[go: up one dir, main page]

HK1260889B - 具有人源化的tmprss基因的啮齿类动物 - Google Patents

具有人源化的tmprss基因的啮齿类动物

Info

Publication number
HK1260889B
HK1260889B HK19120580.6A HK19120580A HK1260889B HK 1260889 B HK1260889 B HK 1260889B HK 19120580 A HK19120580 A HK 19120580A HK 1260889 B HK1260889 B HK 1260889B
Authority
HK
Hong Kong
Prior art keywords
gene
rodent
tmprss
human
humanized
Prior art date
Application number
HK19120580.6A
Other languages
German (de)
English (en)
French (fr)
Other versions
HK1260889A1 (zh
Inventor
Lisa Purcell Ngambo
Alexander O. Mujica
Yajun Tang
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of HK1260889A1 publication Critical patent/HK1260889A1/zh
Publication of HK1260889B publication Critical patent/HK1260889B/zh

Links

HK19120580.6A 2016-02-29 2017-02-27 具有人源化的tmprss基因的啮齿类动物 HK1260889B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62/301,023 2016-02-29

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
HK42022046510.8A Division HK40057446A (zh) 2016-02-29 2019-03-07 具有人源化的tmprss基因的啮齿类动物

Related Child Applications (1)

Application Number Title Priority Date Filing Date
HK42022046510.8A Addition HK40057446A (zh) 2016-02-29 2019-03-07 具有人源化的tmprss基因的啮齿类动物

Publications (2)

Publication Number Publication Date
HK1260889A1 HK1260889A1 (zh) 2019-12-20
HK1260889B true HK1260889B (zh) 2022-02-25

Family

ID=

Similar Documents

Publication Publication Date Title
EP3422845B1 (en) Rodents having a humanized tmprss gene
AU2025204753A1 (en) Humanized SIRPA-IL15 knockin mice and methods of use thereof
EP3507375B1 (en) Genetically modified non-human animal with human or chimeric ctla-4
WO2018041120A1 (en) Genetically modified non-human animal with human or chimeric tigit
JP2009504183A5 (zh)
WO2002052007A1 (en) Synovial membrane cell protein
KR20210005661A (ko) 변형된 아미노펩티다제 n(anpep) 유전자를 갖는 병원체-내성 동물
US20190328907A1 (en) Genetically Modified Non-Human Animal With Human Or Chimeric TIGIT
US20190373868A1 (en) Genetically modified non-human animal with human or chimeric pd-1
CN106413394A (zh) 人源化二肽基肽酶iv(dpp4)动物
US20250248377A1 (en) Non-human animals having a humanized tslp gene, a humanized tslp receptor gene, and/or a humanized il7ra gene
HK1260889B (zh) 具有人源化的tmprss基因的啮齿类动物
KR20030022762A (ko) Trp 유전자 파괴를 포함하는 형질전환 마우스
HK40057446A (zh) 具有人源化的tmprss基因的啮齿类动物
Min et al. Generation of antiviral transgenic chicken using spermatogonial stem cell transfected in vivo
US20250049006A1 (en) Non-human animals comprising humanized ace2 and tmprss loci
Stephan et al. Analysis of the Functional Interaction of Neurotrypsin and Agrin in the Murine Central Nervous System
WO2024026488A2 (en) Non-human animals comprising a modified transferrin receptor locus
CN113999873A (zh) 一种基因修饰的非人动物的构建方法及其应用
JP2010276505A (ja) 新規癌転移抑制剤の探索法