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HK1244789B - 制备稠合双环2，4-二氨基嘧啶衍生物的方法 - Google Patents

制备稠合双环2，4-二氨基嘧啶衍生物的方法 Download PDF

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Publication number
HK1244789B
HK1244789B HK18103195.7A HK18103195A HK1244789B HK 1244789 B HK1244789 B HK 1244789B HK 18103195 A HK18103195 A HK 18103195A HK 1244789 B HK1244789 B HK 1244789B
Authority
HK
Hong Kong
Prior art keywords
compound
cep
minutes
methods
formula
Prior art date
Application number
HK18103195.7A
Other languages
German (de)
English (en)
French (fr)
Other versions
HK1244789A1 (zh
Inventor
P. ALLWEIN Shawn
P. BAKALE Roger
R. MOWREY Dale
E. Petrillo Daniel
KLUWER Sander
Original Assignee
Cephalon, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon, Inc. filed Critical Cephalon, Inc.
Publication of HK1244789A1 publication Critical patent/HK1244789A1/zh
Publication of HK1244789B publication Critical patent/HK1244789B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK18103195.7A 2014-12-23 2015-12-23 制备稠合双环2，4-二氨基嘧啶衍生物的方法 HK1244789B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462095861P 2014-12-23 2014-12-23
US62/095,861 2014-12-23
PCT/US2015/000301 WO2016105529A1 (en) 2014-12-23 2015-12-23 Methods for preparing fused bicyclic 2, 4-diaminopyrimidine derivatives

Publications (2)

Publication Number Publication Date
HK1244789A1 HK1244789A1 (zh) 2018-08-17
HK1244789B true HK1244789B (zh) 2019-12-06

Family

ID=55221488

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18103195.7A HK1244789B (zh) 2014-12-23 2015-12-23 制备稠合双环2，4-二氨基嘧啶衍生物的方法

Country Status (9)

Country Link
US (1) US10259794B2 (zh)
EP (1) EP3237408B1 (zh)
JP (1) JP6849594B2 (zh)
CA (1) CA2971415A1 (zh)
ES (1) ES2707123T3 (zh)
HK (1) HK1244789B (zh)
IL (1) IL252945B (zh)
MX (1) MX2017008430A (zh)
WO (1) WO2016105529A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE027976T2 (en) * 2012-03-06 2016-11-28 Cephalon Inc Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor
ES2738493T3 (es) 2013-03-14 2020-01-23 Tolero Pharmaceuticals Inc Inhibidores de JAK2 y ALK2 y métodos para su uso
JP2021524835A (ja) 2018-04-05 2021-09-16 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド Ａｘｌキナーゼ阻害剤およびその使用
US11040038B2 (en) 2018-07-26 2021-06-22 Sumitomo Dainippon Pharma Oncology, Inc. Methods for treating diseases associated with abnormal ACVR1 expression and ACVR1 inhibitors for use in the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01149775A (ja) * 1987-12-07 1989-06-12 Kawaken Fine Chem Co Ltd 光学活性２−メチルピペラジンの製造方法
CN101679237A (zh) * 2007-05-03 2010-03-24 赛福伦公司 制备(r)-2-甲基吡咯烷和(s)-2-甲基吡咯烷及其酒石酸盐的方法
EP2062906A1 (en) 2007-11-22 2009-05-27 Universiteit van Amsterdam Coordination complex system comprising tautomeric ligands
HUE027976T2 (en) * 2012-03-06 2016-11-28 Cephalon Inc Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor

Also Published As

Publication number Publication date
JP2018507173A (ja) 2018-03-15
US10259794B2 (en) 2019-04-16
JP6849594B2 (ja) 2021-03-24
IL252945A0 (en) 2017-08-31
EP3237408A1 (en) 2017-11-01
CA2971415A1 (en) 2016-06-30
EP3237408B1 (en) 2018-10-31
IL252945B (en) 2020-05-31
US20170369451A1 (en) 2017-12-28
MX2017008430A (es) 2018-03-23
ES2707123T3 (es) 2019-04-02
WO2016105529A1 (en) 2016-06-30

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20241223