HK1261649A1 - Anti-allergic cosmetic composition - Google Patents

Description

Cosmetic composition for resisting skin allergy

Technical Field

The present invention belongs to the field of cosmetics, and more particularly, to an anti-skin allergy cosmetic composition having a mast cell protecting effect, which comprises a combination of D-panthenol, allantoin, and oat kernel extract, and ingredients commonly used in cosmetic compositions.

Background

As a result of environmental deterioration, increased living and working pressures, and excessive skin cleansing, more and more of the human skin barrier is compromised and inflammatory symptoms such as erythema, itching, stinging begin to appear. At the same time, improper use of cosmetics exacerbates these symptoms. Therefore, cosmetics with obvious anti-inflammatory effect, safety and no adverse reaction are urgently needed to achieve the purpose of relieving allergic symptoms.

Mast cells are widely distributed around the microvasculature under the skin and visceral mucosa and contain within their cells specific cytoplasmic granules in which inflammatory mediators are stored. It has been suggested that mast cells drive immediate allergic reactions and are involved in the progression of various allergic diseases. In the diseased tissue of atopic dermatitis and the like, the increase in the number of mast cells and degranulation are common pathological phenomena. In allergic contact dermatitis, mast cells are involved in the activation and migration of antigen presenting cells, and substances released by degranulation of the mast cells mediate the progress of the initial stage of inflammation. Mast cells express a large number of lgE Fc receptors on their surface, and in immediate allergy, antigen re-invasion upon binding to Fc receptors rapidly triggers mast cells to release inflammatory mediators and initiate an inflammatory signaling cascade. Mast cells release inflammatory mediators such as histamine, tryptase, etc. extracellularly, a process known as degranulation. The release of inflammatory mediators directly mediates a series of immunoinflammatory responses elicited by mast cells.

In current cosmetics, there is a lack of anti-inflammatory soothing products that are effective in protecting mast cells and inhibiting the release of inflammatory mediators. Therefore, in order to overcome the defects of the existing products, the product which can protect mast cells, relieve and resist inflammation and relieve skin allergy needs to be provided.

Disclosure of Invention

In one aspect, the invention relates to the use of a combination of D-panthenol, allantoin and oat kernel extract to protect mast cells against skin irritation.

In yet another aspect, the present invention provides an anti-skin allergy cosmetic composition having mast cell protecting effect comprising a combination of D-panthenol, allantoin and oat kernel extract, and ingredients commonly used in cosmetic compositions.

In yet another aspect, the present invention is a cosmetic method of combating skin allergy comprising applying to the skin a cosmetic composition comprising a combination of D-panthenol, allantoin, and oat kernel extract, and ingredients commonly used in cosmetic compositions.

The cosmetic composition for resisting skin allergy can repair fragile skin, strengthen skin barrier, effectively protect mast cells and inhibit the release of inflammation mediums, so that the cosmetic composition has good anti-inflammatory and relieving effects. The combination of the anti-skin allergy cosmetic composition according to the invention comprising D-panthenol, allantoin and oat kernel extract provides significantly improved mast cell protection and anti-inflammatory soothing efficacy compared to the individual components used alone or compared to the use of conventional anti-inflammatory substances, indicating a synergistic or synergistic effect of the components of the combination.

The D-panthenol, also called vitamin B5, can be converted into pantothenic acid after being absorbed by skin for a long time, and is organized to synthesize coenzyme A, which can be present in tissues and is necessary for metabolism of cell substances, so that the vitamin B5 can improve cell activity, repair damaged skin and enhance the barrier function of skin after being used for a long time. D-panthenol used in the present invention is commercially available, for example, from suppliers such as DSM.

The D-panthenol may be present in the cosmetic composition in an amount of about 0.02 to 3%, preferably about 0.05 to 2%, more preferably about 0.1 to 1%, based on the total weight of the cosmetic composition.

The allantoin can enhance the water absorption capacity of the outermost layer of the skin, improve the hydrophilic power of stratum corneum protein, repair the damaged stratum corneum and restore the natural hydrophilic capacity of the stratum corneum. Allantoin for use in the present invention is commercially available, for example, from a supplier such as Clariant.

The allantoin may be present in the cosmetic composition in an amount of about 0.01 to 1.5%, preferably about 0.03 to 1%, more preferably about 0.05 to 0.5%, based on the total weight of the cosmetic composition.

The oat kernel extract can promote the growth of fibroblasts, inhibit the degradation of hyaluronic acid in skin and promote the synthesis of hyaluronic acid; on the other hand, the composition also has the characteristics of anti-irritation, anti-histamine, UV erythema alleviation and the like. The oat kernel extract employed in the present invention is a pale yellow clear liquid, the main component of which is an avenanthramide benzoic acid, which can be obtained using known extraction techniques, e.g., it can be obtained using a water and polyol system. The oat kernel extract is commercially available, for example from the supplier Symrise et al.

The oat kernel extract may be present in the cosmetic composition in an amount of about 0.2-5%, preferably about 0.5-4%, more preferably about 1-3%, based on the total weight of the cosmetic composition.

The anti-skin allergy cosmetic composition of the present invention further comprises ingredients commonly used in cosmetics, examples of which include, but are not limited to, any ingredients known in the art, such as active ingredients, vehicles, surfactants, and adjuvants, which are known to those skilled in the art, and the type and amount thereof may be specifically selected as needed.

The active ingredient is any active known and commonly used in the art, including, for example, emollients, moisturizers, skin conditioners, and the like.

Examples of such emollients include, but are not limited to, one or more of tri (ethyl hexanoate), caprylic/capric triglyceride, shea butter, cetyl alcohol, dimethicone, pentaerythritol tetra (ethyl hexanoate), olive oil, grape seed oil, meadowfoam seed oil, avocado oil, corn oil, squalane, dioctyl carbonate, isopropyl myristate, hydrogenated polydecene, sunflower seed oil, isohexadecane, jojoba seed oil, lanolin, paraffin, microcrystalline wax, beeswax and the like. In the compositions of the present invention, the emollient constitutes about 1-50% of the total weight of the usual ingredients.

Examples of such humectants include, but are not limited to, one or more of birch juice, glycerol, betaine, glyceryl polyether-26, trehalose, sucrose, propylene glycol, 1, 2-pentanediol, mannitol, rhamnose, raffinose, erythritol, xylitol, urea, polyethylene glycol-8, polyethylene glycol-32, methyl gluceth-10, methyl gluceth-20, PEG/PPG-17/6 copolymer, sodium polyglutamate, hydrolyzed sclerotium rolfsii gum, pullulan, tremella polysaccharide, sodium polyglutamate, glyceryl glucoside, PPG-10 methyl glucose ether, PPG-20 methyl glucose ether, and the like. In the compositions of the present invention, the humectant constitutes from about 1% to about 95% of the total weight of the conventional ingredients.

Examples of such vehicles include, but are not limited to, diluents, dispersants or carriers, and the like, all of which are known in the art, and the type and amount thereof can be selected as desired by those skilled in the art, and examples thereof include, but are not limited to, water, ethanol, dipropylene glycol, butylene glycol, and the like. In the compositions of the present invention, the vehicle comprises about 1-20% of the total weight of the usual ingredients.

The skin conditioner may be any kind known in the art, which has moisturizing, anti-wrinkle, spot-removing, acne-removing, oil-controlling, etc. effects. Examples of such skin conditioning agents include, but are not limited to, one or more of phytosterol/octyldodecanol lauroyl glutamate, hydrolyzed sodium hyaluronate, acetyl phytosphingosine, turmeric root extract, ceramide 2, ceramide 3, cholesterol, kojic acid, ascorbic acid, ascorbyl glucoside, arbutin, tranexamic acid, niacinamide, birch bark extract, acetyl phytosphingosine, resveratrol, Pterocarpus marsupium bark extract, Coleus forskohlii root extract, pepper seed extract, ubiquinone, bisabolol, tetraisopalmitate ascorbate, pyridoxine dicaprylate, pyridoxine dipalmitate, retinol palmitate, and the like. Typically, in the cosmetic compositions of the present invention, the skin conditioning agent comprises from about 0.05% to about 50% by weight of the total weight of the conventional ingredients.

The surfactant may be any type of surfactant commonly used in cosmetics for lowering the surface tension of the interface for the purpose of cleaning, emulsifying, stabilizing the system. For example, examples of the surfactant include, but are not limited to, fatty acid soaps (e.g., sodium laurate, sodium palmitate, etc.), higher alkyl sulfates (e.g., sodium lauryl sulfate, etc.), N-acyl sarcosines (e.g., sodium lauroyl sarcosinate, etc.), higher fatty acid amide sulfonates (e.g., sodium lauryl methyl taurate, etc.), alkylbenzene sulfonates, higher fatty acid ester sulfates (e.g., sodium hardened coconut fatty acid glycerol sulfate, etc.), N-acyl glutamates, lauryl dimethylaminoacetic acid betaine, alkyl betaines, amido betaines, sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate) One or more of glycerol polyglycerin fatty acid esters (e.g., glycerol mono erucate, glycerol sesquioleate, glycerol monostearate malate, etc.), PEG-fatty acid esters (e.g., PEG-distearate, ethylene glycol distearate, etc.), PEG-alkyl ethers (e.g., PEG-2-octyldodecyl ether, etc.), sucrose fatty acid esters, and the like. The surfactant is present in the compositions of the present invention in amounts known in the art, typically from about 0.05 to 50% by weight of the total weight of the usual ingredients.

Such adjuvants include, but are not limited to, emulsifiers, thickeners, preservatives, flavors, pH adjusters, and the like.

Examples of such emulsifiers include, but are not limited to, PEG-60 hydrogenated castor oil, glyceryl stearate/PEG-100 stearate, sorbitan olivate, steareth-21, PPG-13-decyltetraeth-24, cetearyl glucoside, polyglyceryl-10 stearate, polyglyceryl-10 myristate, polyglyceryl-10 dioleate, and the like. Typically, in the compositions of the present invention, the emulsifier comprises from 0.5 to 10% by weight of the total weight of the conventional ingredients.

Examples of such thickeners include, but are not limited to, carbomer, xanthan gum, SIMUGEL EG, acacia, polyethylene glycol-14M, polyethylene glycol-90M, succinoglycan, hydroxyethyl cellulose, hydroxypropyl cellulose, and the like. Typically, in the compositions of the present invention, the thickening agent comprises about 0.1 to 10% by weight of the total of the conventional ingredients.

Examples of such preservatives include, but are not limited to, methylparaben, propylparaben, phenoxyethanol, benzyl alcohol, phenylethyl alcohol, potassium sorbate, sodium benzoate, chlorphenesin, and the like, as well as other preservative synergists such as pentanediol, hexanediol, octanediol, p-hydroxyacetophenone, and the like. Typically, in the compositions of the present invention, the preservative comprises about 0.01 to 2% of the total weight of the commonly used ingredients.

Examples of such pH adjusters include, but are not limited to, citric acid, sodium citrate, arginine, sodium hydroxide, potassium hydroxide, and the like. The type and amount can be specifically selected by those skilled in the art as desired.

The cosmetic compositions of the present invention may be prepared by any suitable method known in the art. For example, the preparation can be carried out according to a process known in the art using a dissolving tank, an emulsifying pot, a disperser, a transfer pump, and the like, which are generally used in the cosmetic field.

For example, the water-soluble substance can be first put into the water-phase dissolving kettle, the oil-soluble substance can be put into the oil-phase dissolving kettle, and the two kettles are respectively heated to about 80 ℃, wherein, for the raw material which is easy to cake, the raw material can be pre-dispersed by a disperser; after the dissolution is finished, delivering the oil phase and the water phase into an emulsifying pot, and carrying out homogeneous emulsification for about 5-15 minutes; after emulsification is finished, cooling the temperature of the material body to normal temperature, optionally adding essence, preservative and the like, and adjusting the pH of the product as required; and after the relevant detection indexes are qualified, the products can be filled and delivered.

The above preparation processes are merely exemplary, and those skilled in the art can prepare various dosage forms such as spray, emulsion, ointment, cream or gel by increasing or decreasing or adjusting according to the dosage form requirement.

Examples

The present invention will be described in further detail with reference to examples. It should be understood that the specific embodiments described herein are merely illustrative of the technical solutions of the present invention and do not limit the scope of the present invention. All such substitutions and modifications will be apparent to those skilled in the art and are intended to be included within the scope of the present invention.

Example 1: preparation of an anti-allergic spray A

In this example, an anti-skin allergy spray a of the present invention having the following formulation was prepared.

The preparation process of the spray A is as follows:

(1) heating water to 80 deg.C, sequentially adding allantoin, glycerol, panthenol and betaine, mixing, stirring and dissolving;

(2) cooling the mixture to 40 deg.C, adding oat kernel extract, and discharging.

Spray a was obtained as a pale yellow clear liquid.

Example 2 (comparative): preparation of control sprays B, C, D and E

In this example, using a procedure similar to that described above, control sprays B, C, D and E were prepared having the following formulations, all of which did not contain a combination of panthenol, allantoin, and oat kernel extract. Wherein spray B is a colorless clear liquid and spray C, D, E is a pale yellow clear liquid.

Example 3 Effect of sprays A-E on allergic reaction to RBL-2H3 cells

The effect of the sprays A-E prepared above on cell allergy was tested according to the following method.

The experimental principle is as follows: compound 48/80 is a tool drug that causes a mast cell degranulation reaction by a mechanism that acts on the mast cell membrane, causing an increase in intracellular calcium ions that alter the amount of the second messengers cAMP and cGMP, resulting in degranulation of the mast cell and the release of histamine.

Experimental materials: the RBL-2H3 cell strain is provided by animal center of Zhejiang medical science institute; the test samples included the preparation of 5 sprays a-E as described above; the reagent comprises fetal calf serum, RPM1640 culture medium, table salt (mainly composed of sodium chloride, phosphate, calcium chloride, glucose, etc.), compound 48/80, and histamine Elisa kit.

The experimental steps are as follows:

the experimental results are as follows: the results of the experiments are summarized in table 1 below.

Table 1: cell model histamine release amount test results

The results of the above cell experiments show that spray a within the scope of the present invention significantly reduces the amount of histamine release compared to the control sprays B-E, which indicates that the combination of panthenol, allantoin and oat kernel extract has a synergistic or synergistic effect on the inhibition of histamine release.

Example 4 protective Effect of sprays A-E on mast cells in zebra fish juvenile Fish

The protective effect of the sprays A to E prepared as described above on the mast cells of the zebrafish larvae was tested according to the following method.

Experimental animals: 5dpf (days post fertilization) zebrafish

Experimental reagent: substance P (SP, molecular formula C63H98N18O13S) is a neuropeptide belonging to the tachykinin family. SP can induce the degranulation of mast cells, cause the rapid release of mediators such as histamine, tryptase and the like, and directly mediate a series of immune inflammatory reactions caused by the mast cells.

And (4) investigation indexes are as follows: tryptase release

Experimental samples: sprays a-E prepared as described above, and 60ug/ml ketotifen used as a positive control.

The experimental method comprises the following steps: wild type zebrafish embryos were collected and cultured in an incubator at 28.5 ℃ with E3buffer (containing 5mM NaCl, 0.17mM KCl, 0.33mM CaCl for juvenile fish culture)₂，0.33mM MgSO₄Water is used for supplementing to the final volume) to 5dpf (days post fertilization), liquid is changed every day, 5dpf zebra fish is randomly transferred into 48-hole cell culture plates according to the number of 10 tails per hole to be grouped into 4 multiple holes, and the grouping condition is as follows:

model group M_SP: pure water + 15. mu.g/ml SP

Positive group T_SP: 60ug/ml ketotifen +15 ug/ml SP

Sample group X to be tested_SP: spray sample to be tested + 15. mu.g/ml SP

Wherein, the positive medicament ketotifen is firstly prepared into mother solution by DMSO and stored at-20 ℃, and pure water is used for preparing 60 mug/ml working solution during the test.

Correspondingly to each group added with SP degranulation, 4 groups of negative control groups without SP are additionally arranged, and each group is provided with multiple holes; setting a background control group (not containing zebra fish juvenile fish) corresponding to an SP degranulation induction group and a SP-free negative control group, carrying out two-hole reaction on each group, sucking up E3buffer participating in each group of holes, adding 250 ul of solution corresponding to each group, carrying out dark reaction in an incubator at 28.5 ℃ for 60min, taking 200 ul of supernatant of each group into a 96-hole cell culture plate after 60min, respectively adding an enzyme reaction substrate BAPNA (trypsin substrate) to enable the concentration to reach 400 ug/ml, covering the 96-hole plate in the incubator at 28.5 ℃ in a dark manner, carrying out reaction for 2h, measuring the light absorption value of the whole plate at 405nm after 2h, wherein the numerical value reflects the release condition of trypsin-like enzyme in the zebra fish mast cells, and calculating the protection rate of the mast cells to be measured according to the following formula:

the mast cell protection rate of the sample to be tested is [ [ (M)_sp-M_sp.bg)-(RO-RO_bg)]-[(X_sp-X_sp.bg)-(X-X_bg)]/(M_sp-M_sp.bg)-(RO-RO_bg)*100％

Wherein:

M_sp-M_sp.bgrepresenting the absorbance of the SP degranulation induction group (namely the model group) minus the absorbance of the corresponding background control group (not containing the zebra fish juvenile fish);

RO-RO_bgrepresenting the absorbance of the ultra-clean water group without SP (namely, the negative control group of the model group) minus the absorbance of the corresponding background control group;

X_sp-X_sp.bgrepresenting the absorbance of the sample group induced by adding SP degranulation minus the absorbance of the corresponding background control group;

X-X_bgsample group without SP additionAbsorbance was subtracted from its corresponding background control absorbance.

The results of the experiments are summarized in table 2 below.

TABLE 2 Zebra fish juvenile fish mast cell protection model efficacy experimental results

Note: p <0.05, p <0.01 (compared to model group); the mast cell protection rate is 100% when it is greater than 100%, and 0 when it is less than 0.

The results in table 2 show that spray a within the scope of the invention has significantly improved mast cell protection compared to the model and control sprays B-E, indicating that the combination of oat kernel extract, panthenol, allantoin has a synergistic effect in protecting mast cell degranulation.

Example 5 anti-inflammatory efficacy of sprays A-E in mouse models

The anti-inflammatory efficacy of sprays a-E in a mouse model was tested according to the following method.

Irritant contact dermatitis test

Irritant Contact Dermatitis (ICD) is due to the strong irritability (e.g., strong acids and bases) or toxicity of the contact itself. The histopathology of the human body is characterized by vasodilatation and plasma exudation, and leukocytes in blood infiltrate into local tissues to cause inflammatory reaction. ICD is generally considered to be a non-immune inflammatory response. According to the experimental model scheme, a chemical reagent is used for stimulating naked skin (10% sodium dodecyl sulfate and SDS) of the abdomen of a mouse to cause damage of the skin barrier and aggravate local inflammatory reaction of the skin, and whether the model is established or not is determined through an inflammatory factor index to be used for a later-stage anti-inflammatory efficacy evaluation experiment.

Experimental animals: ICR mice, 20-25g, male.

Experimental materials: 10% sodium dodecyl sulfate solution (SDS), 1% hydrocortisone ointment, depilatory cream.

The experimental method comprises the following steps: ICR mice were randomly grouped by weight, 12 mice per group, normal group, model group, positive group, and each spray test group. The skin hair was removed from the abdomen of each group of mice in an area of about 2 x 2cm by depilatory cream 1d before molding. Wherein the model group, the positive group and each test group are as follows: on the day of modeling, 50 mu L of 10% sodium dodecyl sulfate solution is sucked by a pipette gun and evenly smeared on the bare skin of the abdomen of the mouse for 5 days continuously. After molding: the positive group is smeared on the skin with 1% hydrocortisone ointment for 3 times a day for 2 days; the model set is not processed. The solutions of each test group were administered in the same manner as the positive group. The normal group mice were treated with the same method except that the abdominal mice were deprived of fur and raised for 7 days before control. On the 7 th day of the experiment, the skin condition of each group of experimental mice was observed, and the serum of the mice was taken to determine the content of the inflammatory factor IL-1 a.

And (4) investigation indexes are as follows: and (3) measuring the content of the inflammatory factor IL-1a in serum.

Specification of indexes: acute barrier function disruption can cause MyD pathway activation, with increased synthesis of the inflammatory factor IL-1a downstream of it, a response that is repeatedly observed in skin inflammatory states. The experiment mainly compares a model group, a positive group and a normal group, observes the feasibility of irritant dermatitis caused by a chemical reagent of 10 percent SDS, and carries out treatment verification by using a positive drug of hydrocortisone.

Allergic contact dermatitis test

The cosmetic allergy refers to cosmetic allergic contact dermatitis, and the number of people is up to 30.0-46.2% of the cosmetic dermatitis. Cosmetic allergic contact dermatitis tends to be more severe than irritant reactions, and cross-allergic reactions also occur, and treatment is relatively difficult. We therefore established an allergic contact dermatitis model (ACD) in mice using 2, 4-Dinitrofluorobenzene (DNFB) sensitization and challenge, and given a 1% hydrocortisone ointment as a positive control, and performed test group efficacy evaluation experiments.

Experimental animals: ICR mice, 20-25g, male.

Experimental materials: DNFB acetone in olive oil (4:1), hydrocortisone ointment (1%), depilatory cream.

The experimental method comprises the following steps: ICR mice were randomly grouped by weight, 12 mice per group, normal group, model group, positive group, and each spray test group. The skin hair was removed from the abdomen of each group of experimental mice in an area of about 2 x 2cm by depilatory cream 1d before molding. On the day of model building, mice in the positive group and the test groups absorb 100 mu L of acetone olive oil solution containing 5% DNFB and evenly spread on the naked skin of the abdomen of the mice for sensitization, continuously spread for 2 days, and evenly spread 1% DNFB acetone olive oil solution 30 mu L per ear on the inner ear surface and the outer ear surface of the ears of the mice on the 5 th day for excitation, so as to establish the allergic contact dermatitis model of the mice. Normal mice were controlled by applying acetone olive oil solution (4:1) evenly to the abdomen and ears.

Administration was started 16 hours after challenge, and each test group was pipetted 30 ul/ear with a pipette and the inside and outside ear surfaces were smeared evenly with a cotton swab 1 time each day in the morning, at noon and at night for 2 days. The model groups were sprayed with distilled water and the positive groups were coated with a 1% hydrocortisone ointment. Blood was taken 4h after the last dose and sacrificed.

And (4) investigation indexes are as follows:

ear thickness index: measuring the thicknesses of two ears of the mouse after the death, and taking the average value of the thicknesses of the two ears;

ear weight index: after the sacrifice, respectively taking two ears of each experimental mouse by using a puncher (with the diameter of 8 mm), and weighing the total weight;

and (3) determination of inflammation indexes: and (3) taking mouse serum, and detecting the content of the inflammatory factor IFN-gamma in the mouse ear tissues by using an ELISA kit.

The indexes indicate that the imbalance of Th1/Th2 is an important link or initiating factor in the onset of allergic diseases, under normal conditions, Th1 cells and Th2 cells are in dynamic balance and mutually inhibit by secreting respective cytokines (Th1 type cytokines such as IFN-r, Th2 type cytokines such as IL-4), Th1 cells generate IFN-Y, TNF- α, IL-2 and the like to enable contact hypersensitivity to occur, and Th2 cells generate IL-4, IL-5, IL-10, IL-13 and the like to play a role in inhibiting contact hypersensitivity.

The results of the experiments are summarized in table 3 below.

Table 3: anti-inflammatory Effect testing on mouse model

The above results show that the anti-inflammatory effect of spray a within the scope of the invention is significantly better in each index than sprays B-E, which indicates that the combination of panthenol, allantoin and oat kernel extract has a synergistic effect on the relief of contact dermatitis in mice.

Example 6: preparation of anti-skin allergy toner

This example provides an anti-skin allergy toner composition having the following formulation:

the toner composition is prepared as follows:

1, heating the birch juice to 80 ℃, sequentially adding citric acid, panthenol, allantoin, 3 parts of glycerol, methylparaben, butanediol, pentanediol and betaine, mixing, and stirring to dissolve uniformly;

2, heating phytosterol/octyldodecanol lauroyl glutamate, glycerol tri (ethyl hexanoate), 2 parts of glycerol, glyceryl polyether-26 and PEG-60 hydrogenated castor oil to 80 ℃, uniformly stirring, and adding the mixture obtained in the step 1;

3, cooling to 40 ℃, adding the oat kernel extract and phenoxyethanol in turn, adjusting the pH value with arginine, and discharging.

The toner has excellent skin care effects of resisting sensitivity, relieving and the like.

Example 7: preparation of anti-skin allergy emulsion

This example provides an anti-skin allergy emulsion composition having the following formulation:

the anti-skin allergy emulsion composition is prepared as follows:

1, water phase: mixing water, glycerol, panthenol, allantoin, hydrolyzed sodium hyaluronate, dipropylene glycol, xanthan gum, carbomer and methyl hydroxybenzoate, heating to 80 deg.C, stirring and dissolving;

2, oil phase: cetyl alcohol, glyceryl stearate/PEG-100 stearate, caprylic/capric triglyceride, glyceryl tri (ethylhexanoate), shea butter. Heating the raw materials to 80 ℃, and uniformly stirring and dissolving;

3 mixing the water phase and the oil phase, homogenizing and emulsifying for 5min, adding water-soluble arginine after emulsification, stirring for 15min, cooling to 40 deg.C, and sequentially adding oat kernel extract and phenoxyethanol.

The emulsion has excellent skin care effects of resisting allergy, relieving and the like.

Example 8: preparation of anti-skin allergy face cream

This example provides an anti-skin allergy cream composition, which is formulated as follows:

the anti-skin allergy cream composition is prepared as follows:

1, water phase: water, glycerol, panthenol, allantoin, hydrolyzed sodium hyaluronate, glyceryl polyether-26, xanthan gum, carbomer, and methylparaben;

2, oil phase: cetyl alcohol, glyceryl caprylate/caprate, pentaerythritol tetra (ethyl hexanoate), glyceryl stearate/PEG-100 stearate, shea butter, dimethicone, propyl hydroxybenzoate. Heating the raw materials to 80 ℃, and uniformly stirring and dissolving;

3 mixing the water phase and the oil phase, homogenizing and emulsifying for 5min, adding water-soluble arginine after emulsification, stirring for 15min, cooling to 40 deg.C, and sequentially adding oat kernel extract, phenoxyethanol, and caprylyl glycol.

The cream has excellent skin care effects of resisting sensitivity, relieving and the like.

The above-described embodiments are preferred embodiments of the present invention, and in addition, the soothing and anti-sensitivity composition of the present invention can be applied to various cosmetics such as essence, BB cream, sunscreen cream, etc., and several modifications and changes can be made without departing from the principle of the present invention, and these modifications and changes should be considered to be within the scope of the present invention.

Claims (7)

1. Use of a combination of D-panthenol, allantoin and oat kernel extract to protect mast cells against skin irritations.
2. 2. An anti-skin allergy cosmetic composition comprises a combination of D-panthenol, allantoin and oat kernel extract, and ingredients commonly used in cosmetic compositions.
3. 3. The cosmetic composition of claim 2 wherein said D-panthenol is present in an amount of about 0.02-3%, said allantoin is present in an amount of about 0.01-1.5%, and said oat kernel extract is present in an amount of about 0.2-5%, based on the total weight of said cosmetic composition.
4. 4. The cosmetic composition of claim 3 wherein said D-panthenol is present in an amount of about 0.05-2%, said allantoin is present in an amount of about 0.03-1%, and said oat kernel extract is present in an amount of about 0.5-4%.
5. 5. An anti-skin allergy cosmetic method comprising applying to the skin a cosmetic composition comprising a combination of D-panthenol, allantoin and oat kernel extract, together with ingredients commonly used in cosmetic compositions.
6. 6. The cosmetic method of claim 5 wherein said D-panthenol is present in an amount of about 0.02-3%, said allantoin is present in an amount of about 0.01-1.5%, and said oat kernel extract is present in an amount of about 0.2-5%, based on the total weight of the cosmetic composition.
7. 7. The cosmetic method of claim 6 wherein said D-panthenol is present in an amount of about 0.05-2%, said allantoin is present in an amount of about 0.03-1%, and said oat kernel extract is present in an amount of about 0.5-4%.