrane complex, providing lubrication, reducing friction, and creating a hydrophobic surface.

The part of hair that protrudes from the scalp is called the hair shaft, and this area changes with the age and length of the hair. It also changes due to things like cutting, shampooing, using a hair dryer, combing, perming, dyeing, and other environmental factors, such as dryness, ultraviolet rays, seawater, and limescale from swimming pools. The cuticles on the outer edge of the hair shaft, in particular, can become damaged through multiple, cumulative effects, even if they aren't directly affected by the external environment. Damaged hair is characterized by the ends of the cuticle protruding or a portion peeling off, causing the hair to shed layer by layer. This scatters light, resulting in a lack of luster and smoothness. When hair is more severely damaged, the cuticles fall away completely, exposing the sebum within, leading to split ends and increased breakage.

As mentioned above, 18-MEA has been experimenting with various treatments to improve the surface of damaged hair. These products, such as hair waxes and hair serums that use silicone to coat the hair surface, are now commercially available or available for trial at beauty salons. Recently, there has been an increase in the commercialization of products that impart skin or hair care effects.

However, when such a care ingredient is used on the skin and hair, the effect is short-lived during the period from treatment to washing, and further treatment is required after washing, which is cumbersome.

Generally speaking, blocking ultraviolet rays means protecting human skin, hair, and fibers from ultraviolet rays that we are exposed to in daily life, thereby preventing harm and damage caused by ultraviolet rays.

Ultraviolet rays typically emit wavelengths between 100 and 400 nm. These wavelengths are categorized, in descending order, as vacuum ultraviolet rays (100-190 nm), UVC (190-280 nm), UVB (280-320 nm), and UVA (320-400 nm). Of the ultraviolet rays contained in sunlight, the long-wavelength UVB and UVA rays are the only ones that reach the Earth's surface. The skin, which forms the outermost layer of the human body, is subject to various harmful effects from ultraviolet rays. Short-wavelength UVB rays are absorbed and scattered by the epidermis, causing significant damage to living things and causing many acute injuries within the epidermis. In contrast, long-wavelength UVA rays are less harmful to living things, and their effects on the skin have not been considered. However, the effects of UVA rays in sunlight cannot be ignored. Furthermore, UVA rays penetrate the skin and can reach the subdermis. Therefore, the direct effects of UV rays on the dermis should be considered in the context of chronic UV damage known as photoaging.

Comparing UVA and UVB, a large amount of UVA reaches the standard, but the ultraviolet intensity is weak, penetrating the epidermis and dermis, causing skin darkening, destroying collagen, elastin and other components that affect skin elasticity, and becoming the cause of skin aging (wrinkles). Although the surface reaching amount of UVB is relatively smaller than that of UVA, the ultraviolet intensity is high, and most of it is scattered and reflected on the epidermis, causing erythema and inflammation, and abnormal keratinization of the skin.

Generally, the UV blocking effect is expressed by SPF (Sun Protection Factor), where SPF = MED of skin using UV blocking products / MED of skin not using UV blocking products.

MED (Minimal Erythma Does - the minimum amount of UV light (time) required to cause erythema). However, the time it takes for UV exposure to cause erythema varies depending on weather, race, and individual, but in Japan, the MED in summer is approximately 10 to 30 minutes. SPF refers to the degree of protection against erythema caused by UV rays, primarily referring to the effectiveness of blocking UVB. Therefore, when applying a product with a high SPF and exposing yourself to the sun, you risk being completely exposed to UVA, which has a significant impact on skin darkening and aging. Therefore, it is crucial to develop products that have both a high SPF and effective UVA blocking properties. The UVA blocking effect is expressed as PA+, PA++, or PA+++ and is calculated using the following formula.

PFA = MPPD of skin using UV-blocking products / MPPD of skin not using UV-blocking products. Here, MPPD (Minimal Persistent Pigment Darkening Dose) is the minimum amount (time) required to cause immediate, sustained darkening. Unlike SPF, it's difficult to express with a specific value, so it's expressed in a range. For example, PFA of 2 or more but less than 4 (PA+) indicates a good UVA blocking effect; PFA of 4 or more but less than 8 (PA++) indicates a very good UVA blocking effect; and PFA of 8 or more (PA+++) indicates an extremely good UVA blocking effect.

Skin damage caused by ultraviolet rays can be divided into acute damage such as sunburn, erythema, melanization (immediate melanization, delayed melanization), and immunosuppression, as well as chronic damage such as photoaging and skin cancer.

Generally, UV blockers can be categorized as: UV absorbers (compounds with double bonds within their molecules), UV scatterers, resins, and polymer film-forming agents. When exposed to UV light, these compounds with double bonds raise the energy level of their electrons, becoming excited and absorbing UV rays. Examples of these UV absorbers include para-aminobenzoic acid, cinnamic acid derivatives, salicylic acid derivatives, and benzophenone derivatives. UV scatterers, such as titanium oxide and zinc oxide, physically scatter UV rays, preventing them from directly contacting the skin. Resins and polymer film-forming agents, such as cellulose, PVP/α-olefin polymers, acrylic polymers, silicone resins, and fluorine-modified silicone resins, are designed to increase water resistance.

Conventional raw materials used in the formulation of these UV-blocking cosmetics include oily raw materials such as fats, waxes, hydrocarbons, higher fatty acids, higher alcohols, ester oils, and silicone oils; anionic, cationic, amphoteric, and nonionic surfactants, UV blockers, thickeners, polymer compounds used as film-forming agents, UV absorbers and blockers, antioxidants, metal ion blocking agents, colorants containing dyes or pigments, fragrances, preservatives, and the like.

In addition, as active ingredients that actually block ultraviolet rays, in addition to the above ingredients, cinnamic acid, glyceryl p-aminobenzoate, benzotriazolyl methylphenol (Drometrizole), gallyl gallate trioleate, 3-(4-methylbenzyl)-camphor, anthranilate, benzophenone-3, benzophenone-4, benzophenone-8, butyl methoxybenzoylmethane, ethyl methoxycinnamate, adenosine, octocrylene, octyldimethyl p-aminobenzoic acid, octyl methoxycinnamate, octyl salicylate, octyl triazone, p-aminobenzoic acid, 2-benzimidazole-5-sulfonic acid, trimethylcyclohexyl salicylate, zinc oxide, titanium dioxide, isopentyl-p-methoxycinnamate, bis-ethylhexyloxyphenol methoxyphenyl triazine (BisEthylhexyloxyphenol Methoxyphenyl Triazine) Triazine), sodium salt of phenylenediphenylimidazolyl sulfonate, amodi-drometrizole trisiloxane, diethylhexyl butamido triazone, polysilicone-15 (dimethicodiethylbenzal Malonate), methylene bisbenzotriazole tetramethylbutylphenol, terephthalylidene dicamphorsulfonic acid and its salts, etc.

However, when these UV-blocking ingredients are applied to skin, hair, or fabrics, their effects are only short-lived, from the time of treatment until the next wash. Therefore, they require further application after washing, which is cumbersome.

Generally, trauma is a state in which the continuity of the normal structure of body tissues is destroyed due to external force. Depending on the different causes, it can be divided into bruises in which the capillaries of subcutaneous tissue are injured by external force, abrasions caused by sharp external force, puncture wounds caused by ice chips, nails, branches, etc., cuts caused by knives, broken glass and surgery, contusions in which the skin is torn due to blunt external force, and lacerations caused by skin being tightened or stretched.

To maximize the therapeutic effect of wounds, an initial drying treatment method is used, covering the wound and maintaining dryness to heal it. Methods for eliminating the drawback of known drying agents, namely, their adherence to the wound surface without damaging the epithelium, include non-woven gauze, non-adherent gauze, and non-adherent absorbent pads. As a moistening treatment method, representative agents with significant efficacy in treating chronic, intractable skin ulcers, such as drug wounds, include films, filled beads, hydrocolloids, alginates, foaming gels, and hydrogels. Recently, drug delivery systems have become widely used as an effective treatment for intractable chronic wounds. Growth factors regulate the wound healing process and can effectively treat wounds. Representative bioadhesive components include growth factors, physiologically active substances, necrotic tissue removers, and antibacterial lotions.

As described above, the purpose of the bioadhesive composition for treating skin damaged areas such as wounds is to treat the wound area more quickly and effectively, leaving as few scars as possible, and beautify the skin of the scar area to resemble the original skin, thereby increasing its attractiveness.

Furthermore, the composition for body joining can be used for joining split ends of hair.

Compositions for biobonding that can bond to the skin or hair generally include skin- or hair-bonding compositions used for skin care, such as face washes, hair styling, and foundations, as well as foundations and topical products. Compositions for scalp applications that can bond to the skin or hair include those used for cleansing, conditioning, hair purifying, hair nourishment, and hair growth treatments.

Conventional raw materials used to form such compositions having bonding functions between skin and hair include: oily raw materials such as fats, waxes, hydrocarbons, higher fatty acids, higher alcohols, ester oils, silicone oils, anionic, cationic, zwitterionic, and nonionic surfactants, moisturizers, thickeners, and high molecular weight compounds used as film-forming agents, ultraviolet absorbers and blockers, antioxidants, metal ion blocking agents, colorants containing dyes and pigments, fragrances, preservatives, and the like.

However, when these biobonding composition raw materials and drug components capable of bonding between skin and hair are applied only to the skin or hair, the effect is short-lived during the period between treatment and rinsing. This necessitates further treatment after rinsing, which is cumbersome and limits the long-lasting effect.

Patent Document 1 discloses a non-aqueous personal care product for skin or hair, which has at its non-aqueous end one or more care ingredients selected from the following functional groups, wherein the functional groups are capable of forming covalent bonds with protein residues on the surface of hair or skin, and wherein the functional groups are carbonate, aldehyde, propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, redox compound, tosylate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinyl sulfone, vinylimide, sulfide, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide, ketone, and RX The present invention relates to a method for preparing a hair or skin composition comprising a plurality of functional groups (R is any one selected from the group consisting of an alkyl group, an aryl group, an aralkyl group, a cycloalkyl group, and an unsaturated cycloalkyl group, and X is I, Br, or Cl), and wherein the functional groups are divided into a non-aqueous end and a hydrous end, and the mixture is mixed immediately before use. The use of multiple functional groups as mentioned above is harmful to the human body. Alternatively, among the amino acids constituting the proteins of hair or skin, the content of lysine is as low as approximately 1.9 to 3.1% in hair (1.9 to 3.1%) and keratin (3.1 to 6.9%), or the content of cysteine is as high as approximately 16.6 to 18% in hair (16.6 to 18%) and keratin (2.3 to 3.8%). This leads to problems such as reduced reaction efficiency and the need to synthesize each substance separately.

Background Art Literature

Patent Document 1: Korean Patent Publication No. 2008-0064467

Summary of the Invention

The object of the present invention is to provide a dye composition that can provide a semi-permanent dyeing effect without damaging hair, skin, fiber or leather.

Another object of the present invention is to provide a moisturizing cosmetic composition that can provide a semi-permanent moisturizing effect without damaging the hair or skin.

Another object of the present invention is to provide a conditioning cosmetic composition that can provide a semi-permanent conditioning effect without damaging the hair or skin.

Another object of the present invention is to provide a composition for blocking ultraviolet rays that can provide a semi-permanent ultraviolet blocking effect without damaging hair, skin or fibers.

Another object of the present invention is to provide a body-joining composition that can provide a semi-permanent body-joining effect without damaging hair or skin.

In order to solve the above-mentioned problems, the present invention provides a dye composition comprising a carbodiimide compound and a dye.

In order to solve the above-mentioned other problem, the present invention provides a moisturizing cosmetic composition comprising a carbodiimide compound and a moisturizing component.

In order to solve the above-mentioned other problem, the present invention provides a care cosmetic composition comprising a carbodiimide compound and a care ingredient.

In order to solve the above-mentioned other problem, the present invention provides an ultraviolet blocking composition comprising a carbodiimide compound and an ultraviolet blocking component.

In order to solve the above-mentioned other problem, the present invention provides a composition for bioadhesion, comprising a carbodiimide compound and a bioadhesion component.

Effects of the Invention

The dye composition according to the present invention comprises a reactive dye and/or a carbodiimide compound into which a specific functional group capable of covalently bonding with a protein residue of hair, skin, fiber or leather is introduced, thereby forming a covalent bond without damaging the hair, skin, fiber or leather, thereby providing a semi-permanent desired color.

The moisturizing cosmetic composition of the present invention comprises a reactive moisturizing ingredient and/or a carbodiimide compound into which a specific functional group capable of covalently bonding with protein residues in hair or skin has been introduced, thereby forming a covalent bond without damaging the hair or skin, thereby providing a semi-permanent moisturizing effect.

The conditioning cosmetic composition of the present invention comprises a reactive conditioning ingredient and/or a carbodiimide compound into which a specific functional group capable of covalently bonding with protein residues of hair or skin has been introduced, thereby forming a covalent bond without damaging the hair or skin, thereby providing a semi-permanent conditioning effect.

The UV-blocking cosmetic composition of the present invention comprises a reactive UV-blocking ingredient and/or a carbodiimide compound into which specific functional groups capable of covalently bonding with protein residues in hair, skin, or fibers have been introduced, thereby forming a covalent bond without damaging the hair, skin, or fibers, thereby providing a semi-permanent UV-blocking effect.

The cosmetic composition for body bonding according to the present invention comprises a reactive body bonding component and/or a carbodiimide compound into which a specific functional group capable of covalently bonding to protein residues in hair or skin has been introduced, thereby forming a covalent bond without damaging the hair or skin, thereby providing a semi-permanent body bonding effect.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows the dyed state of the yak hair of Comparative Example 1 and Example 1 after shampooing 10 times.

FIG. 2 shows the dyeing states of the wool fibers of Examples 4 and 5 after shampooing once and shampooing ten times.

FIG3 is a photograph showing the state of hair before and after treatment with the composition for biological adhesion of Example 42 of the present invention.

DETAILED DESCRIPTION

The invention relates to a dye composition, which contains a carbodiimide compound and a dye.

According to the dye composition of the present invention, for example, a carbodiimide compound is reacted with a known dye, and the reactive dye combined with the carbodiimide group forms a covalent bond with the protein of hair, skin, fiber or leather, thereby maximizing the activity of the dye.

The carbodiimide compound is used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight, relative to 100 parts by weight of the total composition. If the amount is less than 0.001 parts by weight, a sustained dyeing effect may be difficult to achieve. If the amount exceeds 10 parts by weight, the amount exceeds the reactive points in the skin, and the excess carbodiimide compound reacts with the active ingredient without reacting with the skin, thus failing to improve the sustained dyeing effect and becoming a wasted component.

The dyes used in the present invention may contain, as chromogenic groups, one or more atomic groups selected from the group consisting of _NO2 , N=N, C=O, C=C, C=N, C=S, N=O, and N=NO, but are not limited thereto. Furthermore, the dyes may contain, as tinting groups, one or more atomic groups selected from the group consisting of _-OCH3 , -N( _CH3 ) ₂ , -NH( _CH3 ), _-NO2 , _-CF3 , -OH, _-OCH3 , -CL, and _-NH2 , but are not limited thereto. Furthermore, the dyes may contain, as reactive groups, one or more atomic groups selected from the group consisting of -COONa, -COOK, -COOH, _-NH2 , -NHR, _NR2 , -CL, -Br, -I, and -F, but are not limited thereto. In addition, the above-mentioned dyes may be natural dyes or synthetic dyes used for hair, skin, fiber, leather, etc. The above-mentioned natural dyes may be purpurin, munjistin, melanin, or a precursor of melanin, but are not limited thereto. The above-mentioned synthetic dyes may be Red 3, Red 104, Red 105, Red 201, Red 202, Red 220, Red 230, Red 231, Red 232, Red 401, Red 405, Yellow 4, Yellow 202, Orange 207, Red 106, Red 213, Red 214, Red 215, Yellow 404, Yellow 405, Cyan 403, Disperse Blue 1, Disperse Violet 1, Disperse Orange 3, Disperse Black 9, HC Blue 2, HC Red 3, HC Yellow 5, or HC Red 1, but are not limited thereto.

The dye is used in an amount of 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight, or 0.1 to 5 parts by weight, relative to 100 parts by weight of the total composition. If the dye content is less than 0.001 parts by weight, its performance may not be effectively exerted. If the dye content exceeds 50 parts by weight, problems may arise in formulation and dosage form stability.

In particular, the dye of the present invention contains a carboxyl group or an amino group in the molecule, which can improve the reaction efficiency with the carbodiimide compound.

Furthermore, the pigments of the present invention contain functional groups that can form covalent bonds with protein residues on the surface of hair, skin, fibers or leather.

The functional group capable of forming a covalent bond with the protein is selected from the group consisting of carbodiimide, imide ester, arylazide, diazomethane, hydroxymethylphosphonium, pentafluorophenyl ester, pyridinium sulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosylate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinyl sulfone, vinylimine, thioether, acrylonitrile, acrylic or methacrylic ester, disulfonate, and ketone, but is not limited thereto.

Furthermore, the above-mentioned proteins may include reactive residues of thiol, hydroxyl, carboxyl or amino groups.

The carbodiimide compound is a general term for compounds containing a structure represented by the following Chemical Formula 1 in the molecule.

Chemical formula 1

-N＝C＝N-

The carbodiimide compound preferably contains about 1 to 1000 structures of Chemical Formula 1 in the molecule, more preferably about 1 to 100 structures of Chemical Formula 1 in the molecule, and even more preferably about 1 to 10 structures of Chemical Formula 1 in the molecule.

In this case, when the number of carbodiimide groups represented by Chemical Formula 1 in the molecule exceeds 1,000, the viscosity of the raw material is too high, the molecular weight is too large, there are too many reaction points that can react, and the molecules containing carbodiimide groups are very large, which blocks the part of the molecule with actual function that exhibits functional effects, resulting in a problem of reduced efficiency.

In the present invention, specific examples of carbodiimide compounds include the compound represented by the following Chemical Formula 2. In the following Chemical Formula 2, the compound wherein n is 4 and m is 11 is named 1,3-bis(1-isocyanato-1-methylethyl)phenyl-homopolymer, polyethylene glycol mono-methylethyl copolymer (Benzene, 1,3-bis(1-isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked) (hereinafter referred to as the polymeric carbodiimide compound of Chemical Formula 2).

Chemical formula 2

In the above Chemical Formula 2, n is 1 to 100, and m is 1 to 100.

In the present invention, as another example of the carbodiimide compound, the compound represented by the following Chemical Formula 3, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride can be used.

Chemical formula 3

According to a preferred embodiment of the dye composition of the present invention, a dye containing a carboxyl group is prepared as a reactive ester dye that is directly bioactive. Alternatively, amino acids (e.g., aspartic acid and glutamic acid) present in excess in hair (17.5-21.9%), keratin (15.5-23.5%), or fiber (19-23%) are reactively esterified and then prepared as a reactive ester (reactive dye) using a carbodiimide compound that can be targeted by an amino group-containing dye. This enhances the reaction efficiency and, therefore, the effect. Furthermore, dyes containing functional groups within the molecule that can target other amino acids, such as carbodiimides, iminoesters, aryl groups, diazomethanes, hydroxymethylphosphonium, pentafluorophenyl esters, pyridinium thioesters, thio-hydroxysuccinimide esters, alkoxyamines, hydrazides, halogenated acetyl groups, and azides, can be used to enhance the effect.

As a more preferred specific example, a high-molecular-weight carbodiimide compound such as that shown in Chemical Formula 2, or a carbodiimide compound such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, is first reacted with a dye molecule having a carboxyl group or a protein surface on skin or hair to form a reactive ester. This reactive ester group is then reacted with a dye having an amino group within the molecule or with amino groups on the surface of hair, skin, fiber, or leather. This results in excellent dyeing effects under conditions that are mild and compatible with the human body. The above reaction is preferably carried out at a pH of 2 to 10, more preferably at a pH of 3 to 9, and most preferably at an acidic pH of 4 to 5 or in a weakly acidic aqueous solution to increase reaction efficiency. The reaction is completed within 1 to 30 minutes.

The following reaction formula 1 shows a reaction pattern in which a dye molecule having a carboxyl group reacts with a carbodiimide compound to form a reactive ester, which then reacts with an amino acid having an amino residue to form a covalent bond.

Reaction 1

The following reaction formula 2 shows a reaction pattern in which aspartic acid and glutamic acid, biological amino acids with carboxyl groups on the surface of hair proteins, react primarily with a carbodiimide compound to form a reactive ester, which then reacts with a dye having an amino residue to form a covalent bond.

Reaction 2

Carbodiimide compounds increase the reaction efficiency between hair proteins and dyes. The reactive dyes attached to the hair will not be washed away by regular washing with shampoo, detergent, soap, etc., and can almost remain attached to the hair permanently.

The above reaction formula is a representative example related to hair, and can also be applied to skin, fiber, leather, etc. other than hair.

The dye of the present invention may also include a reactive dye having one or more functional groups capable of forming a covalent bond with a protein and selected from the group consisting of: carbodiimide, imine ester, arylazide, diazomethane, hydroxymethylphosphonium, pentafluorophenyl ester, pyridinium sulfide, sulfo-hydroxysuccinimide ester, ester), alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosylate, succinimide, hydroxysuccinimidylester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinyl sulfone, vinyl imine, thioether, acrylonitrile, acrylic or methacrylic ester, disulfonate, and ketone.

For example, as in the above reaction formula 1, a carbodiimide-bound dye (reactive dye) generated by a primary reaction of a carbodiimide compound may be included.

Furthermore, the present invention may also comprise a dye composition having a reactive dye.

According to the dye composition of the present invention, in order to increase the effect, cationic surfactants such as fatty acids such as palmitic acid and stearic acid, fatty alcohols, straight or branched long-chain alkyl quaternary ammonium salts, cationic polymers such as cationized cellulose, cationized guar gum, and cationized polyvinyl pyrrolidone, and silicon can be mixed to facilitate formulation. In addition, for formulation, solvents, surfactants, tackifiers, stabilizers, preservatives, colorants, pH regulators, metal ion blocking agents, colorants, bulking agents, appearance improvers, pigments, split particles and other formulation components can be added. The formulation components can be used in an amount of 40 to 99 parts by weight relative to 100 parts by weight of the total composition.

The dye composition according to the present invention includes a dye component having a functional group and can be used in the formulation of all hair and skin dye compositions. Examples of dye compositions include pre-shampoo compositions, shampoos, hair conditioners, hair waxes, sprays, mousses, hair lotions, essences, hair creams, permanent hair dyes, temporary hair dyes, perms, non-woven fabrics, sheets, and all other cosmetic preparations that can be used on the hair or human body. For skin, all preparations can also be included. In the case of fiber products, preparations such as dyes can also be included.

More preferably, when the dye composition according to the present invention comprises carbodiimide compounds, there is the dyestuff of reactive functional group, under the situation that the activity of above-mentioned preparation in water system reduces, more easily in non-aqueous formulation, keep its activity, before use, in order to adjust pH, mix with buffer solution, in washing process, the method for contacting with water makes it react.As the example of non-aqueous formulation, as the preparation of conventional non-aqueous cosmetics, can be liquid, sheet type, powder powder type, lozenge type, oil, wax, injection (ampoule), gel etc.In addition, carbodiimide compounds and dyestuff can preparation form the single formulation of capsule form or two formulations separated respectively.In addition, can also adopt by encapsulation, the method for the derivative and moisture blocking of the form that the composition with reactive functional group and dye function are combined.

According to the dye composition of the present invention, in order to increase the effect of the dye with functional group, 2-hydrochloride ester oils such as dioctyl succinate, dioctyl adipate, diethyl sebacate and polyols, polyethylene glycol, propylene glycol, hexylene glycol, butylene glycol, and their isomers, glycerol, benzyl alcohol, ethoxydiethylene glycol and derivatives can be used. The above-mentioned solvent can increase the permeability of hair, skin, fiber or leather and is used as a solvent for insoluble substances. In order to increase the activity maintenance effect of the dye with functional group, preferably diethyl sebacate, ethoxydiethylene glycol, bis-ethoxy glycol cyclohexane, 1,4-dicarboxylic ester etc. are used.

The present invention relates to a moisturizing cosmetic composition comprising a carbodiimide compound and a moisturizing component.

According to the moisturizing cosmetic composition of the present invention, for example, a carbodiimide compound is reacted with a known moisturizing ingredient, and the moisturizing ingredient bound to the carbodiimide group forms a covalent bond with proteins in the hair and skin, thereby maximizing the moisturizing effect.

The carbodiimide compound is used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight relative to 100 parts by weight of the total cosmetic composition. If the amount is less than 0.001 parts by weight, a sustained moisturizing effect may be difficult to achieve. If the amount exceeds 10 parts by weight, the carbodiimide compound may react with the active ingredient without reacting with the skin, failing to improve the moisturizing effect and resulting in a wasted component.

In the present invention, "moisturizing effect" means maintaining normal moisture in human skin, hair, etc., making them soft and lively, and preventing damage such as split ends and roughness.

The moisturizing ingredients used in the present invention may include extracts from natural products such as animals, plants, and minerals, amino acids, peptides, proteins, sugars, vitamins, etc., which can fill damaged areas of the skin or hair, but are not limited thereto. For example, the present invention may include at least one selected from the group consisting of glycerin, propylene glycol, butylene glycol, dipropylene glycol, caprylyl glycol, diglycerin, methyl glucol polyether, ethoxylated glycol, glycerol, propylene glycol, diethoxydiglycol pyrrolidone carboxylic acid, sodium lactate, sodium pyrrolidone carboxylate (PCA-Na), mineral oil, petrolatum, lanolin, jojoba oil, olive oil, glycosphingolipids, phospholipids, lipid mixtures, isononyl isononanoate, betaine, carboxymethyl chitosan, ceramide, glucosylceramide, glucosaminoglycans, α-glucan, hyaluronic acid, hydrolyzed hyaluronic acid, betaine, chitosan, chitosan succinamide, tocopherol, and urea. Urea, Hydroxyethyl Urea, Glucosides, γ-PGA, Xylitol Glucoside, Xylitol, Pentaerythrityl Tetraisostearate, Sodium Chondroitin Sulfate, Chondroitin 4-Sulfate, Atelocollagen, β-Glucan, PEG, Pyridoxine Trihexyldecanoate, PCA-K, Sodium Poly-γ-Glutamate, Polyglutamic Acid, Glyceryl Polyacrylate, Glactoarabinan, Polyglyceryl-3 Crosspolymer, Sodium Hyaluronate, Bis-PEG-18 Methyl Ether Dimethyl Silane, Bis-Ethoxydiglycol Succinate, Lecithin, Ascorbyl Tetraisopalmitate, Glycosyl Trehalose, Hydrogenated Starch Hydrolysate Starch Hydrolysate), 1,2-hexanediol, mannitol, arginine, serine, sucrose, PCA, citrulline, glycogen, histidine hydrochloride, alanine, threonine, glutamic acid, lysine hydrochloride, phosphate buffered saline, creatine, cholesterol isostearate, cholesterol chloride, cholesterol nonanoate, BHT, sodium di(laurylamidoglutamine) lysine, maltodextrin, polyquaternium-39, cholecalciferol PEG-12 esters, saccharide isomers, sorbitol and their derivatives.

The moisturizing component is used in an amount of 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight, or 0.1 to 5 parts by weight, relative to 100 parts by weight of the total composition. If the moisturizing component is present in an amount less than 0.001 parts by weight, its performance may not be effectively exerted. If the moisturizing component is present in an amount exceeding 50 parts by weight, problems may arise with formulation and dosage form stability.

In particular, the moisturizing component of the present invention contains a carboxyl group or an amino group in the molecule, which can improve the reaction efficiency with the carbodiimide compound.

Furthermore, the moisturizing component of the present invention may contain a functional group capable of forming a covalent bond with a protein residue on the surface of the hair or skin.

The functional group capable of forming a covalent bond with the protein is selected from the group consisting of, but not limited to, carbodiimide, imide ester, arylazide, diazomethane, hydroxymethylphosphonium, pentafluorophenyl ester, pyridinium sulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosylate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinyl sulfone, vinylimine, thioether, acrylonitrile, acrylic or methacrylic ester, disulfonate, and ketone.

Furthermore, the above-mentioned proteins may include reactive residues of thiol, hydroxyl, carboxyl or amino groups.

The carbodiimide compound is a general term for compounds containing a structure represented by the following Chemical Formula 1 in the molecule.

Chemical formula 1

-N＝C＝N-

The carbodiimide compound preferably contains at least about 1 to 1000 structures of Chemical Formula 1 in the molecule, more preferably about 1 to 100 structures of Chemical Formula 1 in the molecule, and even more preferably about 1 to 10 structures of Chemical Formula 1 in the molecule.

In this case, when the number of carbodiimide groups represented by Chemical Formula 1 in the molecule exceeds 1,000, the viscosity of the raw material is too high, the molecular weight is too large, there are too many reaction points that can react, and the molecules containing carbodiimide groups are very large, which blocks the part of the molecule with actual function that exhibits functional effects, resulting in a problem of reduced efficiency.

In the present invention, specific examples of carbodiimide compounds include compounds represented by the following Chemical Formula 2. In the following Chemical Formula 2, the compound wherein n is 4 and m is 11 is named 1,3-bis(1-isocyanato-1-methylethyl)-phenyl homopolymer, polyethylene glycol mono-methylethyl copolymer (hereinafter referred to as the polymeric carbodiimide compound of Chemical Formula 2).

Chemical formula 2

In the above Chemical Formula 2, n is 1 to 100, and m is 1 to 100.

In the present invention, as another example of the carbodiimide compound, the compound represented by the following chemical formula 3, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide HCl can be used.

Chemical formula 3

According to a preferred example of the moisturizing cosmetic composition of the present invention, a carboxyl-containing moisturizing ingredient is prepared as a reactive ester moisturizing ingredient that is directly bioreactive. Alternatively, amino acids (e.g., aspartic acid and glutamic acid) present in excess in hair (17.5-21.9%) and keratin (15.5-23.5%) are reactively esterified and prepared as a reactive ester (reactive moisturizing ingredient) using a carbodiimide compound that can be targeted by the amino-containing moisturizing ingredient. This enhances the reaction efficiency and, in turn, the effectiveness of the moisturizing ingredient. Furthermore, moisturizing ingredients containing functional groups within their molecules that can target amino acids, such as carbodiimides, imine esters, arylazides, diazomethanes, hydroxymethylphosphonium, pentafluorophenyl esters, pyridinium thioesters, sulfo-hydroxysuccinimide esters, alkoxyamines, hydrazides, halogenated acetyl groups, and azides, can be used to enhance the effectiveness of the moisturizing ingredient.

As a more preferred specific example, a high-molecular-weight carbodiimide compound such as that in Chemical Formula 2, or a carbodiimide compound such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, is first reacted with a carboxyl-containing moisturizing ingredient molecule or a protein surface on the skin or hair to form a reactive ester. This reactive ester group is then reacted with a moisturizing ingredient containing an amino group within the molecule, or with amino groups on the hair or skin surface, to achieve excellent moisturizing effects. The above reaction is preferably carried out at a pH of 2 to 10, more preferably at a pH of 3 to 9, and most preferably at an acidic pH of 4 to 5 or in a weakly acidic aqueous solution to increase reaction efficiency. The reaction is completed within 1 to 30 minutes.

The following reaction formula 3 shows a reaction pattern in which a moisturizing component molecule having a carboxyl group reacts with a carbodiimide compound to form a reactive ester, which then reacts with a biological amino acid having an amino residue to form a covalent bond.

Reaction 3

Reaction formula 4 below shows a reaction pattern in which aspartic acid and glutamic acid, biological amino acids with carboxyl groups on the surface of hair or skin proteins, react primarily with a carbodiimide compound to form a reactive ester, which then reacts with a moisturizing ingredient with an amino residue to form a covalent bond.

Reaction 4

Carbodiimide compounds increase the efficiency of the reaction between hair or skin proteins and moisturizing ingredients. The reactive moisturizing ingredients bound to the hair or skin will not be washed away by regular washing with shampoo, soap, etc., and can remain almost permanently attached to the hair or skin.

The moisturizing component of the present invention may further comprise a reactive moisturizing component to which one or more functional groups capable of forming a covalent bond with a protein are bound, and the functional groups include: carbodiimide, imine ester, arylazide, diazomethane, hydroxymethylphosphonium, pentafluorophenyl ester, pyridinium thioate, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosylate, succinimide, hydroxysuccinimide ester. esters), imidazoles, oxycarbonylimidazoles, imides, thiols, maleimides, vinyl sulfones, vinyl imines, sulfides, acrylonitrile, acrylic or methacrylic esters, disulfonates, and ketones.

For example, it may include a moisturizing component having a carbodiimide group bonded thereto, produced by a single reaction of a carbodiimide compound as described in Reaction Formula 1. Furthermore, the present invention may also include a moisturizing cosmetic composition comprising the reactive moisturizing component.

To enhance the moisturizing cosmetic composition of the present invention, cationic surfactants such as fatty acids such as palmitic acid and stearic acid, fatty alcohols, linear or branched long-chain alkyl quaternary ammonium salts, cationic polymers such as cationized cellulose, cationized guar gum, and cationized polyvinyl pyrrolidone, and silicon may be mixed for enhanced effectiveness, thereby facilitating formulation. Furthermore, to facilitate formulation, ingredients useful for cosmetic formulations, such as solvents, surfactants, thickeners, stabilizers, preservatives, colorants, pH adjusters, metal ion blocking agents, colorants, bulking agents, appearance-enhancing agents, pigments, and fractionated particles, may be added. The ingredients used for formulation may be present in an amount of 40 to 99 parts by weight relative to 100 parts by weight of the total composition.

The moisturizing cosmetic composition according to the present invention comprises a moisturizing functional ingredient having a functional group, and is used in the formulation of the moisturizing cosmetic composition. Examples of applicable skin products generally include basic cosmetics for skin protection (toners, essences, serums, lotions, creams, etc.), color cosmetics (makeup bases, foundations, powders, eye shadows, lip glosses, lipsticks, lip balms, etc.), nail cosmetics (manicures, nutrients, enhancers, face paints, etc.), cleansing cosmetics (facial cleansers, cleansing oils, cleansing liquids, cleansing creams, cleansing gels, facial masks, masks, soaps, face towels, etc.), sunscreen cosmetics, and moisturizing cosmetics (skin lotions, shower gels, moisturizing creams, moisturizing oils, etc.). For hair, these may include all preparations such as shampoos, conditioning solutions, conditioners, hair masks, hair essences, waxes, gels, and sprays.

More preferably, the moisturizing cosmetic composition according to the present invention includes a carbodiimide compound and a moisturizing ingredient having a reactive functional group. When the activity of the above-mentioned preparation in the aqueous system is reduced, it is easier to maintain its activity in a non-aqueous dosage form. In order to adjust the pH before use, it is mixed with a buffer solution and reacted by contacting it with water during the washing process. As an example of a non-aqueous dosage form, it can be a preparation as a conventional non-aqueous cosmetic, which can be a liquid, sheet, powder, tablet, oil, wax, injection (ampoule), gel, etc. In addition, the carbodiimide compound and the moisturizing ingredient can be formulated into a single dosage form in the form of a capsule or two dosage forms separated respectively. In addition, a method of blocking moisture by forming a capsule to form a derivative having a reactive functional group and a component having a moisturizing function can also be used.

To enhance the moisturizing effect of functional group-containing ingredients, the moisturizing cosmetic composition of the present invention may include 2-hydrochloride ester oils such as dioctyl succinate, dioctyl adipate, and diethyl sebacate; polyols; polyethylene glycol; propylene glycol; hexylene glycol; butylene glycol; and their isomers; glycerol; benzyl alcohol; ethoxydiethylene glycol; and derivatives. These solvents can be used as solvents for poorly soluble substances, enhancing their permeability into hair, skin, fibers, or leather. To enhance the active maintenance effect of functional group-containing moisturizing ingredients, diethyl sebacate, ethoxydiethylene glycol, bis-ethoxyethylene glycol cyclohexane, and 1,4-dicarboxylic acid esters are preferred.

The invention relates to a care cosmetic composition, which contains a carbodiimide compound and a care component.

According to the care cosmetic composition of the present invention, for example, a carbodiimide compound is reacted with a known care ingredient, and the reactive care ingredient combined with the carbodiimide group forms a covalent bond with the protein of the hair or skin, thereby maximizing the care effect.

The carbodiimide compound is used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight, relative to 100 parts by weight of the total composition. If the amount is less than 0.001 parts by weight, it may be difficult to achieve a sustained care effect. If the amount exceeds 10 parts by weight, the excess carbodiimide compound exceeds the reactive points in the skin and reacts with the active ingredient without reacting with the skin, resulting in a problem of not improving the sustained effect and causing the compound to become a wasted component.

In the present invention, "care" refers to imparting excellent properties such as smoothness, softness, suppleness, luster, and plumpness to the skin or hair, thereby beautifying the skin or hair, enhancing attractiveness, and changing appearance, or maintaining healthy hair and skin by applying or spreading on the body, or similar methods. Care effects include imparting luster and moisturizing, and reducing static electricity.

The conditioning ingredients used in the present invention may include, but are not limited to, natural extracts from animals, plants, minerals, amino acids, carboxylates, proteins, and the like that can fill damaged areas of the skin or hair. For example, one or more of the following may be selected from the group consisting of polymers, silicones, fatty alcohols, fatty acids, paraffins, ester oils, and their derivatives.

The above-mentioned extracts derived from natural substances include seaweed extract, sunflower oil extract, sophora flavescens extract, ginseng extract, coptis root extract, calendula extract, birch sap, birch extract, Zanthoxylum bungeanum extract, bergamot extract, cypress extract, alpine rhodiola rosea extract, atractylodes extract, colchicine extract, red ginseng water, fritillaria extract, lily of the valley extract, honeycomb extract, black currant extract, pomegranate extract, lemon extract, pine needle extract, green tea extract, broccoli extract, honey extract, blueberry extract, berry extract, lavender extract, lentil bean extract, ginger water extract, etc., and the above-mentioned proteins and peptides can include silkworm silk, silk, polylysine, seaweed, wool and hair, proteins and peptides obtained from wheat, etc.

The amino acids include glycine, alanine, valine, leucine, isoleucine, threonine, serine, cysteine, cystine, methionine, aspartic acid, asparagine, glutamic acid, diiodotyrosine, lysine, arginine, histidine, phenylalanine, tyrosine, tryptophan, proline, hydroxyproline and the like.

Furthermore, the polymers may be linear, branched, or network polymers having a molecular weight of approximately 1,000 to 1,000,000. Polymers containing various substitutions such as carbon-carbon double bonds or cyclic structures may also be used as needed. Preferably, the polymers contain at least one or more residues reactive for attaching a bioreactive group, such as -COONa, -COOK, -COOH, _-NH2 , -NHR, _-NR2 , -Cl, -Br, -I, or -F, at either end of the molecule to facilitate the bioreactive functional group attachment reaction. More preferably, linear or branched polymers having a carbon number of approximately 10,000 to 500,000 are used, and contain at least one or more residues reactive for attaching a bioreactive group, such as -COONa, -COOK, -COOH, _-NH2 , -NHR, _-NR2 , -Cl, -Br, -I, or -F, at either end of the molecule to facilitate the bioreactive functional group attachment reaction. For example, amphoteric polymers such as polyamine polymers, polycarboxylic acid polymers, methacryloylethyl betaine/methacrylate copolymer, and octylacrylamide/acrylates/butylaminoethyl methacrylate copolymer; nonionic polymers such as polyvinyl pyrrolidone, PVP/VA copolymer, and PVP/dimethylaminoethylmethacrylate copolymer; and anionic polymers such as acrylate-methacrylate copolymer and VA/crotonates/vinyl neodecanoate copolymer, but are not limited thereto.

Examples of the silicones include, but are not limited to, dimethicone, trimethicone, phenyl trimethicone, aminodimethicone, aminophenyl trimethicone, amino-pentaphenyl trimethicone, dimethylpolysiloxane, methylphenyl polysiloxane, decamethylcyclopentasiloxane, methyl trimethicone, phenyl trimethicone, methyl silicone, cyclomethicone, alkyl methyl silicone, dimethicone copolyol, and trimethylsilyl amodimethicone.

The aliphatic alcohols are linear and branched aliphatic alcohol compounds having about 10 to 50 carbon atoms, and for example, lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, etc. are preferably used, but are not limited thereto.

The fatty acids are linear and branched aliphatic acid compounds having about 10 to 50 carbon atoms, and for example, 18-methyleicosenoic acid, hexadecanoic acid, octadecanoic acid, isooctadecanoic acid, etc. are preferably used, but are not limited thereto.

Examples of the waxes include, but are not limited to, candelilla wax, carnauba wax, rice wax, beeswax, lanolin, ozokerite, ceresine wax, paraffin wax, microcrystalline wax, and polyethylene wax.

Examples of the ester oil include, but are not limited to, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, isopropyl linoleate, decyl myristate, cetyl myristate, cetyl palmitate, and hydrogenated polyisobutaine.

The amount of the aforementioned conditioning ingredient used is 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight, or 0.1 to 5 parts by weight, relative to 100 parts by weight of the total composition. If the amount is less than 0.001 parts by weight, the effect provided by the active ingredient is limited. If the amount exceeds 50 parts by weight, there are problems with formulation and the stability of the dosage form over time, and there is a risk that the ingredient will not react and be lost.

In particular, the care component of the present invention contains a carboxyl group or an amino group in the molecule, which can improve the reaction efficiency with the carbodiimide compound.

Furthermore, the conditioning ingredients of the present invention contain functional groups that can form covalent bonds with protein residues on the surface of the hair or skin.

The functional group capable of forming a covalent bond with the protein may be one or more selected from the group consisting of carbodiimide, imide ester, arylazide, diazomethane, hydroxymethylphosphonium, pentafluorophenyl ester, pyridinium sulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosylate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinyl sulfone, vinylimine, thioether, acrylonitrile, acrylic or methacrylic ester, disulfonate, and ketone, but is not limited thereto.

Furthermore, the above-mentioned proteins may include reactive residues of thiol, hydroxyl, carboxyl or amino groups.

The carbodiimide compound is a general term for compounds containing a structure represented by the following Chemical Formula 1 in the molecule.

Chemical formula 1

-N＝C＝N-

The carbodiimide compound preferably contains about 1 to 1000 structures of Chemical Formula 1 in the molecule, more preferably about 1 to 100 structures of Chemical Formula 1 in the molecule, and even more preferably about 1 to 10 structures of Chemical Formula 1 in the molecule.

In this case, when the number of structures of Chemical Formula 1 in the molecule exceeds 1,000, the viscosity of the raw material is too high, the molecular weight is too large, there are too many reaction points that can react, and the molecules containing the carbodiimide group are very large, which blocks the functional effect portion of the molecule with actual function, resulting in reduced efficiency.

In the present invention, specific examples of carbodiimide compounds include compounds represented by the following Chemical Formula 2. In the following Chemical Formula 2, the compound wherein n is 4 and m is 11 is named 1,3-bis(1-isocyanato-1-methylethyl)-phenyl homopolymer, polyethylene glycol mono-methylethyl copolymer (hereinafter referred to as the polymeric carbodiimide compound of Chemical Formula 2).

Chemical formula 2

In the above Chemical Formula 2, n is 1 to 100, and m is 1 to 100.

In the present invention, as another example of the carbodiimide compound, the compound represented by the following Chemical Formula 3, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride can be used.

Chemical formula 3

According to preferred embodiments of the cosmetic care composition of the present invention, a carboxyl-containing care ingredient is prepared as a reactive ester care ingredient that is directly bioreactive. Alternatively, amino acids (e.g., aspartic acid and glutamic acid) present in excess in hair (17.5-21.9%) and keratin (15.5-23.5%) are reactively esterified and then prepared as a reactive ester (reactive care ingredient) using a carbodiimide compound that can bind to the amino-containing care ingredient. This enhances the reaction efficiency and, in turn, the effectiveness of the care ingredient. Furthermore, other care ingredients containing functional groups within their molecules that can bind to amino acids, such as carbodiimides, imine esters, arylazides, diazomethanes, hydroxymethylphosphonium, pentafluorophenyl esters, pyridinium thioesters, sulfo-hydroxysuccinimide esters, alkoxyamines, hydrazides, halogenated acetyl groups, and azides, can be used to enhance the effectiveness of the care ingredient.

As a more preferred specific example, a high-molecular-weight carbodiimide compound of Formula 2, or a carbodiimide compound such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, is first reacted with a carboxyl-containing conditioning ingredient molecule or a protein surface on the skin or hair to form a reactive ester. This reactive ester is then reacted with a conditioning ingredient containing an amino group within the molecule, or with amino groups on the hair or skin surface, to achieve excellent conditioning effects. This reaction is preferably carried out at a pH of 2 to 10, more preferably at a pH of 3 to 9, and most preferably at an acidic pH of 4 to 5 or in a weakly acidic aqueous solution to increase reaction efficiency. The reaction is completed within 1 to 30 minutes.

The following reaction formula 5 shows a reaction pattern in which a care ingredient molecule having a carboxyl group reacts with a carbodiimide compound to form a reactive ester, which then reacts with a biological amino acid having an amino residue to form a covalent bond.

Reaction 5

Reaction Scheme 6 below shows a reaction pattern in which aspartic acid and glutamic acid, biological amino acids with carboxyl groups on the surface of hair or skin proteins, react primarily with a carbodiimide compound to form a reactive ester, which then reacts with a conditioning ingredient having an amino residue to form a covalent bond.

Reaction 6

Carbodiimide compounds increase the reaction efficiency between hair or skin proteins and conditioning ingredients. The reactive conditioning ingredients bound to the hair or skin will not be washed away by regular washing with shampoo, soap, etc., and can remain almost permanently attached to the hair or skin.

The care ingredients of the present invention may further comprise a reactive care ingredient to which one or more functional groups capable of forming a covalent bond with a protein are bound, namely, carbodiimide, imine ester, arylazide, diazomethane, hydroxymethylphosphonium, pentafluorophenyl ester, pyridine thioester, sulfo-hydroxysuccinimide ester, ester), alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosylate, succinimide, hydroxysuccinimidylester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinyl sulfone, vinyl imine, thioether, acrylonitrile, acrylic or methacrylic ester, disulfonate, and ketone.

For example, it may include a carbodiimide-bound care ingredient generated by a single reaction of a carbodiimide compound as described in Reaction Formula 1. Furthermore, the present invention may also include a care cosmetic composition comprising the reactive care ingredient.

To enhance the effectiveness of the cosmetic care composition of the present invention, cationic surfactants such as fatty acids such as palmitic acid and stearic acid, fatty alcohols, linear or branched long-chain alkyl quaternary ammonium salts, cationic polymers such as cationized cellulose, cationized guar gum, and cationized polyvinyl pyrrolidone, and silicone may be mixed for easier formulation. Furthermore, to facilitate the formulation of the cosmetic preparation, ingredients useful for cosmetic formulations, such as solvents, surfactants, thickeners, stabilizers, preservatives, colorants, pH adjusters, metal ion blocking agents, colorants, bulking agents, appearance-enhancing agents, pigments, and fractionated particles, may be included. The above ingredients used for formulation may be used in an amount of 40 to 99 parts by weight per 100 parts by weight of the total composition.

The skin care cosmetic composition according to the present invention comprises a skin care functional ingredient having a functional group, and is used in the formulation of the skin care cosmetic composition. Applicable examples of skin care products generally include basic cosmetics for skin protection (toners, essences, serums, lotions, creams, etc.), color cosmetics (makeup base, foundation, powder, eye shadow, lip gloss, lipstick, lip balm, etc.), nail care cosmetics (manicure, nutrients, enhancers, face paint, etc.), cleansing cosmetics (facial cleansers, makeup remover oils, makeup remover liquids, makeup remover creams, makeup remover gels, facial masks, masks, soaps, face towels, etc.), sunscreen cosmetics, and moisturizing cosmetics (body lotions, shower gels, moisturizing creams, body oils, etc.). For hair, all preparations such as shampoo, care lotions, conditioners, hair masks, hair essences, waxes, gels, and sprays can be included.

More preferably, the cosmetic composition according to the present invention contains both a carbodiimide compound and a care ingredient having a reactive functional group. When the activity of such a formulation is reduced in aqueous systems, it is easier to maintain its activity in a non-aqueous formulation. Before use, the formulation is mixed with a buffer solution to adjust the pH, and the reaction is caused by contact with water during the washing process. Examples of non-aqueous formulations include conventional non-aqueous cosmetic formulations, such as liquids, tablets, powders, tablets, oils, waxes, ampoules, and gels. Furthermore, the carbodiimide compound and the care ingredient can be formulated into a single encapsulated formulation or two separate formulations. Furthermore, a method can be used to form a derivative that combines a reactive functional group with a care ingredient by encapsulating the formulation to block moisture.

To enhance the care effects of functional group-bearing ingredients, the cosmetic compositions of the present invention may utilize 2-hydrochloride ester oils such as dioctyl succinate, dioctyl adipate, and diethyl sebacate; polyols; polyethylene glycol; propylene glycol; hexylene glycol; butylene glycol; and their isomers; glycerol; benzyl alcohol; ethoxydiethylene glycol; and derivatives. These solvents can enhance permeability into hair and skin and serve as solvents for poorly soluble substances. To enhance the activity-maintaining effects of functional group-bearing care ingredients, diethyl sebacate, ethoxydiethylene glycol, bis-ethoxyethylene glycol cyclohexane, and 1,4-dicarboxylic acid esters are preferred.

The present invention relates to an ultraviolet blocking composition, which contains a carbodiimide compound and an ultraviolet blocking component.

According to the ultraviolet blocking composition of the present invention, for example, a carbodiimide compound is reacted with a known ultraviolet blocking ingredient, and the ultraviolet blocking ingredient bound to the carbodiimide group forms a covalent bond with the protein of the hair or skin, thereby maximizing the ultraviolet blocking effect.

The carbodiimide compound is used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight, relative to 100 parts by weight of the total composition. If the amount is less than 0.001 parts by weight, a sustained UV blocking effect may be difficult to achieve. If the amount exceeds 10 parts by weight, the excess carbodiimide compound exceeds the reactive sites in the skin and reacts with the active ingredient without reacting with the skin or fibers, resulting in a problem in which the sustained effect is not improved and the compound becomes a wasted component.

In the present invention, the "ultraviolet shielding effect" refers to a function of protecting the skin and hair exposed to ultraviolet rays in daily life and preventing the harmful effects and damages caused by ultraviolet rays.

The ultraviolet blocking ingredients used in the present invention include: ultraviolet absorbers such as para-aminobenzoic acid derivatives (PABA), cinnamic acid derivatives, salicylic acid derivatives, and benzophenone derivatives; ultraviolet scatterers such as titanium oxide and zinc oxide; resins such as cellulose, PVP/α-olefin polymers, acrylic polymers, silicone resins, and fluorine-modified silicone resins; and polymer film-forming agents. Furthermore, as an effective ingredient that actually blocks ultraviolet rays, for example, it can be selected from the group consisting of cinnamic acid, glyceryl p-aminobenzoate, benzotriazolylmethylphenol (Drometrizole), gallyl gallate trioleate, 3-(4-methylbenzyl)-camphor, anthranilate, benzophenone-3, benzophenone-4, benzophenone-8, butyl methoxybenzoylmethane, ethyl methoxycinnamate, adenosine, octocrylene, octyldimethyl p-aminobenzoic acid, octyl methoxycinnamate, octyl salicylate, octyl triazone, p-aminobenzoic acid, 2-benzimidazole-5-sulfonic acid, trimethylcyclohexyl salicylate, zinc oxide, titanium dioxide, isopentyl-p-methoxycinnamate, bis-ethylhexyloxyphenol methoxyphenyl triazine (BisEthylhexyloxyphenol Methoxyphenyl Triazine) Triazine), sodium salt of phenylenediphenylimidazolate, amodi-drometrizole trisiloxane, diethylhexyl butamido triazone, polysilicone-15 (dimethicodiethylbenzal Malonate), methylene bisbenzotriazole tetramethylbutylphenol, terephthalylidene dicamphorsulfonic acid and its salts.

The UV blocking component is used in an amount of 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight, or 0.1 to 5 parts by weight, relative to 100 parts by weight of the total composition. If the UV blocking component is present in an amount less than 0.001 parts by weight, its performance may not be effectively exerted. If the UV blocking component is present in an amount exceeding 50 parts by weight, problems may arise in formulation and dosage form stability.

In particular, the ultraviolet blocking component of the present invention contains a carboxyl group or an amino group in the molecule, which can improve the reaction efficiency with the carbodiimide compound.

Furthermore, the ultraviolet blocking component of the present invention may contain a functional group capable of forming a covalent bond with a protein residue on the surface of hair, skin, or fibers.

The functional groups capable of forming a covalent bond with the protein are selected from the group consisting of at least one of carbodiimide, imide ester, arylazide, diazomethane, hydroxymethylphosphonium, pentafluorophenyl ester, pyridinium sulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosylate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinyl sulfone, vinylimine, thioether, acrylonitrile, acrylic or methacrylic ester, disulfonate, and ketone, but are not limited thereto.

Furthermore, the above-mentioned proteins may include reactive residues of thiol, hydroxyl, carboxyl or amino groups.

The carbodiimide compound is a general term for compounds containing a structure represented by the following Chemical Formula 1 in the molecule.

Chemical formula 1

-N＝C＝N-

The carbodiimide compound preferably contains about 1 to 1000 structures of Chemical Formula 1 in the molecule, more preferably about 1 to 100 structures of Chemical Formula 1 in the molecule, and even more preferably about 1 to 10 structures of Chemical Formula 1 in the molecule.

In this case, when the number of structures of Chemical Formula 1 in the molecule exceeds 1,000, the viscosity of the raw material is too high, the molecular weight is too large, there are too many reaction points that can react, and the molecules containing the carbodiimide group are very large, which blocks the functional effect portion of the molecule with actual function, resulting in reduced efficiency.

In the present invention, specific examples of carbodiimide compounds include compounds represented by the following Chemical Formula 2. In the following Chemical Formula 2, the compound wherein n is 4 and m is 11 is named 1,3-bis(1-isocyanato-1-methylethyl)-phenyl homopolymer, polyethylene glycol mono-methylethyl copolymer (hereinafter referred to as the polymeric carbodiimide compound of Chemical Formula 2).

Chemical formula 2

In the above Chemical Formula 2, n is 1 to 100, and m is 1 to 100.

In the present invention, as another example of the carbodiimide compound, the compound represented by the following Chemical Formula 3, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride can be used.

Chemical formula 3

According to a preferred example of the ultraviolet blocking composition of the present invention, a carboxyl-containing ultraviolet blocking component is prepared in the form of a reactive ester ultraviolet blocking component that is directly bioreactive, or amino acids (such as aspartic acid and glutamic acid) that are present in excess in hair (17.5-21.9%), keratin (15.5-23.5%), and fiber (19-23%) are reactively esterified, and a carbodiimide compound that can be targeted by the amino-containing ultraviolet blocking component is used to prepare a reactive ester form (reactive ultraviolet blocking component), thereby enhancing the reaction efficiency and further enhancing its effect. In addition, other ultraviolet blocking ingredients having functional groups that can be labeled with amino acids, such as carbodiimide, imine ester, arylazide, diazomethane, hydroxymethyl phosphine, pentafluorophenyl ester, pyridinium sulfide, sulfo-hydroxy succinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, etc., can also be used in the molecule to enhance the effect.

As a more preferred specific example, a high-molecular-weight carbodiimide compound of Chemical Formula 2, or a carbodiimide compound such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, is first reacted with a UV-blocking component molecule having carboxyl groups or with a protein surface on skin or hair to form a reactive ester. This reactive ester is then reacted with a UV-blocking component having an amino group within the molecule, or with amino groups on the surface of hair or skin, to achieve an excellent UV-blocking effect. The above reaction is preferably carried out at a pH of 2 to 10, more preferably at a pH of 3 to 9, and most preferably at an acidic pH of 4 to 5 or in a weakly acidic aqueous solution to increase reaction efficiency. The reaction is completed within 1 to 30 minutes.

The following reaction formula 7 shows a reaction pattern in which a UV blocking component molecule having a carboxyl group reacts with a carbodiimide compound to form a reactive ester, which then reacts with a biological amino acid having an amino residue to form a covalent bond.

Reaction 7

Reaction Scheme 8 below shows a reaction pattern in which aspartic acid and glutamic acid, biological amino acids with carboxyl groups on the surface of proteins in hair, skin, or fibers, react primarily with a carbodiimide compound to form a reactive ester, which then reacts with a UV-blocking component having an amino residue to form a covalent bond.

Reaction 8

Carbodiimide compounds increase the reaction efficiency between the proteins in hair, skin, or fibers and the UV blocking ingredients. The reactive UV blocking ingredients bound to the hair, skin, or fibers will not be washed away by regular washing with shampoo, detergent, soap, etc., and can remain almost permanently attached to the hair, skin, or fibers.

The ultraviolet blocking component of the present invention may further include an ultraviolet blocking component to which one or more functional groups capable of forming a covalent bond with a protein are bound, namely, carbodiimide, imide ester, arylazide, diazomethane, hydroxymethylphosphonium, pentafluorophenyl ester, pyridinium thioate, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosylate, succinimide, hydroxysuccinimide ester. esters), imidazoles, oxycarbonylimidazoles, imides, thiols, maleimides, vinyl sulfones, vinyl imines, sulfides, acrylonitrile, acrylic or methacrylic esters, disulfonates, and ketones.

For example, it may include a UV blocking cosmetic composition having a carbodiimide group bonded thereto, produced by a single reaction of a carbodiimide compound as described in Reaction Formula 1. Furthermore, the present invention may also include a UV blocking composition containing the reactive UV blocking ingredient.

The UV-blocking cosmetic composition of the present invention can be mixed with cationic surfactants such as palmitic acid, stearic acid, and other fatty acids, fatty alcohols, linear or branched long-chain alkyl quaternary ammonium salts, cationic polymers such as cationized cellulose, cationized guar gum, and cationized polyvinyl pyrrolidone, and silicon to enhance its effectiveness, thereby facilitating formulation. Furthermore, to facilitate formulation of the cosmetic preparation, ingredients for cosmetic formulations, such as solvents, surfactants, thickeners, stabilizers, preservatives, colorants, pH adjusters, metal ion blocking agents, colorants, bulking agents, appearance enhancers, pigments, and fractionated particles, can be added. The ingredients used for formulation can be used in an amount of 40 to 99 parts by weight relative to 100 parts by weight of the total composition.

The ultraviolet blocking composition according to the present invention contains an ultraviolet blocking functional component having a functional group, and can be used in the formulation of an ultraviolet blocking cosmetic composition. Examples of applicable skin products generally include basic cosmetics for skin protection (toner, essence, serum, lotion, cream, etc.), color cosmetics (isolation cream, foundation, powder, eye shadow, lip gloss, lipstick, lip balm, etc.), nail cosmetics (manicure, nutrients, strengtheners, face paint, etc.), cleansing cosmetics (facial cleansers, makeup remover oils, makeup remover liquids, makeup remover creams, makeup remover gels, facial masks, masks, soaps, facial towels, etc.), sunscreen cosmetics, moisturizing cosmetics (body lotions, shower gels, moisturizing creams, body oils, etc.); for hair, all preparations such as shampoo, care liquids, conditioners, hair masks, hair essences, waxes, gels, sprays, etc.; in the case of fiber products, all preparations such as fiber softeners, liquid detergents, powder detergents, sheet detergents, fiber dyes, fiber care agents, fiber rinses, bleaching agents, partial stain treatment agents, fiber setting agents, ironing aids, clothing storage agents, etc.

More preferably, when the ultraviolet blocking composition according to the present invention comprises carbodiimide compounds, comprise the ultraviolet blocking component with reactive functional group, when the activity of above-mentioned preparation in water system reduces, more easily maintain its activity in non-aqueous formulation, before use in order to adjust pH, mix with buffer solution, react it by the method for contacting with water in washing process.As the example of non-aqueous formulation, it can be the preparation as conventional non-aqueous cosmetics, can be liquid, sheet type, powder powder type, tablet type, oil, wax, injection (ampoule), gel etc.In addition, carbodiimide compounds and ultraviolet blocking component, can the single formulation of preparation formation capsule form or two formulations separated respectively.In addition, can also utilize by forming capsule, the derivative of the form that the composition with reactive functional group and blocking ultraviolet function is combined with moisture blocking method.

According to the ultraviolet blocking composition of the present invention, in order to increase the effect of ultraviolet blocking with functional group, 2-hydrochloric acid ester oils such as dioctyl succinate, dioctyl adipate, diethyl sebacate and polyols, polyethylene glycol, propylene glycol, hexylene glycol, butylene glycol, and their isomers, glycerol, benzyl alcohol, ethoxydiethylene glycol and derivatives can be used. The above-mentioned solvent can increase the permeability of hair, skin or fiber and is used as a solvent for insoluble substances. In order to increase the active maintenance effect of the ultraviolet blocking component with functional group, diethyl sebacate, ethoxydiethylene glycol, bis-ethoxyethylene glycol cyclohexane, 1,4-dicarboxylic acid ester etc. are preferably used.

The present invention relates to a composition for bioadhesion, comprising a carbodiimide compound and a bioadhesion component.

According to the bioadhesive composition of the present invention, for example, a carbodiimide compound is reacted with a known bioadhesive component, and the bioadhesive component to which the carbodiimide group is bound forms a covalent bond with proteins in hair or skin, thereby maximizing the bioadhesive effect.

The carbodiimide compound is used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight relative to 100 parts by weight of the total composition. If the content is less than 0.001 parts by weight, a sustained bioadhesive effect may be difficult to achieve. If the content exceeds 50 parts by weight, the excess carbodiimide compound exceeds the reactive sites in the skin and remains unreacted, resulting in a problem of being a wasted component.

In the present invention, the "bioreconnection effect" refers to the function of preventing or improving skin damage or hair split ends by causing damaged parts of biological tissues such as skin and hair to regenerate or reconnect to their original state more effectively and quickly.

The bioadhesive components used in the present invention may include fibrin, albumin, glucosamine, n-acetylglucosamine, alginate, hydrogel, growth factor, physiologically active factor, necrotic tissue remover, split-end adhesive, antibacterial coating, and the like. Examples of the growth factors include FGF (Fibroblast Growth Factor), KGF (Keratinocyte Growth Factor), VEGF (Vascular Endothelial Growth Factor), EGF (Epidermal Growth Factor), PDGF-AA (Platelet Derived Growth Factor AA), PDGF-AB (Platelet Derived Growth Factor AB), PDGF-BB (Platelet Derived Growth Factor BB), TGF-(Transforming Growth Factor), TGF-, IGF (Insulin-like Growth Factor), TNF (Tumor Necrosis Factor), GM-CSF (Granulocyte Macrophage Colony Stimulating Factor), NGF (Nerve Growth Factor), and TNF-α (Tumor Necrosis Factor). Factor; nerve growth factor) and the like. Examples of the aforementioned physiologically active factors include interferon, erythropoietic factor, IL-1 (interleukin-1), IL-2, IL-6, and IL-8. Examples of the aforementioned split-end binder include N-(4-carboxy-3-hydroxyphenyl)maleimide and transglutaminase. Examples of the aforementioned antibacterial coating agents include benzalkonium chloride, benzethonium chloride, 2,4,4-trichloro-2-hydroxyphenol, triclosan, triclocarban, isopropylmethylphenol, pinyon, allantoin, ε-aminocaproic acid, and glycyrrhizic acid.

The amount of the bioadhesive component used is 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight, or 0.1 to 5 parts by weight, relative to 100 parts by weight of the total composition. If the content is less than 0.001 parts by weight, its performance cannot be effectively exerted. If the content exceeds 50 parts by weight, there are problems with formulation and stability of the dosage form over time, and the component may not react and become lost.

In particular, the bioadhesive component of the present invention contains a carboxyl group or an amino group in the molecule, which can improve the reaction efficiency with the carbodiimide compound.

Furthermore, the bioadhesive component of the present invention contains a functional group capable of forming a covalent bond with a protein residue on the surface of hair or skin.

The functional groups capable of forming a covalent bond with the protein may be one or more selected from the group consisting of carbodiimide, imide ester, arylazide, diazomethane, hydroxymethylphosphonium, pentafluorophenyl ester, pyridinium sulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosylate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinyl sulfone, vinylimide, thioether, acrylonitrile, acrylic or methacrylic ester, disulfonate, and ketone, but are not limited thereto.

Furthermore, the above-mentioned proteins may include reactive residues of thiol, hydroxyl, carboxyl or amino groups.

The carbodiimide compound is a general term for compounds containing a structure represented by the following Chemical Formula 1 in the molecule.

Chemical formula 1

-N＝C＝N-

The carbodiimide compound preferably contains about 1 to 1000 structures of Chemical Formula 1 in the molecule, more preferably about 1 to 100 structures of Chemical Formula 1 in the molecule, and even more preferably about 1 to 10 structures of Chemical Formula 1 in the molecule.

In this case, when the number of structures of Chemical Formula 1 in the molecule exceeds 1,000, the viscosity of the raw material is too high, the molecular weight is too large, there are too many reaction points that can react, and the molecules containing the carbodiimide group are very large, which blocks the functional effect portion of the molecule with actual function, resulting in reduced efficiency.

In the present invention, specific examples of carbodiimide compounds include compounds represented by the following Chemical Formula 2. In the following Chemical Formula 2, the compound wherein n is 4 and m is 11 is named 1,3-bis(1-isocyanato-1-methylethyl)-phenyl homopolymer, polyethylene glycol mono-methylethyl copolymer (hereinafter referred to as the polymeric carbodiimide compound of Chemical Formula 2).

Chemical formula 2

In the above Chemical Formula 2, n is 1 to 100, and m is 1 to 100.

In the present invention, as another example of the carbodiimide compound, the compound represented by the following Chemical Formula 3, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride can be used.

Chemical formula 3

According to a preferred embodiment of the biobonding composition of the present invention, a biobonding component having a carboxyl group is prepared as a reactive ester biobonding component that is directly bioreactive. Alternatively, amino acids (e.g., aspartic acid and glutamic acid) present in excess in hair (17.5-21.9%) and keratin (15.5-23.5%) are reactively esterified and prepared as a reactive ester (reactive biobonding component) using a carbodiimide compound that can be targeted by the biobonding component containing an amino group. This enhances the reaction efficiency and, therefore, the effect. Furthermore, the effect can be enhanced by using a biobonding component having a functional group within the molecule that can be targeted by amino acids, such as carbodiimide, iminoester, arylate, diazomethane, hydroxymethylphosphonium, pentafluorophenyl ester, pyridinium thioate, thio-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, or azide.

As a more preferred specific example, a high-molecular-weight carbodiimide compound of Chemical Formula 2, or a carbodiimide compound such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, is first reacted with a bio-bonding component having a carboxyl group or with a protein surface on skin or hair to form a reactive ester. This reactive ester is then reacted with a bio-bonding component having an amino group within the molecule, or with amino groups on the surface of hair or skin, to achieve an excellent bio-bonding effect. This reaction is preferably carried out at a pH of 2 to 10, more preferably at a pH of 3 to 9, and most preferably at an acidic pH of 4 to 5 or in a weakly acidic aqueous solution to increase reaction efficiency. The reaction is completed within 1 to 30 minutes.

Reaction Scheme 9 below shows a reaction pattern in which aspartic acid and glutamic acid in skin or hair proteins with carboxyl terminals react once with a carbodiimide compound to form a reactive ester, which then reacts with lysine present in skin or hair proteins with an amino residue to form a covalent bond.

Reaction 9

The following reaction formula 10 shows a bioconjugation model of the reaction between a skin and hair protein containing the amino acid cysteine, a bioconjugation substance having both a carboxylic acid residue and a maleimide group within one molecule that binds to the bioreactive group of the bioamino acid cysteine at pH 7-8, and a carbodiimide compound, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, to form a reactive ester, and the reaction of the generated reactive ester with the amino group of lysine amino acid in the scalp and hair.

Reaction 10

Carbodiimide compounds increase the reaction efficiency between hair or skin proteins and bio-binding components. The reactive bio-binding components bound to the hair or skin are not washed away by regular washing with shampoo, soap, etc., and remain almost permanently attached to the hair or skin.

The biobinding component of the present invention may further comprise a reactive biobinding component to which is bound at least one functional group selected from the group consisting of carbodiimide, imide ester, arylazide, diazomethane, hydroxymethylphosphonium, pentafluorophenyl ester, pyridinium thioate, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosylate, succinimide, hydroxysuccinimide ester, esters), imidazoles, oxycarbonylimidazoles, imides, thiols, maleimides, vinyl sulfones, vinyl imines, sulfides, acrylonitrile, acrylic or methacrylic esters, disulfonates, and ketones.

For example, it may include a bioadhesive component having a carbodiimide group bonded thereto, produced by a single reaction of a carbodiimide compound as in the above reaction formula 1. Furthermore, the present invention may include a bioadhesive composition comprising the above-mentioned reactive bioadhesive component.

To enhance the effectiveness of the bioadhesive composition of the present invention, cationic surfactants such as fatty acids such as palmitic acid and stearic acid, fatty alcohols, linear or branched long-chain alkyl quaternary ammonium salts, cationic polymers such as cationized cellulose, cationized guar gum, and cationized polyvinyl pyrrolidone, and silicon may be mixed to facilitate formulation. Furthermore, formulation ingredients such as solvents, surfactants, thickeners, stabilizers, preservatives, colorants, pH adjusters, metal ion blocking agents, colorants, bulking agents, appearance-enhancing agents, pigments, and fragmented particles may be added for formulation. The formulation ingredients may be used in an amount of 40 to 99 parts by weight relative to 100 parts by weight of the total composition.

The bioadhesive composition of the present invention contains a bioadhesive functional component having a functional group and can be used in the formulation of a cosmetic composition for bioadhesive use. Examples of hair products include pre-shampoo compositions, shampoos, hair conditioners, waxes, sprays, mousses, hair treatments, essences, hair creams, permanent hair dyes, temporary hair dyes, perms, non-woven fabrics, and sheets. Skin products typically include base cosmetics for skin care (toners, essences, serums, lotions, creams, etc.), color cosmetics (makeup primers, foundations, powders, eyeshadows, lip glosses, lipsticks, lip balms, etc.), nail cosmetics (manicure supplements, nutrients, enhancers, face paints, etc.), cleansing cosmetics (facial cleansers, cleansing oils, cleansing liquids, cleansing creams, cleansing gels, facial masks, face masks, soaps, face towels, etc.), sunscreen cosmetics, and moisturizing cosmetics (body lotions, body washes, body creams, body oils, etc.).

More preferably, the composition for biobonding according to the present invention contains a carbodiimide compound and a biobonding component having a reactive functional group. When the activity of the above-mentioned preparation is reduced in an aqueous system, it is easier to maintain its activity in a non-aqueous dosage form, and the reaction is caused by mixing with a buffer solution before use to adjust the pH, or by contacting with water during the washing process. Examples of non-aqueous dosage forms include preparations such as conventional non-aqueous cosmetics, which can be liquid, tablet, powder, tablet, oil, wax, injection (ampoule), gel, etc. In addition, the carbodiimide compound and the biobonding component can be formulated into a single dosage form in the form of a gel or two separate dosage forms. In addition, a method can be used to form a derivative in which the reactive functional group and the component having a biobonding function are combined by forming a gel and blocking moisture.

To enhance the bioadhesive effect of the functional group-bearing bioadhesive composition of the present invention, 2-hydrochloride ester oils such as dioctyl succinate, dioctyl adipate, and diethyl sebacate, as well as polyols, polyethylene glycol, propylene glycol, hexylene glycol, butylene glycol, and their isomers, glycerol, benzyl alcohol, ethoxydiethylene glycol, and their derivatives can be used. These solvents can enhance permeability into hair or skin and serve as solvents for poorly soluble substances. To enhance the activity-maintaining effect of the functional group-bearing bioadhesive component, diethyl sebacate, ethoxydiethylene glycol, bis-ethoxyethylene glycol cyclohexane, and 1,4-dicarboxylic acid esters are preferably used.

Specific types for implementation

The present invention will be described in detail below based on the following examples and experimental examples. However, the following examples and experimental examples are merely examples of the present invention, and the present invention is not limited to the following examples and experimental examples.

Examples 1 to 5 and Comparative Examples 1 to 2: Dyeing agent compositions

According to the compositions and amounts shown in Table 1 below, dye compositions of Examples 1-5 and Comparative Examples 1-2 were prepared. White yak hair and wool fibers (5 cm x 5 cm) with very similar protein compositions were immersed in 10 g of the prepared compositions. After reacting at 25°C for 10 minutes, the fibers were washed once with running water and once with shampoo, and then dried. The a* values (red) and b* values (blue) were measured and compared using a colorimeter to compare the initial dye amounts. The shampooing and rinsing steps were repeated 10 times for the identically treated yak hair and wool fibers, followed by drying. The a* and b* values were then measured and compared using a colorimeter to confirm the sustainability of the reaction. (Comparative Example 1 and Example 1 used yak hair, while Comparative Example 2 and Examples 3-5 used wool.)

Table 1

The experimental results of Examples 1 to 5 and Comparative Examples 1 and 2 (Table 2) show that compared to Comparative Examples 1 and 2, which used a dye that did not contain a carbodiimide as a dye with an unsubstituted bioreactive group, Example 1, which used a derivative with a substituted bioreactive group, was evaluated as having excellent dyeability and long-lasting properties. Examples 2 to 5, which were prepared by reacting a carbodiimide compound with a dye to produce a reactive dye, showed even better dyeability and long-lasting properties due to the formation of a covalent bond with the carbodiimide. In particular, Examples 4 and 5, which used the carbodiimide compound of Chemical Formula 2 in a polymer form, showed the best dyeability and long-lasting properties.

Table 2

FIG1 shows the dyeing state of the yak hair of Comparative Example 1 and Example 1 after dyeing under the above conditions and shampooing ten times.

FIG2 shows the dyeing states of the wool fibers of Example 4 and Example 5 dyed under the above conditions, after shampooing once and after shampooing ten times.

Examples 6 to 12 and Comparative Examples 3 to 5: Moisturizing Compositions

Moisturizing compositions for Examples 6-12 and Comparative Examples 3-5 were prepared according to the compositions and amounts shown in Table 3 below. 10g of each composition was applied to ten 5g bundles of hair. The hair was then left at room temperature for 30 minutes to induce a reaction. The hair was then rinsed once with running water, then shampooed once with a 15% aqueous sodium laureth sulfate (SLES) solution, and dried. This process was repeated once. The moisture content at 60°C was measured using a loss-on-drying scale on 1g of the hair. This washing and drying process with a 15% SLES solution was repeated ten times. The moisture content at 60°C on 1g of the hair was then measured using a loss-on-drying scale to confirm the durability of the moisturizing effect.

Table 3

The experimental results of Examples 6 to 12 and Comparative Examples 3 to 5 (Table 4) show that Example 6, which used a derivative with a substituted bioreactive group, was evaluated as having excellent moisturizing properties and long-lasting moisturizing effects, compared to Comparative Examples 3 to 5, which did not contain carbodiimide as a moisturizing component with an unsubstituted bioreactive group. Examples 7 to 12, which did not use a substituted bioreactive group but contained a carbodiimide, showed even better moisturizing properties and long-lasting moisturizing effects due to the formation of covalent bonds with the carbodiimide. In particular, Examples 10 to 12, which used a carbodiimide polymer, showed the best moisturizing properties and long-lasting moisturizing effects.

Table 4

Preparation Example 1: Preparation of Moisturizing Hair Conditioner

A conventional cosmetic preparation method was used to prepare moisturizing cosmetics according to the ingredients and contents shown in Table 5 below.

Table 5

Examples 13 to 19 and Comparative Examples 6 to 8: Care Compositions

Hair care compositions for Examples 13-19 and Comparative Examples 6-8 were prepared according to the compositions and amounts shown in Table 6 below. 10 g of each composition was applied to a 4 g section of hair. The hair was then left at room temperature for 30 minutes to induce a reaction. The hair was then washed once with running water and shampoo to compare the initial treatment effects. Subsequently, the hair was shampooed once daily, and the treatment effects after ten days were evaluated using a 5-point rating system (5: very good; 4: relatively good; 3: no change; 2: no effect; 1: no effect at all).

Table 6

The experimental results of Examples 13 to 19 and Comparative Examples 6 to 8 (Table 7) show that Example 13, which used a derivative with a substituted bioreactive group, was evaluated as having superior conditioning effect and long-lasting effect compared to Comparative Examples 6 to 8, which used a conditioning ingredient with an unsubstituted bioreactive group and did not contain a carbodiimide. Examples 14 to 19, which did not use a substituted bioreactive group but contained a carbodiimide, showed even better conditioning effect and long-lasting effect due to the formation of a covalent bond with the carbodiimide. In particular, Examples 17 to 19, which used a carbodiimide polymer, showed the best conditioning effect and long-lasting effect.

Table 7

Examples 20 to 26 and Comparative Examples 9 to 11: Care Compositions

Hair care compositions for Examples 20-26 and Comparative Examples 9-11 were prepared according to the compositions and amounts shown in Table 8 below. 10 g of each composition was applied to approximately 4 g of hair. The hair was then left at room temperature for 30 minutes to induce a reaction. The hair was then washed once with running water and shampoo to compare the initial treatment effects. Subsequently, the hair was shampooed once daily, and the treatment effects after ten days were evaluated using a 5-point rating system (5: very good; 4: relatively good; 3: no change; 2: no effect; 1: no effect at all).

Table 8

The experimental results of Examples 20 to 26 and Comparative Examples 9 to 11 (Table 9) show that Example 20, which used a derivative with a substituted bioreactive group as a care component, was evaluated as having superior care effect and long-lasting effect compared to Comparative Examples 9 to 11, which did not contain carbodiimide as a care component with unsubstituted bioreactive groups. Examples 21 to 26, which did not have a substituted bioreactive group but contained a carbodiimide, showed even better care effect and long-lasting effect due to the formation of covalent bonds with the carbodiimide. In particular, Examples 24 to 26, which used carbodiimide polymers, showed the best care effect and long-lasting care effect.

Table 9

Examples 27 to 30 and Comparative Examples 12 to 13: Care Compositions

Hair care compositions for Examples 27-30 and Comparative Examples 12-13 were prepared according to the compositions and amounts shown in Table 10 below. 10 g of each composition was applied to approximately 4 g of hair. The hair was then left at room temperature for 30 minutes to induce a reaction. The hair was then washed with running water and shampoo for the first time, and then washed twice daily for two days. The coating and swelling of the hair after drying were compared. Thereafter, the hair was shampooed once daily, and the coating and swelling effects after 15 days were evaluated using a 5-point rating system (5: very good; 4: relatively good; 3: no change; 2: no effect; 1: no effect at all).

Table 10

Experimental example

The experimental results of Examples 27 to 30 and Comparative Examples 12 and 13 (Table 11) show that compared with Comparative Examples 12 and 13, which did not contain carbodiimide but contained a polymer, Examples 27 to 30, which contained carbodiimide, exhibited a superior hair-swelling effect due to the formation of covalent bonds with the carbodiimide. In particular, Examples 29 and 30, which used a carbodiimide polymer, exhibited the most superior hair-swelling effect.

Table 11

Preparation Example 2: Preparation of hair products for hair conditioner

According to the conventional method for preparing hair products, products were prepared according to the ingredients and contents in Table 12 below.

Table 12

Examples 31 to 38 and Comparative Examples 14 to 17: Ultraviolet Blocking Compositions

According to the composition and content shown in Table 13 below, ultraviolet blocking compositions of Examples 31 to 38 and Comparative Examples 14 to 17 were prepared. 3 g of the composition prepared in each example was applied to the backs of ten test subjects, and the mixture was left at room temperature for 30 minutes to induce a reaction. The mixture was washed off with running water for the first time, then with soap, and dried. The mixture was applied twice a day, in the morning and in the afternoon. This process was repeated for two days. After five days, the applied part was irradiated with ultraviolet rays for 5 minutes every day for three consecutive days. The ultraviolet protection effect was evaluated according to a 5-point evaluation system to confirm that the ultraviolet protection substance maintained a long-term ultraviolet protection effect due to the biological reaction (5 points: very good; 4 points: relatively good; 3 points: no change; 2 points: no effect; 1 point: no effect at all).

Table 13

The experimental results of the above-mentioned Examples 31 to 38 and Comparative Examples 14 to 17 (Table 14) show that compared with Comparative Examples 14 to 17 that do not contain carbodiimide, Examples 31 to 38 containing carbodiimide show better ultraviolet blocking properties and sustainability due to the formation of covalent bonds of carbodiimide. In particular, Examples 35 to 38 using carbodiimide polymers show the best ultraviolet blocking properties and sustainability.

Table 14

Preparation Example: Preparation of UV-blocking Cosmetics

According to a conventional cosmetic preparation method, ultraviolet blocking cosmetics were prepared according to the ingredients and contents in Table 15.

Table 15

Examples 39 to 40 and Comparative Example 18: Composition for bioadhesion

Hair joining compositions of Examples 39 and 40 and Comparative Example 18 were prepared according to the compositions and amounts shown in Table 16 below. 3 g of each composition was applied to the forks of 20 split ends of hair. The hair was then left at room temperature for 30 minutes to induce a reaction. The hair was then washed off with running water and shampoo. This process was repeated twice daily for three consecutive days, and the number of hairs joined was compared.

Table 16

Examples 41-42 and Comparative Example 19: Composition for bioadhesion

Hair joining compositions of Examples 41 and 42 and Comparative Example 19 were prepared according to the compositions and amounts shown in Table 17 below. 3 g of the prepared composition (1 dose) was evenly applied to the forks of 20 split ends of hair. After washing with running water, 3 g of the prepared composition (2 doses) was evenly applied to the forks of the split ends of the hair. The hair was then left at room temperature for 30 minutes to induce a reaction. The hair was then washed off with running water and shampoo. This process was repeated twice daily for three consecutive days, and the number of hairs joined was compared.

Table 17

The experimental results of Examples 39 to 42 and Comparative Examples 18 and 19 (Table 18) show that compared to Comparative Example 18, which did not contain carbodiimide but contained ε-aminocaproic acid, Examples 39 to 40, which contained carbodiimide, formed covalent bonds with the carbodiimide, thereby exhibiting superior hair bonding effects. In particular, Example 40, which used a carbodiimide polymer, exhibited the most superior hair bonding effects.

Furthermore, when N-(4-carboxy-3-hydroxy-phenyl)maleimide having a carboxyl group and a maleimide group in its molecule was used, the same excellent hair bonding effect as in Examples 41 and 42 containing a carbodiimide compound was obtained.

FIG3 shows the state of hair before and after treatment with the above composition.

Table 18

Preparation Example 4: Preparation of cosmetics for body bonding

According to a conventional cosmetic preparation method, a cosmetic for body bonding was prepared according to the ingredients and contents shown in Table 19 below.

Table 19

Claims (37)

1. A dyeing composition comprising a carbodiimide compound and a dye, The carbodiimide compound is the carbodiimide compound represented by the following chemical formula 2. Chemical formula 2 In the above chemical formula 2, n is from 1 to 100, and m is from 1 to 100. 2. The dyeing composition according to claim 1, wherein the dye contains a carboxyl group or an amino group within its molecule. 3. The dyeing composition according to claim 1, wherein the dye is a natural dye or a synthetic dye. 4. The dyeing composition according to claim 3, wherein the natural dye is erythropurin, madder pigment, melanin, or a precursor of melanin. 5. The dyeing composition according to claim 3, wherein the synthetic dye is Red 3, Red 104, Red 105, Red 201, Red 202, Red 220, Red 230, Red 231, Red 232, Red 401, Red 405, Yellow 4, Yellow 202, Orange 207, Red 106, Red 213, Red 214, Red 215, Yellow 404, Yellow 405, Cyan 403, Disperse Blue 1, Disperse Orange 3, Disperse Black 9, HC Blue 2, HC Red 3, HC Yellow 5, or HC Red 1. 6. The dye composition according to claim 1, wherein the dye has functional groups capable of forming covalent bonds with protein residues on the surface of hair, skin, fibers or leather. 7. The staining composition according to claim 6, wherein the functional group forming a covalent bond with the protein is selected from one or more of the group consisting of carbodiimide, imine ester, aryl azide, diazomethane, hydroxymethylphosphorus, pentafluorophenyl ester, pyridine thiocyanate, alkoxyamine, acyl hydrazine, halogenated acetyl, azide, carbonate, aldehyde, aziridine, isocyanate, thiocyanate, epoxy compound, toluenesulfonate, succinimide, imidazole, imine, thiol, maleimide, vinyl sulfone, thioether, acrylonitrile, acrylic acid or methacrylate, disulfonate, and ketone. 8. The dye composition according to claim 1, wherein the carbodiimide compound is 0.001 to 10 parts by weight relative to 100 parts by weight of the total composition. 9. The dyeing composition according to claim 1, wherein the carbodiimide compound and the dye formulation are in a single dosage form in capsule form, or in a two-dosage form in which the carbodiimide compound and the dye are separately separated. 10. A moisturizing cosmetic composition comprising a carbodiimide compound and a moisturizing ingredient. The carbodiimide compound is the carbodiimide compound represented by the following chemical formula 2. Chemical formula 2 In the above chemical formula 2, n is from 1 to 100, and m is from 1 to 100. 11. The moisturizing cosmetic composition according to claim 10, wherein the moisturizing ingredient contains a carboxyl group or an amino group within its molecule. 12. The moisturizing cosmetic composition according to claim 10, wherein the moisturizing ingredient is selected from glycerin, propylene glycol, butylene glycol, dipropylene glycol, octyl ethylene glycol, diglycerin, methyl glucetol polyether, ethoxyethylene glycol, glycerol, diethoxydiethylene glycol pyrrolidone carboxylic acid, sodium lactate, sodium pyrrolidone carboxylic acid, mineral oil, petrolatum, lanolin, jojoba oil, olive oil, glycosphingolipids, phospholipids, lipid mixtures, isononyl isononanoate, betaine, carboxymethyl chitosan, ceramide, glucosamine polysaccharide, α-glucan, hyaluronic acid, hydrolyzed hyaluronic acid, chitosan, deacetylated chitosan succinate, vitamin E, urea, hydroxyethyl urea, glucosides, γ-PGA, xylitol, pentaerythritol tetraisostearate, chondroitin sulfate sodium, chondroitin 4-sulfate, telogen collagen, β-glucan, PEG, pyridoxine. The group consisting of one or more of the following: tri-hexyldecanoate, potassium pyrrolidone carboxylate, sodium polygamma-glutamate, glyceryl polyacrylate, pine polysaccharide, polyglycerol-3 cross-linked copolymer, sodium hyaluronate, bis-PEG-18 methyl ether dimethylsilane, bis-ethoxydiethylene glycol succinate, ascorbic acid tetraisopalmitate, glycosyl trehalose, hydrogenated starch hydrolysate, 1,2-hexanediol, mannitol, arginine, serine, sucrose, PCA, citrulline, glycogen, histidine hydrochloride, alanine, threonine, glutamic acid, lysine hydrochloride, phosphate-buffered saline, creatine, cholesterol isostearate, cholesterol chloride, cholesterol nonanoate, BHT, sodium bis(lauramide-glutamine)lysine, maltodextrin, polyquaternium-39, cholecalciferol PEG-12 ester, saccharide isomers, sorbitol, and derivatives thereof. 13. The moisturizing cosmetic composition according to claim 10, wherein the moisturizing ingredient has functional groups capable of forming covalent bonds with protein residues on the surface of hair or skin. 14. The moisturizing cosmetic composition according to claim 13, wherein the functional group forming a covalent bond with the protein is selected from one or more of the group consisting of carbodiimide, imine ester, aryl azide, diazomethane, hydroxymethylphosphorus, pentafluorophenyl ester, pyridine thiocyanate, alkoxyamine, acyl hydrazine, halogenated acetyl, azide, carbonate, aldehyde, aziridine, isocyanate, thiocyanate, epoxy compound, toluenesulfonate, succinimide, imidazole, imine, thiol, maleimide, vinyl sulfone, thioether, acrylonitrile, acrylic acid or methacrylate, disulfonate, and ketone. 15. The moisturizing cosmetic composition according to claim 10, wherein the carbodiimide compound is 0.001 to 10 parts by weight relative to 100 parts by weight of the total composition. 16. The moisturizing cosmetic composition according to claim 10, wherein the carbodiimide compound and the moisturizing ingredient are formulated into a single dosage form in capsule form, or into a two-dosage form in which the carbodiimide compound and the moisturizing ingredient are separately separated. 17. A cosmetic composition for skincare, comprising a carbodiimide compound and skincare ingredients, The carbodiimide compound is the carbodiimide compound represented by the following chemical formula 2. Chemical formula 2 In the above chemical formula 2, n is from 1 to 100, and m is from 1 to 100. 18. The cosmetic composition for nursing use according to claim 17, wherein the nursing ingredient contains a carboxyl group or an amino group within its molecule. 19. The cosmetic composition for nursing use according to claim 17, wherein the nursing ingredient is selected from one or more of the group consisting of polymers, fatty amines, silicones, fatty alcohols, fatty acids, paraffins, ester oils, and their derivatives. 20. The cosmetic composition for care according to claim 17, wherein the care ingredient has functional groups capable of forming covalent bonds with protein residues on the surface of hair or skin. 21. The cosmetic composition for nursing use according to claim 20, wherein the functional group forming a covalent bond with the protein is selected from one or more of the group consisting of carbodiimide, imine ester, aryl azide, diazomethane, hydroxymethylphosphorus, pentafluorophenyl ester, pyridine thiocyanate, alkoxyamine, acyl hydrazine, halogenated acetyl, azide, carbonate, aldehyde, aziridine, isocyanate, thiocyanate, epoxy compound, toluenesulfonate, succinimide, imidazole, imine, thiol, maleimide, vinyl sulfone, thioether, acrylonitrile, acrylic acid or methacrylate, disulfonate, and ketone. 22. The cosmetic composition for nursing use according to claim 17, wherein the carbodiimide compound is 0.001 to 10 parts by weight relative to 100 parts by weight of the total composition. 23. The cosmetic composition for nursing use according to claim 17, wherein the carbodiimide compound and the nursing ingredient are formulated into a single dosage form in capsule form, or into a two-dosage form in which the carbodiimide compound and the nursing ingredient are separately separated. 24. A composition for blocking ultraviolet light, comprising a carbodiimide compound and an ultraviolet-blocking component, The carbodiimide compound is the carbodiimide compound represented by the following chemical formula 2. Chemical formula 2 In the above chemical formula 2, n is from 1 to 100, and m is from 1 to 100. 25. The composition for blocking ultraviolet light according to claim 24, wherein the ultraviolet-blocking component contains a carboxyl group or an amino group within the molecule. 26. The composition for blocking ultraviolet radiation according to claim 24, wherein the ultraviolet-blocking component is selected from cinnamic acid, glyceryl para-aminobenzoate, benzotriazolyl methylphenol, galloyl gallate trioleate, 3-(4-methylbenzylene)-camphor, anthranilate, benzophenone-3, benzophenone-4, benzophenone-8, butyl methoxybenzoylmethane, methoxymethylethyl ester, adenine nucleoside, octyl cyanadiene acrylate, octyl dimethyl para-aminobenzoic acid, octyl methoxycinnamate, octyl salicylate, octyl... One or more of the following groups: triazine ketone, p-aminobenzoic acid, 2-benzimidazole-5-sulfonic acid, trimethylcyclohexyl salicylate, zinc oxide, titanium dioxide, isopentyl-p-methoxycinnamate, bis-ethylhexyloxyphenol methoxyphenyl triazine, sodium salt of phenylene diphenylimidazolium sulfonate, amodi-cresoltrazol trisiloxane, diethylhexylbutamidotriazine ketone, polysiloxane-15 (benzylidene malonate polysiloxane), methylenebisbenzotriazole tetramethylbutylphenol, terephthalimide dicamphor sulfonic acid and their salts. 27. The composition for blocking ultraviolet light according to claim 24, wherein the ultraviolet-blocking component has functional groups capable of forming covalent bonds with protein residues on the surface of hair, skin or fibers. 28. The composition for blocking ultraviolet radiation according to claim 27, wherein the functional group forming a covalent bond with the protein is selected from one or more of the group consisting of carbodiimide, imine ester, aryl azide, diazomethane, hydroxymethylphosphorus, pentafluorophenyl ester, pyridine thiocyanate, alkoxyamine, acylhydrazine, halogenated acetyl, azide, carbonate, aldehyde, aziridine, isocyanate, thiocyanate, epoxy compound, toluenesulfonate, succinimide, imidazole, imine, thiol, maleimide, vinyl sulfone, thioether, acrylonitrile, acrylic acid or methacrylate, disulfonate, and ketone. 29. The composition for blocking ultraviolet radiation according to claim 24, wherein the carbodiimide compound is 0.001 to 10 parts by weight relative to 100 parts by weight of the total composition. 30. The composition for blocking ultraviolet radiation according to claim 24, wherein the above-mentioned carbodiimide compound and the ultraviolet blocking component are formulated into a single dosage form in capsule form, or into a two-dosage form in which the carbodiimide compound and the ultraviolet blocking component are separately separated. 31. A composition for bioconjugation, comprising a carbodiimide compound and a bioconjugation component, The carbodiimide compound is the carbodiimide compound represented by the following chemical formula 2. Chemical formula 2 In the above chemical formula 2, n is from 1 to 100, and m is from 1 to 100. 32. The bio-conjugation composition according to claim 31, wherein the bio-conjugation component contains a carboxyl group or an amino group within its molecule. 33. The bio-binding composition according to claim 31, wherein the bio-binding component is selected from one or more of the group consisting of fibrin, albumin, glucosamine, n-acetylglucosamine, alginate, hydrogel, growth factor, physiologically active factor, necrotic tissue remover, cross-linking agent, and antimicrobial coating agent. 34. The bio-binding composition according to claim 31, wherein the bio-binding component has functional groups capable of forming covalent bonds with protein residues on the surface of hair or skin. 35. The bioconjugation composition according to claim 34, wherein the functional group forming a covalent bond with the protein is selected from one or more of the group consisting of carbodiimide, imine ester, aryl azide, diazomethane, hydroxymethylphosphorus, pentafluorophenyl ester, pyridine thiocyanate, alkoxyamine, acylhydrazine, halogenated acetyl, azide, carbonate, aldehyde, aziridine, isocyanate, thiocyanate, epoxy compound, toluenesulfonate, succinimide, imidazole, imine, thiol, maleimide, vinyl sulfone, thioether, acrylonitrile, acrylic acid or methacrylate, disulfonate, and ketone. 36. The bioconjugation composition according to claim 31, wherein the carbodiimide compound is 0.001 to 10 parts by weight relative to 100 parts by weight of the total composition. 37. The bioconjugation composition according to claim 31, wherein the carbodiimide compound and the bioconjugation component are formulated into a single dosage form in gel form, or into a two dosage form in which the carbodiimide compound and the bioconjugation component are separately separated.